Compound as reactive (2104)

NADPH + (E)-5-(methylsulfanyl)pentanal oxime + H⁺ + L-cysteine + oxygen → 2 H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-ω-(methylsulfanyl)pentan-1-imine + NADP⁺

H⁺ + L-glutamate → 4-aminobutanoate + CO₂

3-carboxy-8-(methylsulfanyl)-2-oxooctanoate + H⁺ → 8-(methylsulfanyl)-2-oxooctanoate + CO₂

NAD(P)H + H⁺ + (-)-phaseollin + oxygen → H₂O + NAD(P)+ + 1α-hydroxy-phaseollone

2 2,4,6-tribromophenol + 4 a reduced ferredoxin [iron-sulfur] cluster + 5 H⁺ + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 2,6-dibromo-4-(2,4,6-tribromophenoxy)phenol + bromide

H₂O + 2'-deoxycytidine + H⁺ → 2'-deoxyuridine + ammonium

NAD(P)H + H⁺ + oxygen + cytoglobosin D → 2 H₂O + NAD(P)+ + chaetoglobosin J

2 NADPH + 2 H⁺ + 2 oxygen + L-tryptophan → 2 NADP⁺ + 3 H₂O + (E)-(indol-3-yl)acetaldehyde oxime + CO₂

NADPH + H⁺ + 2-nonaprenylphenol + oxygen → H₂O + NADP⁺ + 2-(all-trans-nonaprenyl)benzene-1,4-diol

NADH + H⁺ + 1,3-dichlorobenzene + oxygen → NAD⁺ + (1R,2S)-3,5-dichlorocyclohexa-3,5-diene-1,2-diol

2 NADH + 2 H⁺ + 6-hydroxy-3-succinoyl-pyridine + oxygen → 2 NAD⁺ + H₂O + succinate semialdehyde + 2,5-dihydroxypyridine

H₂O + (2Z,4E)-2-aminomuconate + H⁺ → (3E)-2-oxohex-3-enedioate + ammonium

8 NAD(P)+ + 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate ← 8 NAD(P)H + 8 H⁺ + 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate

H₂O + H⁺ + gluconapin → 2-butenyl-thiohydroximate-O-sulfate + α-D-glucopyranose

(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + NADPH + H⁺ + oxygen → 2 H₂O + NADP⁺ + berbamunine

3 NADH + 3 H⁺ + nitrite → 2 OH^- + 3 NAD⁺ + ammonium

2 NADPH + 3 H⁺ + malonyl-CoA + stearidonoyl-CoA → 2 NADP⁺ + coenzyme A + H₂O + (8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA + CO₂

NADPH + H⁺ + oxygen + 20-hydroxy-prefusarin → H₂O + NADP⁺ + 20-hydroxy-13-14 epoxy-prefusarin

an oxidized electron donor + H⁺ + rifamycin W → a reduced electron donor + rifamycin W hemiacetal

2 an oxidized ferredoxin [iron-sulfur] cluster + mesobiliverdin ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (Z,Z)-biliverdin-IX α

N,N-dihydroxy-L-isoleucine + H⁺ → H₂O + (1E,2S)-2-methylbutanal oxime + CO₂

2-amino-5-chlorophenyl carbonate + H⁺ → 2-amino-5-chlorophenol + CO₂

2-oxoglutarate + H⁺ + oxygen + (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate → 2 CO₂ + H₂O + succinate + 3-[(E)-2-isocyanoethenyl]-1H-indole

H⁺ + trans-feruloyl-CoA + kaempferol 3-O-β-D-glucoside → coenzyme A + kaempferol 3-O-(6"-O-feruloyl)-glucoside

(S)-3-hydroxybutanoyl-CoA + NADP⁺ ← NADPH + acetoacetyl-CoA + H⁺

C37-phenolcarboxyphthiodiolenone + H⁺ → C36-phenolphthiodiolenone A + CO₂

salicylate + H⁺ → phenol + CO₂

4β-hydroxymethyl-4α-methyl-5α-cholesta-8-en-3β-ol + NADH + H⁺ + oxygen → 2 H₂O + 4β-formyl-4α-methyl-5α-cholesta-8-en-3β-ol + NAD⁺

NADH + H⁺ + oxygen + 2-hydroxycanthaxanthin → H₂O + NAD⁺ + 2,2'-dihydroxycanthaxanthin

H⁺ + 3-nonaprenyl-4-hydroxybenzoate → 2-nonaprenylphenol + CO₂

GDP-6-deoxy-4-keto-D-lyxo-heptose + NAD(P)H + H⁺ → GDP-6-deoxy-D-manno-heptose + NAD(P)+

2 H⁺ + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate → indole + sn-glycerol 3-phosphate

L-ornithine + H⁺ → putrescine + CO₂

2 NADPH + 2 H⁺ + 2 oxygen + (+)-epi-isozizaene → 2 NADP⁺ + 3 H₂O + albaflavenone

NADPH + H⁺ + versicolorone + oxygen → H₂O + NADP⁺ + versiconol acetate

2-(4-hydroxyphenyl)-2-oxoacetate + H⁺ → 4-hydroxybenzaldehyde + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-18:2-digalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-18:2-digalactosyldiacylglycerol

(E)-4-coumaroyl-CoA + H⁺ + cyanidin 3-O-β-D-sambubioside → coenzyme A + cyanidin 3-O-β-D-(p-coumaroyl)-sambubioside

NAD(P)+ + 5-chloro-3-oxoadipate ← 2-chloromaleylacetate + NAD(P)H + H⁺

H₂O + dimethyl sulfoxide + NAD⁺ ← NADH + dimethyl sulfone + H⁺

a tRNAtyr + H⁺ + L-tyrosine + ATP → an L-tyrosyl-[tRNAtyr] + diphosphate + AMP

H⁺ + CO₂ → formate

2 H⁺ + 3,6-dihydronicotinate → 1,2-dihydropyrimidine + CO₂

H₂O + H⁺ + melamine → ammonium + ammeline

(2R)-3-{[1-(5,6-dihydropyridin-2-yl)-2-hydroxy-2-{3-[(1E)-prop-1-en-1-yl]oxiran-2-yl}ethyl]sulfanyl}-2-acetamidopropanoate + H⁺ → N-[(3R)-6-(5,6-dihydropyridin-2-yl)-7-hydroxy-8-[(2E)-1-hydroxybut-2-en-1-yl]-2-oxo-1,5-oxathiocan-3-yl]acetamide

miltiradiene + NADPH + H⁺ + oxygen → 2 H₂O + abietatriene + NADP⁺

NADPH + 2-hydroxycyclohexan-1-one + H⁺ + oxygen → 6-hydroxyhexan-6-olide + H₂O + NADP⁺

NADPH + H⁺ + oxygen + notoamide E → H₂O + NADP⁺ + notoamide D

2 NADPH + 2 H⁺ + myristoyl-CoA → 2 NADP⁺ + coenzyme A + tetradecan-1-ol

NADPH + H⁺ + 2-decaprenylphenol + oxygen → H₂O + NADP⁺ + 3-(all-trans-decaprenyl)benzene-1,2-diol

H⁺ + malonyl-CoA + ricinoleoyl-CoA → coenzyme A + 3-oxo-lesqueroloyl-CoA + CO₂

2,2',3-trihydroxybiphenyl + NADH + H⁺ + oxygen → 2,2',3,3'-tetrahydroxybiphenyl + H₂O + NAD⁺

2 H⁺ + 2-methoxy-6-(all-trans-nonaprenyl)phenol + oxygen → H₂O + 2-methoxy-6-all trans-nonaprenyl-1,4-benzoquinol

pimeloyl-CoA + H⁺ + L-alanine → coenzyme A + 8-amino-7-oxononanoate + CO₂

2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H⁺ → 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO₂

L-dopa + H⁺ → dopamine + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2'-N-hydroxy-nocardicin c + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 2'-N,N-dihydroxy-nocardicin c

H⁺ + 4-hydroxybenzoate → phenol + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + narbomycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + pikromycin

a reduced electron donor + H⁺ + oxygen + 15-demethoxy-aclacinomycin A → an oxidized electron donor + H₂O + 10-decarboxymethyl, 10-hydroxyaclacinomycin A + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-oleoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-linoleoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol

4-nitrobenzyl alcohol + NADP⁺ ← 4-nitrobenzaldehyde + NADPH + H⁺

(2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H⁺ → (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + CO₂

an oxidized electron donor + pseudo-conhydrine ← a reduced electron donor + H⁺ + 5-hydroxy-γ-coniceine

2 NADPH + 2 S-adenosyl-L-methionine + 2 oxygen + 4-methylsalicylate + H⁺ + all-trans-hexaprenyl diphosphate → 2 H₂O + 2 S-adenosyl-L-homocysteine + 2 NADP⁺ + 3-demethylubiquinol-6 + diphosphate + CO₂

6 glycolate + H⁺ → 2 succinate + 2 CO₂ + 4 H₂O + acetate

H⁺ + 3-octaprenyl-4-hydroxybenzoate → 2-octaprenylphenol + CO₂

4-(methylsulfanyl)-2-oxobutanoate + H⁺ → 3-(methylsulfanyl)propanal + CO₂

quinolin-2-ol + NADH + H⁺ + oxygen → 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD⁺

L-ornithine + NADPH + 2-oxoglutarate + H⁺ → H₂O + ornaline + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + dihydrorhizobitoxine + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + rhizobitoxine

2 an oxidized electron donor + 3 H₂O + thiosulfate ← 2 a reduced electron donor + 2 sulfite + 3 H⁺

NADP⁺ + 4-hydroxybutanoate ← succinate semialdehyde + NADPH + H⁺

NADH + H⁺ + oxygen + 2-iodobenzoate → catechol + NAD⁺ + iodide + CO₂

17 NADPH + 17 H⁺ + 9 malonyl-CoA + acetyl-CoA → 10 coenzyme A + 17 NADP⁺ + 8 H₂O + 9 CO₂ + (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate

(R)-propane-1,2-diol + NADP⁺ ← NADPH + H⁺ + (R)-lactaldehyde

H⁺ + geranylgeranyl diphosphate + bacteriochlorophyllide b → diphosphate + geranylgeranyl bacteriochlorophyllide b

dTDP-L-pneumose + NAD⁺ ← NADH + dTDP-4-dehydro-β-L-rhamnose + H⁺

NADH + H⁺ + dimethyl sulfide + oxygen → H₂O + formaldehyde + methanethiol + NAD⁺

4,6-dihydroxy-2-(hydroxymethyl)-3,5-dimethylbenzoate + H⁺ → H₂O + 5,7-dihydroxy-4,6-dimethylphthalide

(S)-acetoin + NAD⁺ ← NADH + diacetyl + H⁺

H⁺ + L-lysine → cadaverine + CO₂

NADH + 2,6-dihydroxypyridine + H⁺ + oxygen → H₂O + 2,3,6-trihydroxypyridine + NAD⁺

H₂O + H⁺ + 2-iminopropanoate → pyruvate + ammonium

NAD⁺ + (3Z)-hex-3-en-1-ol ← NADH + (Z)-3-hexanal + H⁺

prenyl diphosphate + H⁺ + ATP → N⁶-(Δ²-isopentenyl)-adenosine 5'-triphosphate + diphosphate

H⁺ + 3-decaprenyl-4-hydroxybenzoate → 2-decaprenylphenol + CO₂

2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate ← H⁺ + 2,4-dichloro-cis,cis-muconate

2 H⁺ + H₂O + 3-ureidopropanoate → β-alanine + ammonium + CO₂

cholesterol + NADPH + H⁺ + oxygen → H₂O + (24S)-24-hydroxycholesterol + NADP⁺

NADP⁺ + cerotoyl-CoA ← NADPH + H⁺ + trans-cerot-2-enoyl-CoA

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-stearoyl-2-palmitoyl-glycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-oleoyl-2-palmitoyl-glycerol

D-glycero-β-D-manno-heptose 1-phosphate + H⁺ + ATP → ADP-D-glycero-β-D-manno-heptose + diphosphate

3 H⁺ + chlorophyll a → Mg²⁺ + pheophytin a

2,3,5,6-tetrachlorohydroquinone + H⁺ + glutathione → 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone + chloride

NADPH + H⁺ + dimethyl sulfide + oxygen → H₂O + dimethyl sulfoxide + NADP⁺

2-oxoglutarate + H⁺ + chloride + oxygen + ambiguine I → H₂O + succinate + ambiguine E + CO₂

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + demethylspheroidene → 3 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + demethylspheroidenone

3 H⁺ + 3 malonyl-CoA + acetyl-CoA + 1,4,5-trihydroxy-Δ^2,3-protoilludene → 3 CO₂ + 4 coenzyme A + H₂O + melleolide F

H⁺ + trans-caffeoyl-CoA + cyanidin 3-O-β-D-sambubioside → coenzyme A + cyanidin 3-O-β-D-(caffeoyl)-sambubioside

NADPH + H⁺ + UDP-α-D-glucose → H₂O + NADP⁺ + UDP-β-L-rhamnose

NADH + H⁺ + oxygen + benzoate → 3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD⁺

H₂O + NADP⁺ + D-lysopine ← NADPH + pyruvate + H⁺ + L-lysine

3 H₂O + 3 NADP⁺ + hydrogen sulfide ← 3 NADPH + 5 H⁺ + sulfite

H₂O + 3,5-dihydro-4H-imidazol-4-one + H⁺ → N-formimino-glycine

2 hydrogen peroxide + 2 chloride + H⁺ + sulochrin → 4 H₂O + dihydrogeodin

H⁺ + 3,6,8-trimethyl-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline → S-(+)-3,6,8-trimethylallantoin + CO₂

dTDP-β-D-oliose + NADP⁺ ← NADPH + dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + cholesterol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + (25R)-26-hydroxycholesterol + H₂O

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + spirilloxanthin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2-hydroxyspirilloxanthin + H₂O

H⁺ + 6α-hydroxy-germacra-1(10),4,11(13)-trien-12-oate → H₂O + (+)-costunolide (12,6α)

H⁺ + betalamate + leucodopachrome → H₂O + betanidin

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + pikromycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + novapikromycin

NADH + dibenzo-p-dioxin + H⁺ + oxygen → 4,4a-dihydroxy-dihydro-dibenzo-p-dioxin + NAD⁺

H⁺ + meso-diaminopimelate → L-lysine + CO₂

H⁺ + oxygen + dihydrochelerythrine → hydrogen peroxide + chelerythrine

H₂O + hydroxyatrazine + H⁺ → N-isopropylammelide + ethylamine

2 H⁺ + 6-hydroxynicotinate + NADH + oxygen → H₂O + 2,5-dihydroxypyridine + NAD⁺ + CO₂

H⁺ + 1,3-dicarboxyurea → urea-1-carboxylate + CO₂

2 an oxidized ferredoxin [iron-sulfur] cluster + 5-methyltetrahydropteroyl mono-L-glutamate ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 5,10-methylenetetrahydropteroyl mono-L-glutamate

4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + H⁺ → H₂O + 1,4-dihydroxy-2-naphthoyl-CoA

3-iodo-L-tyrosine + NADP⁺ + iodide ← 3,5-diiodo-L-tyrosine + NADPH + H⁺

NADH + 3-oxo-24-ethyl-cholest-4-ene + H⁺ + oxygen → H₂O + NAD⁺ + 3-oxo-24-ethyl-26-hydroxy-cholest-4-ene

2 mycothiol + NAD(P)+ ← mycothione + NAD(P)H + H⁺

14-demethyllanosterol + NADP⁺ ← 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + NADPH + H⁺

2 H⁺ + NADH + 5-methylsalicylate + oxygen → H₂O + 4-methylcatechol + NAD⁺ + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + candicinolide + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 18-hydroxy candicinolide

H₂O + NAD(P)+ + nitrite ← NAD(P)H + H⁺ + nitrate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 18-hydroxy candicinolide + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 18-oxo candicinolide

4α-methyl-5α-cholesta-8,24-dien-3β-ol + NADP⁺ ← 4α-methyl-5α-cholesta-8,14,24-trien-3β-ol + NADPH + H⁺

NADPH + 20-deoxo-20-dihydro-12,13-deepoxyrosamicin + H⁺ + oxygen → H₂O + 20-deoxo-20-dihydrorosamicin + NADP⁺

H₂O + 4-aminophenol + H⁺ → hydroquinone + ammonium

(E)-cinnamoyl-CoA + 4-coumaroyl-diketide + H⁺ → coenzyme A + (1E,6E)-1-(4-hydroxyphenyl)-7-phenylhepta-1,6-diene-3,5-dione + CO₂

2 NADPH + 2 H⁺ + cis-vaccenoyl-CoA → 2 NADP⁺ + coenzyme A + cis-vaccenyl alcohol

NADPH + (E)-7-(methyltsulfanyl)heptanal oxime + H⁺ + L-cysteine + oxygen → 2 H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-ω-(methylsulfanyl)heptan-1-imine + NADP⁺

11 H⁺ + 5 NADPH + 5 (S)-methylmalonyl-CoA + malonyl-CoA → 2 H₂O + 5 NADP⁺ + 6 coenzyme A + 6 CO₂ + 10-deoxymethynolide

(S)-2-amino-6-oxohexanoate + NADP⁺ + diphosphate + AMP ← NADPH + L-2-aminoadipate + H⁺ + ATP

NADPH + H⁺ + oxygen + (-)-isodihydrocarvone → H₂O + NADP⁺ + (4S,7R)-4-isopropenyl-7-methyloxepan-2-one

H₂O + NADP⁺ + (+)-afzelechin ← NADPH + H⁺ + (2R,3S,4S)-leucopelargonidin

FAD + H₂O + trans-zeatin riboside + H⁺ → FADH₂ + 3-methyl-4-trans-hydroxy-2-butenal + adenosine

H⁺ + 3-oxo-palmitate → 2-pentadecanone + CO₂

carboxynorspermidine + H⁺ → norspermidine + CO₂

(E)-4-coumaroyl-CoA + H⁺ + malonyl-CoA → coenzyme A + 4-coumaroylacetyl-CoA + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:1-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:2-monogalactosyldiacylglycerol

ammonia + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine + H⁺ → H₂O + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2 flaviolin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 3,3'-biflaviolin

11 NADPH + 2 (S)-methylmalonyl-CoA + 22 H⁺ + 9 malonyl-CoA → 11 coenzyme A + 11 NADP⁺ + 11 CO₂ + 5 H₂O + spinosyn macrolactone

2 H⁺ + (1Z,3Z)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate → (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate

H⁺ + Δ⁹-tetrahydrocannabinolate → Δ⁹-tetrahydrocannabinol + CO₂

3-carboxy-9-(methylsulfanyl)-2-oxononanoate + H⁺ → 9-(methylsulfanyl)-2-oxononanoate + CO₂

H⁺ + sn-glycerol 3-phosphate + CTP → CDP-glycerol + diphosphate

NADPH + stipitaldehydate + H⁺ + oxygen → 2 H₂O + stipitatonate + NADP⁺

androsta-1,4-diene-3,17-dione + NADH + H⁺ + oxygen → 9α-hydroxyandrosta-1,4-diene-3,17-dione + H₂O + NAD⁺

2-oxoglutarate + H⁺ → succinate semialdehyde + CO₂

NADPH + H⁺ + methyl (2E,6E)-farnesoate + oxygen → H₂O + juvenile hormone III + NADP⁺

coenzyme A + (15Z)-tetracos-15-enal + NAD⁺ ← NADH + H⁺ + (Z)-15-tetracosenoyl-CoA

2 H⁺ + siroheme → 2 CO₂ + 12,18-didecarboxysiroheme

2-(2,8-dihydroxytridecyl)-6-oxopyran-4-olate + NADP⁺ ← NADPH + H⁺ + 2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate

1-carboxybiuret + H⁺ → biuret + CO₂

malonate + H⁺ + n Na⁺ → acetate + CO₂ + n Na⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + pheophorbide a → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + epoxypheophorbide a

H⁺ + 27-O-demethyl-25-O-deacetyl-rifamycin S → 27-O-demethyl-25-O-deacetyl-rifamycin SV

H⁺ + 3,4,8,9,10-pentahydroxy-6-oxobenzo[c]chromene-1-carboxylate → urolithin M5 + CO₂

NADP⁺ + L-proline ← 2 H⁺ + 1-pyrroline-2-carboxylate + NADPH

H₂O + 3-hydroxyquinaldate + NADP⁺ ← NADPH + 3-hydroxykynurenate + H⁺

2 H⁺ + chlorophyllide a → Mg²⁺ + pheophorbide a

H⁺ + Na⁺ + (E)-glutaconyl-CoA → crotonyl-CoA + Na⁺ + CO₂

NADPH + trans-cinnamate + H⁺ + oxygen → H₂O + 2-coumarate + NADP⁺

a reduced electron donor + H⁺ + 4-hydroxylamino-2,6-dinitrotoluene → an oxidized electron donor + H₂O + 4-amino-2,6-dinitrotoluene

2 NADPH + 2 H⁺ + (11E)-tetradecenoyl-CoA → 2 NADP⁺ + coenzyme A + (11E)-tetradecenol

L-ascorbate + H⁺ + oxygen + portulacaxanthin II → H₂O + L-dehydro-ascorbate + dopaxanthin

2 H⁺ + 3 NADPH + 3 oxygen + 4α,14α-dimethyl-5α-cholesta-8,24-dien-3β-ol → 3 NADP⁺ + 4 H₂O + 4α-methyl-5α-cholesta-8,14,24-trien-3β-ol + formate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + adonirubin → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (3S,3'S)-astaxanthin

phytenoyl-CoA + NADPH + H⁺ → phytanoyl-CoA + NADP⁺

(E)-4-coumaroyl-CoA + H⁺ + quercetin-3-glucoside → coenzyme A + quercetin 3-O-(6"-O-p-coumaroyl)-glucoside

4 Fe²⁺ + 4 H⁺ + oxygen → 2 H₂O + 4 Fe³⁺

H⁺ + 3-oxo-dodecanoate → 2-undecanone + CO₂

N-dimethylethanolamine phosphate + H⁺ + CTP → CDP-N-dimethylethanolamine + diphosphate

NADP⁺ + isochenodeoxycholate ← NADPH + H⁺ + 7α-hydroxy-3-oxo-5β-cholanate

α-D-glucosamine 1-phosphate + H⁺ + GTP → diphosphate + GDP-D-glucosamine

NADP⁺ + sitosterol ← NADPH + isofucosterol + H⁺

coniferyl alcohol + NADP⁺ ← NADPH + coniferaldehyde + H⁺

2 H⁺ + 2 malonyl-CoA + hexanoyl-CoA → 2 coenzyme A + 2 CO₂ + 3,5-dioxodecanoyl-CoA

monacolin L acid + H⁺ → H₂O + monacolin L lactone

2 an oxidized ferredoxin [iron-sulfur] cluster + chlorophyll c₁ ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + chlorophyll c₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (4S)-limonene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (4S)-perillyl alcohol

4 Mn²⁺ + 4 H⁺ + oxygen → 2 H₂O + 4 Mn⁺³

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + spirilloxanthin → 3 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 2-oxospirilloxanthin

25-hydroxycholesterol + NADPH + H⁺ + oxygen → H₂O + 7α,25-dihydroxycholesterol + NADP⁺

N⁵-phospho-L-glutamine + H⁺ + CTP → N⁵-(cytidine 5'-diphosphoramidyl)-L-glutamine + diphosphate

abietatriene + NADPH + H⁺ + oxygen → ferruginol + H₂O + NADP⁺

zeinoxanthin + NADPH + H⁺ + oxygen → lutein + H₂O + NADP⁺

NADPH + H⁺ + arachidonate + oxygen → H₂O + (15R)-hydroxyicosapentaenoate + NADP⁺

NAD⁺ + (R)-3-(phenyl)lactate ← NADH + 3-phenyl-2-oxopropanoate + H⁺

2-(sulfomethyl)thiazolidine-4-carboxylate + a reduced electron donor + H⁺ → an oxidized electron donor + sulfoethylcysteine

H⁺ + 3-oxopropanoate → acetaldehyde + CO₂

NADPH + (Z)-3-hexanal + H⁺ → NADP⁺ + (3Z)-hex-3-en-1-ol

2 NADPH + 2 oxygen + (+)-dihydrokaempferol + H⁺ → 2 H₂O + 2 NADP⁺ + (+)-dihydromyricetin

H⁺ + oxygen + violaceinate → H₂O + violacein + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 2,4-dibromophenol + H⁺ + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 3,3',5,5'-tetrabromo-2,2'-biphenyldiol

17-α-hydroxyprogesterone + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + 11-desoxycortisol

an oxidized electron donor + 4'-hydroxy-rot-2'-enonate + H⁺ → a reduced electron donor + amorphigenin

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + cholesterol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + (25S)-26-hydroxycholesterol + H₂O

2 3-amino-4-hydroxybenzoate + 2 oxygen + N-acetyl-L-cysteine + H⁺ → 4 H₂O + grixazone B + CO₂

H⁺ + 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate → 2-methoxy-6-(all-trans-octaprenyl)phenol + CO₂

cyclopentanone + NADPH + H⁺ + oxygen → H₂O + 5-valerolactone + NADP⁺

H⁺ + 4-[(Z)-2-aminoethenyl]phenol → 4-(2-iminoethyl)phenol

NAD(P)H + aurachin B + H⁺ + oxygen → H₂O + NAD(P)+ + aurachin B epoxide

NADP⁺ + (3R)-3-hydroxy-behenoyl-CoA ← NADPH + H⁺ + 3-oxo-behenoyl-CoA

6 H⁺ + 7 malonyl-CoA → 7 coenzyme A + 7 CO₂ + H₂O + heptaketide pyrone

NADPH + H⁺ + oxygen + (indol-3-yl)pyruvate → H₂O + NADP⁺ + (indol-3-yl)acetate + CO₂

H⁺ + linoleate + ATP → linoleyl-AMP + diphosphate

NAD(P)+ + tetrahydromethanopterin ← NAD(P)H + 7,8-dihydromethanopterin + H⁺

H⁺ + malonyl-CoA + densipoloyl-CoA → coenzyme A + 3-oxo-auricoloyl-CoA + CO₂

biotin + H⁺ + ATP → diphosphate + biotinyl-5'-adenylate

mercuriphenyl acetate + H⁺ → Hg²⁺ + acetate + benzene

NADPH + H⁺ + mycinamicin IV + oxygen → H₂O + NADP⁺ + mycinamicin I

NADP⁺ + stearoyl-CoA ← NADPH + H⁺ + (2E)-octadec-2-enoyl-CoA

NADPH + H⁺ + oxygen + prefusarin → H₂O + NADP⁺ + 20-hydroxy-prefusarin

H₂O + H⁺ + malonyl-CoA + (S)-1-pyrroline-5-carboxylate → coenzyme A + (2S,5S)-5-carboxymethyl proline + CO₂

2-benzyl-3-oxobutanedioate + H⁺ → 2-oxo-4-phenylbutanoate + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (25R)-26-hydroxycholest-4-en-3-one + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + (25R)-26-oxocholest-4-en-3-one

β-nicotinamide D-ribonucleotide + diphosphate ← 5-phospho-α-D-ribose 1-diphosphate + nicotinamide + H⁺

NAD(P)H + 4-methyl-proline + H⁺ + oxygen → H₂O + NAD(P)+ + 3-hydroxy-4-methyl-L-proline

methane + NAD(P)H + H⁺ + oxygen → H₂O + NAD(P)+ + methanol

NADP⁺ + apiforol ← (2S)-naringenin + NADPH + H⁺

3'-phosphoadenylyl-sulfate + coelenterazine h ← luciferyl sulfate + adenosine 3',5'-bisphosphate + H⁺

2 9-hydroxyrubrofusarin + NAD(P)H + H⁺ + oxygen → 2 H₂O + NAD(P)+ + dimeric 9-hydroxyrubrofusarin

propene + NADH + H⁺ + oxygen → H₂O + NAD⁺ + (S)-1,2-epoxypropane

propene + NADH + H⁺ + oxygen → H₂O + NAD⁺ + (R)-1,2-epoxypropane

2 an oxidized ferredoxin [iron-sulfur] cluster + phosphate + ADP + bacteriochlorophyllide a ← 2 a reduced ferredoxin [iron-sulfur] cluster + H₂O + H⁺ + ATP + 3-acetyl-3-devinylchlorophyllide a

H⁺ + 3-oxo-myristate → 2-tridecanone + CO₂

NADPH + H⁺ + 7,8-dihydroberberine → (R)-canadine + NADP⁺

NADH + H⁺ + oxygen + indole → NAD⁺ + cis-indole-2,3-dihydrodiol

N²acetyl-L-2-aminoadipate 6-phosphate + NADPH + H⁺ → N²-acetyl-L-2-aminoadipate semialdehyde + NADP⁺ + phosphate

H⁺ + ATP + D-alanine → (D-alanyl)adenylate + diphosphate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + lanosterol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 30-hydroxylanosterol + H₂O

2 H⁺ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H₂O + Fe²⁺ + biliverdin-IX δ + carbon monoxide

anhydrotetracycline + NADPH + H⁺ + oxygen → H₂O + 5a,11a-dehydrotetracycline + NADP⁺

muconolactone ← H⁺ + cis,cis-muconate

β-D-fructofuranose 6-phosphate + H⁺ + CTP → diphosphate + CDP-D-fructose

H⁺ + (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + oxygen → hydrogen peroxide + 5,10-dihydrophenazine + CO₂

NAD⁺ + 1-hexanol ← NADH + 1-hexanal + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (25R)-26-hydroxycholesterol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + (25R)-26-oxocholesterol

2 NADPH + 2 H⁺ + 16-hydroxypalmitoyl-CoA → 2 NADP⁺ + coenzyme A + 1,16-hexadecane-diol

NADP⁺ + UDP-β-L-rhamnose ← NADPH + H⁺ + UDP-4-dehydro-β-L-rhamnose

H⁺ + malonyl-CoA + cyanidin 3-O-[2"-O-(xylosyl)-6"-O-(p-coumaroyl) glucoside] 5-O-glucoside → coenzyme A + cyanidin 3-O-[2"-O-(xylosyl)-6"-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside

NADH + H⁺ + 2,2'-dihydroxybiphenyl + oxygen → H₂O + 2,2',3-trihydroxybiphenyl + NAD⁺

NAD(P)+ + 3-oxoadipate ← NAD(P)H + 2-maleylacetate + H⁺

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-undecaprenyl diphosphate → demethylmenaquinol-11 + diphosphate + CO₂

(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NAD(P)H + H⁺ → NAD(P)+ + 2-dehydro-3-deoxy-D-gluconate

H⁺ + 6α,8β-dihydroxy-germacra-1(10),4,11(13)-trien-12-oate → H₂O + eupatolide

α-linolenate + hydrogen peroxide + H⁺ → 2 H₂O + 1E,8Z,11Z,14Z-heptadecatetraene + CO₂

NAD(P)+ + dTDP-α-D-fucopyranose ← NAD(P)H + dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H⁺

NADH + H⁺ + oxygen + protoasukamycin → H₂O + NAD⁺ + 4-hydroxyprotoasukamycin

6-oxo-1,8-cineole + NADPH + H⁺ + oxygen → H₂O + 1,6,6-trimethyl-2,7-dioxobicyclo-(3,2,2)nonan-3-one + NADP⁺

NAD(P)H + phenylacetone + H⁺ + oxygen → H₂O + NAD(P)+ + benzyl acetate

NADH + H⁺ + oxygen → hydrogen peroxide + NAD⁺

valienol 1-phosphate + H⁺ + GTP → GDP-valienol + diphosphate

neoabietadiene + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + neoabietadienol

2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + oxygen + pentalen-13-al → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 1-deoxypentalenate

NADH + H⁺ + 1,3-dimethylbenzene + oxygen → H₂O + 3-methylbenzyl alcohol + NAD⁺

orotidine 5'-phosphate + H⁺ → UMP + CO₂

NADP⁺ + luteoforol ← 2 H⁺ + NADPH + (2S)-eriodictyol

NADH + H⁺ + benzene + oxygen → (1R,2S)-cyclohexa-3,5-diene-1,2-diol + NAD⁺

H⁺ + anthraniloyl-CoA + 3-oxodecanoate → coenzyme A + H₂O + 2-heptyl-4-quinolone + CO₂

2 NADPH + 3 H⁺ + oxygen + (4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one → 2 NADP⁺ + H₂O + 4-demethylpremithracinone

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + N-methyl-L-valyl-L-tryptophanol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + (-)-indolactam V

1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H⁺ → H₂O + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO₂

H⁺ + 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + CTP → saturated CDP-archaeol + diphosphate

NADPH + H⁺ + oxygen + (2-ethylpyridin-4-yl)(imino)methanesulfinate → H₂O + sulfur dioxide + NADP⁺ + 2-ethyl-4-amidopyridine

L-ascorbate + H⁺ + (S)-amphetamine + oxygen → H₂O + L-dehydro-ascorbate + (-)-norephedrine

D-gluconate + H⁺ → D-gluconate + H⁺

2 oxygen + (S)-scoulerine + H⁺ → 2 hydrogen peroxide + dehydroscoulerine

(2R,3S)-2-decyl-3-hydroxytetradecanoate + NADP⁺ ← NADPH + (2R)-2-decyl-3-oxotetradecanoate + H⁺

zeaxanthin + NAD(P)H + H⁺ + oxygen → antheraxanthin + H₂O + NAD(P)+

cotinine + NADPH + H⁺ + oxygen → H₂O + 5'-hydroxycotinine + NADP⁺

behenate + H⁺ + ATP → (behenoyl)adenylate + diphosphate

NADPH + H⁺ + palmitoleoyl-CoA + (S)-methylmalonyl-CoA → 2 coenzyme A + 2-methyl-octadec-2,9-dienoate + NADP⁺ + CO₂

H⁺ + malonyl-CoA + lignoceroyl-CoA → coenzyme A + 3-oxo-cerotoyl-CoA + CO₂

L-ascorbate + dopamine + H⁺ + oxygen → H₂O + L-dehydro-ascorbate + (R)-noradrenaline

NAD(P)+ + 1,5-anhydro-D-mannitol ← NAD(P)H + 1,5-anhydro-D-fructose + H⁺

NAD(P)H + H⁺ + oxygen + asperlicin C → H₂O + NAD(P)+ + asperlicin E

ursodeoxycholate + NADP⁺ ← 7-oxolithocholate + NADPH + H⁺

3 H⁺ + cacodylate → H₂O + dimethylarsinous acid

an oxidized electron donor + H⁺ + 2-(glutathion-S-yl)-2-carboxypropane → a reduced electron donor + 2-(glutathion-S-yl)-propene + CO₂

H⁺ + L-leucine + LEU-tRNAs + ATP → Charged-LEU-tRNAs + diphosphate + AMP

salicylate + NADH + H⁺ + oxygen → H₂O + gentisate + NAD⁺

D-sorbitol 6-phosphate + NADP⁺ ← NADPH + β-D-glucose 6-phosphate + H⁺

2,5-xylenol + NADH + H⁺ + oxygen → H₂O + 5-(hydroxymethyl)-2-methylphenol + NAD⁺

L-proline betaine + NAD(P)H + H⁺ + oxygen → H₂O + N-methyl-L-proline + NAD(P)+ + formaldehyde

