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H2O + L-tryptophan → pyruvate + ammonium + indole (R2069)
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L-tryptophan + H+ ↔ L-tryptophan + H+ (R00786)
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L-glutamine + chorismate ↔ anthranilate + pyruvate + H+ + L-glutamate (R10)
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Overexpression
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Feedback insensitive
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N-(5-phosphoribosyl)-anthranilate + diphosphate ↔ anthranilate + 5-phospho-α-D-ribose 1-diphosphate (R423)
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1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H+ → H2O + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 (R600)
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Overexpression
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Feed-forward insensitive
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N-(5-phosphoribosyl)-anthranilate → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate (R562)
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Overexpression
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Feed-forward insensitive
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L-serine + indole → H2O + L-tryptophan (R747)
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(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate ↔ D-glyceraldehyde 3-phosphate + indole (R503)
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NAD+ + 3-phospho-D-glycerate ↔ 3-phosphooxypyruvate + NADH + H+ (R51)
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Overexpression
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Feedback insensitive
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D-erythrose 4-phosphate + phosphoenolpyruvate + H2O ↔ 3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (R576)
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H2O + pyruvate + ATP ↔ H+ + phosphoenolpyruvate + phosphate + AMP (R346)
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D-erythrose 4-phosphate + D-xylulose 5-phosphate ↔ β-D-fructofuranose 6-phosphate + D-glyceraldehyde 3-phosphate (R372)
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D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate ↔ aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate (R584)
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pyruvate + ATP ↔ phosphoenolpyruvate + H+ + ADP (R345)
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phosphoenolpyruvate + β-D-glucopyranose → β-D-glucose 6-phosphate + pyruvate (R4216)
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D-Glucose + H+ → D-Glucose + H+ (R00800)
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ATP + D-Glucose → ADP + D-glucopyranose 6-phosphate + H+ (R00472)
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acetyl-CoA + phosphate ↔ coenzyme A + acetyl phosphate (R424)
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pyruvate + GTP ← phosphoenolpyruvate + H+ + GDP (R1153)
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H+ + phosphoenolpyruvate + UDP → pyruvate + UTP (R00861)
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phosphoenolpyruvate + CDP + H+ → pyruvate + CTP (R00862)
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phosphoenolpyruvate + dTDP + H+ → pyruvate + dTTP (R00863)
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ammonium + L-glutamate + ATP → H+ + L-glutamine + phosphate + ADP (R1195)
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Silencing
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Overexpression
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Feedback insensitive
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NADP+ + D-threo-isocitrate → NADPH + 2-oxoglutarate + CO2 (R384)
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H2O + NADP+ + L-glutamate ↔ NADPH + 2-oxoglutarate + H+ + ammonium (R1179)
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acetate + ATP ↔ acetyl phosphate + ADP (R45)
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H2O + pyruvate + ubiquinone-8 → acetate + ubiquinol-8 + CO2 (R4535)
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aldehydo-D-ribose 5-phosphate + ATP ↔ 5-phospho-α-D-ribose 1-diphosphate + H+ + AMP (R115)
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Overexpression
-
Feedback insensitive
-
NADH + NADP+ + H+ → NADPH + NAD+ + H+ (R427)
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coenzyme A + acetate + ATP ↔ acetyl-CoA + diphosphate + AMP (R1142)
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H2O + glyoxylate + acetyl-CoA ↔ coenzyme A + (S)-malate + H+ (R1258)
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(S)-malate + NAD+ ↔ NADH + H+ + oxaloacetate (R616)
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oxaloacetate + ATP ↔ phosphoenolpyruvate + ADP + CO2 (R569)
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phosphate + oxaloacetate ↔ phosphoenolpyruvate + hydrogencarbonate (R390)
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H2O + acetyl-CoA + oxaloacetate → coenzyme A + H+ + citrate (R92)
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shikimate + NADP+ ↔ 3-dehydroshikimate + NADPH + H+ (R607)
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shikimate + ATP ↔ shikimate 3-phosphate + H+ + ADP (R400)
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H2O + 3-phospho-L-serine → L-serine + phosphate (R429)
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2-oxoglutarate + 3-phospho-L-serine ↔ 3-phosphooxypyruvate + L-glutamate (R555)
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β-D-fructofuranose 6-phosphate + phosphate → D-erythrose 4-phosphate + acetyl phosphate + H2O (R2193)
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prephenate + H+ ↔ H2O + 3-phenyl-2-oxopropanoate + CO2 (R511)
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chorismate ↔ prephenate (R69)
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prephenate + NAD+ → NADH + 3-(4-hydroxyphenyl)pyruvate + CO2 (R727)
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citrate ↔ H2O + cis-aconitate (R131)
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H2O + cis-aconitate ↔ D-threo-isocitrate (R669)
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pyruvate + hydrogencarbonate + ATP → H+ + phosphate + oxaloacetate + ADP (R754)
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L-glutamate + NADP+ ← NADPH + 2-oxoglutarate + H+ + L-glutamine (R553)
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L-tryptophan → L-tryptophan (R00629)