2 NADPH + 2 bromide + 2 oxygen + 5 H⁺ + protocatechuate → 2 NADP⁺ + 4 H₂O + 3,5-dibromocatechol + CO₂

H₂O + 4-hydroxylaminobenzoate + H⁺ → protocatechuate + ammonium

H⁺ + malonyl-CoA + stearoyl-CoA → coenzyme A + 3-oxoicosanoyl-CoA + CO₂

H₂O + (E)-4-coumaroyl-CoA + H⁺ + malonyl-CoA → 2 coenzyme A + 2 CO₂ + 4-hydroxybenzalacetone

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + 3,5-dibromocatechol + 2,4-dibromophenol → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 6,6'-oxybis(2,4-dibromophenol)

NADH + H⁺ + 3-methylphenol + oxygen → H₂O + 3-hydroxybenzyl alcohol + NAD⁺

NADPH + H⁺ + oxygen + (+)-α-santalene → H₂O + NADP⁺ + (+)-α-santalol

2 oxygen + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + nocardicin C → 3 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + nocardicin A

2 H₂O + thiocyanate + H⁺ → ammonium + OH^- + carbonyl sulfide

H⁺ + oxygen + (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate → H₂O + paerucumarin

2 H⁺ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H₂O + Fe²⁺ + biliverdin-IX β + carbon monoxide

testosterone + NADP⁺ ← androst-4-ene-3,17-dione + NADPH + H⁺

NAD⁺ + festuclavine ← NADH + H⁺ + 6,8-dimethyl-6,7-didehydroergoline

3 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + hydrogen sulfide ← 6 a reduced ferredoxin [iron-sulfur] cluster + 8 H⁺ + sulfite

12-ethyl-8-propylbacteriochlorophyllide c + H⁺ + (2E,6E)-farnesyl diphosphate → 12-ethyl-8-propylbacteriochlorophyll c + diphosphate

NADH + H⁺ + fluorene + oxygen → H₂O + NAD⁺ + 9-fluorenol

(3R,6E)-nerolidol + NADPH + H⁺ + oxygen → 2 H₂O + but-3-en-2-one + NADP⁺ + (3E)-4,8-dimethylnona-1,3,7-triene

C36-phenolphthiotriol A + NADP⁺ ← NADPH + C36-phenolphthiodiolone A + H⁺

3 H⁺ + NAD⁺ + (24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl CoA → NADH + 3α,7α,12α-trihydroxy-24-oxo-5-β-cholestanoyl CoA

2 oxygen + (S)-canadine + H⁺ → 2 hydrogen peroxide + berberine

NADP⁺ + 5-α-pregnane-3,20-dione ← progesterone + NADPH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + cholest-4-en-3-one + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (25S)-26-hydroxycholest-4-en-3-one

(3R,11Z,14Z)-3-hydroxyicosadienoyl-CoA + NADP⁺ ← (11Z,14Z)-3-oxoicosadienoyl-CoA + NADPH + H⁺

H⁺ + Na⁺ + (S)-methylmalonyl-CoA → propanoyl-CoA + Na⁺ + CO₂

2 H⁺ + protocatechuate + NADPH + bromide + oxygen → 2 H₂O + NADP⁺ + 3-bromo-4,5-dihydroxybenzoate

2 L-ascorbate + 2 H⁺ + hydrogen peroxide → 2 H₂O + 2 monodehydroascorbate radical

H⁺ + (indol-3-yl)pyruvate → (indol-3-yl)acetaldehyde + CO₂

NADPH + H⁺ + 2-chlorophenol + oxygen → H₂O + NADP⁺ + 3-chlorocatechol

1,3,5-trihydroxyxanthone + NADPH + H⁺ + oxygen → H₂O + 1,3,5,8-tetrahydroxyxanthone + NADP⁺

2-methylprop-1-ene + NADH + H⁺ + oxygen → H₂O + 1,2-epoxy-2-methylpropane + NAD⁺

NAD(P)+ + reduced riboflavin ← 2 H⁺ + riboflavin + NAD(P)H

NAD(P)H + prejadomycin + H⁺ + oxygen → 2 H₂O + NAD(P)+ + 8-methyltetraphene-1,5,6,11,12-pentol

an oxidized electron donor + carlactone carboxylate + H⁺ → (+)-5-deoxystrigol + a reduced electron donor

2 H⁺ + NADH + 5-chlorosalicylate + oxygen → H₂O + NAD⁺ + 4-chlorocatechol + CO₂

pyruvate + H⁺ + phosphate + oxygen → acetyl phosphate + hydrogen peroxide + CO₂

NADPH + aurachin D + H⁺ + oxygen → H₂O + 9'-hydroxy-aurachin D + NADP⁺

(+)-taxifolin + NADPH + H⁺ + oxygen → H₂O + (+)-dihydromyricetin + NADP⁺

1D-myo-inositol 3-monophosphate + H⁺ + CTP → diphosphate + CDP-1L-myo-inositol

N-acetyl-α-D-muramate 1-phosphate + H⁺ + UDP → phosphate + UDP-N-acetyl-α-D-muramate

3,5-dihydroxy-1,4-naphthoquinol + NAD⁺ ← 2 H⁺ + 3,5-dihydroxy-1,4-naphthoquinone + NADH

NADH + methyl tert-butyl ether + H⁺ + oxygen → H₂O + tert-butoxymethanol + NAD⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-oleoyl-2-palmitoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-oleoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol

2 γ-L-glutamyl-L-cysteine + NADP⁺ ← NADPH + H⁺ + bis-γ-glutamylcystine

3-hydroxy-2-methylpyridine-4,5-dicarboxylate + H⁺ → 3-hydroxy-2-methylpyridine-5-carboxylate + CO₂

H₂O + H⁺ + 2'-deoxyadenosine → ammonium + 2'-deoxyinosine

H⁺ + GTP + adenosyl-cobinamide phosphate → diphosphate + adenosylcobinamide-GDP

palmitaldehyde + NADP⁺ ← (2E)-hexadecenal + NADPH + H⁺

NAD(P)+ + glycolaldehyde ← NAD(P)H + glyoxal + H⁺

kievitone hydrate ← kievitone + H₂O + H⁺

2 H⁺ + an oxidized electron donor + hydrodidemethylasterriquinone D + prenyl diphosphate → ochrindole D + H₂O + a reduced electron donor + diphosphate

19-(4-hydroxyphenyl)nonadecanoate + H⁺ + ATP → 19-(4-hydroxyphenyl)nonadecanoyl adenylate + diphosphate

NADH + 1,2,4-trichlorobenzene + H⁺ + oxygen → NAD⁺ + (1R,2S)-3,4,6-trichlorocyclohexa-3,5-diene-1,2-diol

(2S)-2-phospholactate + H⁺ + GTP → (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 4-nitrotoluene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 4-nitrobenzyl alcohol

2 NADP⁺ + (6R)-L-threo-5,6,7,8-tetrahydrobiopterin ← 2 NADPH + 2 H⁺ + (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin

2 H⁺ + 3 malonyl-CoA + H₂O + (E)-4-coumaroyl-CoA → 3 CO₂ + 4 coenzyme A + p-coumaroyltriacetate

NAD⁺ + isochenodeoxycholate ← NADH + H⁺ + 7α-hydroxy-3-oxo-5β-cholanate

NADPH + H⁺ + oxygen + tetracycline → H₂O + NADP⁺ + 11a-hydroxytetracycline

2 H⁺ + 4-oxo-4-(3-pyridyl)-butanoate → 4-hydroxy-4-(3-pyridyl)-butanoate

2 NADP⁺ + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin ← 2 NADPH + 2 H⁺ + (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin

D-ribitol 5-phosphate + H⁺ + CTP → CDP-ribitol + diphosphate

3 H⁺ + cyanate + hydrogencarbonate → 2 CO₂ + ammonium

(R)-2-hydroxy-4-methylpentanoate + NADP⁺ ← NADPH + 4-methyl-2-oxopentanoate + H⁺

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-nonaprenyl diphosphate → demethylmenaquinol-9 + diphosphate + CO₂

NADH + H⁺ + 2,4-dichlorotoluene + oxygen → NAD⁺ + (1R,2S)-4,6-dichloro-3-methylcyclohexa-3,5-diene-1,2-diol

2 NADPH + 2 H⁺ + 17-α-hydroxypregnenolone + oxygen → 2 H₂O + 2 NADP⁺ + acetaldehyde + 3-β-hydroxyandrost-5-en-17-one

2 NAD(P)H + 2 H⁺ + 2 oxygen + zeaxanthin → 2 H₂O + 2 NAD(P)+ + violaxanthin

2 NADPH + 2 H⁺ + 7,2'-dihydroxy-4',5'-methylenedioxyisoflavan + oxygen → 2 NADP⁺ + H₂O + 10,2'-dihydroxy-4',5'-methylenedioxy-isoflav-8-ene-7-one

Coα-[α-(5-hydroxybenzimidazolyl)]-cobamide + methanol + H⁺ → H₂O + Coα-[α-(5-hydroxybenzimidazolyl)]-Coβ-methylcobamide

NADP⁺ + bacteriochlorophyll b ← NADPH + H⁺ + tetrahydrogeranylgeranyl bacteriochlorophyllide b

NAD(P)H + 1-methylxanthine + H⁺ + oxygen → xanthine + H₂O + NAD(P)+ + formaldehyde

3 NADP⁺ + bacteriochlorophyll a ← 3 NADPH + 3 H⁺ + geranylgeranyl bacteriochlorophyllide a

2-oxoglutarate + H⁺ + chloride + oxygen + 12-epi-fischerindole U → H₂O + succinate + CO₂ + 12-epi-fischerindole G

H⁺ + malonyl-CoA + stearidonoyl-CoA → coenzyme A + (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO₂

H₂O + (2Z,4Z)-2-amino-5-chlorohexa-2,4-dienedioate + H⁺ → (2Z,4Z)-2-chloro-5-hydroxyhexa-2,4-dienedioate + ammonium

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + neopikromycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + novapikromycin

NADH + H⁺ + chlorobenzene + oxygen → NAD⁺ + (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol

H₂O + H⁺ + barbiturate → ureidomalonate

NAD⁺ + isodeoxycholate ← NADH + H⁺ + 3-dehydrodeoxycholate

NADPH + H⁺ + 2-octaprenylphenol + oxygen → H₂O + NADP⁺ + 3-(all-trans-octaprenyl)benzene-1,2-diol

NAD(P)H + H⁺ + 3-chloro-4-(3-chloro-2-nitrosophenyl)-1H-pyrrole + oxygen → H₂O + pyrrolnitrin + NAD(P)+

H⁺ + ammonium hydroxide → H₂O + ammonium

2 NADPH + 2 oxygen + benzaldehyde + H⁺ → 2 NADP⁺ + H₂O + 6-hydroxy-2-cyclohexen-one-carboxylate

dTDP-L-daunosamine + NADP⁺ ← NADPH + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-β-L-glucose + H⁺

H₂O + H⁺ + ETH-NAD-imine adduct → ammonium + ETH-NAD adduct

triethylamine + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + triethylamine N-oxide

NAD(P)H + dihydroxyacetone + H⁺ → NAD(P)+ + glycerol

2 H⁺ + NADH + 5-methylphenazine-1-carboxylate + oxygen → H₂O + NAD⁺ + pyocyanin + CO₂

NADPH + 5-methyl-N-(4-nitrophenyl)thiophene-2-carboxamide + H⁺ + oxygen → H₂O + 5-methyl-N-(4-nitrophenyl)-1-oxo-1λ⁴-thiophene-2-carboxamide + NADP⁺

(S)-3-chloro-1-phenyl-1-propanol + NADP⁺ ← NADPH + 3-chloro-1-phenyl-1-propanone + H⁺

prephytoene diphosphate + NADPH + H⁺ → lycopaoctaene + NADP⁺ + diphosphate

3 2-oxoglutarate + 3 H⁺ + 3 oxygen + L-arginine → 2 ethene + 3 H₂O + 7 CO₂ + guanidinium + (S)-1-pyrroline-5-carboxylate + succinate

dehydroprephenate + H⁺ → H₂O + 3-(cyclohexa-1,3-dien-1-yl)-2-oxopropanoate + CO₂

H⁺ + L-threonine + ATP → (L-threonyl)adenylate + diphosphate

H⁺ + L-serine → ethanolamine + CO₂

NADP⁺ + SCB1 ← 2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone + NADPH + H⁺

2 H⁺ + 3 NADPH + 3 oxygen + decarboxy-demycosaminyl-nystatin → 3 NADP⁺ + 4 H₂O + demycosaminyl-nystatin

2 2,4-dibromophenol + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 2-bromo-4-(2,4-dibromophenoxy)phenol + bromide

NADH + dihydro-4-hydroxyphenyl pyruvate isomer + H⁺ → tetrahydro-4-hydroxyphenylpyruvate + NAD⁺

NADPH + H⁺ + tryptoquialanone → NADP⁺ + tryptoquialanol

(1S,4R)-1-hydroxymenth-8-en-2-one + NADPH + H⁺ + oxygen → (4R)-7-hydroxy-4-isoprenyl-7-methyl-2-oxo-oxepanone + H₂O + NADP⁺

phthalate + NADH + H⁺ + oxygen → phthalate 4,5-cis-dihydrodiol + NAD⁺

H⁺ + malonyl-CoA + anthraniloyl-CoA → coenzyme A + (2-aminobenzoyl)acetyl-CoA + CO₂

NADPH + dihydrocurcumin + H⁺ → tetrahydrocurcumin + NADP⁺

NADPH + H⁺ + 2-heptaprenylphenol + oxygen → H₂O + NADP⁺ + 3-(all-trans-heptaprenyl)benzene-1,2-diol

NADPH + H⁺ + oxygen + premithramycin B → H₂O + NADP⁺ + premithramycin B lactone

4'-phosphopantetheine + H⁺ + ATP → 3'-dephospho-CoA + diphosphate

2 H⁺ + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate → thiamine phosphate + diphosphate + CO₂

NADPH + H⁺ + 3-heptaprenyl-4-hydroxybenzoate + oxygen → 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + H₂O + NADP⁺

dimethyl sulfoxide + NAD(P)H + H⁺ → H₂O + NAD(P)+ + dimethyl sulfide

NADPH + H⁺ + γ-coniceine → NADP⁺ + coniine

nicotinate + NADPH + H⁺ → 3,6-dihydronicotinate + NADP⁺

H⁺ + malonyl-CoA + α-linolenoyl-CoA → coenzyme A + (11Z,14Z,17Z)-3-oxoicosatrienoyl-CoA + CO₂

H₂O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-α-D-glucose ← NAD(P)H + H⁺ + CDP-4-dehydro-6-deoxy-α-D-glucose

NADH + H⁺ + dibenzothiophene + oxygen → H₂O + NAD⁺ + dibenzothiophene-5-oxide

3 H⁺ + 3 malonyl-CoA + NADPH + S-adenosyl-L-methionine + acetyl-CoA → 3 CO₂ + 4 coenzyme A + H₂O + S-adenosyl-L-homocysteine + 3-methylorcinaldehyde + NADP⁺

H⁺ + S-methyl-L-methionine → dimethylsulfoniopropanoate-amine + CO₂

H⁺ + L-alanine + ATP → (L-alanyl)adenylate + diphosphate

2 H⁺ + NAD(P)H + 4-hydroxybenzoate + oxygen → H₂O + NAD(P)+ + hydroquinone + CO₂

NADPH + H⁺ + 7α-hydroxycholest-4-en-3-one → 7α-hydroxy-5β-cholestan-3-one + NADP⁺

NADPH + 7-(methylsulfanyl)heptyl-glucosinolate + H⁺ + oxygen → H₂O + NADP⁺ + 7-(methylsulfinyl)heptyl-glucosinolate

2 a reduced ferredoxin [iron-sulfur] cluster + 30-oxolanosterol + H⁺ + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + H₂O + formate

NADH + H⁺ + 3,4-dichlorotoluene + oxygen → NAD⁺ + (1R,2S)-3,4-dichloro-6-methylcyclohexa-3,5-diene-1,2-diol

H₂O + L-phenylalanine + H⁺ + oxygen → hydrogen peroxide + phenylacetaldehyde + ammonium + CO₂

6-deoxyerythronolide B + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + erythronolide B

NADPH + H⁺ + oxygen + (S)-autumnaline → 2 H₂O + NADP⁺ + (S)-isoandrocymbine

3 H⁺ + 3 malonyl-CoA + 3-phenylpropanoyl-CoA → 4 coenzyme A + 4 CO₂ + dihydropinosylvin

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-oxo-23,24-bisnorchol-1,4-dien-22-yl-CoA + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 9α-hydroxy-3-oxo-23,24-bisnorchol-1,4-dien-22-yl-CoA

H⁺ + GTP + α-D-glucopyranose 1-phosphate → GDP-α-D-glucose + diphosphate

4 an oxidized ferredoxin [iron-sulfur] cluster + (3Z)-phycoerythrobilin ← 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + (Z,Z)-biliverdin-IX α

4-hydroxy-L-tryptophan + H⁺ → 4-hydroxytryptamine + CO₂

coenzyme A + cinnamaldehyde + NADP⁺ ← (E)-cinnamoyl-CoA + NADPH + H⁺

NADP⁺ + (3R,9Z,12Z,15Z,18Z)-3-hydroxytetracosatetraenoyl-CoA ← (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + NADPH + H⁺

3 H⁺ + 3 malonyl-CoA + NADPH + acetyl-CoA → 3 CO₂ + 4 coenzyme A + H₂O + 6-methylsalicylate + NADP⁺

NADH + theophylline + H⁺ + oxygen → H₂O + 3-methylxanthine + formaldehyde + NAD⁺

(S)-propane-1,2-diol + NADP⁺ ← NADPH + H⁺ + (S)-lactaldehyde

2 NADPH + 3 H⁺ + (10E,12Z)-10,12-hexadecadienoate → 2 NADP⁺ + H₂O + bombykol

H⁺ + malonyl-CoA + anthraniloyl-CoA → 2 coenzyme A + 4-hydroxy-2(1H)-quinolone + CO₂

(R)-acetoin + NAD⁺ ← NADH + diacetyl + H⁺

NADPH + H⁺ + 4-(3'-acetyl-5'-hydroxy-4'-oxo-1',4'-dihydronapthalen-2'-yl)-3-oxobutanoate → NADP⁺ + (S)-4-(3'-acetyl-5'-hydroxy-4'-oxo-1',4'-dihydronapthalen-2'-yl)-3-hydroxybutanoate

(3E)-2-oxohex-3-enedioate + H⁺ → (2Z)-2-hydroxypenta-2,4-dienoate + CO₂

NADPH + H⁺ + acrolein → 1-propanal + NADP⁺

4-fluorophenol + NADH + H⁺ + oxygen → 4-fluorocatechol + H₂O + NAD⁺

2 H⁺ + N-(carboxyaminomethyl)urea → N-(aminomethyl)urea + CO₂

erythromycin D + NADPH + H⁺ + oxygen → H₂O + erythromycin C + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (25S)-26-hydroxycholesterol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + (25S)-26-oxocholesterol

N,N-dihydroxyhexahomomethioniate + H⁺ → H₂O + (E)-9-(methylsulfanyl)nonanal oxime + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:0-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:1-monogalactosyldiacylglycerol

NAD(P)H + 3-methylorcinaldehyde + H⁺ + oxygen → H₂O + NAD(P)+ + (2R,6Z)-2-hydroxy-6-(hydroxymethylidene)-2,5-dimethylcyclohex-4-ene-1,3-dione

2 an oxidized electron donor + 2 H⁺ + H₂O + 4-(3-methylbut-2-enyl)-L-abrine → 2 a reduced electron donor + CO₂ + chanoclavine-I

pyruvate + H⁺ + D-glyceraldehyde 3-phosphate → 1-deoxy-D-xylulose 5-phosphate + CO₂

NADPH + H⁺ + oxygen + daunorubicin → H₂O + NADP⁺ + doxorubicin

pent-1-en-3-one + NADPH + H⁺ → 1-pentan-3-one + NADP⁺

H₂O + NAD⁺ + 1-deoxy-D-xylulose 5-phosphate ← D-ribulose 5-phosphate + NADH + H⁺

8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP⁺ ← NADPH + H⁺ + dinor-12-oxo-phytodienoate

H⁺ + L-histidine → histamine + CO₂

NADH + H⁺ + 1,4-dichlorobenzene + oxygen → (1R,2S)-3,6-dichlorocyclohexa-3,5-diene-1,2-diol + NAD⁺

NAD(P)H + iso-arabidopaldehyde + H⁺ → NAD(P)+ + iso-arabidopyl alcohol

5α-cholesta-7,24-dien-3β-ol + NAD(P)H + H⁺ + oxygen → 2 H₂O + 7-dehydrodesmosterol + NAD(P)+

3,5-xylenol + NADH + H⁺ + oxygen → H₂O + 3-(hydroxymethyl)-5-methylphenol + NAD⁺

NADPH + H⁺ + phenylacetyl-CoA + oxygen → H₂O + 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP⁺

cacodylate + a reduced electron donor + H⁺ → an oxidized electron donor + H₂O + dimethylarsinous acid

H⁺ + dopaxanthin quinone → betanidin

coenzyme A + palmitaldehyde + NADP⁺ ← NADPH + H⁺ + palmitoyl-CoA

H⁺ + 3-hexaprenyl-4-amino-5-methoxybenzoate → 2-hexaprenyl-6-methoxyaminobenzene + CO₂

NADPH + H⁺ + oxygen + aklavinone → H₂O + ε-rhodomycinone + NADP⁺

H⁺ + C34-carboxyphthiodiolenone → C33-phthiodiolenone A + CO₂

NADPH + H⁺ + oxygen + 13-dihydrodaunorubicin → 2 H₂O + NADP⁺ + daunorubicin

4 an oxidized ferredoxin [iron-sulfur] cluster + (2R,3Z)-phycocyanobilin ← 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + (Z,Z)-biliverdin-IX α

NAD(P)H + 3-amino-4-hydroxybenzoate + H⁺ + ATP → 3-amino-4-hydroxybenzaldehyde + NAD(P)+ + diphosphate + AMP

pyruvate + H⁺ → acetaldehyde + CO₂

NADPH + H⁺ + palmitoyl-CoA + oxygen → H₂O + NADP⁺ + 16-hydroxypalmitoyl-CoA

3 oxygen + 4 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + cyclo(L-leucyl-L-leucyl) → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + pulcherriminic acid

(R)-reticuline + NADPH + H⁺ + oxygen → 2 H₂O + salutaridine + NADP⁺

H₂O + H⁺ + dCMP → ammonium + dUMP

2,5-dichloromaleylacetate + NADH + H⁺ → 5-chloromaleylacetate + NAD⁺ + chloride

an oxidized electron donor + formate + H⁺ → a reduced electron donor + CO₂

H⁺ + GDP + α-D-mannose 1-phosphate → GDP-α-D-mannose + phosphate

2 H⁺ + H₂O + N-carbamoylputrescine → putrescine + ammonium + CO₂

3 H⁺ + 3 malonyl-CoA + dihydro-4-coumaroyl-CoA → 3 CO₂ + 4 coenzyme A + phloretin

NADPH + H⁺ + oxygen + 4-aminobenzoate → H₂O + 4-hydroxylaminobenzoate + NADP⁺

2 H⁺ + 4-nitrophenol + NADH + oxygen → H₂O + 4-nitrocatechol + NAD⁺

2 H⁺ + L-2-amino-3-oxobutanoate → aminoacetone + CO₂

NADPH + H⁺ + 2-chloro-4-methylphenol + oxygen → H₂O + NADP⁺ + 3-chloro-5-methylcatechol

NADPH + H⁺ + oxygen + 2-cis-abscisate → H₂O + NADP⁺ + 8'-hydroxyabscisate

NADPH + resorcinol + H⁺ + oxygen → H₂O + NADP⁺ + hydroxyquinol

4-pyridoxate + H⁺ → 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate

NADPH + H⁺ + 5,10-methylenetetrahydropteroyl mono-L-glutamate + dUMP → NADP⁺ + 5,6,7,8-tetrahydrofolate + dTMP

3 NADPH + 3 H⁺ + 3 oxygen + ethionamide → 3 H₂O + 3 NADP⁺ + sulfur dioxide + 2-ethyl-4-amidopyridine

sinapyl alcohol + NADP⁺ ← NADPH + sinapaldehyde + H⁺

molybdopterin adenine dinucleotide + H⁺ + molybdate → H₂O + MoO₂-molybdopterin cofactor + AMP

L-glutamate-5-semialdehyde + NADP⁺ + phosphate ← γ-L-glutamyl 5-phosphate + NADPH + H⁺

H₂O + H⁺ + 6-amino-6-deoxyfutalosine → ammonium + futalosine

butanoyl-CoA + NADP⁺ ← crotonyl-CoA + NADPH + H⁺

H₂O + H⁺ + 2-iminobutanoate → 2-oxobutanoate + ammonium

H⁺ + (2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)-2-isocyanoprop-2-enoate → paerucumarin

2 rubrofusarin + NAD(P)H + H⁺ + oxygen → 2 H₂O + NAD(P)+ + dimeric rubrofusarin

2 H⁺ + H₂O + ammelide → ammonium + cyanuric acid

H₂O + H⁺ + ferric-[N-(2,3-dihydroxybenzoyl)-L-serine trimer] complex → N-(2,3-dihydroxybenzoyl)-L-serine + ferric-[(2,3-dihydroxybenzoylserine)₂] complex

NADP⁺ + tetrahydrogeranylgeranyl bacteriochlorophyllide b ← NADPH + H⁺ + dihydrogeranylgeranyl bacteriochlorophyllide b

17S-hydroperoxydocosahexaenoate + NADPH + H⁺ → 17S-hydroxydocosahexaenoate + H₂O + NADP⁺

5 H⁺ + MoO₂-molybdopterin cofactor + GTP → 2 H₂O + guanylyl molybdenum cofactor + diphosphate

NADH + H⁺ + flaviolin + oxygen → H₂O + NAD⁺ + mompain

2 4-sulfanylbutanoate + NAD⁺ ← NADH + H⁺ + 4,4'-disulfanediyldibutanoate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:3-2-18:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-18:3-monogalactosyldiacylglycerol

4 a reduced ferredoxin [iron-sulfur] cluster + 5 H⁺ + 2-hexaprenyl-3-methyl-6-methoxyaminophenol + oxygen → 4 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + ammonium + 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol

NADH + H⁺ + toluene + oxygen → H₂O + NAD⁺ + 2-methylphenol

2 NADPH + 2 H⁺ + 18-hydroxystearoyl-CoA → 2 NADP⁺ + coenzyme A + 1,18-octadecane-diol

NAD⁺ + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin ← L-erythro-7,8-dihydrobiopterin + NADH + H⁺

NADPH + H⁺ + oxygen + 3,6,7,4'-tetramethylquercetagetin → H₂O + NADP⁺ + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin

phytyl diphosphate + H⁺ + chlorophyllide b → diphosphate + chlorophyll b

FAD + all-trans-4,4'-diapophytofluene + H⁺ → FADH₂ + all-trans-4,4'-diapo-ζ-carotene

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + vitamin D₃ + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + calcidiol

NADP⁺ + (2R,3S,4S)-leucopelargonidin ← (+)-dihydrokaempferol + NADPH + H⁺

NADP⁺ + (3R)-3-hydroxy-arachidoyl-CoA ← NADPH + H⁺ + 3-oxoicosanoyl-CoA

H⁺ + 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate → 2-methoxy-6-(all-trans-nonaprenyl)phenol + CO₂

hydrogen peroxide + arachidate + H⁺ → 2 H₂O + 1-nonadecene + CO₂

NADP⁺ + UDP-N-acetyl-α-D-muramate ← NADPH + H⁺ + UDP-N-acetyl-α-D-glucosamine-enolpyruvate

NADP⁺ + coprostanone ← NADPH + H⁺ + cholest-4-en-3-one

NADP⁺ + (3R,4R)-7,2',4'-trihydroxyisoflavanol ← (3R)-2'-hydroxydihydrodaidzein + NADPH + H⁺

2 H⁺ + (+)-taxifolin + NAD(P)H + oxygen → H₂O + NAD(P)+ + 2,3-dihydrogossypetin

2-oxoglutarate + H⁺ + oxygen + (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate → 2 CO₂ + H₂O + succinate + 4-[(E)-2-isocyanoethenyl]phenol

NADPH + H⁺ + oxygen + 7¹-hydroxychlorophyllide a → H₂O + NADP⁺ + 7¹-dihydroxychlorophyllide a

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + p-cymene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 4-isopropylbenzyl alcohol

3-(4-hydroxyphenyl)pyruvate + H⁺ → (4-hydroxyphenyl)acetaldehyde + CO₂

NADPH + H⁺ + oxygen + tetracenomycin A2 → H₂O + NADP⁺ + 4-hydroxytetracenomycin A2

an oxidized electron donor + H₂O + ammonium ← hydroxylamine + a reduced electron donor + H⁺

2 H⁺ + NAD(P)H + oxygen + fumiquinazoline F → H₂O + NAD(P)+ + fumiquinazoline F-indoline-3'-ol

NADP⁺ + lignoceroyl-CoA ← NADPH + H⁺ + trans-lignocer-2-enoyl-CoA

NADPH + H⁺ + leukotriene B₄ + oxygen → H₂O + NADP⁺ + 20-hydroxy-leukotriene B₄

NAD⁺ + indole-3-ethanol ← NADH + H⁺ + (indol-3-yl)acetaldehyde

(24R)-cholest-5-ene-3β,24-diol + NADPH + H⁺ + oxygen → H₂O + (24R)-cholest-5-ene-3β,7α,24-triol + NADP⁺

2 H⁺ + 2-heptaprenylphenol + oxygen → H₂O + 3-(all-trans-heptaprenyl)benzene-1,2-diol

NAD(P)H + H⁺ + 4-hydroxybenzoate + oxygen → protocatechuate + H₂O + NAD(P)+

NADPH + H⁺ + oxygen + geraniol → H₂O + NADP⁺ + 9-hydroxygeraniol

H₂O + H⁺ + pheophorbide a → methanol + C-13²-carboxypyropheophorbide a

2 2,4-dibromophenol + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + bromide + 4',4,6-tribromo-2,2-biphenol

2 H⁺ + 3 malonyl-CoA + (E)-4-coumaroyl-CoA → 3 CO₂ + 4 coenzyme A + p-coumaroyltriacetic acid lactone

2-hydroxybiphenyl + NADH + H⁺ + oxygen → H₂O + biphenyl-2,3-diol + NAD⁺

NADPH + H⁺ + trans-lesqueroloyl-CoA → NADP⁺ + lesqueroloyl-CoA

stemmadenine + NADP⁺ ← intermediate II + NADPH + H⁺

protocatechuate + H⁺ → catechol + CO₂

glycine + H⁺ + succinyl-CoA → coenzyme A + 5-aminolevulinate + CO₂

L-threonine 3-O-phosphate + H⁺ → (R)-1-amino-2-propanol O-2-phosphate + CO₂

menadione + NADH + H⁺ → menadiol + NAD⁺

N-(1-phenylpropan-2-yl)hydroxylamine + NADPH + H⁺ + oxygen → 2 H₂O + (E)-N-(1-phenylpropan-2-ylidene)hydroxylamine + NADP⁺

4-methylpentanoyl-CoA + NAD⁺ ← NADH + 4-methylpent-2-enoyl-CoA + H⁺

(R)-mevalonate + NAD⁺ ← (R)-mevaldate + NADH + H⁺

H⁺ + malonyl-CoA + 3,5-dioxodecanoyl-CoA → coenzyme A + 3,5,7-trioxododecanoyl-CoA + CO₂

3 S-adenosyl-L-methionine + 3 L-cysteine + 8 H⁺ + NADPH + (salicyl)adenylate + malonyl-CoA → 3 S-adenosyl-L-homocysteine + 8 H₂O + coenzyme A + NADP⁺ + yersiniabactin + AMP

3 oxygen + 5 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + cholesterol → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + (25S)-3β-hydroxycholest-5-en-26-oate

NAD(P)H + H⁺ + oxygen + protodeoxyviolaceinate → H₂O + NAD(P)+ + protoviolaceinate

progesterone + NADPH + H⁺ + oxygen → H₂O + 11-deoxycorticosterone + NADP⁺

H₂O + NADP⁺ + nitrite ← NADPH + H⁺ + nitrate

5β-cholestane-3α,7α-diol + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + (25R)-5β-cholestane-3α,7α,26-triol

L-firefly luciferin + H⁺ + ATP → (L-firefly luciferyl)adenylate + diphosphate

NADPH + glycolaldehyde + H⁺ → ethylene glycol + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:1-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:1-monogalactosyldiacylglycerol

3 oxygen + 5 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + cholesterol → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + (25R)-3β-hydroxycholest-5-en-26-oate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1,4-dimethylbenzene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 4-methylbenzyl alcohol

dimethyl sulfoxide + NADH + H⁺ → H₂O + NAD⁺ + dimethyl sulfide

an oxidized electron donor + 5'-hydroxy-rot-2'-enonate + H⁺ → a reduced electron donor + amorphigenin

2 H⁺ + 4 oxygen + 5 a reduced electron donor + protoheme → 4 H₂O + 5 an oxidized electron donor + Fe²⁺ + formaldehyde + δ-staphylobilin

NADPH + H⁺ + oxygen + elymoclavine → 2 H₂O + NADP⁺ + elymoclavine aldehyde

H⁺ + malonyl-CoA + salicyl-CoA → 2 coenzyme A + 4-hydroxycoumarin + CO₂

an oxidized electron donor + H⁺ + (S)-2-acetolactate → a reduced electron donor + diacetyl + CO₂

NAD(P)+ + UDP-N-acetyl-α-D-quinovosamine ← NAD(P)H + H⁺ + UDP-2-acetamido-2,6-dideoxy-α-D-xylo-hex-4-ulose

2 3,5-dibromocatechol + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 3-bromo-5-(3,5-dibromo-2-hydroxyphenoxy)benzene-1,2-diol + bromide

an oxidized ferredoxin [iron-sulfur] cluster + (2R,3Z)-phycocyanobilin ← 4 H⁺ + a reduced ferredoxin [iron-sulfur] cluster + (Z,Z)-biliverdin-IX α

NADPH + (-)-pluviatolide + H⁺ + oxygen → 2 H₂O + hinokinin + NADP⁺

2 Fe²⁺ + 2 N-(2,3-dihydroxybenzoyl)-L-serine + NADP⁺ ← 2 Fe³⁺-[N-(2,3-dihydroxybenzoyl)-L-serine] complex + 3 H⁺ + NADPH

4-coumarate + H⁺ → 4-vinylphenol + CO₂

11 NADPH + 18 H⁺ + 8 malonyl-CoA + S-adenosyl-L-methionine + acetyl-CoA → 11 NADP⁺ + 6 H₂O + 8 CO₂ + 9 coenzyme A + S-adenosyl-L-homocysteine + dihydromonacolin L lactone

desmosterol + NADP⁺ ← 7-dehydrodesmosterol + NADPH + H⁺

H⁺ + (3Z)-2-chloro-5-oxohex-3-enedioate → (3Z)-5-chloro-2-oxopent-3-enoate + CO₂

NADP⁺ + mithramycin ← NADPH + H⁺ + mithramycin DK

leachianone G + prenyl diphosphate + H⁺ → sophoraflavanone G + diphosphate

NADP⁺ + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin ← NADPH + H⁺ + (6R)-6-lactoyl-5,6,7,8-tetrahydropterin

NADH + H⁺ + oxygen + echinenone → H₂O + NAD⁺ + 3'-hydroxyechinenone

H⁺ + oxygen + 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol → H₂O + 3-demethylubiquinol-8

(3¹R)-8-ethyl-12-methylbacteriochlorophyllide d + H⁺ + (2E,6E)-farnesyl diphosphate → (3¹R)-8-ethyl-12-methylbacteriochlorophyll d + diphosphate

H₂O + H⁺ + adenine → ammonium + hypoxanthine

H⁺ + tribromopyrrole-2-carboxylate → 2,3,4-tribromo-1H-pyrrole + CO₂

5-aminoimidazole-4-carboxylate + H⁺ → 4-aminoimidazole + CO₂

an oxidized electron donor + L-phenylalanine + H⁺ + L-proline + L-alanine + lysergate → 3 H₂O + a reduced electron donor + ergotamine

NAD(P)+ + UDP-N-acetyl-α-D-fucosamine ← NAD(P)H + H⁺ + UDP-2-acetamido-2,6-dideoxy-α-D-xylo-hex-4-ulose

11 NADPH + 11 H⁺ + 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA → 11 NADP⁺ + 3 H₂O + 8 coenzyme A + 8 CO₂ + tylactone

NADH + 4β-hydroxymethyl-4α-methyl-5α-cholest-7-en-3β-ol + H⁺ + oxygen → 2 H₂O + NAD⁺ + 3β-hydroxy-4α-methyl-5α-cholest-7-ene-4β-carbaldehyde

androst-4-ene-3,17-dione + NADPH + H⁺ + oxygen → H₂O + testololactone + NADP⁺

NADPH + H⁺ + (-)-maackiain → NADP⁺ + 7,2'-dihydroxy-4',5'-methylenedioxyisoflavan

unsaturated archaetidylserine + H⁺ → unsaturated archaetidylethanolamine + CO₂

H⁺ + 8β-hydroxy-germacra-1(10),4,11(13)-trien-12-oate → H₂O + inunolide

(E)-5-methyl-2-oxo-3-hex-3-enedioate + H⁺ → (4E)-2-oxo-hex-4-enoate + CO₂

3-sulfopyruvate + H⁺ → sulfoacetaldehyde + CO₂

NADP⁺ + kanamycin A ← NADPH + H⁺ + 2'-dehydrokanamycin A

NADH + H⁺ + oxygen + (indol-3-yl)acetate → H₂O + NAD⁺ + (2-hydroxy-1H-indol-3-yl)acetate

C33-phthiotriol A + NADP⁺ ← NADPH + C33-phthiodiolone A + H⁺

(5R)-albaflavenol + NADPH + H⁺ + oxygen → 2 H₂O + NADP⁺ + albaflavenone

3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H⁺ + oxygen → 5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline + NAD⁺

NADPH + H⁺ + (-)-medicarpin → NADP⁺ + 7,2'-dihydroxy-4'-methoxyisoflavan

2 NADPH + 2 oxygen + (2S)-naringenin + H⁺ → 2 H₂O + 2 NADP⁺ + (2S)-dihydrotricetin

a reduced electron donor + 15-demethoxy-ε-rhodomycinone + H⁺ + oxygen → an oxidized electron donor + H₂O + β-rhodomycinone + CO₂

D-gluconate + NADP⁺ ← NADPH + 2-keto-D-gluconate + H⁺

2 hydrogen peroxide + 2 H⁺ + Fe-coproporphyrin III → 2 CO₂ + 4 H₂O + protoheme

NADPH + H⁺ + (-)-jasmonate + oxygen → trans-tuberonic acid + H₂O + NADP⁺

H⁺ + UTP + α-D-glucopyranose 1-phosphate → diphosphate + UDP-α-D-glucose

2 NAD(P)H + 2 H⁺ + anthraniloyl-CoA + oxygen → 2 NAD(P)+ + H₂O + 2-amino-5-oxocyclohex-1-enecarboxyl-CoA

hydrogen peroxide + H⁺ + chloride → H₂O + hypochlorous acid

3 H⁺ + 3 malonyl-CoA + (9Z,12Z,15Z)-hexadeca-9,12,15-trienoyl-CoA → 4 coenzyme A + 4 CO₂ + 5-pentadecatrienyl resorcinol

3-methylbutanol + NAD(P)+ ← NAD(P)H + 3-methylbutanal + H⁺

4 H⁺ + 7-oxoheptanoate + sulfide(2-) → H₂O + 7-mercaptoheptanoate

2 NADPH + 3 H⁺ + (8E,10E)-dodeca-8,10-dienoate → 2 NADP⁺ + H₂O + (8E,10E)-dodeca-8,10-dienol

3 (R)-methylmalonyl-CoA + 6 NADPH + 9 H⁺ + stearoyl-CoA → 3 coenzyme A + 3 H₂O + 3 CO₂ + 6 NADP⁺ + C27-mycolipanoyl-CoA

trans-cinnamate + H⁺ → styrene + CO₂

NADH + H⁺ + toluene + oxygen → H₂O + benzyl alcohol + NAD⁺

N-(3-hydroxybutan-2-yl)acetamide + NADP⁺ ← NADPH + N-(3-oxobutan-2-yl)acetamide + H⁺

erythromycin B + NADPH + H⁺ + oxygen → H₂O + erythromycin A + NADP⁺

coenzyme A + NADP⁺ + glutathione ← NADPH + H⁺ + CoA-glutathione mixed disulfide

H⁺ + MoO₂-molybdopterin cofactor + ATP → adenylyl molybdenum cofactor + diphosphate

H⁺ + cannabichromenate → cannabichromene + CO₂

NADPH + episterol + H⁺ + oxygen → 2 H₂O + ergosta-5,7,24(28)-trien-3β-ol + NADP⁺

H⁺ + oxygen + dihydroartemisinic acid hydroperoxide → H₂O + artemisinin

[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + NADPH + H⁺ + oxygen → H₂O + [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + NADP⁺

(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + H⁺ + malonyl-CoA → coenzyme A + (5Z,8Z,11Z,14Z,17Z)-3-oxodocosapentaenoyl-CoA + CO₂

2 H⁺ + 3 NADPH + 3 oxygen + magnesium-protoporphyrin IX 13-monomethyl ester → 3 NADP⁺ + 5 H₂O + 3,8-divinyl protochlorophyllide a

nicotinate + D-ribulose 1-phosphate + H⁺ → β-D-ribosylnicotinate + phosphate

NADP⁺ + aklavinone ← NADPH + H⁺ + aklaviketone

taxa-4(20),11-dien-5α-ol + NADPH + H⁺ + oxygen → H₂O + taxa-4(20),11-dien-5α,13α-diol + NADP⁺

H⁺ + L-dopachrome → 5,6-dihydroxyindole + CO₂

H⁺ + ADP + ATP → P¹,P³-bis(5'-adenosyl) triphosphate + diphosphate

H⁺ + N-acetyldemethyl-L-phosphinothricin + ATP → N-acetyldemethylphosphinothricin adenylate + diphosphate

NADPH + H⁺ + L-tryptophan + oxygen → H₂O + 9-N-hydroxy-L-tryptophan + NADP⁺

NADPH + L-2-aminodecanoate + H⁺ + oxygen → H₂O + L-2-amino-8-hydroxydecanoate + NADP⁺

H₂O + pseudopaline + NADP⁺ ← (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + NADPH + 2-oxoglutarate + H⁺

4 H⁺ + 2-methoxy-6-(all-trans-octaprenyl)phenol + oxygen → H₂O + 2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol

H⁺ + phytate + ATP → 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + ADP

2-oxo-3-carboxy-4,5-cyclopropylhex-5-enoate + H⁺ → β-methylenecyclopropyl pyruvate + CO₂

NAD(P)H + H⁺ + CDP-3,6-dideoxy-D-glycero-4-hexulose → NAD(P)+ + CDP-ascarylose

NAD(P)H + 2,3,5,6-tetramethylpyrazine + H⁺ + oxygen → NAD(P)+ + (Z)-N,N'-(but-2-ene-2,3-diyl)diacetamide

2 H⁺ + 2 3-[(8Z,11E,13Z)-pentadeca-8,11,13-trien-1-yl] )catechol + oxygen → 2 H₂O + 8'-(3,4-dihydroxy-5-alkenyl)phenyl-3-[9'E,11'E,13'Z-pentadecatrienyl]catechol

H⁺ + 3,4-bis(7-chloro-1H-indol-3-yl)-2,5-diiminohexanedioate → ammonium + dichlorochromopyrrolate

NADP⁺ + GDP-β-L-fucose ← NADPH + H⁺ + GDP-4-dehydro-6-deoxy-β-L-galactose

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2-hydroxy-5-methyl-1-naphthoate + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2,7-dihydroxy-5-methyl-1-naphthoate + H₂O

NAD⁺ + lithocholoyl-CoA ← 3-oxocholan-24-oyl-CoA + NADH + H⁺

3 coenzyme A + an oxidized electron donor + H₂O + Δ^2,5-3,4,4-trimethylpimeloyl-CoA + H⁺ → 3 acetyl-CoA + a reduced electron donor + isobutanoyl-CoA

β-L-fucose 1-phosphate + H⁺ + GTP → diphosphate + GDP-β-L-fucose

2 H⁺ + 2-hydroxy-5-methylquinone + NADH → NAD⁺ + 2,4,5-trihydroxytoluene

NAD(P)+ + dTDP-6-deoxy-α-D-allose ← NAD(P)H + dTDP-4-dehydro-6-deoxy-α-D-gulose + H⁺

2 H⁺ + L-canaline + NADPH → L-homoserine + NADP⁺ + ammonium

H⁺ + heptaketide pyrone intermediate → aloesone + CO₂

H⁺ + L-tryptophan + oxygen → ammonium + indole-3-glycol aldehyde + CO₂

2 H⁺ + oxygen + 5,6-dihydroxyindole → 2 H₂O + indole-5,6-quinone

propane + NADH + H⁺ + oxygen → H₂O + propan-1-ol + NAD⁺

NADP⁺ + CDP-α-D-paratose ← NADPH + H⁺ + CDP-4-dehydro-3,6-dideoxy-α-D-glucose

2 hydrogen peroxide + palmitate + H⁺ → 3 H₂O + pentadecanal + CO₂

N,N-dihydroxy-L-tyrosine + H⁺ → H₂O + (E)-(4-hydroxyphenyl)acetaldehyde oxime + CO₂

NADPH + putrescine + H⁺ + oxygen → H₂O + 2-hydroxyputrescine + NADP⁺

NAD(P)H + H⁺ + oxygen + phenazine-1-carboxylate → H₂O + 2-hydroxyphenazine-1-carboxylate + NAD(P)+

NADPH + H⁺ + (-)-jasmonate + oxygen → trans-11-hydroxyjasmonate + H₂O + NADP⁺

NADH + H⁺ + oxygen + 2-bromobenzoate → catechol + NAD⁺ + bromide + CO₂

2 NADPH + 5 malonyl-CoA + 6 H⁺ + acetyl-CoA + oxygen → 2 NADP⁺ + 3 H₂O + 5 CO₂ + 6 coenzyme A + hexaketide pyrone

NADPH + H⁺ + (4S)-limonene + oxygen → H₂O + NADP⁺ + (-)-trans-carveol

2 a reduced ferredoxin [iron-sulfur] cluster + NAD⁺ + H⁺ + Na⁺ → 2 an oxidized ferredoxin [iron-sulfur] cluster + NADH + Na⁺

NADH + H⁺ + oxygen + 2-propylphenol → H₂O + 3-propylcatechol + NAD⁺

(+)-lariciresinol + NADP⁺ ← NADPH + (+)-pinoresinol + H⁺

3-hydroxypropanoate + NADP⁺ ← NADPH + H⁺ + 3-oxopropanoate

2 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + ammonium ← 6 a reduced ferredoxin [iron-sulfur] cluster + 8 H⁺ + nitrite

allopregnanolone + NADP⁺ ← NADPH + H⁺ + 5-α-pregnane-3,20-dione

15 malonyl-CoA + 28 NADPH + 4 (S)-methylmalonyl-CoA + 47 H⁺ + 4-aminobenzoyl-CoA → 15 CO₂ + 16 H₂O + 20 coenzyme A + 28 NADP⁺ + candicinolide

H₂O + adenosine + H⁺ → inosine + ammonium

H⁺ + (S)-methylmalonyl-CoA → propanoyl-CoA + CO₂

2 NADP⁺ + 1-chloro-4-hydroxylaminobenzene + H₂O ← 2 NADPH + 2 H⁺ + 1-chloro-4-nitrobenzene

H₂O + H⁺ + AMP → ammonium + IMP

NAD(P)+ + D-gluconate 6-phosphate ← NAD(P)H + 2-dehydro-6-phospho-D-gluconate + H⁺

H⁺ + (R)-methylmalonyl-CoA → propanoyl-CoA + CO₂

NADP⁺ + docosanoyl-CoA ← NADPH + H⁺ + trans-docos-2-enoyl-CoA

coumarinate + H⁺ → H₂O + coumarin

an oxidized electron donor + rot-2'-enonate + H⁺ → a reduced electron donor + deguelin

an oxidized electron donor + rot-2'-enonate + H⁺ → a reduced electron donor + rotenone

coenzyme A + 3-hydroxypropanoate + NADPH + H⁺ + ATP → H₂O + propanoyl-CoA + NADP⁺ + diphosphate + AMP

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + androst-4-ene-3,17-dione + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 1α-hydroxyandrost-4-ene-3,17-dione + H₂O

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + androsta-1,4-diene-3,17-dione + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 9α-hydroxyandrosta-1,4-diene-3,17-dione + H₂O

NADP⁺ + (2R,3S,4S)-leucodelphinidin ← 2 H⁺ + (+)-dihydromyricetin + NADPH

NADH + H⁺ + 1,4-dimethylbenzene + oxygen → H₂O + 4-methylbenzyl alcohol + NAD⁺

H⁺ + (S)-2-acetolactate → (R)-acetoin + CO₂

4 NADH + 4 oxygen + 6 H⁺ + dichlorochromopyrrolate → 2 CO₂ + 4 NAD⁺ + 6 H₂O + dichloro-arcyriaflavin A

Se-methyl-Se-L-methionine + H⁺ → dimethylselenopropanoate-amine + CO₂

2 H⁺ + 3 NAD(P)H + 3 oxygen + 4,4-dimethyl-5α-cholesta-8-en-3β-ol → 3 NAD(P)+ + 4 H₂O + 4α-carboxy-4β-methyl-5α-cholesta-8-en-3β-ol

NADPH + H⁺ + oxygen + demecolcine → H₂O + formaldehyde + NADP⁺ + deacetylcolchicine

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + 3,5-dibromocatechol + 2,4-dibromophenol → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 2,4-dibromo-6-(2,4-dibromo-6-hydroxyphenoxy)phenol

9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] + NADP⁺ ← NADPH + 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + H⁺

H⁺ + (S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline → CO₂ + (S)-(+)-allantoin

2 NADPH + 2 bromide + 2 oxygen + 5 H⁺ + 4-hydroxybenzoate → 2 NADP⁺ + 4 H₂O + 2,4-dibromophenol + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + butachlor + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + butyl formate + 2-chloro-N-(2,6-diethylphenyl)acetamide

H⁺ + (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + oxygen → hydrogen peroxide + 5,10-dihydrophenazine-1,6-dicarboxylate + CO₂

2 NADPH + 2 H⁺ + (11Z)-tetradecenoyl-CoA → 2 NADP⁺ + coenzyme A + (11Z)-tetradecenol

NADP⁺ + isocholate ← NADPH + H⁺ + 3-dehydrocholate

NAD(P)H + H⁺ + 3-oxodihomo γ-linolenoyl-CoA → NAD(P)+ + (3R)-hydroxydihomo γ-linolenoyl-CoA

molybdopterin + H⁺ + MoO₂-molybdopterin cofactor → H₂O + bis(molybdenum cofactor)

2-((2-(1,3-dioxan-2-yl)ethyl)thio)-5-phenyl-1,3,4-oxadiazole + NADPH + H⁺ + oxygen → H₂O + 2-[2-(1,3-dioxan-2-yl)ethanesulfinyl]-5-phenyl-1,3,4-oxadiazole + NADP⁺

2 3,5-dibromocatechol + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 3-bromo-5-(2,4-dibromo-6-hydroxyphenoxy)benzene-1,2-diol + bromide

3-carboxy-2-hydroxymuconate semialdehyde + H⁺ → (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + CO₂

NADPH + H⁺ + oxygen + ethionamide → H₂O + NADP⁺ + ethionamide S-oxide

NADPH + 9'-hydroxy-aurachin D + H⁺ + oxygen → H₂O + aurachin RE + NADP⁺

NADPH + H⁺ + oxygen + 3-hydroxybenzoate → protocatechuate + H₂O + NADP⁺

formate + H⁺ + ATP → H₂O + dATP + CO₂

3 H⁺ + NADPH + bromide + oxygen + 3-bromo-4,5-dihydroxybenzoate → 2 H₂O + NADP⁺ + 3,5-dibromocatechol + CO₂

H⁺ + malonyl-CoA + icosanoyl-CoA → coenzyme A + 3-oxo-behenoyl-CoA + CO₂

H⁺ + (S)-4-hydroxymandelate + oxygen → hydrogen peroxide + 4-hydroxybenzaldehyde + CO₂

NADPH + H⁺ + oxygen + 13-deoxycarminomycin → H₂O + NADP⁺ + 13-dihydrocarminomycin

H⁺ + malonyl-CoA + linoleoyl-CoA → coenzyme A + (11Z,14Z)-3-oxoicosadienoyl-CoA + CO₂

NAD(P)+ + L-proline ← 2 H⁺ + NAD(P)H + (S)-1-pyrroline-5-carboxylate

2 caldariellaquinol + 5 H⁺ + oxygen → 2 caldariellaquinone + 2 H₂O + 5 H⁺

H⁺ + oxygen + protoviolaceinate → H₂O + CO₂ + proviolacein

trans-4-hexen-3-one + NADPH + H⁺ → hexan-3-one + NADP⁺

NADH + H⁺ + 1,2-dichlorobenzene + oxygen → NAD⁺ + (1R,2S)-3,4-dichlorocyclohexa-3,5-diene-1,2-diol

2 H⁺ + 2,3-dihydroxybenzoate + NADH + oxygen → H₂O + pyrogallol + NAD⁺ + CO₂

2 H⁺ + H₂O + 3-(carbamoylamino)-2-methylpropanoate → (R)-3-amino-2-methylpropanoate + ammonium + CO₂

cotinine + NADPH + H⁺ + oxygen → H₂O + N'-hydroxymethyl-norcotinine + NADP⁺

H⁺ + 1,4-dihydroxy-6-naphthoate + all-trans-hexaprenyl diphosphate → demethylmenaquinol-6 + diphosphate + CO₂

10 malonyl-CoA + 14 NADPH + 23 H⁺ + acetyl-CoA → 10 CO₂ + 11 coenzyme A + 14 NADP⁺ + 9 H₂O + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate

2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂ + NAD⁺ ← 2 a reduced ferredoxin [iron-sulfur] cluster + 5 H⁺ + NADH

NADPH + (E)-6-(methylsulfanyl)hexanal oxime + H⁺ + L-cysteine + oxygen → 2 H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-ω-(methylsulfanyl)hexan-1-imine + NADP⁺

2 L-glutamate + NAD⁺ ← NADH + 2-oxoglutarate + H⁺ + L-glutamine

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-chlorotoluene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 3-chlorobenzyl alcohol

NADPH + H⁺ + oxygen + (S)-nicotine → H₂O + 2'-hydroxynicotine + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + toluene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + benzyl alcohol

NADH + H⁺ + oxygen + 2-fluorobenzoate → catechol + NAD⁺ + fluoride + CO₂

2 H⁺ + 2-hydroxy-1,4-benzoquinone + NADH → NAD⁺ + hydroxyquinol

10 malonyl-CoA + 9 H⁺ + H₂O → 10 coenzyme A + 10 CO₂ + 3,5,7,9,11,13,15,17,19-nonaoxoicosanoate

2 glutathione + NADP⁺ ← NADPH + H⁺ + glutathione disulfide

4α-hydroxymethyl-4β-methyl-5α-cholesta-8-en-3β-ol + NAD(P)H + H⁺ + oxygen → 2 H₂O + 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol + NAD(P)+

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2 flaviolin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 3,8'-biflaviolin

NADPH + H⁺ + oxygen + neoabietadienol → H₂O + NADP⁺ + neoabietadiene-diol

H₂O + (R)-4'-phosphopantothenoyl-L-cysteine + H⁺ → (R)-4'-phosphopantothenate + cysteamine + CO₂

4 H⁺ + 2-methoxy-6-(all-trans-heptaprenyl)phenol + oxygen → H₂O + 2-methoxy-6-all trans-heptaprenyl-1,4-benzoquinol

thiomorpholine-3-carboxylate + NAD(P)+ ← 2 H⁺ + NAD(P)H + 3,4-dehydrothiomorpholine-3-carboxylate

NADPH + H⁺ + andiconin + oxygen → H₂O + NADP⁺ + andilesin D

progesterone + NADPH + H⁺ + oxygen → H₂O + 17-α-hydroxyprogesterone + NADP⁺

2-phenylethanol + NADP⁺ ← NADPH + phenylacetaldehyde + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:3-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:3-monogalactosyldiacylglycerol

NADPH + SCB2 butanolide intermediate + H⁺ → SCB2 + NADP⁺

formate + H⁺ + UTP → H₂O + dUTP + CO₂

formate + H⁺ + CTP → H₂O + dCTP + CO₂

an oxidized electron donor + 3-phosphonomethylmalate + H⁺ → a reduced electron donor + 2-oxo-4-phosphonobutanoate + CO₂

2 NADPH + octadecanal + H⁺ + oxygen → 2 NADP⁺ + H₂O + formate + heptadecane

NADPH + H⁺ + mycinamicin VIII + oxygen → H₂O + NADP⁺ + mycinamicin VII

H₂O + strombine + NAD⁺ ← glycine + NADH + pyruvate + H⁺

phosphocholine + H⁺ + CTP → CDP-choline + diphosphate

isoprene + NADH + H⁺ + oxygen → H₂O + (3R)-3,4-epoxy-3-methylbut-1-ene + NAD⁺

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-hexaprenyl diphosphate → demethylmenaquinol-6 + diphosphate + CO₂

NADH + H⁺ + oxygen + β-carotene → β-cryptoxanthin + H₂O + NAD⁺

H₂O + H⁺ + N-cyclopropylmelamine → ammonium + N-cyclopropylammeline

N,N-dihydroxyhomomethionine + H⁺ → H₂O + (E)-4-(methylsulfanyl)butanal oxime + CO₂

NADPH + H⁺ + L-glutamate + ATP → L-glutamate-5-semialdehyde + NADP⁺ + phosphate + ADP

2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + (25S)-26-oxocholest-4-en-3-one + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (25S)-3-oxocholest-4-en-26-oate

NADH + 4-methylbenzoate + H⁺ + oxygen → H₂O + 4-carboxybenzyl alcohol + NAD⁺

oxidized coenzyme F₄₂₀-2 + H⁺ + ATP → diphosphate + coenzyme F₃₉₀-A

NAD(P)+ + hydrogen sulfide ← NAD(P)H + H⁺ + S⁰

(9Z)-12,13-dihydroxyoctadeca-9-enoate + NADPH + H⁺ + oxygen → H₂O + (9Z)-12,13,17-trihydroxyoctadeca-9-enoate + NADP⁺

5-phospho-α-D-ribose 1-diphosphate + H⁺ + 4-hydroxybenzoate → 4-(β-D-ribofuranosyl)hydroxybenzene 5'-phosphate + diphosphate + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 5 H⁺ + NAD⁺ → 2 an oxidized ferredoxin [iron-sulfur] cluster + 4 H⁺ + NADH

NADH + H⁺ + melilotate + oxygen → H₂O + 3-(2,3-dihydroxyphenyl)propanoate + NAD⁺

2 H⁺ + 2 iodide + hydrogen peroxide → 2 H₂O + I₂

NADP⁺ + α-D-glucopyranose ← 3-dehydro-D-glucopyranose + NADPH + H⁺

2 H⁺ + 3 NADPH + 3 oxygen + 5β-cholestane-3α,7α,12α-triol → 3 NADP⁺ + 4 H₂O + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate

(+)-marmesin + NADPH + H⁺ + oxygen → 2 H₂O + psoralen + acetone + NADP⁺

NAD(P)H + H⁺ + oxygen + (4'R)-11'-hydroxy-10'-methoxy-5'-azaspiro[cyclohexane-1,2'-tricyclo[6.3.1.04,ï¿½ï¿½]dodecane]-'(12'),2,5,8',10'-pentaen-4-one → H₂O + NAD(P)+ + formaldehyde + (4'R)-10',11'-dihydroxy-5'-azaspiro[cyclohexane-1,2'-tricyclo[6.3.1.04,ï¿½ï¿½]dodecane]-'(12'),2,5,8',10'-pentaen-4-one

NAD(P)H + H⁺ + oxygen + dimeric rubrofusarin → H₂O + NAD(P)+ + dimeric rubrofusarin-9-hydroxyrubrofusarin

3-oxocholan-24-oyl-CoA + NAD⁺ ← NADH + H⁺ + 3-oxochol-4-en-24-oyl-CoA

2 Na⁺ + H⁺ + oxaloacetate → 2 Na⁺ + pyruvate + CO₂

an oxidized ferredoxin [iron-sulfur] cluster + H₂O + benzoyl-CoA ← 2 H⁺ + a reduced ferredoxin [iron-sulfur] cluster + 4-hydroxybenzoyl-CoA

2-oxoglutarate + H⁺ + chloride + oxygen + hapalindole U → H₂O + succinate + hapalindole G + CO₂

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-dodecaprenyl diphosphate → demethylmenaquinol-12 + diphosphate + CO₂

ent-isokaurene + NADPH + H⁺ + oxygen → H₂O + ent-isokauren-2α-ol + NADP⁺

NADPH + H⁺ + oxygen + 7,10-diketo-pre-bikaverin → H₂O + NADP⁺ + 6-hydroxy-norbikaverin

an oxidized electron donor + H⁺ + betalamate + 2-descarboxy-cyclo-dopa → H₂O + a reduced electron donor + 2-descarboxy-betanidin

NAD(P)H + 4α-methyl-5α-cholesta-8-en-3-ol + H⁺ + oxygen → 4α-hydroxymethyl-5α-cholesta-8-en-3β-ol + H₂O + NAD(P)+

2 H⁺ + 24-methyldesmosterol → 24-epi-campesterol

NADPH + H⁺ + 4-hydroxybenzoate + oxygen → protocatechuate + H₂O + NADP⁺

oxidized coenzyme F₄₂₀-2 + H⁺ + GTP → coenzyme F₃₉₀-G + diphosphate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-linoleoyl-2-palmitoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-α-linolenoyl-2-palmitoyl-phosphatidylglycerol

NADPH + H⁺ + benzoyl-CoA + oxygen → 2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP⁺

2 an oxidized ferredoxin [iron-sulfur] cluster + primary fluorescent chlorophyll catabolite ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + red chlorophyll catabolite

cotinine + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + trans-3'-hydroxycotinine

NADP⁺ + 24-methylenecholesterol ← NADPH + ergosta-5,7,24(28)-trien-3β-ol + H⁺

2 coenzyme A + NAD⁺ ← NADH + H⁺ + CoA-disulfide

NADH + H⁺ + oxygen + (-)-α-pinene → α-pinene oxide + H₂O + NAD⁺

NADPH + H⁺ + 3-decaprenyl-4-hydroxybenzoate + oxygen → 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + H₂O + NADP⁺

17-(4-hydroxyphenyl)heptadecanoate + H⁺ + ATP → 17-(4-hydroxyphenyl)heptadecanoyl adenylate + diphosphate

dTDP-β-L-4-epi-vancosamine + NADP⁺ ← NADPH + dTDP-2,3,6-trideoxy-3-C-methyl-3-amino-4-dehydro-α-D-gulose + H⁺

H⁺ + oxalate → formate + CO₂

NAD(P)H + (6E)-8-oxogeranial + H⁺ → NAD(P)+ + (1R, 4aS,7S,7aR)-nepetalactol

2 H₂O + 2-(hydroxymethyl)-3-(acetamidomethylene)succinate + H⁺ → acetate + 2-hydroxymethyl-4-oxobutanoate + ammonium + CO₂

2 NADP⁺ + (-)-afzelechin ← 2 NADPH + 3 H⁺ + pelargonidin

2 NADP⁺ + (+)-epiafzelechin ← 2 NADPH + 3 H⁺ + pelargonidin

pyridin-1-ium-3,5-dicarboxylate mononucleotide + H⁺ + ATP → 5-carboxy-1-(5-O-phospho-β-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate + diphosphate

NADH + H⁺ + D-proline → 5-aminopentanoate + NAD⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-linoleoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-α-linolenoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol

5β-cholestane-3α,7α,12α-triol + NADPH + H⁺ + oxygen → H₂O + (25R)-5β-cholestane-3α,7α,12α,26-tetraol + NADP⁺

NADPH + ethanol + H⁺ + oxygen → 2 H₂O + acetaldehyde + NADP⁺

NADP⁺ + β-anaerubin ← NADPH + H⁺ + anaerobilin

NADPH + H⁺ + oxygen + ethionamide S-oxide → H₂O + NADP⁺ + (2-ethylpyridin-4-yl)(imino)methanesulfinate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-18:2-digalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-18:3-digalactosyldiacylglycerol

NADP⁺ + δ-anaerubin ← NADPH + H⁺ + anaerobilin

pyruvate + H⁺ + trans-2-octenal → (S)-3-acetyloctanal + CO₂

NADPH + H⁺ + mycinamicin IV + oxygen → H₂O + NADP⁺ + mycinamicin V

2 NAD(P)H + 2 H⁺ + oxygen → 2 H₂O + 2 NAD(P)+

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-18:3-digalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-18:3-digalactosyldiacylglycerol

FAD + H⁺ + spinosyn macrolactone → FADH₂ + 15-oxo spinosyn macrolactone

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:1-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:1-monogalactosyldiacylglycerol

5-guanidino-2-oxopentanoate + H⁺ → 4-guanidinobutyraldehyde + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:0-digalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:0-digalactosyldiacylglycerol

2 Fe²⁺ + 2 N-(2,3-dihydroxybenzoyl)-L-serine trimer + NADP⁺ ← 2 ferric-[N-(2,3-dihydroxybenzoyl)-L-serine trimer] complex + 9 H⁺ + NADPH

NADP⁺ + chlorophyllide a ← NADPH + H⁺ + 3,8-divinyl chlorophyllide a

calcitriol + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + calcitetrol

2 H⁺ + 4-(3-pyridyl)-3-butenoate → 4-(3-pyridyl)-butanoate

(3R)-2'-hydroxydihydrodaidzein + NADP⁺ ← NADPH + 2'-hydroxydaidzein + H⁺

pregnenolone + NADPH + H⁺ + oxygen → H₂O + 17-α-hydroxypregnenolone + NADP⁺

NADH + H⁺ + 3-chlorobenzoate + oxygen → NAD⁺ + 3-chloro-3,5-cyclohexadiene-l,2-diol-1-carboxylate

(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ ← NAD(P)H + (S)-2,3-dihydrodipicolinate + H⁺

3 H⁺ + 3 malonyl-CoA + H₂O + acetyl-CoA → 3 CO₂ + 4 coenzyme A + H₂O + orsellinate + H⁺

5-phospho-α-D-ribose 1-diphosphate + H⁺ + trans,octacis-decaprenyl phosphate → trans,octacis-decaprenylphospho-β-D-ribofuranose 5-phosphate + diphosphate

(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate ← H⁺ + 3-carboxy-cis,cis-muconate

H₂O + H⁺ + N-cyclopropylammeline → ammonium + N-cyclopropylammelide

3-methylxanthine + NADH + H⁺ + oxygen → xanthine + H₂O + formaldehyde + NAD⁺

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + zeaxanthin → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + violaxanthin

NADH + phenanthrene + H⁺ + oxygen → (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD⁺

H⁺ + 3'-dephospho-CoA + ATP → 2'-(5''-triphospho-α-D-ribosyl)-3'-dephospho-CoA + adenine

NADPH + daidzein + H⁺ → (S)-dihydrodaidzein + NADP⁺

NADPH + H⁺ + dehydrogriseofulvin → NADP⁺ + griseofulvin

2 H⁺ + 3 NADH + 3 oxygen + 4,4-dimethyl-5α-cholesta-8-en-3β-ol → 3 NAD⁺ + 4 H₂O + 4β-carboxy-4α-methyl-5α-cholesta-8-en-3β-ol

2 H⁺ + cyclo-dopa glucuronosyl glucoside + betalamate → H₂O + amaranthin

(+)-isopimara-7,15-diene + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + isopimara-7,15-dienol

3 NADP⁺ + chlorophyll a ← 3 NADPH + 3 H⁺ + geranylgeranyl chlorophyll a

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:2-monogalactosyldiacylglycerol

phytyl diphosphate + homogentisate + H⁺ → 2-methyl-6-phytyl-1,4-benzoquinol + diphosphate + CO₂

2 H⁺ + N-carbamoylsarcosine + H₂O → sarcosine + ammonium + CO₂

2,3-dehydrokievitone + NADPH + H⁺ → kievitone + NADP⁺

NAD(P)H + H⁺ + oxygen + rubrofusarin → H₂O + NAD(P)+ + 9-hydroxyrubrofusarin

H⁺ + oxygen + 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol → H₂O + 3-demethylubiquinol-9

NADPH + H⁺ + oxygen + (+)-epi-isozizaene → H₂O + (5R)-albaflavenol + NADP⁺

H₂O + H⁺ + oxygen + 5-methoxytryptamine → hydrogen peroxide + ammonium + 5-methoxyindoleacetaldehyde

3 H⁺ + 3 malonyl-CoA + (E)-cinnamoyl-CoA → 4 coenzyme A + 4 CO₂ + pinosylvin

NADP⁺ + (S)-lactaldehyde ← NADPH + H⁺ + methylglyoxal

NADPH + H⁺ + mycinamicin V + oxygen → H₂O + NADP⁺ + mycinamicin II

NAD(P)H + H⁺ + 9H carbazole + oxygen → NAD(P)+ + 2'-aminobiphenyl-2,3-diol

NADPH + H⁺ + oxygen + previridicatumtoxin → 2 H₂O + NADP⁺ + viridicatumtoxin

2 H⁺ + 2 GTP + bis(molybdenum cofactor) → 2 diphosphate + bis(guanylyl molybdopterin) cofactor

(+)-pulegone + NADPH + H⁺ + oxygen → 2 H₂O + (+)-menthofuran + NADP⁺

formate + H⁺ → H₂ + CO₂

2 NADH + 2 H⁺ + 2 oxygen + β-carotene → 2 H₂O + 2 NAD⁺ + zeaxanthin

2 H⁺ + H₂O + Fe³⁺-[salmochelin S2] complex → N-(2,3-dihydroxybenzoyl)-L-serine + H⁺ + Fe³⁺-[diglucosyl-(2,3-dihydroxybenzoylserine)₂] complex

4 L-ascorbate + 4 H⁺ + oxygen → 2 H₂O + 4 monodehydroascorbate radical

prephenate + H⁺ → 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO₂

2,3,5-trichloro-cis,cis-muconate + H⁺ → 2-chloro-2-(2,4-dichloro-5-oxofuran-2-yl)acetate

2 H⁺ + anthranilate + oxygen → H₂O + 3-hydroxyanthranilate

12 H⁺ + 5 NADPH + 6 malonyl-CoA + NADH → 4 H₂O + 5 NADP⁺ + 6 coenzyme A + 6 CO₂ + (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + NAD⁺

3-phenyl-2-oxopropanoate + H⁺ → phenylacetaldehyde + CO₂

prephenate + H⁺ → dihydro-4-hydroxyphenylpyruvate + CO₂

cholesterol + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + 7α-hydroxycholesterol

H⁺ + L-glutamate + ATP → (L-glutamyl)adenylate + diphosphate

NAD⁺ + isolithocholate ← 3-dehydrolithocholate + NADH + H⁺

NADH + H⁺ + salicyl-CoA + oxygen → H₂O + NAD⁺ + gentisyl-CoA

3 oxygen + 5 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + cholest-4-en-3-one → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + (25R)-3-oxocholest-4-en-26-oate

H⁺ + betalamate + cyclo-dopa 5-O-glucoside → H₂O + betanin

H₂O + creatinine + H⁺ → N-methylhydantoin + ammonium

NADP⁺ + isethionate ← sulfoacetaldehyde + NADPH + H⁺

3-carboxy-10-(methylsulfanyl)-2-oxodecanoate + H⁺ → 10-(methylsulfanyl)-2-oxodecanoate + CO₂

H⁺ + malonyl-CoA + pelargonidin-3-O-β-D-glucoside → coenzyme A + pelargonidin-3-O-(6"-O-malonyl-β-D-glucoside)

H⁺ + L-tyrosine → tyramine + CO₂

7-dehydrocholesterol + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + 7-ketocholesterol

quinoxaline-2-carboxylate + H⁺ + ATP → quinoxaline-2-carboxyl adenylate + diphosphate

NADPH + (E)-4-coumaroyl-CoA + H⁺ → coenzyme A + 4-coumaraldehyde + NADP⁺

2 (E) 1-propenylsulfenate + H⁺ → H₂O + thiosulfinate

2 an oxidized ferredoxin [iron-sulfur] cluster + protochlorophyllide a ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3,8-divinyl protochlorophyllide a

N, N-dihydroxy-tetrahomomethionine + H⁺ → H₂O + (E)-7-(methyltsulfanyl)heptanal oxime + CO₂

NAD(P)H + H⁺ + CDP-D-xylulose → NAD(P)+ + CDP-D-arabinitol

octanoate + schizokinen + H⁺ → H₂O + rhizobactin 1021

NAD(P)H + choline + H⁺ + oxygen → H₂O + NAD(P)+ + glycolaldehyde + trimethylamine

(E)-4-coumaroyl-CoA + H⁺ + quercetin-3-glucoside → coenzyme A + quercetin 3-O-(3'-O-p-coumaroyl)-glucoside

H⁺ + 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate → 2-methoxy-6-(all-trans-heptaprenyl)phenol + CO₂

dihydromacarpine + H⁺ + oxygen → hydrogen peroxide + macarpine

NADPH + H⁺ + oxygen + desmethylanthrotainin → H₂O + NADP⁺ + 5-hydroxy-desmethylanthrotainin

NADH + H⁺ + 3-chlorobenzoate + oxygen → NAD⁺ + 5-chloro-3,5-cyclohexadiene-l,2-diol-1-carboxylate

NADP⁺ + (3R)-hydroxy-auricoloyl-CoA ← NADPH + H⁺ + 3-oxo-auricoloyl-CoA

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:3-2-16:0-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:1-monogalactosyldiacylglycerol

H⁺ + (indol-3-yl)acetate → skatole + CO₂

ethene + NADH + H⁺ + oxygen → H₂O + ethylene oxide + NAD⁺

hydrogen peroxide + H⁺ + harderoheme III → 2 H₂O + protoheme + CO₂

O-carbamoyl-L-serine + H⁺ → ammonium + 2-aminoprop-2-enoate + CO₂

2 H₂O + 2 H⁺ + N²-succinyl-L-arginine → 2 ammonium + N²-succinyl-L-ornithine + CO₂

4 H⁺ + 4 Cu⁺ + oxygen → 2 H₂O + 4 Cu²⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:0-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:1-2-16:1-monogalactosyldiacylglycerol

FAD + H₂O + N⁶-dimethylallyladenine + H⁺ → FADH₂ + 3-methyl-2-butenal + adenine

NADH + H⁺ + toluene + oxygen → (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD⁺

2 NADPH + 2 H⁺ + 2 oxygen + echinocandin D → 2 H₂O + 2 NADP⁺ + echinocandin C

indolmycenate + NAD⁺ ← NADH + H⁺ + (R)-3-(indol-3-yl)-2-oxobutanoate

NAD⁺ + (R)-3-(4-hydroxyphenyl)lactate ← NADH + 3-(4-hydroxyphenyl)pyruvate + H⁺

2 NADPH + 2 H⁺ + 7-hydroxylauroyl-CoA → 2 NADP⁺ + coenzyme A + dodecane-1,7-diol

D-glycero-α-D-manno-heptose 1-phosphate + H⁺ + GTP → GDP-D-glycero-α-D-manno-heptose + diphosphate

H₂O + H⁺ + Fe³⁺-[salmochelin S2] complex → salmochelin SX + Fe³⁺-[salmochelin S1] complex

4-nitrophenol + NAD(P)H + H⁺ + oxygen → H₂O + 1,4-benzoquinone + NAD(P)+ + nitrite

3 oxygen + 5 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + cholest-4-en-3-one → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + (25S)-3-oxocholest-4-en-26-oate

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + β-carotene → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + zeaxanthin

aldehydo-L-galactonate + NADP⁺ ← NADPH + aldehydo-D-galacturonate + H⁺

carboxyphosphinopyruvate + H⁺ → 3-(hydroxyphosphinoyl)pyruvate + CO₂

3,4-dihydroxyphenylglycol + NAD⁺ ← NADH + 3,4-dihydroxyphenylglycolaldehyde + H⁺

2 NADPH + 2 oxygen + 3 H⁺ + chlorophyllide a → 2 NADP⁺ + 3 H₂O + chlorophyllide b

2 H₂O + H⁺ + (Z)-phenylacetaldehyde oxime → hydrogen peroxide + phenylacetaldehyde + ammonium

NADPH + Δ^24-25-sitosterol + H⁺ → NADP⁺ + sitosterol

NAD⁺ + trans,octacis-decaprenylphospho-β-D-arabinofuranose ← trans,octacis-decaprenylphospho-β-D-erythro-pentofuranosid-2-ulose + NADH + H⁺

D-idonate + NADP⁺ ← 5-dehydro-L-gluconate + NADPH + H⁺

2 H⁺ + 3 malonyl-CoA + isovaleryl-CoA → 3 CO₂ + 4 coenzyme A + 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone

NADPH + H⁺ + oxygen + furostanol-26-alcohol → 2 H₂O + NADP⁺ + furostanol-26-aldehyde

2 H⁺ + NADH + 4-chlorosalicylate + oxygen → H₂O + NAD⁺ + 4-chlorocatechol + CO₂

dTDP-β-L-digitoxose + NADP⁺ ← NADPH + dTDP-4-dehydro-2,6-dideoxy-α-L-glucose + H⁺

(2R)-3-sulfopropanediol + NAD⁺ ← 1-hydroxy-2-oxo-3-sulfopropane + NADH + H⁺

2 H⁺ + oxygen + oxalate → 2 CO₂ + hydrogen peroxide

NADH + H⁺ + oxygen + 3-hydroxy-5-methyl-benzoate → H₂O + NAD⁺ + 3-methylgentisate

NADH + H⁺ + oxygen + (3S,3'S)-astaxanthin → H₂O + NAD⁺ + 2-hydroxyastaxanthin

NADP⁺ + dihydro-4-coumaroyl-CoA ← NADPH + (E)-4-coumaroyl-CoA + H⁺

NADPH + (E)-8-(methylsulfanyl)octanal oxime + H⁺ + L-cysteine + oxygen → 2 H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-ω-(methylsulfanyl)octan-1-imine + NADP⁺

4,4-dimethyl-5α-cholesta-8-en-3β-ol + NAD(P)H + H⁺ + oxygen → 4α-hydroxymethyl-4β-methyl-5α-cholesta-8-en-3β-ol + H₂O + NAD(P)+

2-oxoglutarate + H⁺ + oxygen + luteoforol → 2 H₂O + luteolinidin + succinate + CO₂

2 NADH + 2 H⁺ + carbon disulfide + oxygen → 2 NAD⁺ + H₂O + hydrogen sulfide + carbonyl sulfide

C33-phthiodiolone A + NADP⁺ ← NADPH + C33-phthiodiolenone A + H⁺

H⁺ + malonyl-CoA + (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA → coenzyme A + (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO₂

NAD⁺ + 2,5-bis-hydroxymethylfuran ← NADH + 5-hydroxymethylfurfural + H⁺

NADPH + H⁺ + hydroxyversicolorone + oxygen → H₂O + NADP⁺ + versiconal hemiacetal acetate

NADPH + H⁺ + oxygen + benzoate → NADP⁺ + 6-hydroxy-2-cyclohexen-one-carboxylate

(3E)-2-oxohex-3-enedioate + H⁺ → 2-oxopent-4-enoate + CO₂

D-ribitol 5-phosphate + NADP⁺ ← D-ribulose 5-phosphate + NADPH + H⁺

3 H⁺ + 3 malonyl-CoA + benzoyl-CoA → 3 CO₂ + 4 coenzyme A + 2,4,6-trihydroxybenzophenone

NAD(P)H + 3-methylxanthine + H⁺ + oxygen → xanthine + H₂O + NAD(P)+ + formaldehyde

10-deoxysarpagine + NADP⁺ ← vellosimine + NADPH + H⁺

NAD⁺ + 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one ← 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NADH + H⁺

2 H⁺ + 1-hydroxy-2-naphthoate + NAD(P)H + oxygen → H₂O + naphthalene-1,2-diol + NAD(P)+ + CO₂

a reduced electron donor + H⁺ + perchlorate → 2 H₂O + an oxidized electron donor + chlorite

8-methyl-6-nonenoate + coniferyl alcohol + H⁺ → H₂O + capsiconiate

2 H⁺ + 3 NAD(P)H + 3 oxygen + 4,4-dimethyl-5α-cholest-7-en-3β-ol → 3 NAD(P)+ + 4 H₂O + 3β-hydroxy-4β-methyl-5α-cholest-7-ene-4α-carboxylate

N-methylethanolamine phosphate + H⁺ + CTP → diphosphate + CDP-N-methylethanolamine

NADP⁺ + adrenoyl-CoA ← NADPH + H⁺ + (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA

imidazole-pyruvate + NADH + H⁺ → imidazole-lactate + NAD⁺

NAD(P)H + 2,5-didehydro-D-gluconate + H⁺ → NAD(P)+ + 2-keto-L-gulonate

3-(3,4-dihydroxyphenyl)pyruvate + H⁺ → 3,4-dihydroxyphenylacetaldehyde + CO₂

NADPH + H⁺ + 3-chlorophenol + oxygen → H₂O + NADP⁺ + 3-chlorocatechol

5-dehydro-4-deoxy-D-glucarate + H⁺ → H₂O + 2,5-dioxopentanoate + CO₂

NADPH + prostaglandin-H₂ + H⁺ → prostaglandin F_2α + NADP⁺

[(1R,2R,3S,4S)-4-{5-cyano-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,3-dihydroxycyclopentyl]methyl phosphate + NADP⁺ + ammonium ← 2 H⁺ + 5-phospho-α-D-ribose-1-preQ₀ + NADPH

NADPH + H⁺ + oxygen + decarboxy-dehydroxy-demycosaminyl-nystatin → H₂O + NADP⁺ + decarboxy-demycosaminyl-nystatin

H₂O + H⁺ + (Z)-2-methylureidoacrylate peracid → (Z)-2-methyl-peroxyaminoacrylate + ammonium + CO₂

2 H⁺ + menaquinone-8 + (S)-malate → menaquinol-8 + oxaloacetate

2 NADH + 2 H⁺ + oxygen → 2 H₂O + 2 NAD⁺

propane + NADH + H⁺ + oxygen → H₂O + propan-2-ol + NAD⁺

quinolin-4-ol + NADH + H⁺ + oxygen → H₂O + quinolin-3,4-diol + NAD⁺

NADPH + H⁺ + benzoyl-CoA + oxygen → H₂O + NADP⁺ + salicyl-CoA

H⁺ + 3-(1H-indol-3-yl)propanoate cation radical + superoxide → kynurate

NAD(P)H + H⁺ + linoleate + oxygen → 2 H₂O + crepenynate + NAD(P)+

2'-deoxymugineate + NAD(P)+ ← NAD(P)H + 3''-deamino-3''-oxonicotianamine + H⁺

NADP⁺ + (10bS,4aR)-oxomaritinamine ← NADPH + H⁺ + (4aR,10bS)-noroxomaritidine

H₂O + H⁺ + N-carbobenzyloxy-L-glutamine → benzyl alcohol + L-glutamine + CO₂

NADP⁺ + isodeoxycholate ← NADPH + H⁺ + 3-dehydrodeoxycholate

NADPH + H⁺ + taurochenodeoxycholate + oxygen → H₂O + NADP⁺ + taurohyocholate

dimethyl sulfoxide + NADPH + H⁺ + oxygen → H₂O + dimethyl sulfone + NADP⁺

campesterol + NADP⁺ ← NADPH + H⁺ + 24-methylenecholesterol

H⁺ + geranylgeranyl diphosphate + chlorophyllide a → diphosphate + geranylgeranyl chlorophyll a

6-methylsalicylate + H⁺ → 3-methylphenol + CO₂

(+)-bornane-2,5-dione + NADH + H⁺ + oxygen → H₂O + (+)-5-oxo-1,2-campholide + NAD⁺

NADPH + H⁺ + (indol-3-yl)acetaldehyde → NADP⁺ + indole-3-ethanol

H⁺ + trans-caffeoyl-CoA + pelargonidin 3-O-β-D-sambubioside → coenzyme A + pelargonidin 3-O-β-D-(caffeoyl)-sambubioside

NADP⁺ + (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA ← (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NADPH + H⁺

NADPH + H⁺ + oxygen + (-)-menthol → H₂O + (1R,3R,4R)-p-menthane-3,8-diol + NADP⁺

pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + H⁺ + ATP → 1-(5-O-phospho-β-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate + diphosphate

H₂O + sulfonopine + NADP⁺ ← NADPH + pyruvate + H⁺ + S-methyl-L-methionine

NAD(P)H + H⁺ + oxygen + protodeoxyviolaceinate → H₂O + NAD(P)+ + deoxyviolaceinate

2 H₂O + E-2-(acetamidomethylidene)succinate + H⁺ → acetate + succinate semialdehyde + ammonium + CO₂

phosphonoacetaldehyde + H⁺ + oxaloacetate → 2-keto-4-hydroxy-5-phosphopentanoate + CO₂

NADP⁺ + GDP-β-L-fucose ← GDP-4-dehydro-α-D-rhamnose + NADPH + H⁺

L-ascorbate + 4-hydroxyamphetamine + H⁺ + oxygen → H₂O + L-dehydro-ascorbate + 4-hydroxynorephedrine

NADPH + H⁺ + leukotriene-E4 + oxygen → H₂O + NADP⁺ + 20-hydroxy-leukotriene-E4

NADH + H⁺ + 3-chlorotoluene + oxygen → (1R,2S)-5-chloro-3-methylcyclohexa-3,5-diene-1,2-diol + NAD⁺

NADP⁺ + (2R,3S,4S)-leucocyanidin ← 2 H⁺ + (+)-taxifolin + NADPH

NAD(P)H + caffeine + H⁺ + oxygen → H₂O + NAD(P)+ + theobromine + formaldehyde

NADH + H⁺ + 9-fluorenone + oxygen → NAD⁺ + 1,10-dihydro-1,10-dihydroxyfluoren-9-one

13 NADPH + 21 H⁺ + 9 malonyl-CoA + acetyl-CoA → 10 coenzyme A + 13 NADP⁺ + 8 H₂O + 9 CO₂ + (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate

(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ← NAD(P)H + 3-(3,4-dihydroxyphenyl)pyruvate + H⁺

4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol + NAD(P)H + H⁺ + oxygen → 2 H₂O + 4α-formyl-5α-cholesta-8,24-dien-3β-ol + NAD(P)+

NADPH + H⁺ + α-tocopherol + oxygen → H₂O + 13'-hydroxy-α-tocopherol + NADP⁺

NADPH + H⁺ + benzoyl-CoA + oxygen → H₂O + 2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP⁺

H₂O + 13(S)-HOT + NADP⁺ ← NADPH + H⁺ + 13(S)-HPOTE

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:3-monogalactosyldiacylglycerol

2-oxoglutarate + H⁺ + chloride + oxygen + ambiguine C → H₂O + succinate + ambiguine B + CO₂

NADP⁺ + CAI-1 ← NADPH + tridecane-3,4-dione + H⁺

3-dehydroquinate + H⁺ + ammonium → 4 H₂O + 4-aminobenzoate

12 H⁺ + 6 NADPH + 6 (S)-methylmalonyl-CoA + acetyl-CoA → 6 NADP⁺ + 6 CO₂ + 7 coenzyme A + H₂O + 8,8a-deoxyoleandolide

NAD(P)H + H⁺ + preaspyridone A + oxygen → 2 H₂O + NAD(P)+ + aspyridone A

H₂O + N-isopropylammelide + H⁺ → isopropylamine + cyanuric acid

NAD(P)+ + 4-hydroxypentanoyl-CoA ← NAD(P)H + H⁺ + 4-oxopentanoyl-CoA

NAD(P)+ + (Z,Z)-bilirubin-IX α ← NAD(P)H + H⁺ + (Z,Z)-biliverdin-IX α

4,4-dimethyl-14α-hydroxymethyl-5α-cholesta-8-en-3β-ol + NADPH + H⁺ + oxygen → 2 H₂O + 4,4-dimethyl-14α-formyl-5α-cholesta-8-en-3β-ol + NADP⁺

dTDP-L-megosamine + NADP⁺ ← NADPH + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-L-glucose + H⁺

diadinoxanthin + L-ascorbate + H⁺ → diatoxanthin + H₂O + L-dehydro-ascorbate

(E)-4-coumaroyl-CoA + H⁺ + kaempferol 3-O-β-D-glucoside → coenzyme A + kaempferol 3-O-(6"-O-p-coumaroyl)-glucoside

2 H⁺ + NADPH + oxygen + 4-hydroxyisophthalate → protocatechuate + H₂O + NADP⁺ + CO₂

H₂O + H⁺ + (2Z,4E)-2-amino-5-methyl-muconate → (E)-5-methyl-2-oxo-3-hex-3-enedioate + ammonium

3 H⁺ + NADPH + 4-coumarate + oxygen → H₂O + NADP⁺ + trans-caffeate

NADPH + H⁺ + oxygen + magnesium-protoporphyrin IX 13-monomethyl ester → H₂O + NADP⁺ + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

15 malonyl-CoA + 19 NADPH + 3 (S)-methylmalonyl-CoA + 37 H⁺ + acetyl-CoA → 18 CO₂ + 19 coenzyme A + 19 NADP⁺ + 8 H₂O + decarboxy-dehydroxy-demycosaminyl-nystatin

NAD(P)+ + 3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate ← NAD(P)H + 3-[(2Z,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate + H⁺

GDP-6-deoxy-4-keto-D-arabino-heptose + NADPH + H⁺ → NADP⁺ + GDP-6-deoxy-D-altro-heptose

2-isocapryloyl-3S-(phosphooxy)methyl-γ-butyrolactone phosphate + NADP⁺ ← NADPH + [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H⁺

2 NADPH + 2 H⁺ + (9Z)-tetradecenoyl-CoA → 2 NADP⁺ + coenzyme A + (9Z)-tetradecenol

hydrogen peroxide + H⁺ + Fe-coproporphyrin III → 2 H₂O + harderoheme III + CO₂

2 H⁺ + 5-formiminotetrahydrofolate → ammonium + 5,10-methenyltetrahydrofolate mono-L-glutamate

molybdopterin + H⁺ + ATP → molybdopterin adenine dinucleotide + diphosphate

16 an oxidized ferredoxin [iron-sulfur] cluster + 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate ← 16 a reduced ferredoxin [iron-sulfur] cluster + 16 H⁺ + 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate

2 NADPH + 2 H⁺ + 7,2'-dihydroxy-4'-methoxyisoflavan + oxygen → 2 NADP⁺ + H₂O + 10,2'-dihydroxy-4'-methoxy-isoflav-8-ene-7-one

2 a reduced ferredoxin [iron-sulfur] cluster + 2 2,4-dibromophenol + H⁺ + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 2,4-dibromo-6-(2,4-dibromophenoxy)phenol

2 an oxidized ferredoxin [iron-sulfur] cluster + chlorophyll a ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3,8-divinyl chlorophyll a

FAD + all-trans-4,4'-diaponeurosporene + H⁺ → FADH₂ + all-trans-4,4'-diapolycopene

NAD(P)+ + (R)-2,3-dihydroxy-3-methylpentanoate ← NAD(P)H + H⁺ + (S)-2-aceto-2-hydroxybutanoate

NADPH + H⁺ + dihydroconiferyl aldehyde → dihydroconiferyl alcohol + NADP⁺

2 NADPH + 2 H⁺ + 2 L-arginine + 2 oxygen → 2 H₂O + 2 NADP⁺ + 2 N^ω-hydroxy-L-arginine

NADPH + H⁺ + oxygen + 7¹-hydroxychlorophyllide a → 2 H₂O + NADP⁺ + chlorophyllide b

H₂O + D-nopaline + NADP⁺ ← NADPH + 2-oxoglutarate + H⁺ + L-arginine

dibenzofuran + NADH + H⁺ + oxygen → 2,2',3-trihydroxybiphenyl + NAD⁺

NADH + H⁺ + (25S)-26-hydroxycholest-4-en-3-one + oxygen → 2 H₂O + NAD⁺ + (25S)-26-oxocholest-4-en-3-one

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + canthaxanthin → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + adonirubin

4 H⁺ + uroporphyrinogen-III → 4 CO₂ + coproporphyrinogen III

N-methyl-Δ¹-pyrrolinium cation + H⁺ + acetonedicarboxylate → 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoate + CO₂

3 H₂O + H⁺ + ferric-enterobactin complex → 2 N-(2,3-dihydroxybenzoyl)-L-serine + Fe³⁺-[N-(2,3-dihydroxybenzoyl)-L-serine] complex

H⁺ + ATP + α-D-glucopyranose 1-phosphate → ADP-α-D-glucose + diphosphate

NAD(P)H + H⁺ + aminopyrrolnitrin + oxygen → H₂O + N-[2-chloro-6-(4-chloro-1H-pyrrol-3-yl)phenyl]hydroxylamine + NAD(P)+

NADH + H⁺ + dibenzothiophene-5-oxide + oxygen → H₂O + dibenzothiophene-5,5-dioxide + NAD⁺

dalbergioidin + NADP⁺ ← 2'-hydroxygenistein + NADPH + H⁺

NADP⁺ + isolithocholate ← 3-dehydrolithocholate + NADPH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-16:0-2-18:2-digalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-16:0-2-18:3-digalactosyldiacylglycerol

2 NADPH + 2 H⁺ + 2-nitrobenzoate → 2 NADP⁺ + H₂O + 2-hydroxylaminobenzoate

NAD⁺ + indole-3-ketol ← NADH + H⁺ + indole-3-glyoxal

(+)-cis-isopulegone + NADP⁺ ← (-)-isopiperitenone + NADPH + H⁺

H⁺ + malonyl-CoA + adrenoyl-CoA → coenzyme A + (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO₂

2 H⁺ + orthanilate + NADH + oxygen → NAD⁺ + ammonium + 3-sulfocatechol

NADPH + curcumin + H⁺ → dihydrocurcumin + NADP⁺

glycolate + NADP⁺ ← NADPH + glyoxylate + H⁺

H₂O + NAD⁺ + nitrous oxide ← 2 nitric oxide + NADH + H⁺

NADPH + H⁺ + 4-chlorophenol + oxygen → H₂O + NADP⁺ + 4-chlorocatechol

hydrogen peroxide + H⁺ + linoleate → 2 H₂O + 1E,8Z,11Z-heptadecatriene + CO₂

12-ethyl-8-isobutylbacteriochlorophyllide c + H⁺ + (2E,6E)-farnesyl diphosphate → 12-ethyl-8-isobutylbacteriochlorophyll c + diphosphate

4 H⁺ + 6-(all-trans-decaprenyl)-2-methoxy-phenol + oxygen → H₂O + all trans-decaprenyl-2-methoxy-6-1,4-benzoquinol

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:3-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:3-monogalactosyldiacylglycerol

NADPH + H⁺ + (2E,4E)-tetradeca-2,4-dienoyl-CoA → NADP⁺ + (3E)-tetradec-3-enoyl-CoA

H⁺ + MoO₂-molybdopterin cofactor + CTP → cytidylyl molybdenum cofactor + diphosphate

NAD(P)H + H⁺ + (-)-medicarpin + oxygen → H₂O + NAD(P)+ + 1α-hydroxy-medicarpin

FAD + all-trans-4,4'-diapo-ζ-carotene + H⁺ → FADH₂ + all-trans-4,4'-diaponeurosporene

NAD(P)H + paraxanthine + H⁺ + oxygen → 7-methylxanthine + H₂O + NAD(P)+ + formaldehyde

violaxanthin + L-ascorbate + H⁺ → antheraxanthin + H₂O + L-dehydro-ascorbate

coenzyme A + H⁺ + cis-vaccenate + ATP → H⁺ + cis-vaccenoyl-CoA + diphosphate + AMP

(4-hydroxyphenyl)acetate + H⁺ → 4-methylphenol + CO₂

NADPH + H⁺ + neopatulin → NADP⁺ + ascladiol

N,N-dimethylaniline + NADPH + H⁺ + oxygen → H₂O + N,N-dimethylaniline-N-oxide + NADP⁺

H₂O + alanopine + NAD⁺ ← NADH + pyruvate + H⁺ + L-alanine

NADH + H⁺ + oxygen + 4-hydroxyprotoasukamycin → H₂O + NAD⁺ + asukamycin

2-oxoadipate + NAD⁺ ← NADH + (3E)-2-oxohex-3-enedioate + H⁺

NADPH + H⁺ + (+)-menthone + oxygen → H₂O + NADP⁺ + (4S,7R)-7-isopropyl-4-methyloxepan-2-one

malonate + afrormosin-7-O-glucoside + H⁺ → H₂O + afrormosin-7-O-glucoside-6''-O-malonate

2 L-cysteine + NAD⁺ ← L-cystine + NADH + H⁺

H₂O + 5-methylcytosine + H⁺ → thymine + ammonium

3 H⁺ + NADPH + bromide + oxygen + 3-bromo-4-hydroxybenzoate → 2 H₂O + NADP⁺ + 2,4-dibromophenol + CO₂

14-demethyllanosterol + NAD(P)H + H⁺ + oxygen → 4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol + H₂O + NAD(P)+

nicotine blue leuco form + NAD(P)+ ← 3 H⁺ + NAD(P)H + nicotine blue

an oxidized electron donor + L-3-cyclohex-2'-enylalanine + H⁺ + chloroethylmalonyl-CoA + acetyl-CoA → 2 coenzyme A + a reduced electron donor + salinosporamide A + CO₂

H₂O + NADP⁺ + nitrosobenzene ← NADPH + H⁺ + nitrobenzene

L-gulonate + NADP⁺ ← NADPH + aldehydo-D-glucuronate + H⁺

2 H⁺ + 2-nonaprenylphenol + oxygen → H₂O + 3-(all-trans-nonaprenyl)benzene-1,2-diol

NADP⁺ + 5,6,7,8-tetrahydromonapterin ← 7,8-dihydromonapterin + NADPH + H⁺

NADPH + H⁺ + oxygen + 8-O-methyl-5-hydroxy-fusarubinaldehyde → H₂O + NADP⁺ + 8-O-methyl-5,10-dihydroxy-fusarubinaldehdye

2 H⁺ + 3 NAD(P)H + 3 oxygen + 14-demethyllanosterol → 3 NAD(P)+ + 4 H₂O + 4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol

15-demethoxy-ε-rhodomycinone + H⁺ → 15-decarboxymethyl-ε-rhodomycinone + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2-hydroxyspirilloxanthin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2,2-dihydroxyspirilloxanthin + H₂O

NADH + H⁺ + fluorene + oxygen → NAD⁺ + (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene

3 H⁺ + 3 malonyl-CoA + isovaleryl-CoA → 3 CO₂ + 4 coenzyme A + phlorisovalerophenone

NADPH + dTDP-N-hydroxy-β-L-evernosamine + H⁺ + oxygen → 2 H₂O + NADP⁺ + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-β-L-arabino-hexopyranose

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:3-2-16:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:3-monogalactosyldiacylglycerol

3-phosphonopyruvate + H⁺ → phosphonoacetaldehyde + CO₂

2 H⁺ + menaquinol-8 + fumarate → menaquinone-8 + succinate

2 NADPH + 2 H⁺ + (9Z,11E)-tetradec-9,11-dienoyl-CoA → 2 NADP⁺ + coenzyme A + (9Z,11E)-tetradeca-9,11-dien-1-ol

NADP⁺ + (10bR,4aS)-oxomaritinamine ← NADPH + H⁺ + (4aS,10bR)-noroxomaritidine

L-erythro-7,8-dihydrobiopterin + NADP⁺ ← sepiapterin + NADPH + H⁺

H₂O + (S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ ← NAD(P)H + H⁺ + (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

3 H⁺ + 3 malonyl-CoA + (E)-4-coumaroyl-CoA → 4 coenzyme A + 4 CO₂ + trans-resveratrol

H⁺ + emodin + emodin anthrone → H₂O + emodin dianthrone

4-methyl-2-oxopentanoate + H⁺ → 3-methylbutanal + CO₂

2 an oxidized ferredoxin [iron-sulfur] cluster + 6-oxo-1,4,5,6-tetrahydronicotinate ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 6-hydroxynicotinate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + pheophorbide a → 2 an oxidized ferredoxin [iron-sulfur] cluster + red chlorophyll catabolite

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + 1-deoxypentalenate → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + pentalenate

3 NADP⁺ + bacteriochlorophyll b ← 3 NADPH + 3 H⁺ + geranylgeranyl bacteriochlorophyllide b

2 3,5-dibromocatechol + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 5-bromo-3-(3,5-dibromo-2-hydroxyphenoxy)benzene-1,2-diol + bromide

NAD(P)+ + sn-glycerol 1-phosphate ← glycerone phosphate + NAD(P)H + H⁺

2 3,5-dibromocatechol + 3 H⁺ + 4 a reduced ferredoxin [iron-sulfur] cluster + oxygen → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 5-bromo-3-(2,4-dibromo-6-hydroxyphenoxy)benzene-1,2-diol + bromide

pentane + NADH + H⁺ + oxygen → H₂O + pentan-1-ol + NAD⁺

2 glyoxylate + H⁺ → tartronate semialdehyde + CO₂

4 H⁺ + ubiquinone-7 → ubiquinol-7

4-oxaloisocrotonate + H⁺ → 2-oxopent-4-enoate + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + 2'-hydroxy-2-oxospirilloxanthin → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 2',2'-dihydroxy-2-oxospirilloxanthin

NADH + H⁺ + naphthalene + oxygen → NAD⁺ + (1R,2S)-1,2-dihydronaphthalene-1,2-diol

(4-hydroxyphenyl)acetate + NAD(P)H + H⁺ + oxygen → H₂O + homogentisate + NAD(P)+

NAD⁺ + (R)-3-(indol-3-yl)lactate ← NADH + H⁺ + (indol-3-yl)pyruvate

vanillate + NADH + H⁺ + oxygen → protocatechuate + H₂O + formaldehyde + NAD⁺

H₂O + NADP⁺ + (+)-gallocatechin ← NADPH + H⁺ + (2R,3S,4S)-leucodelphinidin

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-tridecaprenyl diphosphate → demethylmenaquinol-13 + diphosphate + CO₂

2-oxoglutarate + H⁺ + oxygen + gibberellin₄₄ (open lactone form) → H₂O + succinate + gibberellin A₃₈ + CO₂

3-ethyl-2-oxosuccinate + H⁺ → 2-oxovalerate + CO₂

NADPH + H⁺ + 2-trans, 4-trans-undecadienoyl-CoA → NADP⁺ + (3E)-undec-3-enoyl-CoA

butanoate + NAD⁺ ← crotonate + NADH + H⁺

NADH + H⁺ + cholest-4-en-3-one + oxygen → H₂O + NAD⁺ + (25S)-26-hydroxycholest-4-en-3-one

2 an oxidized ferredoxin [iron-sulfur] cluster + (3Z)-phytochromobilin ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (Z,Z)-biliverdin-IX α

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-hexaprenyl-4-aminobenzoate + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 3-hexaprenyl-4-amino-5-hydroxybenzoate

intermediate II + NADP⁺ ← intermediate I + NADPH + H⁺

NADPH + 20-deoxo-20-dihydrorosamicin + H⁺ + oxygen → H₂O + 20-dihydrorosamicin + NADP⁺

NADPH + H⁺ + 3-geranylgeranylindole + oxygen → H₂O + NADP⁺ + 10,11-epoxy-3-geranylgeranylindole

FMNH₂ + NADP⁺ ← 2 H⁺ + FMN + NADPH

isobutanol + NADP⁺ ← NADPH + isobutanal + H⁺

a reduced electron donor + H⁺ + 2-hydroxylamino-4,6-dinitrotoluene → an oxidized electron donor + H₂O + 2-amino-4,6-dinitrotoluene

H⁺ + 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate → 6-(all-trans-decaprenyl)-2-methoxy-phenol + CO₂

5-β-androstane-3,17-dione + NADP⁺ ← androst-4-ene-3,17-dione + NADPH + H⁺

2 H⁺ + oxygen + coproporphyrinogen III → 2 H₂O + 2 CO₂ + protoporphyrinogen IX

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-18:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-18:3-monogalactosyldiacylglycerol

H₂O + H⁺ + 2-iminosuccinate → ammonium + oxaloacetate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + pentalen-13-ol → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + pentalen-13-al

4β-hydroxymethyl-4α-methyl-5α-cholesta-8,24-dien-3β-ol + NADH + H⁺ + oxygen → 2 H₂O + 4β-formyl-4α-methyl-5α-cholesta-8,24-dien-3β-ol + NAD⁺

2-hydroxy-3-oxoadipate + H⁺ → 5-hydroxy-4-oxopentanoate + CO₂

(4R,6R)-actinol + NAD⁺ ← levodione + NADH + H⁺

2-amino-4-phosphonobutanoate + H⁺ + CTP → CMP-5'-3-(aminopropyl)phosphonate + diphosphate + CO₂

H⁺ + geranylgeranyl diphosphate + bacteriochlorophyllide a → geranylgeranyl bacteriochlorophyllide a + diphosphate

H₂O + hydroxyatrazine + H⁺ → isopropylamine + N-ethylammelide

H₂O + H⁺ + O-ureido-D-serine + ATP → ammonium + phosphate + D-cycloserine + ADP + CO₂

quinolin-2-ol + NADH + H⁺ + oxygen → H₂O + quinolin-2,8-diol + NAD⁺

NADPH + H⁺ + oxygen + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester → 2 H₂O + NADP⁺ + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester

2-oxovalerate + H⁺ → butan-1-al + CO₂

NADH + H⁺ + oxygen + 2-hydroxyastaxanthin → H₂O + NAD⁺ + 2,3,2',3'-tetrahydroxy-β,β-carotene-4,4'-dione

NAD(P)H + 2-keto-L-gulonate + H⁺ → NAD(P)+ + L-idonate

NADP⁺ + cycloartanol ← NADPH + H⁺ + cycloartenol

NADH + H⁺ + oxygen + adonixanthin → H₂O + NAD⁺ + 2-hydroxyadonixanthin

propan-1-ol + NAD⁺ ← NADH + 1-propanal + H⁺

(1S)-bornane-2,5-dione + NADH + H⁺ + oxygen → H₂O + (-)-5-oxo-1,2-campholide + NAD⁺

L-tyrosinal + NADP⁺ + diphosphate + AMP ← NADPH + H⁺ + L-tyrosine + ATP

validone 7-phosphate + NAD⁺ ← valienone 7-phosphate + NADH + H⁺

pyruvate + dGTP ← phosphoenolpyruvate + H⁺ + dGDP

oleate + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + 18-hydroxyoleate

3 oxygen + 5 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + lanosterol → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + formate

4,4-dimethyl-5α-cholesta-8-en-3β-ol + NADH + H⁺ + oxygen → 4β-hydroxymethyl-4α-methyl-5α-cholesta-8-en-3β-ol + H₂O + NAD⁺

(1R,4S)-1-hydroxymenth-8-en-2-one + NADPH + H⁺ + oxygen → (4S)-7-hydroxy-4-isoprenyl-7-methyl-2-oxo-oxepanone + H₂O + NADP⁺

H⁺ + L-aspartate → L-alanine + CO₂

NADH + H⁺ + biphenyl + oxygen → NAD⁺ + cis-3-phenylcyclohexa-3,5-diene-1,2-diol

2 an oxidized ferredoxin [iron-sulfur] cluster + 15,16-dihydrobiliverdin ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (Z,Z)-biliverdin-IX α

(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H⁺ → (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate + CO₂

H₂O + (2Z,4Z)-2-amino-5-formylhexa-2,4-dienedioate + H⁺ → (2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + ammonium

homofuraneol + NADP⁺ ← NADPH + H⁺ + (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone

24-epi-campesterol + NADPH + H⁺ + oxygen → 2 H₂O + brassicasterol + NADP⁺

H⁺ + (2-aminobenzoyl)acetate → 2-aminoacetophenone + CO₂

plectaniaxanthin + NAD(P)H + H⁺ + oxygen → myxol + H₂O + NAD(P)+

NAD(P)H + lathosterol + H⁺ + oxygen → 2 H₂O + 7-dehydrocholesterol + NAD(P)+

NAD(P)+ + GDP-α-D-rhamnose ← GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H⁺

NADPH + 4-(methylsulfanyl)butyl-glucosinolate + H⁺ + oxygen → H₂O + NADP⁺ + glucoraphanin

H⁺ + oxygen + 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol → H₂O + 3-demethylubiquinol-10

2 a peptidoglycan dimer (E. faecium, tetrapeptide) + H⁺ → a peptidoglycan tetramer with an L,D cross-link (Enterococcus faecium) + D-alanine

H₂O + (2S)-2-amino-5-iminopentanoate + H⁺ → L-glutamate-5-semialdehyde + ammonium

NADPH + H⁺ + oxygen + 8-O-methylfusarubinaldehyde → H₂O + NADP⁺ + 8-O-methyl-5-hydroxy-fusarubinaldehyde

5-methyl-1-naphthoate + NADPH + H⁺ + oxygen → 3-hydroxy-5-methyl-1-naphthoate + H₂O + NADP⁺

(3R)-sophorol + NADP⁺ ← 2'-hydroxypseudobaptigenin + NADPH + H⁺

dTDP-α-D-olivose + NADP⁺ ← NADPH + dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + H⁺

(+)-muconolactone ← H⁺ + cis,cis-muconate

2 NADPH + 2 H⁺ + 18-hydroxyoleoyl-CoA → 2 NADP⁺ + coenzyme A + (9Z)-octadec-9-ene-1,18-diol

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + cyclo-(L-tyrosyl-L-tyrosyl) + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + mycocyclosin

N,N-dihydroxy-L-dihomomethionine + H⁺ → H₂O + (E)-5-(methylsulfanyl)pentanal oxime + CO₂

NAD(P)H + furfural + H⁺ → furfuryl alcohol + NAD(P)+

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + β-carotene → 2 an oxidized ferredoxin [iron-sulfur] cluster + β-cryptoxanthin + H₂O

NAD⁺ + 3-oxochol-4-en-24-oyl-CoA ← NADH + H⁺ + 3-oxochol-4,6-dien-24-oyl-CoA

2 H⁺ + 4 a reduced electron donor + 4 oxygen + protoheme → 4 an oxidized electron donor + 4 H₂O + Fe²⁺ + β-staphylobilin + carbon monoxide

N,N-dihydroxy-L-phenylalanine + H⁺ → H₂O + (E)-phenylacetaldehyde oxime + CO₂

abietatriene + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + dehydroabietadienol

3-hydroxyquinaldate + H⁺ + ATP → 3-hydroxyquinaldate adenylate + diphosphate

5,5'-dehydrodivanillate + NADH + H⁺ + oxygen → 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + H₂O + formaldehyde + NAD⁺

N-phenylhydroxylamine + NADP⁺ ← NADPH + H⁺ + nitrosobenzene

NADP⁺ + (3R)-3-hydroxy-cerotoyl-CoA ← NADPH + H⁺ + 3-oxo-cerotoyl-CoA

H₂O + NAD⁺ + D-octopine ← NADH + pyruvate + H⁺ + L-arginine

NADP⁺ + (20αS)-19,20--dihydrovomilenine ← NADPH + H⁺ + vomilenine

bupropion + NADPH + H⁺ + oxygen → H₂O + hydroxybupropion + NADP⁺

S-adenosyl-L-methionine + precorrin-6B + H⁺ → S-adenosyl-L-homocysteine + precorrin-7 + CO₂

H⁺ + (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + oxygen → hydrogen peroxide + (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO₂

NADP⁺ + 1,2-dihydrovomilenine ← NADPH + H⁺ + vomilenine

3-dehydrocarnitine + H⁺ → trimethylaminoacetone + CO₂

H₂O + H⁺ + 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one → 5-amino-6-(5-phospho-D-ribitylamino)uracil + ammonium

NADPH + H⁺ + (2E,6E)-farnesoate + oxygen → H₂O + juvenile hormone III acid + NADP⁺

(3¹R)-8-ethyl-12-methylbacteriochlorophyllide c + H⁺ + (2E,6E)-farnesyl diphosphate → (3¹R)-8-ethyl-12-methylbacteriochlorophyll c + diphosphate

H⁺ + 2-[2-(methylsulfanyl)ethyl]-3-oxobutanedioate → 5-(methylsulfanyl)-2-oxopentanoate + CO₂

NADH + H⁺ + 1,2,4,5-tetrachlorobenzene + oxygen → (1R,2S)-1,3,4,6-tetrachlorocyclohexa-3,5-diene-1,2-diol + NAD⁺

NADPH + H⁺ + 3-octaprenyl-4-hydroxybenzoate + oxygen → 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + H₂O + NADP⁺

3,4-dihydroxyphthalate + H⁺ → protocatechuate + CO₂

progesterone + NADPH + H⁺ + oxygen → H₂O + testosterone acetate + NADP⁺

dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADP⁺ ← NADPH + dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose + H⁺

7-methylxanthine + NAD(P)H + H⁺ + oxygen → xanthine + H₂O + NAD(P)+ + formaldehyde

5-phospho-α-D-ribose 1-diphosphate + H⁺ + 4-aminobenzoate → 4-(β-D-ribofuranosyl)aminobenzene-5'-phosphate + diphosphate + CO₂

2 H⁺ + 1-(methylsulfanyl)xylulose 5-phosphate → methanethiol + 1-deoxy-D-xylulose 5-phosphate

NADPH + H⁺ + (4S)-limonene + oxygen → H₂O + NADP⁺ + (-)-cis-carveol

NADH + H⁺ + dimethyl sulfide + oxygen → H₂O + dimethyl sulfoxide + NAD⁺

H₂O + NADP⁺ + carboxyspermidine ← L-aspartate 4-semialdehyde + NADPH + putrescine + H⁺

2 H⁺ + anthranilate + NADPH + oxygen → 2,3-dihydroxybenzoate + NADP⁺ + ammonium

2 H⁺ + NADPH + emodin → H₂O + NADP⁺ + chrysophanol

NADH + urate + H⁺ + oxygen → H₂O + (S)-5-hydroxyisourate + NAD⁺

2 NADH + 2 H⁺ + 2 oxygen + β-carotene → 2 H₂O + 2 NAD⁺ + (2R,2'R)-dihydroxy-all-trans-β-carotene

NAD(P)H + H⁺ + (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA → NAD(P)+ + (3R,8Z,11Z,14Z,17Z)-3-hydroxyicosatetraenoyl-CoA

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-α-linolenoyl-2-palmitoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-α-linolenoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol

3-hydroxy-4-methylanthranilate + H⁺ + ATP → 3-hydroxy-4-methylanthranilyl-adenylate + diphosphate

(2R,3S)-2-octyl-3-hydroxydodecanoate + NADP⁺ ← NADPH + (2R)-2-octyl-3-oxododecanoate + H⁺

NADPH + H⁺ + 2-nonaprenylphenol + oxygen → H₂O + NADP⁺ + 3-(all-trans-nonaprenyl)benzene-1,2-diol

2 an oxidized ferredoxin [iron-sulfur] cluster + phosphate + ADP + 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a ← 2 a reduced ferredoxin [iron-sulfur] cluster + H₂O + H⁺ + ATP + 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a

NADPH + 7,2,2'-trihydroxy-4',5'-methylenedioxyisoflav-3-ene + H⁺ + oxygen → H₂O + NADP⁺ + (3R,4R)-7,2,4,2'-tetrahydroxy-4',5'-methylenedioxyisoflav-3-ene

NADPH + H⁺ + oxygen + 12a-deshydroxy-desmethylanthrotainin → H₂O + NADP⁺ + desmethylanthrotainin

5-carboxyvanillate + H⁺ → vanillate + CO₂

H₂O + H⁺ + 2-aminoprop-2-enoate → pyruvate + ammonium

NADP⁺ + (+)-neomenthol ← NADPH + H⁺ + (-)-menthone

NADP⁺ + (-)-menthol ← NADPH + H⁺ + (-)-menthone

2 Mn²⁺ + 2 H⁺ + hydrogen peroxide → 2 H₂O + 2 Mn⁺³

S-adenosyl-L-methionine + H⁺ + cobalt-precorrin-3 → S-adenosyl-L-homocysteine + cobalt-precorrin-4

N,N-dihydroxy-L-valine + H⁺ → H₂O + (E)-2-methylpropanal-oxime + CO₂

NADH + H⁺ + styrene + oxygen → H₂O + NAD⁺ + (R)-2-phenyloxirane

2 methanethiol + NAD⁺ ← NADH + dimethyl disulfide + H⁺

dTDP-4-O-demethyl-β-L-noviose + NAD⁺ ← NADH + dTDP-4-dehydro-5-methyl-β-L-rhamnose + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + L-aspartate 4-semialdehyde + hydrogen sulfide → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + L-homocysteine

H₂O + L-saccharopine + NADP⁺ ← (S)-2-amino-6-oxohexanoate + NADPH + H⁺ + L-glutamate

3-carboxy-7-(methylsulfanyl)-2-oxoheptanoate + H⁺ → 7-(methylsulfanyl)-2-oxoheptanoate + CO₂

H⁺ + L-2,4-diaminobutanoate → propane-1,3-diamine + CO₂

NADP⁺ + chlorophyllide a ← NADPH + H⁺ + protochlorophyllide a

H⁺ + malonyl-CoA + trans-feruloyl-CoA → coenzyme A + feruloylacetyl-CoA + CO₂

dimethyl sulfoxide + menaquinol-8 + H⁺ → H₂O + menaquinone-8 + dimethyl sulfide

NADH + H⁺ + 2-methylphenol + oxygen → H₂O + 3-methylcatechol + NAD⁺

H₂O + H⁺ + cytosine → ammonium + uracil

NADPH + O-aminobenzaldehyde + H⁺ + oxygen → 2 H₂O + anthranil + NADP⁺

3 NADPH + 5 malonyl-CoA + 8 H⁺ + acetyl-CoA + oxygen → 3 NADP⁺ + 4 H₂O + 6 coenzyme A + 6 CO₂ + 1,8-dihydroxy-3-methylnaphthalene

(6Z,9Z,12Z,15Z)-3-oxo-2-[(2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl]octadeca-6,9,12,15-tetraenoate + H⁺ → hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:2-monogalactosyldiacylglycerol

NADPH + H⁺ + oxygen + (+)-epi-isozizaene → H₂O + (5S)-albaflavenol + NADP⁺

2-hydroxy-3-carboxy-6-oxo-hepta-2,4-dienoate + H⁺ → 2-hydroxy-6-oxohepta-2,4-dienoate + CO₂

hydrogen peroxide + NADPH + H⁺ → 2 H₂O + NADP⁺

H⁺ + 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate → demethylmenaquinol-8 + diphosphate + CO₂

2 NADP⁺ + (+)-epigallocatechin ← 2 NADPH + 3 H⁺ + delphinidin

2 NADP⁺ + (-)-gallocatechin ← 2 NADPH + 3 H⁺ + delphinidin

hydrogen peroxide + NADH + H⁺ → 2 H₂O + NAD⁺

NAD(P)H + theobromine + H⁺ + oxygen → 7-methylxanthine + H₂O + NAD(P)+ + formaldehyde

pseudotropine + NADP⁺ ← tropinone + NADPH + H⁺

2 H⁺ + NADPH + oxygen + senecionine → H₂O + NADP⁺ + senecionine N-oxide

trimethyl sulfonium + 5,6,7,8-tetrahydrofolate ← H⁺ + dimethyl sulfide + 5-methyltetrahydropteroyl mono-L-glutamate

2 oxygen + (S)-tetrahydrocolumbamine + H⁺ → 2 hydrogen peroxide + columbamine

NADPH + H⁺ + (-)-medicarpin → (-)-vestitol + NADP⁺

NADPH + (-)-dihydrocarvone + H⁺ + oxygen → H₂O + NADP⁺ + (3S,6S)-6-isopropenyl-3-methyloxepan-2-one

2 H⁺ + hexahydroxydiphenic acid → 2 H₂O + ellagic acid

N-acetyl-α-D-galactosamine 1-phosphate + H⁺ + UTP → UDP-N-acetyl-α-D-galactosamine + diphosphate

NAD⁺ + 5-methyltetrahydropteroyl mono-L-glutamate ← NADH + H⁺ + 5,10-methylenetetrahydropteroyl mono-L-glutamate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:3-2-16:1-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:2-monogalactosyldiacylglycerol

caloxanthin + NADH + H⁺ + oxygen → nostoxanthin + H₂O + NAD⁺

H₂O + H⁺ + pheophorbide a → methanol + CO₂ + pyropheophorbide a

NADPH + H⁺ + oxygen + diphenyl ether → (1S,2S)-3-phenoxycyclohexa-3,5-diene-1,2-diol + NADP⁺

4-sulfoacetophenone + NADPH + H⁺ + oxygen → H₂O + 4-sulfophenyl acetate + NADP⁺

NADPH + glucoiberverin + H⁺ + oxygen → H₂O + NADP⁺ + glucoiberin

glycerol 2-phosphate + H⁺ + CTP → CDP-2-glycerol + diphosphate

H⁺ + phenylacetyl-CoA + oxygen → 2-[(1R,6S)-1,6-dihydroxycyclohexa-2,4-dien-1-yl]acetyl-coA

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + pentalenene → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + pentalen-13-ol

5-chloromaleylacetate + NADH + H⁺ → 2-maleylacetate + NAD⁺ + chloride

H⁺ + 8-O-methyl-13-carboxynorjavanicin → 8-O-methyl-fusarubinlactone

FAD + H₂O + H⁺ + cis-zeatin → FADH₂ + 3-methyl-4-cis-hydroxy-2-butenal + adenine

NADPH + tert-butyl alcohol + H⁺ + oxygen → H₂O + 2-methylpropane-1,2-diol + NADP⁺

stearate + H⁺ + ATP → (stearoyl)adenylate + diphosphate

NADH + precorrin-3A + H⁺ + oxygen → H₂O + precorrin-3B + NAD⁺

2 H⁺ + 2 sulochrin + oxygen → 2 H₂O + 2 (-)-bisdechlorogeodin

NADH + H⁺ + oxygen + canthaxanthin → H₂O + NAD⁺ + 2-hydroxycanthaxanthin

phenol + NADH + H⁺ + oxygen → H₂O + hydroquinone + NAD⁺

12 H⁺ + 6 NADPH + 6 (S)-methylmalonyl-CoA + propanoyl-CoA → 6 NADP⁺ + 6 CO₂ + 7 coenzyme A + H₂O + 6-deoxyerythronolide B

4α-methyl-5α-cholesta-8,24-dien-3β-ol + NAD(P)H + H⁺ + oxygen → 4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol + H₂O + NAD(P)+

(R)-3,5-bisphosphomevalonate + H⁺ → isopentenyl phosphate + phosphate + CO₂

2 NADPH + 2 H⁺ + 2 oxygen + tetracenomycin B2 → 2 NADP⁺ + H₂O + 8-demethyltetracenomycin C

NADPH + 7-deoxyloganetin + H⁺ + oxygen → H₂O + loganetin + NADP⁺

NAD(P)+ + 3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate ← NAD(P)H + 3-[(2E,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate + H⁺

NADPH + H⁺ + oxygen + tigecycline → H₂O + NADP⁺ + 11-hydroxytigecycline

2 H⁺ + 3 NAD(P)H + 3 oxygen + 4α-methyl-5α-cholesta-8-en-3-ol → 3 NAD(P)+ + 4 H₂O + 4α-carboxy-5α-cholesta-8-en-3β-ol

NADPH + lyngbyatoxin A + H⁺ + oxygen → H₂O + lyngbyatoxin C + NADP⁺

H⁺ + UDP-α-D-glucuronate → UDP-α-D-xylose + CO₂

2 H⁺ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H₂O + Fe²⁺ + mycobilin b

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2 2,4-dibromophenol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 2,6-dibromo-4-(2,4-dibromophenoxy)phenol

coenzyme A + palmitoleate + H⁺ + ATP → H⁺ + palmitoleoyl-CoA + diphosphate + AMP

2 NADP⁺ + (+)-epicatechin ← 2 NADPH + 3 H⁺ + cyanidin

2 NADP⁺ + (-)-catechin ← 2 NADPH + 3 H⁺ + cyanidin

NADPH + acetone + H⁺ + oxygen → H₂O + methyl acetate + NADP⁺

trans-4-hydroxy-L-proline + NAD(P)+ ← 2 H⁺ + (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + NAD(P)H

NADP⁺ + (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol ← (3R)-sophorol + NADPH + H⁺

β-cryptoxanthin + NADH + H⁺ + oxygen → zeaxanthin + H₂O + NAD⁺

NADP⁺ + raucaffrinoline ← NADPH + H⁺ + perakine

pseudomonate C + NADP⁺ ← deoxymupirocin F + NADPH + H⁺

H⁺ + oxygen + 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol → H₂O + 3-demethylubiquinol-7

2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + oxygen + 2,4-dibromophenol + 2,3,4-tribromo-1H-pyrrole → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + pentabromopseudilin

NADPH + H⁺ + (-)-phaseollidin + oxygen → 2 H₂O + NADP⁺ + (-)-phaseollin

GDP-6-deoxy-α-D-talose + NAD(P)+ ← GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H⁺

2-oxoglutarate + H⁺ + chloride + oxygen + ambiguine H → H₂O + succinate + ambiguine A + CO₂

2 H⁺ + 2 oxygen + an oxidized electron donor + hydrogen peroxide + protoheme → 2 carbon monoxide + hematinate + a reduced electron donor + tripyrrole + Fe³⁺

ent-isokaurene + NADPH + H⁺ + oxygen → H₂O + kauralexin B1 + NADP⁺

NADH + H⁺ + oxygen + 3-hydroxy-4-methyl-benzoate → H₂O + 4-methylgentisate + NAD⁺

2 H⁺ + NAD(P)H + oxygen + 4-aminobenzoate → H₂O + 4-aminophenol + NAD(P)+ + CO₂

N, N-dihydroxytrihomomethionine + H⁺ → H₂O + (E)-6-(methylsulfanyl)hexanal oxime + CO₂

L-arogenate + H⁺ → H₂O + L-phenylalanine + CO₂

(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H₂O + H⁺ → 2-dehydro-3-deoxy-D-gluconate + ammonium

2 an oxidized ferredoxin [iron-sulfur] cluster + phosphate + ADP + bacteriochlorophyllide g ← 2 a reduced ferredoxin [iron-sulfur] cluster + H₂O + H⁺ + ATP + 3,8-divinyl chlorophyllide a

NADP⁺ + 5,6,7,8-tetrahydrofolate ← 7,8-dihydrofolate monoglutamate + NADPH + H⁺

24,25-dihydrolanosterol + NADPH + H⁺ + oxygen → 4,4-dimethyl-14α-hydroxymethyl-5α-cholesta-8-en-3β-ol + H₂O + NADP⁺

3 H⁺ + 5 NADPH + 9 malonyl-CoA + H₂O + acetyl-CoA → 10 coenzyme A + 5 NADP⁺ + 9 CO₂ + 3,5,7,9,11,13,15,17,19-nonaoxoicosanoate

H⁺ + carboxyspermidine → spermidine + CO₂

2 H⁺ + H₂O + 5-ureidoimidazole-4-carboxylate → 5-aminoimidazole-4-carboxylate + ammonium + CO₂

D-glucaro-1,5-lactone + H⁺ + sinapoyl-CoA → coenzyme A + O-sinapoylglucarolactone

2-chloro-2-(4-chloro-5-oxo-2H-furan-2-yl)acetate ← 2,5-dichloro-cis,cis-muconate + H⁺

NAD(P)H + H⁺ + preaspyridone A + oxygen → H₂O + NAD(P)+ + 14-hydroxypreaspyridone A

benzaldehyde + NADP⁺ + diphosphate + AMP ← NADPH + H⁺ + ATP + benzoate

2 an oxidized ferredoxin [iron-sulfur] cluster + 2 L-glutamate ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2-oxoglutarate + L-glutamine

3 ATP + H⁺ → 2 diphosphate + pppA2'p5'A2'p5'A

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + myxocoxanthin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + plectaniaxanthin + H₂O

2 ATP + H⁺ → P¹,P⁴-bis(5'-adenosyl) tetraphosphate + diphosphate

H⁺ + roseoflavin 5'-phosphate + ATP → diphosphate + roseoflavin adenine dinucleotide

H₂O + yersinopine + NADP⁺ ← (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + NADPH + pyruvate + H⁺

dimethylamine + NADPH + H⁺ + oxygen → H₂O + methylamine + formaldehyde + NADP⁺

formate + H⁺ + GTP → H₂O + dGTP + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1,3-dimethylbenzene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 3-methylbenzyl alcohol

hydrogen peroxide + oleate + H⁺ → 2 H₂O + 1E,8Z-heptadecadiene + CO₂

NADPH + H⁺ + oxygen + 3,7,4'-trimethylquercetin → H₂O + NADP⁺ + 2'-hydroxy 3,7,4'-trimethylquercetin

NADPH + SCB3 butanolide intermediate + H⁺ → SCB3 + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:3-2-18:2-digalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-18:3-digalactosyldiacylglycerol

2-hydroxyphenazine-1-carboxylate + H⁺ → 2-hydroxyphenazine + CO₂

3-keto-L-gulonate + H⁺ → L-xylulose + CO₂

NADPH + L-kynurenine + H⁺ + oxygen → 3-hydroxy-L-kynurenine + H₂O + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + narbomycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + neopikromycin

H₂O + H⁺ + isoguanine → xanthine + ammonium

H⁺ + phytate + ATP → 1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + ADP

coenzyme A + NAD(P)+ + 1-hexanal ← NAD(P)H + hexanoyl-CoA + H⁺

2 phytyl diphosphate + NADPH + H⁺ → 2 diphosphate + (14E,18E)-lycopadiene + NADP⁺

2 H⁺ + H₂O + (S)-ureidoglycolate → 2 ammonium + glyoxylate + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 30-hydroxylanosterol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 30-oxolanosterol

NADPH + stipitalide + H⁺ + oxygen → H₂O + stipitaldehydate + NADP⁺

NADP⁺ + (3R,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosapentaenoyl-CoA ← (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + NADPH + H⁺

H⁺ + 8α-hydroxy-germacra-1(10),4,11(13)-trien-12-oate → H₂O + 8-epi-inunolide

β-cembratriene-ol + NAD(P)H + H⁺ + oxygen → β-cembratriene-4,6-diol + H₂O + NAD(P)+

NADP⁺ + SCB3 ← 6-dehydro-SCB3 + NADPH + H⁺

palmitate + H⁺ + ATP → (palmitoyl)adenylate + diphosphate

H⁺ + oxygen + protodeoxyviolaceinate → H₂O + CO₂ + prodeoxyviolacein

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 20-oxo-5-O-β-mycaminosyltylactone + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 5-O-β-mycaminosyltylonolide

NADP⁺ + 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone ← NADPH + H⁺ + (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone

2 malonyl-CoA + H⁺ + trans-caffeoyl-CoA → 2 CO₂ + 3 coenzyme A + hispidin

diatoxanthin + NADPH + H⁺ + oxygen → diadinoxanthin + H₂O + NADP⁺

H₂O + H⁺ + sinigrin → 2-propenyl-thiohydroximate-O-sulfate + α-D-glucopyranose

2 L-arginine + 3 NADPH + 4 oxygen + H⁺ → 2 L-citrulline + 2 nitric oxide + 3 NADP⁺ + 4 H₂O

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 10-deoxymethymycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + methymycin

N-methyl-N-[(2S)-1-phenylpropan-2-yl]hydroxylamine + NADPH + H⁺ + oxygen → 2 H₂O + (Z)-methyl(oxido)(1-phenylpropan-2-ylidene)azanium + NADP⁺

NADPH + (22R)-hydroxycholesterol + H⁺ + oxygen → H₂O + NADP⁺ + 22,26-dihydroxycholesterol

NADPH + H⁺ + oxygen + 1-deoxy-11-oxopentalenate → H₂O + NADP⁺ + pentalenolactone D

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:1-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:1-2-16:2-monogalactosyldiacylglycerol

(R)-glycerate + NAD(P)+ ← tartronate semialdehyde + NAD(P)H + H⁺

NADH + 3-hydroxy-trans-cinnamate + H⁺ + oxygen → H₂O + 2,3-dihydroxy-trans-cinnamate + NAD⁺

2 NADPH + 2 H⁺ + 2 oxygen + tetracenomycin A2 → 2 NADP⁺ + H₂O + tetracenomycin C

2 H⁺ + 3 NADPH + 3 oxygen + 5β-cholestane-3α,7α-diol → 3 NADP⁺ + 4 H₂O + (25R)-3α,7α-dihydroxy-5-β-cholestanate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 6-deoxyerythronolide B + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + erythronolide B

3-methyl-2-oxobutanoate + H⁺ → isobutanal + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + 2-oxospirilloxanthin → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 2'-hydroxy-2-oxospirilloxanthin

NADPH + H⁺ + 7α-hydroxycholest-4-en-3-one + oxygen → H₂O + NADP⁺ + 7α,12α-dihydroxycholest-4-en-3-one

NAD(P)+ + 3,4-dihydroxy-2-methyl-4-farnesyl-3H-quinolin-1-ium-1-olate ← NAD(P)H + 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide + H⁺

NADP⁺ + (11Z,14Z)-icosadienoyl-CoA ← NADPH + H⁺ + (2E,11Z,14Z)-icosatrienoyl-CoA

NADPH + H⁺ + bromide + oxygen + 2,4-dibromophenol → 2 H₂O + NADP⁺ + 2,4,6-tribromophenol

NADPH + H⁺ + 2-methoxy-6-(all-trans-octaprenyl)phenol + oxygen → H₂O + 2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol + NADP⁺

2 H⁺ + sulfate + galena → anglesite + hydrogen sulfide

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + acetochlor + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + ethyl formate + 2-chloro-N-(2-ethyl,6-methylphenyl)acetamide

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-18:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-18:2-monogalactosyldiacylglycerol

2 oxygen + NAD(P)H + H⁺ + aminopyrrolnitrin → 2 H₂O + pyrrolnitrin + NAD(P)+

NADPH + H⁺ + oxygen + benzoate → H₂O + NADP⁺ + 4-hydroxybenzoate

2 H⁺ + salicylate + NADH + oxygen → H₂O + catechol + NAD⁺ + CO₂

NADP⁺ + 4α-methyl-5α-cholesta-8-en-3-ol ← 4α-methyl-5α-cholesta-8,24-dien-3β-ol + NADPH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + (25R)-26-oxocholesterol + H⁺ + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + (25R)-3β-hydroxycholest-5-en-26-oate + H₂O

3-amino-4-hydroxybenzoate + H⁺ + ATP → 3-amino-4-hydroxybenzoate-adenylate + diphosphate

NADP⁺ + dihydrogeranylgeranyl bacteriochlorophyllide b ← NADPH + H⁺ + geranylgeranyl bacteriochlorophyllide b

(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate + H⁺ → (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO₂

H⁺ + 10-carboxy-3-deoxycarminomycin → 13-deoxycarminomycin + CO₂

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H⁺ + 4-methyl-5-(2-phosphooxyethyl)thiazole → thiamine phosphate + diphosphate

H⁺ + oxygen + α-hydroxyheme → H₂O + verdoheme + carbon monoxide

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + isocryptoxanthin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + isozeaxanthin + H₂O

NAD(P)+ + dTDP-4-dehydro-2,6-dideoxy-α-D-allose ← 2 H⁺ + NAD(P)H + dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose

S-adenosyl-L-methionine + methanol + H⁺ + 26,27-dehydrozymosterol → S-adenosyl-L-homocysteine + 24-alkyl sterol 2 + a methyl group

3 H⁺ + 3 malonyl-CoA + 2-methylbutanoyl-CoA → 3 CO₂ + 4 coenzyme A + phlormethylbutanophenone

6-dehydro-virginiae butanolide A + NAD⁺ ← NADH + 4-(hydroxymethyl)-3-(5-methylhexanoyl)-5H-furan-2-one + H⁺

2 H⁺ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H₂O + Fe²⁺ + mycobilin a

H₂O + 5-nitroanthranilate + H⁺ → 5-nitrosalicylate + ammonium

FAD + trans,octacis-decaprenylphospho-β-D-ribofuranose + H⁺ → FADH₂ + trans,octacis-decaprenylphospho-β-D-erythro-pentofuranosid-2-ulose

NADP⁺ + L-pipecolate ← 2 H⁺ + 1-piperideine 6-carboxylate + NADPH

(-)-lariciresinol + NADP⁺ ← NADPH + (-)-pinoresinol + H⁺

(3¹R)-8-ethyl-12-methylbacteriochlorophyllide e + H⁺ + (2E,6E)-farnesyl diphosphate → (3¹R)-8-ethyl-12-methylbacteriochlorophyll e + diphosphate

hydrogen peroxide + stearate + H⁺ → 2 H₂O + 1-heptadecene + CO₂

NADPH + aurachin D + H⁺ + oxygen → H₂O + aurachin C + NADP⁺

2 NADPH + 2 oxygen + dTDP-β-L-evernosamine + H⁺ → 2 NADP⁺ + 3 H₂O + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-β-L-arabino-hexopyranose

H⁺ + (-)-dehydrodiconiferyl acid carboxylate → 4,2'-dihydroxy-3,3'-dimethoxy-5'-(2''-carboxyvinyl)stilbene + CO₂

14 NADPH + 22 H⁺ + 9 malonyl-CoA + acetyl-CoA → 10 coenzyme A + 14 NADP⁺ + 8 H₂O + 9 CO₂ + arachidonate

H⁺ + malonyl-CoA + palmitoyl-CoA → coenzyme A + 3-oxooctadecanoyl-CoA + CO₂

H₂O + 7,8-dihydropterin + H⁺ → 7,8-dihydrolumazine + ammonium

3-hydroxyphenylacetate + NAD(P)H + H⁺ + oxygen → H₂O + homogentisate + NAD(P)+

NADP⁺ + glycyrrhetinate ← 3-oxoglycyrrhetinate + NADPH + H⁺

phenol + NADPH + H⁺ + oxygen → H₂O + catechol + NADP⁺

prenyl diphosphate + deoxyhumulone + H⁺ + geranyl diphosphate → 2 diphosphate + adhyperforin

NAD⁺ + D-threo-isocitrate ← oxalosuccinate + NADH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + spheroidene + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + spheroiden-2-ol + H₂O

NAD⁺ + S-(hydroxysulfenamide)glutathione ← NADH + H⁺ + S-nitrosoglutathione

NADP⁺ + (+)-isomenthone ← (+)-pulegone + NADPH + H⁺

NADP⁺ + (-)-menthone ← (+)-pulegone + NADPH + H⁺

5-methyl-N-(4-nitrophenyl)-1-oxo-1λ⁴-thiophene-2-carboxamide + NADPH + H⁺ + oxygen → H₂O + 5-methyl-N-(4-nitrophenyl)-1,1-dioxo-1λ⁶-thiophene-2-carboxamide + NADP⁺

(4Z)-4-[(2E)-3-carboxylato-3-hydroxyprop-2-en-1-ylidene]-3,4-dihydro-2H-pyrrole-2-carboxylate + H⁺ → 4-[(1Z)-3-carboxylato-3-oxoprop-1-en-1-yl]-2,3-dihydro-1H-pyrrole-2-carboxylate

2 an oxidized ferredoxin [iron-sulfur] cluster + chlorophyllide a ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3,8-divinyl chlorophyllide a

NAD⁺ + (11Z,14Z,17Z)-icosatrienoyl-CoA ← NADH + H⁺ + (2E,11Z,14Z,17Z)-icosatetraenoyl-CoA

3,5-dichloro-2-methyl-muconolactone + H⁺ → 3-chloro-2-methyl-dienelactone + chloride

H⁺ + malonyl-CoA + γ-linolenoyl-CoA → coenzyme A + 3-oxodihomo γ-linolenoyl-CoA + CO₂

2 H⁺ + an oxidized electron donor + L-ascorbate → a reduced electron donor + monodehydroascorbate radical

N-3-fumaramoyl-L-2,3-diaminopropanoate + H⁺ + ATP → N-3-fumaramoyl-(S)-2,3-diaminopropanoyl-adenylate + diphosphate

2 H⁺ + coenzyme A + 3-oxo-24-ethyl-cholest-4-en-26-oate + ATP → 3-oxo-24-ethyl-cholest-4-en-26-oyl-CoA + diphosphate + AMP

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + neomethymycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + novamethymycin

γ-butyrobetaine + NAD(P)H + H⁺ + oxygen → H₂O + succinate semialdehyde + NAD(P)+ + trimethylamine

NAD(P)H + H⁺ + pretenellin A + oxygen → 2 H₂O + NAD(P)+ + pretenellin B

2 3-sulfanylpropanoate + NAD⁺ ← NADH + H⁺ + 3,3'-disulfanediyldipropannoate

NADPH + H⁺ + (-)-menthone + oxygen → H₂O + NADP⁺ + (4R,7S)-7-isopropyl-4-methyloxepan-2-one

H⁺ + (2S)-ethylmalonyl-CoA → butanoyl-CoA + CO₂

3-carboxy-6-(methylsulfanyl)-2-oxohexanoate + H⁺ → 6-(methylsulfanyl)-2-oxohexanoate + CO₂

3-keto-L-gulonate 6-phosphate + H⁺ → L-xylulose 5-phosphate + CO₂

3 oxygen + 5 H⁺ + 6 a reduced ferredoxin [iron-sulfur] cluster + candicinolide → 4 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + 18-carboxy candicinolide

2 H⁺ + FAD + 1'-carboxy-chondrochloren B → FADH₂ + chondrochloren B + CO₂

2 NAD(P)H + 2 H⁺ + 4-nitrobenzoate → 2 NAD(P)+ + H₂O + 4-hydroxylaminobenzoate

(25R)-26-hydroxycholesterol + NADPH + H⁺ + oxygen → (25R)-7α,26-dihydroxycholesterol + H₂O + NADP⁺

2 NADPH + 2 H⁺ + stearoyl-CoA → 2 NADP⁺ + coenzyme A + octadecan-1-ol

dTDP-L-olivose + NADP⁺ ← NADPH + dTDP-4-dehydro-2,6-dideoxy-β-L-galactose + H⁺

NADPH + H⁺ + 14α-hydroxy-cholesta-4,7-diene-3,6-dione → NADP⁺ + 3-dehydro-2,22,25-deoxyecdysone

NAD(P)+ + 5-methyltetrahydropteroyl mono-L-glutamate ← NAD(P)H + H⁺ + 5,10-methylenetetrahydropteroyl mono-L-glutamate

3 H⁺ + 3 malonyl-CoA → 3 coenzyme A + 3 CO₂ + phloroglucinol

questin + NADPH + H⁺ + oxygen → demethylsulochrin + NADP⁺ + H⁺

NADPH + H⁺ + oxygen + pentalen-13-ol → 2 H₂O + NADP⁺ + pentalen-13-al

2 H⁺ + deoxyhumulone + oxygen → H₂O + humulone

2 NADPH + 2 H⁺ + 2-methyl-1,4-benzoquinone → 2 NADP⁺ + methyl-1,4-benzoquinol

dimethyl sulfoxide + NADH + H⁺ + oxygen → H₂O + dimethyl sulfone + NAD⁺

NADPH + phosphorylated SCB1 butenolide intermediate + H⁺ → phosphorylated SCB1 butanolide intermediate + NADP⁺

NADPH + H⁺ + 7α,12α-dihydroxycholest-4-en-3-one → 7α,12α-dihydroxy-5β-cholestan-3-one + NADP⁺

seleno-L-homocysteine + H⁺ + 5-methyltetrahydropteroyl tri-L-glutamate → L-selenomethionine + tetrahydropteroyl tri-L-glutamate

2-C-methyl-D-erythritol 4-phosphate + H⁺ + CTP → diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

NADPH + tert-amyl alcohol + H⁺ + oxygen → 2 H₂O + NADP⁺ + isoprenyl alcohol

NADPH + (-)-matairesinol + H⁺ + oxygen → H₂O + (-)-thujaplicatin + NADP⁺

(3E)-2-chloro-5-oxohex-3-enedioate + H⁺ → (3E)-5-chloro-2-oxopent-3-enoate + CO₂

4-coumaryl alcohol + NADP⁺ ← NADPH + 4-coumaraldehyde + H⁺

NADH + butan-2-one + H⁺ + oxygen → H₂O + NAD⁺ + ethyl acetate

a reduced electron donor + H⁺ + L-tryptophan + oxygen → an oxidized electron donor + H₂O + ammonium + (indol-3-yl)acetaldehyde + CO₂

NADPH + 24-methyldesmosterol + H⁺ → campesterol + NADP⁺

NADPH + H⁺ + 16-hydroxypalmitoyl-CoA + oxygen → 10,16-dihydroxypalmitoyl-CoA + H₂O + NADP⁺

N²-hydroxy-L-tryptophan + NADPH + H⁺ + oxygen → H₂O + N²,N²-dihydroxy-L-tryptophan + NADP⁺

orcinol + NADH + H⁺ + oxygen → H₂O + NAD⁺ + 2,3,5-trihydroxytoluene

reduced riboflavin + NADP⁺ ← 2 H⁺ + riboflavin + NADPH

7 H⁺ + 8 malonyl-CoA → 8 coenzyme A + 8 CO₂ + H₂O + octoketide

H⁺ + L-cysteine + sulfite → L-cysteate + hydrogen sulfide

NADPH + H⁺ + (4R)-limonene + oxygen → H₂O + NADP⁺ + (+)-trans-carveol

S-adenosyl-L-methionine + H⁺ + cobalt-precorrin-6B → S-adenosyl-L-homocysteine + CO₂ + cobalt-precorrin-7

H⁺ + 3-heptaprenyl-4-hydroxybenzoate → 2-heptaprenylphenol + CO₂

H₂O + H⁺ + 2-hexaprenyl-3-methyl-6-methoxyaminophenol → ammonium + 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol

5-hydroxy-L-tryptophan + H⁺ → serotonin + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-oleoyl-2-palmitoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-linoleoyl-2-palmitoyl-phosphatidylglycerol

2 H⁺ + 3 NADPH + 3 oxygen + 24,25-dihydrolanosterol → 3 NADP⁺ + 4 H₂O + 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + formate

chlorophyll a + NADP⁺ ← NADPH + H⁺ + tetrahydrogeranylgeranyl chlorophyll a

(E)-4-coumaroyl-CoA + H⁺ + kaempferol 3-O-β-D-glucoside → coenzyme A + kaempferol 3-O-(3"-O-p-coumaroyl)-glucoside

5 H⁺ + 5 malonyl-CoA → 5 coenzyme A + 5 CO₂ + H₂O + 5,7-dihydroxy-2-methylchromone

NADPH + avenasterol + H⁺ + oxygen → 2 H₂O + 5-dehydroavenasterol + NADP⁺

2 H⁺ + H₂O + allantoate → ammonium + (S)-ureidoglycine + CO₂

NADPH + H⁺ + oxygen + 13-deoxydaunorubicin → H₂O + NADP⁺ + 13-dihydrodaunorubicin

2 a peptidoglycan dimer (E. faeciums) + H⁺ → a peptidoglycan tetramer with a D,D cross-link (Enterococcus faecium) + D-alanine

(S)-3-methyl-2-oxopentanoate + H⁺ → 2-methylbutanal + CO₂

H⁺ + GTP + α-D-mannose 1-phosphate → GDP-α-D-mannose + diphosphate

NADH + H⁺ + 2,5-dichlorotoluene + oxygen → NAD⁺ + (1R,2S)-3,6-dichloro-4-methylcyclohexa-3,5-diene-1,2-diol

NAD(P)+ + 5-chloro-3-oxoadipate ← 5-chloromaleylacetate + NAD(P)H + H⁺

3 an oxidized ferredoxin [iron-sulfur] cluster + 3 H₂O + hydrogen sulfide ← 3 a reduced ferredoxin [iron-sulfur] cluster + 8 H⁺ + sulfite

an oxidized electron donor + 1,4-dihydroxy-2-naphthoate + H⁺ → 1,4-naphthoquinone + a reduced electron donor + CO₂

ethanol + NADP⁺ ← NADPH + acetaldehyde + H⁺

(3¹R)-8,12-diethylbacteriochlorophyllide e + H⁺ + (2E,6E)-farnesyl diphosphate → (3¹R)-8,12-diethylbacteriochlorophyll e + diphosphate

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + prenyl diphosphate ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate

NAD(P)+ + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin ← NAD(P)H + H⁺ + (6R)-6,7-dihydrobiopterin

H⁺ + malonyl-CoA + oleoyl-CoA → coenzyme A + 3-oxo-(11Z)-eicos-11-enoyl-CoA + CO₂

H₂O + NADP⁺ + (+)-catechin ← NADPH + H⁺ + (2R,3S,4S)-leucocyanidin

2 H⁺ + 2 sulochrin + oxygen → 2 H₂O + 2 (+)-bisdechlorogeodin

NADH + H⁺ + 2-chlorobenzoate + oxygen → catechol + NAD⁺ + chloride + CO₂

2 H⁺ + 3 malonyl-CoA + 7-hydroxylauroyl-CoA → 3 CO₂ + 4 coenzyme A + 2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate

propanoyl-CoA + NAD⁺ ← NADH + H⁺ + acryloyl-CoA

NADPH + H⁺ + trans-feruloyl-CoA → coenzyme A + coniferaldehyde + NADP⁺

N-[(R)-pantothenoyl]-L-cysteine + H⁺ → pantetheine + CO₂

NADH + 4,4-dimethyl-5α-cholest-7-en-3β-ol + H⁺ + oxygen → H₂O + NAD⁺ + 4β-hydroxymethyl-4α-methyl-5α-cholest-7-en-3β-ol

(E)-4-coumaroyl-CoA + H⁺ + kaempferol 3-O-β-D-glucoside → coenzyme A + kaempferol 3-O-(4"-O-p-coumaroyl)-glucoside

NADPH + H⁺ + (+)-camphor + oxygen → (+)-6-exo-hydroxycamphor + H₂O + NADP⁺

H₂O + H⁺ + Fe³⁺-[diglucosyl-(2,3-dihydroxybenzoylserine)₂] complex → salmochelin SX + Fe³⁺-[salmochelin SX] complex

but-3-en-2-one + NADPH + H⁺ → butan-2-one + NADP⁺

H⁺ + malonyl-CoA + docosanoyl-CoA → coenzyme A + 3-oxo-lignoceroyl-CoA + CO₂

NADPH + H⁺ + 2-methyl-4-chlorophenol + oxygen → H₂O + NADP⁺ + 5-chloro-3-methylcatechol

NADH + H⁺ + oxygen + 3-hydroxybenzoate → H₂O + gentisate + NAD⁺

2 NADH + 2 oxygen + 4 H⁺ + chromopyrrolate → 2 NAD⁺ + 2 CO₂ + 3 H₂O + K-252c

oleate + ethanol + H⁺ → H₂O + ethyl oleate

N²,N²-dihydroxy-L-tryptophan + H⁺ → H₂O + (E)-(indol-3-yl)acetaldehyde oxime + CO₂

L-carnitine + NAD(P)H + H⁺ + oxygen → H₂O + NAD(P)+ + L-malic semialdehyde + trimethylamine

N-ethylmaleimide + NADPH + H⁺ → N-ethylsuccinimide + NADP⁺

2-oxoglutarate + H⁺ + chloride + oxygen + ambiguine L → H₂O + succinate + ambiguine K + CO₂

NADP⁺ + 17-O-acetylnorajmaline ← NADPH + H⁺ + (20αS)-19,20--dihydrovomilenine

S-adenosyl-L-methionine + methanol + H⁺ + 26,27-dehydrozymosterol → S-adenosyl-L-homocysteine + 26-hydroxy-27-methyl-zymosterol + a methyl group

2 H⁺ + 2-oxoglutarate + oxygen + gibberellin A₄₄ (closed lactone form) → succinate + gibberellin A₉₈ + CO₂

2 glutathione amide + NAD⁺ ← NADH + H⁺ + glutathione amide disulfide

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + spheroiden-2-ol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2,2-dihydroxyspheroidene + H₂O

H⁺ + malonyl-CoA + arachidonoyl-CoA → coenzyme A + (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO₂

H₂O + tauropine + NAD⁺ ← taurine + NADH + pyruvate + H⁺

dihydrochelirubine + H⁺ + oxygen → hydrogen peroxide + chelirubine

2 H⁺ + 2-oxoglutarate + oxygen → 3 CO₂ + H₂O + ethene

phytyl diphosphate + 2-carboxy-1,4-naphthoquinone + H⁺ → demethylphylloquinone + diphosphate + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + cholest-4-en-3-one + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (25R)-26-hydroxycholest-4-en-3-one

NADPH + H⁺ + oxygen + 1-deoxy-11-oxopentalenate → H₂O + NADP⁺ + neopentalenolactone D

2 H₂O + 3 NAD⁺ + ammonium ← 3 NADH + 5 H⁺ + nitrite

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2 2,3,4-tribromo-1H-pyrrole + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + hexabromo-2,2'-bipyrrole

FAD + H⁺ + isovaleryl-CoA → FADH₂ + 3-methylcrotonyl-CoA

H₂O + carboxynorspermidine + NADP⁺ ← L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H⁺

NADPH + H⁺ + echinocandin C + oxygen → H₂O + NADP⁺ + echinocandin B

(E)-2-pentenol + NADP⁺ ← NADPH + H⁺ + (E)-2-pentenal

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + pentalenolactone F → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + pentalenolactone

15 H⁺ + 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 7 NADPH + (2S)-ethylmalonyl-CoA → 3 H₂O + 7 NADP⁺ + 8 coenzyme A + 8 CO₂ + tylactone

H⁺ + D-xylulose 5-phosphate + CTP → diphosphate + CDP-D-xylulose

dihydrosanguinarine + H⁺ + oxygen → sanguinarine + hydrogen peroxide

2 L-arginine + 3 NAD(P)H + 4 oxygen + H⁺ → 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H₂O

NADPH + 8-(methylsulfanyl)octyl-glucosinolate + H⁺ + oxygen → H₂O + NADP⁺ + 8-(methylsulfinyl)octyl-glucosinolate

L-phenylalanine + H⁺ → 2-phenylethylamine + CO₂

3 H⁺ + 3 malonyl-CoA + (E)-cinnamoyl-CoA → 3 CO₂ + 4 coenzyme A + pinocembrin chalcone

O-phosphoethanolamine + H⁺ + CTP → CDP-ethanolamine + diphosphate

FAD + H⁺ + glutaryl-CoA → FADH₂ + (E)-glutaconyl-CoA

NADPH + (E)-4-coumaroyl-CoA + H⁺ + oxygen → H₂O + NADP⁺ + trans-caffeoyl-CoA

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (25S)-26-hydroxycholest-4-en-3-one + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + (25S)-26-oxocholest-4-en-3-one

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-16:0-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-16:0-monogalactosyldiacylglycerol

pyruvate + GTP ← phosphoenolpyruvate + H⁺ + GDP

14-demethyllanosterol + NADH + H⁺ + oxygen → 4β-hydroxymethyl-4α-methyl-5α-cholesta-8,24-dien-3β-ol + H₂O + NAD⁺

2 NADP⁺ + 2 iodide + L-tyrosine ← 2 NADPH + 3,5-diiodo-L-tyrosine + H⁺

(16R,19Z)-isositsirikine + NADP⁺ ← 19E-geissoschizine + NADPH + H⁺

6 H⁺ + 6 malonyl-CoA + acetyl-CoA → 7 coenzyme A + 7 CO₂ + H₂O + aloesone

NADP⁺ + 4-hydroxyphenylbutan-2-one ← NADPH + H⁺ + 4-hydroxybenzalacetone

NADH + H⁺ + toluene + oxygen → H₂O + NAD⁺ + 4-methylphenol

hispidin + NADPH + H⁺ + oxygen → H₂O + 3-hydroxyhispidin + NADP⁺

3 H⁺ + 3 malonyl-CoA + 3-hydroxybenzoyl-CoA → 3 CO₂ + 4 coenzyme A + 2,3',4,6-tetrahydroxybenzophenone

2 L-glutamate + NADP⁺ ← NADPH + 2-oxoglutarate + H⁺ + L-glutamine

2 NADPH + 2 H⁺ + trichloroethene + oxygen → 2 NADP⁺ + H₂O + trichloroethanol

NADPH + (S)-dihydrodaidzein + H⁺ → (3R,4S)-tetrahydrodaidzein + NADP⁺

NADPH + 20-oxo-5-O-β-mycaminosyltylactone + H⁺ + oxygen → H₂O + 5-O-β-mycaminosyltylonolide + NADP⁺

propanoyl-CoA + NADP⁺ ← NADPH + H⁺ + acryloyl-CoA

NAD(P)H + H⁺ + CDP-D-fructose → NAD(P)+ + CDP-D-mannitol

H⁺ + monothiocarbonate → hydrogen sulfide + CO₂

2 NADPH + 2 H⁺ + 2-nitrophenol + oxygen → 2 NADP⁺ + H₂O + catechol + nitrite

phylloquinone + NAD(P)H + H⁺ → phylloquinol + NAD(P)+

NADPH + O4,O5--dimethylthujaplicatin + H⁺ + oxygen → 2 H₂O + (-)-yatein + NADP⁺

p-cymene + NADH + H⁺ + oxygen → H₂O + 4-isopropylbenzyl alcohol + NAD⁺

NADPH + H⁺ + 2-trans, 4-cis-undecadienoyl-CoA → NADP⁺ + (3E)-undec-3-enoyl-CoA

cholesterol + NAD(P)H + H⁺ + oxygen → 2 H₂O + 7-dehydrocholesterol + NAD(P)+

D-firefly luciferin + H⁺ + ATP → (D-firefly luciferyl)adenylate + diphosphate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-linoleoyl-2-palmitoyl-phosphatidylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-linoleoyl-2-(3E)-hexadecenoyl-phosphatidylglycerol

hexanoyl-CoA + NAD⁺ ← NADH + trans-hex-2-enoyl-CoA + H⁺

2,3-dihydroxybenzoate + H⁺ + ATP → (2,3-dihydroxybenzoyl)adenylate + diphosphate

H₂O + H⁺ + ferric-[(2,3-dihydroxybenzoylserine)₂] complex → N-(2,3-dihydroxybenzoyl)-L-serine + Fe³⁺-[N-(2,3-dihydroxybenzoyl)-L-serine] complex

NADPH + H⁺ + (2-aminobenzoyl)acetate + oxygen → H₂O + NADP⁺ + 2-(hydroxylamino)benzoylacetate

(2R,3S)-2-hexyl-3-hydroxydecanoate + NADP⁺ ← NADPH + (2R)-2-hexyl-3-oxodecanoate + H⁺

furan-2,5-dicarboxylate + H⁺ → 2-furoate + CO₂

ergosta-7,25(27)-dienol + NADPH + H⁺ → ergost-7-enol + NADP⁺

7-O-methylluteone + NADPH + H⁺ + oxygen → H₂O + 7-O-methylluteone epoxide + NADP⁺

NADPH + H⁺ + cobalt-precorrin-6A → NADP⁺ + cobalt-precorrin-6B

NADP⁺ + icosanoyl-CoA ← NADPH + H⁺ + trans-arachido-2-enoyl-CoA

NADP⁺ + dihydroferuloyl-CoA ← NADPH + H⁺ + trans-feruloyl-CoA

NADPH + H⁺ + (Z)-phenylacetaldehyde oxime + L-cysteine + oxygen → 2 H₂O + (Z)-1-(L-cystein-S-yl)-N-hydroxy-2-phenylethan-1-imine + NADP⁺

2-isopropylphenol + NADH + H⁺ + oxygen → 3-isopropylcatechol + H₂O + NAD⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:2-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:1-2-16:3-monogalactosyldiacylglycerol

N-hydroxy-N-succinyl-putrescine + NADPH + H⁺ + oxygen → 3-[4-amino-3-hydroxybutyl]-hydroxy-carbamoyl-propanoate + H₂O + NADP⁺

NADPH + coniferaldehyde + H⁺ + oxygen → H₂O + 5-hydroxy-coniferaldehyde + NADP⁺

cholesterol + NADP⁺ ← 7-dehydrocholesterol + NADPH + H⁺

NAD(P)H + caffeine + H⁺ + oxygen → H₂O + NAD(P)+ + paraxanthine + formaldehyde

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-decaprenyl diphosphate → demethylmenaquinol-10 + diphosphate + CO₂

isochorismate + 2-oxoglutarate + H⁺ → 2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO₂

(25R)-5β-cholestane-3α,7α,12α,26-tetraol + NADPH + H⁺ + oxygen → 2 H₂O + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-al + NADP⁺

H₂O + H⁺ + dCTP → ammonium + dUTP

(R)-mevalonate + NADP⁺ ← (R)-mevaldate + NADPH + H⁺

NADH + H⁺ + ubiquinone-6 → NAD⁺ + ubiquinol-6

NADPH + H⁺ + vitamin D₃ + oxygen → H₂O + NADP⁺ + calcidiol

homogentisate + H⁺ + geranylgeranyl diphosphate → 2-methyl-6-geranylgeranyl-1,4-benzoquinol + diphosphate + CO₂

NADP⁺ + 3 β-hydroxy-7,12-diketocholanate ← NADPH + H⁺ + dehydrocholate

NADPH + H⁺ + coumarin → NADP⁺ + dihydrocoumarin

H₂O + 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H⁺ → 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium

hop-22(29)-ene + S-adenosyl-L-methionine + H⁺ → L-methionine + adenosyl hopane

H₂O + H⁺ + CTP → ammonium + UTP

2 H₂O + 3-cyano-L-alanine + H⁺ → ammonium + L-aspartate

2-oxoglutarate + H⁺ + chloride + oxygen + 12-epi-hapalindole C → H₂O + succinate + 12-epi-hapalindole E + CO₂

NADPH + (E)-4-(methylsulfanyl)butanal oxime + H⁺ + L-cysteine + oxygen → 2 H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-ω-(methylsulfanyl)butan-1-imine + NADP⁺

NADH + 1,3,7-trimethylurate + H⁺ + oxygen → H₂O + 1,3,7-trimethyl-5-hydroxyisourate + NAD⁺

4α-methyl-5α-cholest-7-en-3β-ol + NADP⁺ ← NADPH + H⁺ + 4α-methyl-5α-cholest-7-en-3-one

deoxymupirocin F + NADP⁺ ← deoxymupirocin C + NADPH + H⁺

5 H⁺ + 5 malonyl-CoA → 5 coenzyme A + 5 CO₂ + H₂O + 1,3,6,8-naphthalenetetrol

1,3,7-trihydroxyxanthone + NADPH + H⁺ + oxygen → H₂O + 1,3,6,7-tetrahydroxyxanthone + NADP⁺

N-acetyl-α-D-glucosamine 1-phosphate + H⁺ + dTTP → dTDP-N-acetyl-α-D-glucosamine + diphosphate

1,5-anhydro-D-glucitol + NADP⁺ ← NADPH + 1,5-anhydro-D-fructose + H⁺

H₂O + H⁺ + N-cyclopropylammelide → cyclopropylamine + cyanuric acid

NADPH + H⁺ + oxygen + 20-hydroxy-13-14 epoxy-prefusarin → H₂O + NADP⁺ + 20-hydroxy-fusarin

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + methymycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + novamethymycin

NADPH + H⁺ + oxygen + griseophenone C → 2 H₂O + NADP⁺ + desmethyl-dehydro-dechlorogriseofulvin

2 NADP⁺ + (2S,5S)-hexanediol ← 2 NADPH + 2 H⁺ + 2,5-hexanedione

2 an oxidized ferredoxin [iron-sulfur] cluster + phosphate + ADP + 3-deacetyl-3-vinylbacteriochlorophyllide a ← 2 a reduced ferredoxin [iron-sulfur] cluster + H₂O + H⁺ + ATP + chlorophyllide a

NADP⁺ + SCB2 ← 6-dehydro-SCB2 + NADPH + H⁺

NADPH + ergosta-5,7,24(28)-trien-3β-ol + H⁺ + oxygen → 2 H₂O + ergosta-5,7,22,24(28)-tetraen-3-β-ol + NADP⁺

NADPH + caranine + H⁺ + oxygen → H₂O + lycorine + NADP⁺

H₂O + β-alanopine + NAD⁺ ← β-alanine + NADH + pyruvate + H⁺

NADPH + H⁺ + oxygen + griseophenone B → 2 H₂O + NADP⁺ + desmethyl-dehydro-griseofulvin

FAD + H⁺ + isobutanoyl-CoA → FADH₂ + methylacrylyl-CoA

porifersta-7,25(27)-dienol + NADPH + H⁺ → poriferst-7-enol + NADP⁺

H₂O + N-ethylammeline + H⁺ → N-ethylammelide + ammonium

FAD + H₂O + H⁺ + trans-zeatin → FADH₂ + 3-methyl-4-trans-hydroxy-2-butenal + adenine

norbelladine + NADP⁺ ← NADPH + norcraugsodine + H⁺

NADPH + H⁺ + oxygen + albendazole → H₂O + albendazole s-oxide + NADP⁺

NAD(P)H + H⁺ + deoxybrevianamide E + oxygen → H₂O + NAD(P)+ + 6-hydroxy-deoxybrevianamide E

NADH + H⁺ + oxygen + (2-hydroxy-1H-indol-3-yl)acetate → H₂O + NAD⁺ + 3-hydroxy-2-oxo-(indol-3-yl)acetate

NADH + trans-cinnamate + H⁺ + oxygen → (2E)-3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD⁺

NAD(P)H + theophylline + H⁺ + oxygen → H₂O + 3-methylxanthine + NAD(P)+ + formaldehyde

2-dehydro-3-deoxy-D-gluconate + NADP⁺ ← (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H⁺

H₂O + H⁺ + 5'-deoxyadenosine → ammonium + 5'-deoxyinosine

FAD + H₂O + H⁺ + isopentenyl adenosine → FADH₂ + adenosine + 3-methyl-2-butenal

3-phospho-L-serine + H⁺ + sulfite → L-cysteate + phosphate

4-toluenesulfonate + NADH + H⁺ + oxygen → H₂O + 4-sulfobenzyl alcohol + NAD⁺

NAD⁺ + 4-pyridoxate ← 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NADH + H⁺

levopimaradiene + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + levopimaradienol

2 H⁺ + 3 NADPH + 3 oxygen + obtusifoliol → 3 NADP⁺ + 4 H₂O + 4α-methyl-5α-ergosta-8,14,24(28)-trien-3β-ol + formate

NADPH + H⁺ + lithocholate + oxygen → H₂O + NADP⁺ + hyodeoxycholate

NADPH + H⁺ + 4-dehydro-tetracenomycin C → NADP⁺ + tetracenomycin C

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2-C-methyl-D-erythritol-2,4-cyclodiphosphate + H⁺

NADP⁺ + pseudomonate A ← mupirocin F1 + NADPH + H⁺

phenylglyoxylate + H⁺ → benzaldehyde + CO₂

2 H⁺ + oxygen + rifamycin B → rifamycin-O + hydrogen peroxide

L-homoserine + NAD(P)+ ← L-aspartate 4-semialdehyde + NAD(P)H + H⁺

NADPH + H⁺ + benzoyl-CoA + oxygen → H₂O + NADP⁺ + 3-hydroxybenzoyl-CoA

NADPH + H⁺ + emindole-SB + oxygen → H₂O + NADP⁺ + 14,15-epoxyemindole-SB

NAD⁺ + (S)-3-hydroxyhexanoyl-CoA ← NADH + H⁺ + 3-oxohexanoyl-CoA

NADP⁺ + versiconol ← NADPH + H⁺ + versiconal

NADP⁺ + (E)-2-hexenol ← NADPH + (E)-2-hexenal + H⁺

3-dehydro-4-phospho-D-erythronate + H⁺ → glycerone phosphate + CO₂

(E)-4-coumaroyl-CoA + H⁺ + quercetin-3-glucoside → coenzyme A + quercetin 3-O-(4"-O-p-coumaroyl)-glucoside

3-dehydro-4-phospho-L-erythronate + H⁺ → glycerone phosphate + CO₂

H⁺ + enolaldehyde → methylglyoxal

hydroxyacetone + NADPH + H⁺ + oxygen → H₂O + hydroxymethylene acetate + NADP⁺

3 H⁺ + H₂O + urea-1-carboxylate → 2 ammonium + 2 CO₂

NADPH + cyclohexane + H⁺ + oxygen → H₂O + cyclohexanol + NADP⁺

dTDP-α-D-fucopyranose + NADP⁺ ← NADPH + dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H⁺

NAD(P)H + H⁺ + (5Z,8Z,11Z,14Z,17Z)-3-oxodocosapentaenoyl-CoA → NAD(P)+ + (3R,5Z,8Z,11Z,14Z,17Z)-3-hydroxydocosapentaenoyl-CoA

3 H⁺ + phytyl diphosphate + 1,4-dihydroxy-2-naphthoate → demethylphylloquinol + diphosphate + CO₂

16 an oxidized ferredoxin [iron-sulfur] cluster + saturated archaetidylglycerol ← 16 a reduced ferredoxin [iron-sulfur] cluster + 16 H⁺ + unsaturated archaetidylglycerol

NADPH + H⁺ + luteolin + oxygen → H₂O + 8-hydroxy-luteolin + NADP⁺

ethylamine + NADPH + H⁺ + oxygen → H₂O + acetaldehyde + NADP⁺ + ammonium

2 H⁺ + a reduced electron donor + oxygen + dihydrogeodin → 2 H₂O + an oxidized electron donor + geodin

O-phospho-L-homoserine + H⁺ + L-selenocysteine → L-selenocystathionine + phosphate

(2R,3S)-2-dodecyl-3-hydroxyhexadecanoate + NADP⁺ ← NADPH + (2R)-2-dodecyl-3-oxohexadecanoate + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + (25S)-26-oxocholesterol + H⁺ + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + (25S)-3β-hydroxycholest-5-en-26-oate + H₂O

phthalate + NADH + H⁺ + oxygen → NAD⁺ + phthalate 3,4-cis-dihydrodiol

NADPH + H⁺ + oxygen + 15,15-dimethyl-2-epi-fumiquinazoline A → ammonia + NADP⁺ + (2R)-3-[(9S, 9aR)-9-hydroxy-2,2-dimethyl-3-oxo-1H, 2H, 3H, 9H, 9aH-imidazolidino[1,2-a] indol-9-yl]-2-(2-acetyl-4-oxo-3,4-dihydroquinazolin-3-yl) propanoate

NAD(P)H + γ-glutamyl-isopropylamide + H⁺ + oxygen → H₂O + N-(γ-L-glutamyl)-L-alaninol + NAD(P)+

2-oxosuberate + H⁺ → 7-oxoheptanoate + CO₂

NADPH + lyngbyatoxin A + H⁺ + oxygen → H₂O + lyngbyatoxin B + NADP⁺

3 malonyl-CoA + 4 H⁺ + NADPH + (E)-4-coumaroyl-CoA → 3 CO₂ + 4 coenzyme A + H₂O + isoliquiritigenin + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 10-deoxymethymycin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + neomethymycin

NADPH + 3-(3,4-dihydroxyphenyl)pyruvate + H⁺ → (R)-3-(3,4-dihydroxyphenyl)lactate + NADP⁺

H₂O + N5-(L-1-carboxyethyl)-L-ornithine + NADP⁺ ← L-ornithine + NADPH + pyruvate + H⁺

ergosterol + NADP⁺ ← ergosta-5,7,22,24(28)-tetraen-3-β-ol + NADPH + H⁺

FAD + 15-cis-4,4'-diapophytoene + H⁺ → FADH₂ + all-trans-4,4'-diapophytofluene

(2R,4E)-2-amino-5-({[(2S,3R)-2-hydroxy-3-(1H-indol-3-yl)butanamido]methanimidoyl}amino)pent-4-enoate + H⁺ → indolmycin B + ammonium

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 15-methyl-palmitate + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 16-hydroxy-15-methyl-palmitate

C34-phenolphthiotriol A + NADP⁺ ← NADPH + C34-phenolphthiodiolone A + H⁺

2 pyruvate + H⁺ → (S)-2-acetolactate + CO₂

C30 botryococcene + NADP⁺ + diphosphate ← NADPH + presqualene diphosphate + H⁺

NADPH + H⁺ + dechloro-dehydrogriseofulvin → NADP⁺ + dechlorogriseofulvin

H₂O + (2E,4E)-2-amino-5-chlorohexa-2,4-dienedioate + H⁺ → (2E,4E)-2-chloro-5-hydroxyhexa-2,4-dienedioate + ammonium

H⁺ + trimethylamine N-oxide → dimethylamine + formaldehyde

(R)-4'-phosphopantothenoyl-L-cysteine + H⁺ → 4'-phosphopantetheine + CO₂

4 H⁺ + an oxidized electron donor + isethionate + oxygen → 2 H₂O + sulfoacetaldehyde + a reduced electron donor

C31-phthiodiolone A + NADP⁺ ← NADPH + C31-phthiodiolenone A + H⁺

H⁺ + L-aspartate → β-alanine + CO₂

dihydroprecondylocarpine acetate + NADP⁺ ← precondylocarpine acetate + NADPH + H⁺

2-oxoglutarate + H⁺ + chloride + oxygen + ambiguine J → H₂O + succinate + ambiguine D + CO₂

NADPH + 6-methylpretetramide + H⁺ + oxygen → H₂O + 4-hydroxy-6-methylpretetramide + NADP⁺

NADPH + H⁺ + 3-dehydroecdysone → NADP⁺ + 3-epiecdysone

2 laurate + 2 H⁺ + lesquerella oil → 2 H₂O + triglyceride estolide

NADH + H⁺ + oxygen + uracil → NAD⁺ + (Z)-3-ureidoacrylate peracid

FAD + H⁺ + 3-(methylsulfanyl)propanoyl-CoA → FADH₂ + 3-(methylsulfanyl)acryloyl-CoA

H₂O + NAD⁺ + nitrite ← NADH + H⁺ + nitrate

NADPH + H⁺ + 2-methoxy-6-(all-trans-nonaprenyl)phenol + oxygen → H₂O + 2-methoxy-6-all trans-nonaprenyl-1,4-benzoquinol + NADP⁺

2 NADPH + 2 H⁺ + 4-nitrotoluene → 2 NADP⁺ + H₂O + 4-hydroxylaminotoluene

NADPH + (E)-9-(methylsulfanyl)nonanal oxime + H⁺ + L-cysteine + oxygen → 2 H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-ω-(methylsulfanyl)nonan-1-imine + NADP⁺

NADPH + 5a,11a-dehydrotetracycline + H⁺ + oxygen → H₂O + NADP⁺ + 5a,11a-dehydrooxytetracycline

a reduced electron donor + H⁺ + oxygen + 15-demethoxyaclacinomycin T → an oxidized electron donor + H₂O + 10-decarboxymethylaclacinomycin T + CO₂

fluorobenzene + NADH + H⁺ + oxygen → 4-fluorophenol + H₂O + NAD⁺

4α-hydroxymethyl-5α-cholesta-8-en-3β-ol + NAD(P)H + H⁺ + oxygen → 2 H₂O + 4α-formyl-5α-cholesta-8-en-3β-ol + NAD(P)+

H₂O + S-methyl-5'-thioadenosine + H⁺ → ammonium + S-methyl-5'-thioinosine

pyruvate + dATP ← phosphoenolpyruvate + H⁺ + dADP

NADH + 2-heptyl-4-quinolone + H⁺ + oxygen → H₂O + 2-heptyl-3-hydroxy-4-quinolone + NAD⁺

H₂O + H⁺ + 5-fluorocytosine → ammonium + 5-fluorouracil

NADP⁺ + auricoloyl-CoA ← NADPH + H⁺ + (2E,11Z,17Z)-14R-hydroxy-icosa-11,17-trienoyl-CoA

2 NADPH + 2 H⁺ + 2 oxygen + L-phenylalanine → 2 NADP⁺ + 3 H₂O + (E)-phenylacetaldehyde oxime + CO₂

2 L-ascorbate + 2 H⁺ + an oxidized electron donor → 2 monodehydroascorbate radical + a reduced electron donor

NADP⁺ + ammonium + IMP ← 2 H⁺ + NADPH + GMP

protocatechuate + H⁺ + ATP → (3,4-dihydroxybenzoate)adenylate + diphosphate

H⁺ + oxalyl-CoA → formyl-CoA + CO₂

arachidate + H⁺ + ATP → (arachidoyl)adenylate + diphosphate

H⁺ + 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP → unsaturated CDP-archaeol + diphosphate

NADPH + SCB1 butanolide intermediate + H⁺ → SCB1 + NADP⁺

H₂O + aminoacrylate + H⁺ → ammonium + 3-oxopropanoate

H₂O + N-methylmyosmine + H⁺ → pseudooxynicotine

1,3,5-trihydroxyxanthone + NADPH + H⁺ + oxygen → H₂O + 1,3,5,6-tetrahydroxyxanthone + NADP⁺

salicylate + H⁺ + ATP → (salicyl)adenylate + diphosphate

dTDP-β-L-mycarose + NADP⁺ ← NADPH + dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose + H⁺

H⁺ + 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate → 2-hydroxy-7-methyl-6-oxo-2,4-octadienoate + CO₂

H⁺ + L-serine + palmitoyl-CoA → coenzyme A + 3-dehydrosphinganine + CO₂

2 H⁺ + carbamate → ammonium + CO₂

H⁺ + L-proline + ATP → (L-prolyl)adenylate + diphosphate

H⁺ + 4-hydroxybenzoate + ATP → diphosphate + 4-hydroxybenzoyl-adenylate

NAD(P)H + H⁺ + oxygen + 20-dihydro-chaetoglobosin A → 2 H₂O + NAD(P)+ + chaetoglobosin A

L-ascorbate + H⁺ + oxygen + tyramine → H₂O + L-dehydro-ascorbate + octopamine

NADPH + 5-O-β-mycaminosyltylactone + H⁺ + oxygen → H₂O + 20-hydroxy-5-O-mycaminosyltylactone + NADP⁺

NADPH + H⁺ + oxygen + α-carotene → zeinoxanthin + H₂O + NADP⁺

N,N-dihydroxypentahomomethionine + H⁺ → H₂O + (E)-8-(methylsulfanyl)octanal oxime + CO₂

NADH + H⁺ + (2E,8Z,11Z,14Z)-icosatetraenoyl-CoA → NAD⁺ + dihomo γ-linolenoyl-CoA

NADPH + H⁺ + 3-nonaprenyl-4-hydroxybenzoate + oxygen → 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + H₂O + NADP⁺

4-amino-2-(methanethioyl)-5-oxo-3-sulfanylpyrrolidine-2-carboxylate + H⁺ → (5E)-3-amino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + (25R)-26-oxocholest-4-en-3-one + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (25R)-3-oxocholest-4-en-26-oate

NADPH + 6-(methylsulfanyl)hexyl-glucosinolate + H⁺ + oxygen → H₂O + NADP⁺ + 6-methylsulfinylhexyl-glucosinolate

NADP⁺ + (6R)-6-lactoyl-5,6,7,8-tetrahydropterin ← NADPH + H⁺ + (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin

2-keto-L-gulonate + NADP⁺ ← NADPH + 2,5-didehydro-D-gluconate + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-oxo-4-pregnene-20-carboxyl-CoA + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 9α-hydroxy-androst-4-en-3-one-17-propanoyl-CoA

NADPH + H⁺ + (+)-sabinene + oxygen → H₂O + (+)-cis-sabinol + NADP⁺

terephthalate + NADH + H⁺ + oxygen → (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD⁺

NADP⁺ + relomycin ← NADPH + H⁺ + tylosin

2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + nocardicin C + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 2'-N-hydroxy-nocardicin c

NADP⁺ + isofucosterol ← NADPH + 5-dehydroavenasterol + H⁺

NADPH + H⁺ + (4S)-limonene + oxygen → H₂O + (4S)-perillyl alcohol + NADP⁺

1,4-dihydroxy-2-naphthoate + H⁺ + geranylgeranyl diphosphate → demethylmenaquinol-4 + diphosphate + CO₂

4,4-dimethyl-5α-cholesta-8-en-3β-ol + NADP⁺ ← 14-demethyllanosterol + NADPH + H⁺

NADPH + H⁺ + oxygen + 13-dihydrocarminomycin → 2 H₂O + NADP⁺ + carminomycin

zeaxanthin + NADH + H⁺ + oxygen → caloxanthin + H₂O + NAD⁺

NADP⁺ + 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone ← NADPH + H⁺ + (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone

NADPH + sitosterol + H⁺ + oxygen → 2 H₂O + NADP⁺ + stigmasterol

α-cembratriene-ol + NAD(P)H + H⁺ + oxygen → α-cembratriene-4,6-diol + H₂O + NAD(P)+

mupirocin F1 + NADP⁺ ← mupirocin C1 + NADPH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + alachlor + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + methyl formate + 2-chloro-N-(2,6-diethylphenyl)acetamide

3 H⁺ + 3 malonyl-CoA + isobutanoyl-CoA → 3 CO₂ + 4 coenzyme A + phlorisobutanophenone

H₂O + (S)-2,3,4,5-tetrahydrodipicolinate + NADP⁺ ← NADPH + H⁺ + (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

ferulate + H⁺ → 4-vinylguaiacol + CO₂

2 H⁺ + selenate + ATP → adenosine 5'-phosphoselenate + diphosphate

H⁺ + L-arginine + ATP → (L-arginyl)adenylate + diphosphate

NADH + 11-deoxycorticosterone + H⁺ → 4-pregnen-20,21-diol-3-one + NAD⁺

NADPH + 4-hydroxy-6-methylpretetramide + H⁺ + oxygen → H₂O + 4-dedimethylamino-4-oxoanhydrotetracycline + NADP⁺

4 malonyl-CoA + 5 H⁺ + NADPH + acetyl-CoA → 4 CO₂ + 5 coenzyme A + 6-hydroxymellein + H₂O + NADP⁺

H₂O + H⁺ + (Z)-3-ureidoacrylate peracid → (Z)-3-peroxyaminoacrylate + ammonium + CO₂

antheraxanthin + L-ascorbate + H⁺ → zeaxanthin + H₂O + L-dehydro-ascorbate

2 H⁺ + NADPH + 4-hydroxybenzoate + bromide + oxygen → 2 H₂O + NADP⁺ + 3-bromo-4-hydroxybenzoate

2 malonyl-CoA + (E)-4-coumaroyl-CoA + H⁺ → 2 CO₂ + 3 coenzyme A + bis-noryangonin

2 H⁺ + 4 oxygen + 5 a reduced electron donor + protoheme → 4 H₂O + 5 an oxidized electron donor + Fe²⁺ + formaldehyde + β-staphylobilin

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + choline + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + betaine aldehyde hydrate

NADPH + H⁺ + oxygen + pentalenene → H₂O + NADP⁺ + pentalen-13-ol

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:2-2-18:3-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:3-2-18:3-monogalactosyldiacylglycerol

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-octaprenyl diphosphate → demethylmenaquinol-8 + diphosphate + CO₂

NADPH + H⁺ + (25R)-5β-cholestane-3α,7α,26-triol + oxygen → 2 H₂O + NADP⁺ + (25R)-3α,7α-dihydroxy-5β-cholestan-26-al

NAD(P)H + arabidopaldehyde + H⁺ → NAD(P)+ + arabidopyl alcohol

12 H⁺ + 5 NADPH + 6 (S)-methylmalonyl-CoA + malonyl-CoA → 2 H₂O + 5 NADP⁺ + 7 coenzyme A + 7 CO₂ + narbonolide

NADPH + H⁺ + oxygen + palustradienol → H₂O + NADP⁺ + palustradiene-diol

dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H⁺ → dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose

hydrogen peroxide + palmitate + H⁺ → 2 H₂O + 1-pentadecene + CO₂

FADH₂ + 2,6-dichlorohydroquinone + H⁺ + oxygen → FAD + H₂O + 6-chlorohydroxyquinol + chloride

NADPH + H⁺ + 2-methoxy-6-(all-trans-heptaprenyl)phenol + oxygen → H₂O + 2-methoxy-6-all trans-heptaprenyl-1,4-benzoquinol + NADP⁺

NADP⁺ + L-pipecolate ← 2 H⁺ + 1-piperideine-2-carboxylate + NADPH

NAD(P)+ + L-pipecolate ← 2 H⁺ + 1-piperideine-2-carboxylate + NAD(P)H

NADPH + (Z)-but-2-enal + H⁺ → butan-1-al + NADP⁺

octanoyl-CoA + H⁺ + (2-aminobenzoyl)acetate → coenzyme A + H₂O + 2-heptyl-4-quinolone + CO₂

D-ribitol 5-phosphate + NAD(P)+ ← D-ribulose 5-phosphate + NAD(P)H + H⁺

NAD(P)H + aurachin C + H⁺ + oxygen → H₂O + NAD(P)+ + 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide

NADP⁺ + dihydrochanoclavine-I aldehyde ← NADPH + H⁺ + chanoclavine-I aldehyde

(R)-glycerate + NADP⁺ ← hydroxypyruvate + NADPH + H⁺

glycerol + NADP⁺ ← NADPH + H⁺ + L-glyceraldehyde

H⁺ + 5'-oxoaverantin → H₂O + (1'S,5'S)-averufin

fusicocca-1,10(14)-diene-8β,16-diol + NAD(P)+ ← 8β-hydroxyfusicocca-1,10(14)-diene-16-al + NAD(P)H + H⁺

15 H⁺ + 3 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 7 NADPH → 4 H₂O + 7 NADP⁺ + 8 coenzyme A + 8 CO₂ + protomycinolide IV

2 an oxidized ferredoxin [iron-sulfur] cluster + (3Z)-phycoerythrobilin ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 15,16-dihydrobiliverdin

NAD⁺ + (R)-lactate ← NADH + pyruvate + H⁺

2 L-ascorbate + hydrogen peroxide + H⁺ → 2 H₂O + L-ascorbate + L-dehydro-ascorbate

C36-phenolphthiodiolone A + NADP⁺ ← NADPH + C36-phenolphthiodiolenone A + H⁺

thiamine diphosphate + pyruvate + H⁺ → 2-(α-hydroxyethyl)thiamine diphosphate + CO₂

H₂O + O-carbamoyl-L-serine + H⁺ → 2 ammonium + pyruvate + CO₂

H₂O + H⁺ + Fe³⁺-[monoglucosyl-(2,3-dihydroxybenzoylserine)₃] complex → N-(2,3-dihydroxybenzoyl)-L-serine + Fe³⁺-[salmochelin S1] complex

NADPH + H⁺ + bisphenol A + oxygen → H₂O + NADP⁺ + 1,2-bis(4-hydroxyphenyl)-2-propanol

4 H⁺ + acetyl-CoA + (R)-2-hydroxyglutarate → acetate + (R)-2-hydroxyglutaryl-CoA

2 H⁺ + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate → thiamine phosphate + diphosphate + CO₂

palustradiene + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + palustradienol

NAD(P)+ + bilirubin-IX β ← NAD(P)H + H⁺ + biliverdin-IX β

2 NADH + 2 H⁺ + 2 oxygen + zeaxanthin → 2 H₂O + 2 NAD⁺ + nostoxanthin

H⁺ + cannabidiolate → cannabidiol + CO₂

3 H⁺ + 3 malonyl-CoA + (E)-4-coumaroyl-CoA → 3 CO₂ + 4 coenzyme A + naringenin chalcone

2 H⁺ + 2 malonyl-CoA + anthraniloyl-CoA → 3 coenzyme A + 3 CO₂ + 2-methyl-4-hydroxyquinoline

NADP⁺ + (3R,7Z,10Z,13Z,16Z)-3-hydroxydocosatetraenoyl-CoA ← (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + NADPH + H⁺

NADPH + H⁺ + (2E,11Z)-icosa-2,11-dienoyl-CoA → NADP⁺ + (11Z)-icosenoyl-CoA

NADPH + H⁺ + 2-hexaprenyl-6-methoxyaminobenzene + oxygen → H₂O + NADP⁺ + 2-hexaprenyl-6-methoxyaminophenol

NAD(P)H + H⁺ + CMP-N-acetyl-β-neuraminate + oxygen → H₂O + NAD(P)+ + CMP-N-glycoloyl-β-neuraminate

C35-phenolcarboxyphthiodiolenone + H⁺ → C34-phenolphthiodiolenone A + CO₂

2 H⁺ + NADPH + oxygen + pheophorbide a → NADP⁺ + red chlorophyll catabolite

NADP⁺ + (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA ← NADPH + H⁺ + (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA

2 oxygen + (S)-tetrahydropalmatine + H⁺ → 2 hydrogen peroxide + palmatine

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + β-cryptoxanthin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + zeaxanthin + H₂O

2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + 18-oxo candicinolide + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 18-carboxy candicinolide

NADPH + H⁺ + oxygen + 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol → H₂O + 3-demethylubiquinol-7 + NADP⁺

NADP⁺ + agroclavine ← NADPH + H⁺ + 6,8-dimethyl-6,7,8,9-tetradehydroergoline

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + pentalenene → 3 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + pentalen-13-al

(4S)-2,3-dehydroleucopelargonidin + H⁺ → pelargonidin + H₂O

H⁺ + diethylamine N-oxide → ethylamine + acetaldehyde

17R-hydroperoxydocosahexaenoate + NADPH + H⁺ → 17R-hydroxydocosahexaenoate + H₂O + NADP⁺

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + canthaxanthin → 2 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + (3S,3'S)-astaxanthin

(11R)-dihydroartemisinic aldehyde + NADP⁺ ← NADPH + artemisinic aldehyde + H⁺

(6E)-8-hydroxylinalool + NADH + H⁺ + oxygen → 2 H₂O + (6E)-8-oxolinalool + NAD⁺

2 H⁺ + 2 superoxide → hydrogen peroxide + oxygen

NADH + acetone + H⁺ + oxygen → hydroxyacetone + H₂O + NAD⁺

2 H⁺ + NADH + 3-methyl-pyrroline-5-carboxylate → 4-methyl-proline + NAD⁺

H⁺ + oxygen + deoxyviolaceinate → H₂O + CO₂ + deoxyviolacein

H⁺ + phytate + ATP → 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + ADP

2 H⁺ + 3 NAD(P)H + 3 oxygen + 4α-methyl-5α-cholesta-8,24-dien-3β-ol → 3 NAD(P)+ + 4 H₂O + 4α-carboxy-5α-cholesta-8,24-dien-3β-ol

NADPH + H⁺ + oxygen + deoxynortryptoquialanone → H₂O + NADP⁺ + tryptoquialanone

cyanate + H⁺ + hydrogencarbonate → carbamate + CO₂

NADPH + squalene + H⁺ + oxygen → H₂O + NADP⁺ + (3S)-2,3-epoxy-2,3-dihydrosqualene

NADPH + H⁺ + (+)-isomenthone → NADP⁺ + (+)-neoisomenthol

NADPH + H⁺ + (+)-isomenthone → NADP⁺ + (+)-isomenthol

2 H⁺ + (2S)-2-amino-3-oxo-4-phosphooxybutanoate → 3-amino-1-hydroxyacetone 1-phosphate + CO₂

C31-phthiotriol + NADP⁺ ← NADPH + C31-phthiodiolone A + H⁺

2 H⁺ + H₂O + L-citrulline → L-ornithine + ammonium + CO₂

NAD(P)+ + L-proline ← 2 H⁺ + 1-pyrroline-2-carboxylate + NAD(P)H

NADPH + H⁺ + oxygen + calcidiol → H₂O + NADP⁺ + secalciferol

S-adenosyl-L-methionine + H⁺ → S-adenosyl 3-(methylsulfanyl)propylamine + CO₂

(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H⁺ → (4Z)-2-oxohept-4-enedioate + CO₂

2 H⁺ + 4 a reduced electron donor + 4 oxygen + protoheme → 4 an oxidized electron donor + 4 H₂O + Fe²⁺ + δ-staphylobilin + carbon monoxide

NADH + H⁺ + 3-chlorotoluene + oxygen → H₂O + 3-chlorobenzyl alcohol + NAD⁺

3 NADP⁺ + phytyl diphosphate ← 3 NADPH + 3 H⁺ + geranylgeranyl diphosphate

2 H⁺ + 4 glutathione + selenite → 3 H₂O + glutathione disulfide + selenodiglutathione

2 H⁺ + 4-nitrophenol + NADPH + oxygen → H₂O + 4-nitrocatechol + NADP⁺

ent-kaurene + NADPH + H⁺ + oxygen → H₂O + kauralexin A1 + NADP⁺

12-ethyl-8-isobutylbacteriochlorophyllide d + H⁺ + (2E,6E)-farnesyl diphosphate → 12-ethyl-8-isobutylbacteriochlorophyll d + diphosphate

2-hydroxy-3-carboxy-6-methoxy-hexa-2,4-dienoate + H⁺ → 2-hydroxy-6-methoxy-hexa-2,4-dienoate + CO₂

2 NADPH + 2 H⁺ + L-valine + L-tryptophan + L-methionine → 2 H₂O + 2 NADP⁺ + L-homocysteine + N-methyl-L-valyl-L-tryptophanol

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 1-18:1-2-16:0-monogalactosyldiacylglycerol + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 1-18:2-2-16:0-monogalactosyldiacylglycerol

demethylphylloquinone + NADPH + H⁺ → demethylphylloquinol + NADP⁺

2 H⁺ + FAD + 1'-carboxy-chondrochloren A → FADH₂ + chondrochloren A + CO₂

coenzyme A + pyruvate + H⁺ + oxygen → hydrogen peroxide + acetyl-CoA + CO₂

homogentisate + H⁺ + all-trans-nonaprenyl diphosphate → 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinol + diphosphate + CO₂

phenol + NADH + H⁺ + oxygen → H₂O + catechol + NAD⁺

(3¹R)-8,12-diethylbacteriochlorophyllide d + H⁺ + (2E,6E)-farnesyl diphosphate → (3¹R)-8,12-diethylbacteriochlorophyll d + diphosphate

NADPH + 5-(methylsulfanyl)pentyl-glucosinolate + H⁺ + oxygen → H₂O + NADP⁺ + 5-(methylsulfinyl)pentyl-glucosinolate

NAD(P)H + H⁺ + (-)-maackiain + oxygen → H₂O + NAD(P)+ + 1α-hydroxy-maackiain

12-ethyl-8-isobutylbacteriochlorophyllide e + H⁺ + (2E,6E)-farnesyl diphosphate → 12-ethyl-8-isobutylbacteriochlorophyll e + diphosphate

allyl alcohol + NADP⁺ ← NADPH + H⁺ + acrolein

an oxidized electron donor + H⁺ + 3-(hydroxyphosphonoylmethyl)malate → a reduced electron donor + deamino α-keto demethylphosphinothricin + CO₂

NADH + H⁺ + oxygen + N⁵-phenyl-L-glutamine → NAD⁺ + γ-glutamylanilide diol

H⁺ + C32-carboxyphthiodiolenone → C31-phthiodiolenone A + CO₂

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + spheroidene → 3 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + spheroiden-2-one

7 H⁺ + 8 malonyl-CoA → 8 coenzyme A + 8 CO₂ + H₂O + octoketide 4b

H⁺ + acetoacetate → acetone + CO₂

D-gluconate + NADP⁺ ← 5-dehydro-D-gluconate + NADPH + H⁺

2 malonyl-CoA + H⁺ + acetyl-CoA → 2 CO₂ + 3 coenzyme A + triacetate lactone

5 H⁺ + 6 malonyl-CoA → 6 coenzyme A + 6 CO₂ + H₂O + hexaketide pyrone

NADP⁺ + 17-O-acetylnorajmaline ← NADPH + H⁺ + 1,2-dihydrovomilenine

12-ethyl-8-propylbacteriochlorophyllide d + H⁺ + (2E,6E)-farnesyl diphosphate → 12-ethyl-8-propylbacteriochlorophyll d + diphosphate

NADH + H⁺ + oxygen + 2-hydroxyadonixanthin → H₂O + NAD⁺ + 2,3,2',3'-tetrahydroxy-β,β-caroten-4-one

H⁺ + L-tryptophan + ATP → (L-tryptophanyl)adenylate + diphosphate

2 H⁺ + 3,4-dichloroaniline + NADPH + oxygen → NADP⁺ + ammonium + 4,5-dichlorobenzene-1,2-diol

NADH + H⁺ + 4-methylphenol + oxygen → H₂O + 4-methylcatechol + NAD⁺

H₂O + H⁺ + guanine → xanthine + ammonium

NADPH + H⁺ + quercetin + oxygen → H₂O + NADP⁺ + gossypetin

loganin + NADPH + H⁺ + oxygen → 2 H₂O + secologanin + NADP⁺

2 H⁺ + 3 NADH + 3 oxygen + 14-demethyllanosterol → 3 NAD⁺ + 4 H₂O + 4β-carboxy-4α-methyl-5α-cholesta-8,24-dien-3β-ol

NADP⁺ + 1-palmitoyl-sn-glycerol 3-phosphate ← 1-palmitoylglycerone 3-phosphate + NADPH + H⁺

NADPH + H⁺ + oxygen + agroclavine → H₂O + NADP⁺ + elymoclavine

saturated archaetidylserine + H⁺ → saturated archaetidylethanolamine + CO₂

2 geranylgeranyl diphosphate + NADPH + H⁺ → 2 diphosphate + lycopaoctaene + NADP⁺

2 H⁺ + NADPH + oxygen + chrysin → H₂O + NADP⁺ + baicalein

NADPH + geranylhydroquinone + H⁺ + oxygen → H₂O + 3''-hydroxy-geranylhydroquinone + NADP⁺

2-amino-4-carboxypyrimidine + H⁺ + L-serine → H₂O + lathyrine + CO₂

H⁺ + 2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] → 2-GDP-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol]

3 S-adenosyl-L-methionine + 3 H⁺ + 3 L-cysteine + 6 NADPH + (salicyl)adenylate + malonyl-CoA → 3 S-adenosyl-L-homocysteine + 6 NADP⁺ + 8 H₂O + coenzyme A + yersiniabactin + AMP

NAD⁺ + indole-3-glycol ← NADH + H⁺ + indole-3-glycol aldehyde

NADPH + coniferaldehyde + H⁺ → NADP⁺ + dihydroconiferyl aldehyde

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-oxo-23,24-bisnorchol-4-en-22-oate + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 3-one-9-hydroxy-23,24-bisnorchol-4-en-22-oate

2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H⁺ → riboflavin + 5-amino-6-(D-ribitylamino)uracil

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 20-hydroxy-5-O-mycaminosyltylactone + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂O + 20-oxo-5-O-β-mycaminosyltylactone

NAD(P)H + H⁺ + oxygen + fuscofusarin → H₂O + NAD(P)+ + dimeric 9-hydroxyrubrofusarin-fuscofusarin

(S)-2-hydroxymethylglutarate + NAD⁺ ← (S)-2-formylglutarate + NADH + H⁺

2-aminomalonate semialdehyde + H⁺ → 2-aminoacetaldehyde + CO₂

(S)-malate + H⁺ → (S)-lactate + CO₂

2 H⁺ + 4-methylsalicylate + NADH + oxygen → H₂O + 4-methylcatechol + NAD⁺ + CO₂

NADPH + (+)-dihydrocarvone + H⁺ + oxygen → H₂O + NADP⁺ + (4R,7R)-4-isopropenyl-7-methyloxepan-2-one

(-)-secoisolariciresinol + NADP⁺ ← NADPH + (+)-lariciresinol + H⁺

NAD(P)H + aurachin C + H⁺ + oxygen → H₂O + NAD(P)+ + aurachin C epoxide

NADP⁺ + palmitoyl-CoA ← NADPH + H⁺ + (2E)-hexadecenoyl-CoA

H⁺ + L-tryptophan → tryptamine + CO₂

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + isopentenyl diphosphate ← 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate

NAD(P)+ + UDP-N-acetyl-β-L-rhamnosamine ← NAD(P)H + H⁺ + UDP-2-acetamido-2,6-dideoxy-β-L-lyxo-4-hexulose

(+)-secoisolariciresinol + NADP⁺ ← NADPH + (-)-lariciresinol + H⁺

NADH + H⁺ + (4R)-limonene + oxygen → H₂O + (4R)-perillyl alcohol + NAD⁺

2 (2E,6E)-farnesyl diphosphate + NADPH + H⁺ → 2 diphosphate + C30 botryococcene + NADP⁺

12-ethyl-8-propylbacteriochlorophyllide e + H⁺ + (2E,6E)-farnesyl diphosphate → 12-ethyl-8-propylbacteriochlorophyll e + diphosphate

NADPH + H⁺ + 6-(all-trans-decaprenyl)-2-methoxy-phenol + oxygen → H₂O + all trans-decaprenyl-2-methoxy-6-1,4-benzoquinol + NADP⁺

NADPH + (+)-dihydrocarvone + H⁺ + oxygen → H₂O + NADP⁺ + (3R,6R)-6-isopropenyl-3-methyloxepan-2-one

pyrrole-2-carboxylate + NADH + H⁺ + oxygen → H₂O + 5-hydroxypyrrole-2-carboxylate + NAD⁺

NADP⁺ + (3R)-3-hydroxy-lignoceroyl-CoA ← NADPH + H⁺ + 3-oxo-lignoceroyl-CoA

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + zeaxanthin + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + antheraxanthin + H₂O

4 a reduced ferredoxin [iron-sulfur] cluster + 5 H⁺ + 2-hexaprenyl-6-methoxyaminophenol + oxygen → 4 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol + ammonium

indole-3-lactate + NAD⁺ ← NADH + H⁺ + (indol-3-yl)pyruvate

O-citryl-L-serine + H⁺ → O-citryl-ethanolamine + CO₂

3 H⁺ + 3 malonyl-CoA + acetyl-CoA + 1,4,5,10,13-pentahydroxy-Δ^2,3-protoilludene → 3 CO₂ + 4 coenzyme A + H₂O + melledonol

(16R,19E)-isositsirikine + NADP⁺ ← 19E-geissoschizine + NADPH + H⁺

NADPH + H⁺ + oxygen + pre-bikaverin → H₂O + NADP⁺ + 7-hydroxy-pre-bikaverin

L-cysteate + H⁺ → taurine + CO₂

methyloxaloacetate + H⁺ → 2-oxobutanoate + CO₂

diphenylamine + NADH + H⁺ + oxygen → aniline + catechol + NAD⁺

(3¹R)-8,12-diethylbacteriochlorophyllide c + H⁺ + (2E,6E)-farnesyl diphosphate → (3¹R)-8,12-diethylbacteriochlorophyll c + diphosphate

H⁺ + 3-sulfomuconate → 4-sulfomuconolactone

22 NADPH + 32 H⁺ + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + heptanoyl-CoA → 10 coenzyme A + 10 CO₂ + 11 H₂O + 22 NADP⁺ + C32-mycoketide-CoA

3-sulfino-L-alanine + H⁺ → hypotaurine + CO₂

ent-kaur-16-en-19-oate + NADPH + H⁺ + oxygen → steviol + H₂O + NADP⁺

(2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-oxopropanoate + H⁺ → 3-[(2-aminophenyl)amino]-2-oxopropanoate + CO₂

3 oxygen + 6 a reduced ferredoxin [iron-sulfur] cluster + 8 H⁺ + protoheme → 3 H₂O + 6 an oxidized ferredoxin [iron-sulfur] cluster + Fe²⁺ + (Z,Z)-biliverdin-IX α + carbon monoxide

NADPH + H⁺ + 2,4-dichlorophenol + oxygen → H₂O + NADP⁺ + 3,5-dichlorocatechol

NAD(P)H + H⁺ + oxygen + protoviolaceinate → H₂O + NAD(P)+ + violaceinate

NADP⁺ + (2S)-flavan-4-ol ← (2S)-flavanone + NADPH + H⁺

H⁺ + UDP-α-D-glucuronate → UDP-D-apiose + CO₂

3 H⁺ + anthranilate + NAD(P)H + oxygen → NAD(P)+ + catechol + ammonium + CO₂

NADH + H⁺ + methylglyoxal → hydroxyacetone + NAD⁺

NADPH + trans-cinnamate + H⁺ + oxygen → H₂O + 4-coumarate + NADP⁺

NADPH + H⁺ + oxygen + 4-hydroxy-3-methylbenzoate → H₂O + NADP⁺ + 4-hydroxy-3-(hydroxymethyl)-benzoate

chloroethene + NADH + H⁺ + oxygen → H₂O + chlorooxirane + NAD⁺

2 NADP⁺ + aniline + N,N-dimethyl-1,4-phenylenediamine ← 2 NADPH + 2 H⁺ + 4-dimethylaminophenylazobenzene

NADPH + H⁺ + 3-chlorophenol + oxygen → H₂O + NADP⁺ + 4-chlorocatechol

aminomalonate + H⁺ → glycine + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose

NADPH + H⁺ + oxygen + (+)-isodihydrocarvone → H₂O + NADP⁺ + (3S,6R)-6-isopropenyl-3-methyloxepan-2-one

NADPH + quinine + H⁺ + oxygen → H₂O + 3-hydroxyquinine + NADP⁺

NADPH + H⁺ + oxygen + notoamide E → H₂O + NADP⁺ + notoamide C

(S)-2-chloropropanoate + NADP⁺ ← 2-chloroacrylate + NADPH + H⁺

H⁺ + trans-feruloyl-CoA + quercetin-3-glucoside → coenzyme A + quercetin 3-O-(6"-O-feruloyl)-glucoside

psoralen + NADPH + H⁺ + oxygen → bergaptol + H₂O + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 5-O-β-mycaminosyltylactone + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 20-hydroxy-5-O-mycaminosyltylactone

(6Z,9Z,12Z,15Z)-3-hydroxy-2-[(2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl]octadeca-6,9,12,15-tetraenoate + NADP⁺ ← NADPH + (6Z,9Z,12Z,15Z)-3-oxo-2-[(2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl]octadeca-6,9,12,15-tetraenoate + H⁺

NADPH + H⁺ + oxygen + benzoate → salicylate + H₂O + NADP⁺

NADPH + H⁺ + 3-hexaprenyl-4-aminobenzoate + oxygen → H₂O + NADP⁺ + 3-hexaprenyl-4-amino-5-hydroxybenzoate

cyclohexanone + NADPH + H⁺ + oxygen → H₂O + NADP⁺ + ε-caprolactone

2 H⁺ + NADPH + oxygen + chlorophyllide a → H₂O + NADP⁺ + 7¹-hydroxychlorophyllide a

2 H⁺ + FMN + NADH + actinorhodin intermediate + oxygen → FMNH₂ + NAD⁺ + actinorhodin

NADPH + 20-dihydrorosamicin + H⁺ + oxygen → 2 H₂O + NADP⁺ + rosamicin

episterone + NADPH + H⁺ → episterol + NADP⁺

H⁺ + trans-aconitate → itaconate + CO₂

2,4,6-trihydroxybenzophenone + NADPH + H⁺ + oxygen → H₂O + 2,3',4,6-tetrahydroxybenzophenone + NADP⁺

NADPH + 2-hexaprenyl-6-methoxyphenol + H⁺ + oxygen → H₂O + 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol + NADP⁺

NADH + H⁺ + 1,2,3-trichlorobenzene + oxygen → NAD⁺ + (1R,2S)-3,4,5-trichlorocyclohexa-3,5-diene-1,2-diol

(5S)-albaflavenol + NADPH + H⁺ + oxygen → 2 H₂O + NADP⁺ + albaflavenone

butane + NADH + H⁺ + oxygen → H₂O + butan-1-ol + NAD⁺

NADH + H⁺ + 3-dehydroecdysone → ecdysone + NAD⁺

2-oxoglutarate + H⁺ + oxygen + (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate → 2 CO₂ + H₂O + succinate + 3-[(Z)-2-isocyanoethenyl]-1H-indole

(R)-lipoate + H⁺ + ATP → (lipoyl)adenylate + diphosphate

2 H⁺ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H₂O + Fe²⁺ + (Z,Z)-biliverdin-IX α + carbon monoxide

NAD(P)H + H⁺ + oxygen → hydrogen peroxide + NAD(P)+

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + β-dihydromenaquinone-9 + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + ω-hydroxy-β-dihydromenaquinone-9

lipoamide + pyruvate + H⁺ → S-acetyldihydrolipoamide + CO₂

NAD⁺ + succinate ← NADH + H⁺ + fumarate

H⁺ + oxygen + 1,2-dihydro-β-NADP → hydrogen peroxide + NADP⁺

H₂O + staphylopine + NADP⁺ ← (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + NADPH + pyruvate + H⁺

3 H⁺ + 3 malonyl-CoA + benzoyl-CoA → 4 coenzyme A + 4 CO₂ + 3,5-dihydroxybiphenyl

NADP⁺ + virginiae butanolide A ← 6-dehydro-virginiae butanolide A + NADPH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + calcidiol → 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + calcitriol

dTDP-D-mycarose + NADP⁺ ← NADPH + dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + H⁺

H₂O + H⁺ + 2-hexaprenyl-6-methoxyaminophenol → 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol + ammonium

3 NADP⁺ + bacteriopheophytin a ← 3 NADPH + 3 H⁺ + geranylgeranyl bacteriopheophytin

4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol + NAD(P)H + H⁺ + oxygen → 2 H₂O + 4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol + NAD(P)+

H⁺ + GTP + D-erythro-D-gluco-octose α-1-phosphate → GDP-D-erythro-α-D-gluco-octose + diphosphate

2,5-dichloro-3-oxoadipate + NAD(P)+ ← 2,5-dichloromaleylacetate + NAD(P)H + H⁺

3 NADPH + 4 H⁺ + oxygen + 3,5,7,9,11,13,15,17,19-nonaoxoicosanoate → 3 NADP⁺ + 5 H₂O + UWM6 + CO₂

antheraxanthin + NAD(P)H + H⁺ + oxygen → violaxanthin + H₂O + NAD(P)+

NADPH + H⁺ + oxygen + indole → H₂O + NADP⁺ + indoxyl

NADPH + H⁺ + oxygen + indole → H₂O + NADP⁺ + 2-hydroxyindole

Fosmidomycin + H⁺ → Fosmidomycin + H⁺

oxidized [cytochrome P450] + NADPH + H⁺ → reduced [cytochrome P450] + NADP⁺

gentisate + H⁺ → gentisate + H⁺

diuron + NAD(P)H + oxygen + H⁺ → N'-(3,4-dichlorophenyl)-N-methylurea + formaldehyde + NAD(P)⁺ + H₂O

isoproturon + H₂O + H⁺ → dimethylamine + CO₂ + 4-(propan-2-yl)aniline

malonate + H⁺ → acetate + CO₂

(2-methylsulfanyl)ethanol + NAD⁺ ← (2-methylsulfanyl)acetaldehyde + NADH + H⁺

malonyl-CoA + dotriacontanoyl-CoA + H⁺ → 3-oxotetratriacontanoyl-CoA + CO₂ + coenzyme A

3,6,8-trimethyl-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H⁺ → 3,6,8-trimethylallantoin + CO₂

acetyl-CoA + 4 malonyl-CoA + 5 NADPH + 9 H⁺ → 7-methylmellein + 5 coenzyme A + 3 CO₂ + 4 H₂O + 5 NADP⁺

monuron + H₂O + H⁺ → dimethylamine + CO₂ + 4-chloroaniline

3-oxo-isoapionate + H⁺ → L-erythrulose + CO₂

chlorotoluron + NAD(P)H + oxygen + H⁺ → N'-(3-chloro-4-methylphenyl)-N-methylurea + formaldehyde + NAD(P)⁺ + H₂O

malonyl-CoA + (15Z)-tetracosenoyl-CoA + H⁺ → (17Z)-3-oxohexacosenoyl-CoA + CO₂ + coenzyme A

cholesterol + NADPH + H⁺ + oxygen → (22R)-hydroxycholesterol + NADP⁺ + H₂O

palmitoyl-CoA + NADPH + oxygen + H⁺ → palmitoleoyl-CoA + NADP⁺ + 2 H₂O

stearoyl-CoA + NADPH + oxygen + H⁺ → oleoyl-CoA + NADP⁺ + 2 H₂O

solanid-3-one + NADH + H⁺ → demissidine + NAD⁺

7-methylmellein + 3 oxygen + 3 NADPH + 2 H⁺ → 7-carboxymellein + 4 H₂O + 3 NADP⁺

malonyl-CoA + triacontanoyl-CoA + H⁺ → 3-oxodotriacontanoyl-CoA + CO₂ + coenzyme A

indole + oxygen + NADH + H⁺ → indoxyl + H₂O + NAD⁺

malonyl-CoA + (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H⁺ → (8Z,11Z,14Z,17Z,20Z,23Z)-3-oxohexacosahexaenoyl-CoA + CO₂ + coenzyme A

prostaglandin F_2α + NADP⁺ ← prostaglandin H₂ + NADPH + H⁺

(3R)-3-hydroxytriacontanoyl-CoA + NADP⁺ ← 3-oxotriacontanoyl-CoA + NADPH + H⁺

NADPH + H⁺ + 3-hexaprenyl-4-hydroxybenzoate + oxygen → 3-all trans-hexaprenyl-4,5-dihydroxybenzoate + H₂O + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-hexaprenyl-4-hydroxybenzoate + oxygen → 2 an oxidized ferredoxin [iron-sulfur] cluster + 3-all trans-hexaprenyl-4,5-dihydroxybenzoate + H₂O

H⁺ + 3-all trans-hexaprenyl-4-hydroxy-5-methoxybenzoate → 2-hexaprenyl-6-methoxyphenol + CO₂

H₂O + H⁺ + 1-pyrroline-4-hydroxy-2-carboxylate → 2,5-dioxopentanoate + ammonium

H₂O + guanosine + H⁺ → xanthosine + ammonium

L-ascorbate + 1-aminocyclopropane-1-carboxylate + H⁺ + oxygen → 2 H₂O + L-dehydro-ascorbate + ethene + hydrogen cyanide + CO₂

dihydroberbine + 2 oxygen + H⁺ → epiberberine + 2 hydrogen peroxide

NADPH + H⁺ + pentachlorophenol + oxygen → H₂O + 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP⁺ + chloride

2 oxygen + 4 a reduced ferredoxin [iron-sulfur] cluster + 4 H⁺ + 2-oxospirilloxanthin → 3 H₂O + 4 an oxidized ferredoxin [iron-sulfur] cluster + 2,2'-dioxospirilloxanthin

2-oxoadipate + NAD⁺ + ammonium ← 2 H⁺ + H₂O + NADH + (2Z,4E)-2-aminomuconate

H₂O + NAD⁺ + ammonium ← 2 H⁺ + hydroxylamine + NADH

H₂O + 2-iminoacetate + H⁺ → glyoxylate + ammonium

H⁺ + 6-carboxy-5,6,7,8-tetrahydropterin → 7-carboxy-7-deazaguanine + ammonium

NADH + resorcinol + H⁺ + oxygen → H₂O + NAD⁺ + hydroxyquinol

D-apiitol + NAD⁺ ← D-apiose + NADH + H⁺

pelargonidin-3-O-β-D-glucoside + 1-O-malyl-β-D-glucose + H⁺ → pelargonidin 3-O-(6"-O-malyl-β-D-glucoside) + D-glucopyranose

O-[5-(oxidonitroso)-4-oxocyclohex-2-en-1-ylidenenitroso]oxidanidolate + a reduced factor 420 + 2 H⁺ → 2,4-dinitrocyclohexan-1-one + an oxidized factor 420

D-galactopyranose + NADP⁺ ← NADPH + H⁺ + 3-keto-β-D-galactose

ursodeoxycholate methyl ester + NADP⁺ ← 7-oxolithocholic acid methyl ester + NADPH + H⁺

WO₂-molybdopterin cofactor + molybdopterin + H⁺ → bis(tungstenpterin) cofactor + H₂O

4 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) + oxygen + 4 H⁺ → 4 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) radical cation + 2 H₂O

2-phospho-L-lactate + GTP + H⁺ → L-lactyl-2-diphospho-5'-guanosine + diphosphate

sucrose + H⁺ → sucrose + H⁺

2 (E)-4-coumaroyl-CoA + H₂O + H⁺ + malonyl-CoA → 2 CO₂ + 3 coenzyme A + bisdemethoxycurcumin

FMN + H⁺ + ATP → FAD + diphosphate

2-oxobutanoate + pyruvate + H⁺ → (S)-2-aceto-2-hydroxybutanoate + CO₂

(R)-pantoate + NADP⁺ ← NADPH + 2-dehydropantoate + H⁺

(2S)-2-isopropyl-3-oxosuccinate + H⁺ → 4-methyl-2-oxopentanoate + CO₂

D-erythro-sphinganine + NADP⁺ ← NADPH + H⁺ + 3-dehydrosphinganine

2 NADPH + decanoyl-CoA + 2 H⁺ → 2 NADP⁺ + decan-1-ol + coenzyme A

2 NADPH + 2 H⁺ + palmitoyl-CoA → 2 NADP⁺ + coenzyme A + 1-hexadecanol

ADP + 3 H+ + phosphate → ATP + 2 H+ + H2O

4-diphospho-1D-myo-inositol pentakisphosphate + ATP + 2 H+ → 4,5-bis(diphospho)-1D-myo-inositol tetrakisphosphate + ADP + H2O

5,10-methylenetetrahydropteroyl mono-L-glutamate + 2 H+ + NADPH → 5-methyltetrahydropteroyl mono-L-glutamate + NADP+

6-diphospho-1D-myo-inositol pentakisphosphate + ATP + 2 H+ → 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate + ADP + H2O

N-(tetracosanoyl)-sphinganine + H+ + NADPH + oxygen → N-(2-hydroxytetracosanoyl)-sphinganine + H2O + NADP+

N-(tetracosanoyl)-sphinganine + H+ + NADPH + oxygen → N-(lignoceroyl)-phytosphingosine + H2O + NADP+

2-methylbutanal + H+ + NADPH → 2-methylbutanol + NADP+

H+ + NADPH + L-arabinose → NADP+ + L-arabinitol

H+ + NADPH + oxygen + zymosterol intermediate 1a → 2 H2O + NADP+ + zymosterol intermediate 1b

H+ + NADPH + oxygen + zymosterol intermediate 1b → H2O + NADP+ + zymosterol intermediate 1c

ceramide-1 (C26) + H+ + NADPH + oxygen → N-(hexacosanoyl)-phytosphingosine + H2O + NADP+

ceramide-1 (C26) + H+ + NADPH + oxygen → ceramide-2' (C26) + H2O + NADP+

N-(lignoceroyl)-phytosphingosine + H+ + NADPH + oxygen → N-(2-hydroxytetracosanoyl)-phytosphingosine + H2O + NADP+

acetyl-CoA + 24 H+ + 8 malonyl-CoA + 16 NADPH → 8 CO2 + 8 coenzyme A + 8 H2O + 16 NADP+ + stearoyl-CoA

2 (2E,6E)-farnesyl diphosphate + H+ + NADPH → 2 diphosphate + NADP+ + squalene

4α-methyl-5α-cholesta-8,24-dien-3β-ol + H+ + NADPH + oxygen → H2O + NADP+ + zymosterol intermediate 1a

14-demethyllanosterol + 3 H+ + 3 NADPH + 3 oxygen → 4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol + 4 H2O + 3 NADP+

N-(hexacosanoyl)-phytosphingosine + H+ + NADPH + oxygen → N-(2-hydroxyhexacosanoyl)-phytosphingosine + H2O + NADP+

N-(2-hydroxytetracosanoyl)-phytosphingosine + H+ + NADPH + oxygen → ceramide-4 (C24) + H2O + NADP+

N-(2-hydroxyhexacosanoyl)-phytosphingosine + H+ + NADPH + oxygen → ceramide-4 (C26) + H2O + NADP+

2 H+ + lanosterol + 3 NADPH + 3 oxygen → 4,4-dimethyl-5-α-cholesta-8,14,24-trien-3-β-ol + formate + 4 H2O + 3 NADP+

ATP + 5 H+ + D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 phosphate → 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate + ADP + 2 H2O

glycerone phosphate + H+ + NADH → glycerol 2-phosphate + NAD+

H+ + glycine + lipoamide → CO2 + S8-aminomethyldihydrolipoamide

H+ + glycine + lipoylprotein → CO2 + S8-aminomethyldihydrolipoylprotein

3-demethylubiquinone-6 + H+ + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + ubiquinol-6

H+ + phosphatidyl-L-serine → CO2 + phosphatidylethanolamine

H+ + NADPH + oxygen + D-erythro-sphinganine → H2O + NADP+ + phytosphingosine

(S)-1-pyrroline-5-carboxylate + 2 H+ + NADPH → L-proline + NADP+

acetaldehyde + H+ + pyruvate → (R)-acetoin + CO2

2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone + H+ + NADH + oxygen → 3-demethylubiquinone-6 + H2O + NAD+

H+ + NADPH + thioredoxin disulfide → NADP+ + Thioredoxin

(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + 2 H+ + NADPH → L-proline + NADP+

2-oxoglutarate + H+ + lipoamide → CO2 + S-succinyl-dihydrolipoamide

acetyl-CoA + 21 H+ + 7 malonyl-CoA + 14 NADPH → 7 CO2 + 7 coenzyme A + 7 H2O + 14 NADP+ + palmitoyl-CoA

acetyl-ACP + carboxyacetyl-ACP + H+ → CO2 + acyl-carrier-protein + acetoacetyl-ACP

H+ + NADH + oxygen + squalene → (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O + NAD+

H+ + L-aspartate 4-semialdehyde + NADH → L-homoserine + NAD+

H+ + L-aspartate 4-semialdehyde + NADPH → L-homoserine + NADP+

H+ + 3-oxo-palmitoyl-CoA + NADPH → NADP+ + (S)-3-hydroxyhexadecanoyl-CoA

H+ + NADPH + 3-oxooctanoyl-ACP → NADP+ + (3R)-3-hydroxyoctanoyl-ACP

H+ + NADPH + trans-but-2-enoyl-ACP → NADP+ + butanoyl-ACP

H+ + palmitoyl-CoA + oxygen + NADH → 2 H2O + palmitoleoyl-CoA + NAD+

H+ + stearoyl-CoA + oxygen + NADH → 2 H2O + NAD+ + oleoyl-CoA

H+ + NADPH + trans-oct-2-enoyl-ACP → NADP+ + octanoyl-ACP

carboxyacetyl-ACP + H+ + butanoyl-ACP → CO2 + acyl-carrier-protein + 3-oxohexanoyl-ACP

H+ + NADPH + acetoacetyl-ACP → NADP+ + 3-hydroxybutanoyl-ACP

H+ + NADPH + 3-oxohexanoyl-ACP → NADP+ + 3-hydroxyhexanoyl-ACP

H+ + 3-oxo-myristoyl-CoA + NADPH → NADP+ + (S)-3-hydroxytetradecanoyl-CoA

H+ + oxygen + NADH + oleoyl-CoA → 2 H2O + NAD+ + linoleoyl-CoA

H+ + NADPH + oxygen + hexadecane → H2O + NADP+ + 1-hexadecanol

H+ + NADPH + oxygen + dodecane → H2O + NADP+ + 1-dodecanol

H+ + NADPH + oxygen + decane → H2O + NADP+ + decan-1-ol

H+ + 3-oxo-behenoyl-CoA + NADPH → NADP+ + 3-hydroxydocosanoyl-CoA

carboxyacetyl-ACP + H+ + C15718 → CO2 + acyl-carrier-protein + 3-oxooctanoyl-ACP

H+ + NADPH + trans-Hex-2-enoyl-ACP → NADP+ + C15718

H+ + 3-oxoicosanoyl-CoA + NADPH → NADP+ + 3-hydroxyicosanoyl-CoA

H+ + 3-oxo-cerotoyl-CoA + NADPH → NADP+ + (S)-3-hydroxyhexacosanoyl-CoA

H+ + NADPH + (2E)-tetradec-2-enoyl-CoA → myristoyl-CoA + NADP+

H+ + NADPH + trans-2-icosenoyl-CoA → icosanoyl-CoA + NADP+

H+ + NADPH + (2E)-hexadecenoyl-CoA → NADP+ + cerotoyl-CoA

H+ + NADPH + trans-2,trans-4-dodecadienoyl-CoA → NADP+ + trans-dodec-3-enoyl-CoA

Compound as product (3333)

3'-phosphoadenylyl-sulfate + serotonin → adenosine 3',5'-bisphosphate + H⁺ + serotonin O-sulfate

dTDP-4-acetamido-4,6-dideoxy-α-D-galactose + N-acetyl-β-D-mannosaminuronyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol → (enterobacterial common antigen)-undecaprenyl diphosphate + H⁺ + dTDP

L-leucine + (-)-jasmonate + ATP → H⁺ + diphosphate + (-)-jasmonoyl-L-leucine + AMP

L-xylo-hex-3-ulono-1,4-lactone → L-ascorbate + H⁺

S-adenosyl-L-methionine + trans-caffeate → 3 H⁺ + S-adenosyl-L-homocysteine + ferulate

NADP⁺ + geraniol → NADPH + geranial + H⁺

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + oxygen → 4-(methylsulfanyl)-2-oxobutanoate + formate + H⁺

(heptosyl)₂-Kdo₂-lipid A + UDP-α-D-glucose → glucosyl-(heptosyl)₂-Kdo₂-lipid A + H⁺ + UDP

S-adenosyl-L-methionine + demethylmenaquinol-12 → S-adenosyl-L-homocysteine + menaquinol-12 + H⁺

H₂O + pyridoxal + oxygen → hydrogen peroxide + 4-pyridoxate + H⁺

prunin + UDP-β-L-rhamnose → narirutin + H⁺ + UDP

S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + H⁺

a reduced electron donor + 3,3',5-triiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3,5-diiodothyronamine

NAD⁺ + 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxybutanoyl)-CoA → NADH + H⁺ + 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3-oxobutanoyl)-CoA

soyasapogenol B-3-O-β-glucuronide + UDP-α-D-galactose → soyasaponin III + H⁺ + UDP

N³-oct-2-enoyl-N³-hydroxy-1,3-diaminopropane + ATP + citrate → N¹-citryl-N³-oct-2-enoyl-N³-hydroxy-1,3-diaminopropane + H⁺ + diphosphate + AMP

vinblastine + oxygen → 2 H⁺ + H₂O + vincristine

3-phospho-D-glycerate + UDP-α-D-glucose → H⁺ + 2-O-(α-D-glucopyranosyl)-3-phospho-D-glycerate + UDP

O-acetyl-L-serine + trans-zeatin → acetate + lupinate + H⁺

NADPH + (S)-nicotine → 3 H⁺ + nicotine-Δ^1'5'-iminium ion + NADP⁺

H₂O + D-glucose 6-sulfate → H⁺ + sulfate + β-D-glucopyranose

ammonium + D-glyceraldehyde 3-phosphate + aldehydo-D-ribose 5-phosphate → 4 H₂O + pyridoxal 5'-phosphate + H⁺ + phosphate

S-adenosyl-L-methionine + (S)-norreticuline → S-adenosyl-L-homocysteine + H⁺ + (S)-norlaudanine

NAD⁺ + L-glucose → NADH + L-glucono-1,5-lactone + H⁺

phenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + anisole + H⁺

3-chlorocatechol + oxygen → 2 H⁺ + 2-chloro-cis,cis-muconate

hydroquinone + oxygen → (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate + H⁺

spermidine + NAD⁺ → NADH + dehydrospermidine + H⁺

S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin → S-adenosyl-L-homocysteine + 8-demethyl-8-(methylamino)riboflavin + H⁺

2 (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate → 2 H⁺ + H₂O + (1R,5aS,6R)-4a-hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate

N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + dTDP-β-L-rhamnose → α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + H⁺ + dTDP

3-hydroxy-L-kynurenine + S-adenosyl-L-methionine → 3-hydroxy-4-methyl-L-kynurenine + S-adenosyl-L-homocysteine + H⁺

H₂O + VAI-1-2 → H⁺ + N-(octanoyl)-L-homoserine

H₂O + S-adenosyl-L-methionine + 12-ethyl-7¹-hydroxy-8-propylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹,7¹-dihydroxy-8-propylbacteriochlorophyllide c

3'-phosphoadenylyl-sulfate + quercetin 3, 4', 7-trisulfate → adenosine 3',5'-bisphosphate + H⁺ + quercetin 3, 3', 4', 7-tetrasulfate

luteolinidin + UDP-α-D-glucose → 2 H⁺ + luteolinidin 5-O-glucoside + UDP

L-alanyl-L-valine + (2S,3S,7R)-2,3-diamino-8-(1-carbamoyl-2-iminoimidazolidin-4-yl)-7-hydroxyoctanoate → H₂O + 6-dehydroguadinomine B + H⁺

α-Kdo-(2->8)-α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP-3-deoxy-β-D-manno-octulosonate → α-Kdo-(2->8)-[α-Kdo-(2->4)]-α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP + H⁺

2'-deamino-2'-hydroxyneamine + UDP-α-D-glucose → H⁺ + kanamycin D + UDP

O-acetyl-L-serine + 3,4-dihydroxypyridin → 2 H⁺ + acetate + L-mimosine

3-2-carboxyphenylcatechol + oxygen → H⁺ + 2-hydroxy-6-(2-carboxyphenyl)-6-oxo-2,4-hexadienoate

(+)-(αR,βS)-guaiacylglycerol-β-guaiacyl ether + NAD⁺ → NADH + (2S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one + H⁺

N-dimethylethanolamine phosphate + S-adenosyl-L-methionine → phosphocholine + S-adenosyl-L-homocysteine + H⁺

thiophene-2-carbonyl-CoA + a reduced electron donor + oxygen → an oxidized electron donor + H₂O + 5-hydroxythiophene-2-carbonyl-CoA + H⁺

3-dehydro-D-erythronate + ATP → 3-dehydro-4-phospho-D-erythronate + H⁺ + ADP

5,5-dihydroxy-leucine → 2 H₂O + 3-methyl-pyrroline-5-carboxylate + H⁺

O-methyl-4-O-[α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + GDP-β-L-fucose → O-methyl-4-O-[α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + H⁺ + GDP

2-methyl-3-pentyl-4,5-dihydro-3H-pyrrole + oxygen → hydrogen peroxide + 2-methyl-3-pentyl-1H-pyrrole + H⁺

H₂O + dodecyl sulfate → H⁺ + 1-dodecanol + sulfate

H₂O + NAD(P)+ + (2S)-3-sulfolactaldehyde → 2 H⁺ + NAD(P)H + (2S)-3-sulfolactate

H₂O + methylsalicylate → salicylate + methanol + H⁺

2 H₂O + NAD⁺ + 1-piperideine → 5-aminopentanoate + NADH + H⁺

(R)-reticuline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + (R)-laudanine

UDP-α-D-glucuronate + baicalein → H⁺ + UDP + baicalin

H₂O + (Z)-1-(L-cystein-S-yl)-N-hydroxy-2-phenylethan-1-imine → pyruvate + H⁺ + ammonium + (Z)-2-phenyl-1-thioacetohydroximate

S-adenosyl-L-methionine + L-olivosyl-oleandolide → S-adenosyl-L-homocysteine + H⁺ + L-oleandrosyl-oleandolide

prenol + ATP → H⁺ + ADP + prenyl phosphate

H₂O + (+)-bisdechlorogeodin → asterrate + H⁺

H₂O + limonin + UDP-α-D-glucose → limonin 17-β-D-glucoside + H⁺ + UDP

L-homoserine + ATP → O-phospho-L-homoserine + H⁺ + ADP

5-ribosylparomamine + UDP-N-acetyl-α-D-glucosamine → 2'''-acetyl-6'''-hydroxyparomomycin + H⁺ + UDP

H₂O + 4-hydroxybenzaldehyde + NAD⁺ → 2 H⁺ + NADH + 4-hydroxybenzoate

2 H₂O + N-methylpyrrolidone + ATP → 4-methylaminobutanoate + H⁺ + phosphate + ADP

salicylaldehyde + UDP-α-D-glucose → H⁺ + helicin + UDP

S-adenosyl-L-methionine + isoliquiritigenin → S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin + H⁺

2 S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-α-D-forosamine

choline + NAD⁺ → NADH + betaine aldehyde + H⁺

β-L-arabinopyranose + ATP → β-L-arabinose 1-phosphate + H⁺ + ADP

S-adenosyl-L-methionine + daphnetin → S-adenosyl-L-homocysteine + H⁺ + 7-hydroxy-8-methoxycoumarin

an oxidized electron donor + L-galactono-1,4-lactone → L-ascorbate + a reduced electron donor + H⁺

Cd²⁺ + H₂O + ATP → Cd²⁺ + H⁺ + phosphate + ADP

S-adenosyl-L-methionine + 13-deoxycarminomycin → S-adenosyl-L-homocysteine + H⁺ + 13-deoxydaunorubicin

NAD⁺ + (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate → NADH + H⁺ + 2,3-dihydroxy-p-cumate

UDP-α-D-glucose + 3,6,7,2',4'-pentamethylquercetagetin → H⁺ + 3,6,7,2',4'-pentamethylquercetagetin 3'-O-β-D-glucoside + UDP

S-adenosyl-L-methionine + DIMBOA-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + HMDBOA-glucoside

D-tagatofuranose 6-phosphate + ATP → D-tagatofuranose 1,6-bisphosphate + H⁺ + ADP

H₂O + dATP → H⁺ + phosphate + dADP

a reduced electron donor + 3-hydroxybenzoyl-CoA + oxygen → an oxidized electron donor + coenzyme A + gentisate + H⁺

H₂O + ADP ribose 1'',2''-cyclic phosphate → H⁺ + ADP ribose 1''-phosphate

pregnenolone + NAD⁺ → progesterone + NADH + H⁺

H₂O + phenylglyoxylyl-CoA → coenzyme A + phenylglyoxylate + H⁺

L-idonate + NAD⁺ → 5-dehydro-D-gluconate + NADH + H⁺

an oxidized electron donor + thymine + H₂O → 5-methyl-barbiturate + a reduced electron donor + H⁺

H₂O + Cu⁺ + ATP → H⁺ + Cu⁺ + phosphate + ADP

Co²⁺ + sirohydrochlorin → 2 H⁺ + cobalt-sirohydrochlorin

2 a reduced electron donor + 7,8-dihydromethanopterin → 2 an oxidized electron donor + 2 H⁺ + tetrahydromethanopterin

(1R,2S)-3,6-dichlorocyclohexa-3,5-diene-1,2-diol + NAD⁺ → NADH + H⁺ + 3,6-dichlorocatechol

an oxidized electron donor + L-sorbosone 1,4-lactone → L-ascorbate + a reduced electron donor + H⁺

H₂O + ATP + cob(I)inamide → H⁺ + phosphate + ADP + cob(I)inamide

S-adenosyl-L-methionine + (+)-norpseudoephedrine → 2 H⁺ + S-adenosyl-L-homocysteine + pseudoephedrine

H₂O + 2,2-dichloroacetate → 2 H⁺ + 2 chloride + glyoxylate

ammonium + phosphoribulosylformimino-AICAR-phosphate → H₂O + D-erythro-imidazole-glycerol-phosphate + H⁺ + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

4 H₂O + 4 S⁰ + oxygen → 2 sulfite + 2 hydrogen sulfide + 4 H⁺

UDP-α-D-glucose + cyanidin-3-O-rutinoside → H⁺ + cyanidin-3-O-rutinoside-5-O-β-D-glucoside + UDP

N⁵-2,4-diaminobutanoate-N¹-citryl-N³-decanoyl-N³-hydroxy-1,3-diaminopropane + 2-oxoglutarate + ATP → baumannoferrin B + H⁺ + diphosphate + AMP

2 lauroyl-CoA + H₂O → 2 coenzyme A + (2R)-2-decyl-3-oxotetradecanoate + H⁺

S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone → S-adenosyl-L-homocysteine + (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H⁺

(R)-1-aminopropan-2-ol + ATP → (R)-1-amino-2-propanol O-2-phosphate + H⁺ + ADP

H₂O + 3-chlorobenzaldehyde + NAD⁺ → 2 H⁺ + NADH + 3-chlorobenzoate

3'-phosphoadenylyl-sulfate + isorhamnetin 3-sulfate → adenosine 3',5'-bisphosphate + H⁺ + isorhamnetin 3, 4'-bisulfate

an oxidized electron donor + L-proline → a reduced electron donor + H⁺ + (S)-1-pyrroline-5-carboxylate

H₂O + acetaldehyde + NADP⁺ → 2 H⁺ + acetate + NADPH

felinine + acetyl-CoA → coenzyme A + N-acetylfelinine + H⁺

H₂O + 2-deoxy-D-glucono-1,5-lactone → 2-deoxygluconate + H⁺

hesperitin-7-O-β-D-glucoside + UDP-β-L-rhamnose → hesperidin + H⁺ + UDP

cis-tuberonic acid + 3'-phosphoadenylyl-sulfate → cis-12-sulfojasmonate + adenosine 3',5'-bisphosphate + H⁺

2-(2-phenylethyl)-thiohydroximate-O-sulfate → 3-phenylpropionitrile + H⁺ + sulfate + S⁰

2-dehydro-3-deoxy-L-galactonate + NAD⁺ → 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H⁺

H₂O + NAD(P)+ + coniferaldehyde → 2 H⁺ + NAD(P)H + ferulate

S-adenosyl-L-methionine + scutellarein 7-methyl ether → S-adenosyl-L-homocysteine + H⁺ + ladanein

H₂O + huvastatin lactone → huvastatin acid + H⁺

S-adenosyl-L-methionine + 4-demethyl-7-(3-amino-3-carboxypropyl)wyosine → S-adenosyl-L-homocysteine + H⁺ + 7-[(3S)-(3-amino-3-carboxypropyl)-4-methyl]wyosine

1D-myo-inositol 3-monophosphate + ATP → D-myo-inositol (3,6)-bisphosphate + H⁺ + ADP

UDP-β-L-rhamnose + quercetin-3-gentiobioside → H⁺ + quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP

H₂O + 1,6-anhydro-N-acetyl-β-muramate + ATP → N-acetyl-D-muramate 6-phosphate + H⁺ + ADP

ATP + 5-dehydro-2-deoxy-D-gluconate → H⁺ + ADP + 5-dehydro-2-deoxy-D-gluconate 6-phosphate

H₂O + (2E)-3-methyl-4,6-dioxohept-2-enedioate → citraconate + pyruvate + H⁺

delphinidin + UDP-α-D-glucose → H⁺ + delphinidin-3-O-β-D-glucoside + UDP

p-HBAD-I + dTDP-β-L-rhamnose → O-methyl-4-O-[α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + H⁺ + dTDP

hydrogen cyanide + 3-mercaptopyruvate → pyruvate + thiocyanate + H⁺

UDP-α-D-xylose + delphinidin-3-O-β-D-glucoside → H⁺ + delphinidin 3-O-β-D-sambubioside + UDP

S-adenosyl-L-methionine + C30 botryococcene → S-adenosyl-L-homocysteine + showacene + H⁺

NAD⁺ + 24-hydroxy-3-oxocholest-4-en-26-oyl-CoA → NADH + H⁺ + 3,24-dioxocholest-4-en-26-oyl-CoA

H₂O + digallate → 2 gallate + H⁺

H₂O + (2-aminobenzoyl)acetyl-CoA → coenzyme A + H⁺ + (2-aminobenzoyl)acetate

FADH₂ + H₂O + 3,5,6-trichloro-2-pyridinol + oxygen → 3 chloride + 4 H⁺ + FAD + 3,6-dihydroxypyridine-2,5-dione

NADP⁺ + 3-hydroxy-3-phenylpropanoyl-CoA → NADPH + H⁺ + 3-oxo-3-phenylpropanoyl-CoA

H₂O + adenosine 2',3'-cyclic monophosphate → H⁺ + adenosine 3'-monophosphate

3-oxo-24-ethyl-cholest-4,24-dien-26-oyl-CoA + hydrogencarbonate + ATP → 3-oxo-24-(isopropanoyl)-cholest-4,24-dien-26-oyl-CoA + H⁺ + phosphate + ADP

H₂O + adenosine 2',3'-cyclic monophosphate → H⁺ + adenosine 2'-monophosphate

5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate → 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl 1-phosphate + H⁺

soyasapogenol E + UDP-α-D-glucose → soyasapogenol-E-3-O-β-D-glucoside + H⁺ + UDP

dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose + acetyl-CoA → coenzyme A + dTDP-3-acetamido-3,6-dideoxy-α-D-glucopyranose + H⁺

S-adenosyl-L-methionine + 3-hydroxy-D-kynurenine → S-adenosyl-L-homocysteine + H⁺ + 3-hydroxy-4-methyl-D-kynurenine

H₂O + mycophenolate mofetil → mycophenolate + H⁺ + 2-morpholinoethanol

S-adenosyl-L-methionine + L-tryptophan → S-adenosyl-L-homocysteine + H⁺ + 2-methyl-L-tryptophan

3'-phosphoadenylyl-sulfate + desulfosinalbin → adenosine 3',5'-bisphosphate + H⁺ + sinalbin

N-demethylvindolidine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + vindolidine + H⁺

NAD⁺ + (1R,2S)-3,4,5-trichlorocyclohexa-3,5-diene-1,2-diol → 2 H⁺ + NADH + 3,4,5-trichlorocatechol

NAD⁺ + (3R)-hydroxy, 6-trans-tridecenoyl-CoA → NADH + H⁺ + 6-trans-3-oxo-tridecenoyl-CoA

S-adenosyl-L-methionine + furaneol (enol form) → S-adenosyl-L-homocysteine + H⁺ + mesifurane (enol form)

D-alanyl-D-alanine + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + ATP → H⁺ + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + phosphate + ADP

2 coenzyme A + 2 H₂O + 2 NAD⁺ + 2 oxygen + 9-cis, 11-trans-octadecadienoyl-CoA → 2 hydrogen peroxide + 2 NADH + 2 H⁺ + 2 acetyl-CoA + 5-cis, 7-trans-tetradecadienoyl-CoA

N-3-fumaramoyl-L-2,3-diaminopropanoate + L-isoleucine + ATP → dapdiamide B + H⁺ + phosphate + ADP

2 D-alanine + ATP → D-alanyl-D-alanine + H⁺ + phosphate + ADP

5-chloro-3-methylcatechol + oxygen → 2 H⁺ + 4-chloro-2-methyl-cis,cis-muconate

H₂O + 5-(4-acetoxybut-1-ynyl)-2-2'-bithiophene → acetate + 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene + H⁺

UDP-4-acetamido-4,6-dideoxy-α-L-galactose + 4-[(E)-2-isocyanoethenyl]phenol → H⁺ + rhabduscin + UDP

S-adenosyl-L-methionine + 3,7,3'-trimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',5'-tetramethylmyricetin

H₂O + 2,6-dichlorohydroquinone + oxygen → 2 H⁺ + 2-chloromaleylacetate + chloride

5-hydroxy-feruloyl-CoA + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + sinapoyl-CoA

hydrogencarbonate + nicotinate adenine dinucleotide → 2 H⁺ + pyridin-1-ium-3,5-dicarboxylate mononucleotide + AMP

H₂O + 3-sulfopropanal + NAD(P)+ → 2 H⁺ + 3-sulfopropanoate + NAD(P)H

(S)-2-chloropropanoate + H₂O → H⁺ + (R)-lactate + chloride

H₂O + estrone 3-sulfate → estrone + H⁺ + sulfate

demycosaminyl-nystatin + GDP-mycosamine → H⁺ + nystatin A1 + GDP

L-glutamate-5-semialdehyde + acetyl-CoA → coenzyme A + N-acetyl-L-glutamate 5-semialdehyde + H⁺

H₂O + L-selenocystathionine → seleno-L-homocysteine + pyruvate + H⁺ + ammonium

gentisate + UDP-α-D-xylose → H⁺ + gentisate 5-O-β-D-xylopyranoside + UDP

3 ATP + anthranilate + L-tryptophan + L-alanine → 2 H⁺ + 3 diphosphate + 3 AMP + H₂O + ardeemin FQ

H₂O + acetaldehyde + NAD⁺ → 2 H⁺ + acetate + NADH

H₂O + pheophytin b → phytol + H⁺ + pheophorbide b

S-adenosyl-L-methionine + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 2'-hydroxy 3,6,7,3',4'-pentamethylquercetagetin

dTDP-α-D-olivose + premithramycin A3 → H⁺ + dTDP + 3A-deolivosylpremithramycin B

H₂O + NADP⁺ + methylglyoxal → 2 H⁺ + NADPH + pyruvate

S-adenosyl-L-methionine + laricitrin → syringetin + S-adenosyl-L-homocysteine + H⁺

oxygen + tetracenomycin F1 → H₂O + H⁺ + tetracenomycin D3

L-aspartate + ATP + cyanophycin primer → H⁺ + phosphate + ADP + cyanophycin primer-L-aspartate

quercetin 3-O-sophoroside + UDP-α-D-glucose → H⁺ + quercetin 3-O-β-D-glucosyl-(1->2)-glucosyl-(1->2)-β-D-glucoside + UDP

β-nicotinate D-ribonucleotide + 5-methoxy-6-methylbenzimidazole → nicotinate + 5-methoxy-6-methylbenzimidazole ribotide phosphate + H⁺

a reduced electron donor + 3,3'-diiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3-iodothyronamine

catechol + oxygen → (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H⁺

H₂O + 2,6-dihydroxynicotinate + oxygen → maleamate + formate + H⁺ + CO₂

H₂O + formyl-CoA → coenzyme A + formate + H⁺

(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate → cis-dienelactone + H⁺ + chloride

3,6-dichlorocatechol + oxygen → 2 H⁺ + 2,5-dichloro-cis,cis-muconate

H₂O + cyclic di-3',5'-guanylate → 5'-phosphoguanylyl(3'→5')guanosine + H⁺

urolithin A + UDP-α-D-glucuronate → H⁺ + urolithin A 8-O-glucuronide + UDP

H₂O + methylglyoxal + oxygen → hydrogen peroxide + pyruvate + H⁺

a reduced electron donor + 3,5-diiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3-iodothyronamine

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + 5-chloro-4-hydroxy-2-oxopentanoate → 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + 4-chloro-3-hydroxybutyryl-CoA + CO₂

GDP-α-D-mannose + α-D-mannosyl-(1→3)-α-D-mannosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol → α-D-mannosyl-(1→3)-α-D-mannosyl-(1→3)-α-D-mannosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + GDP

H₂O + crotonobetainyl-CoA → coenzyme A + crotono-betaine + H⁺

S-adenosyl-L-methionine + 3-demethylubiquinol-10 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-10

spermidine + ATP + citrate → N-citryl-spermidine + H⁺ + diphosphate + AMP

3-demethylubiquinol-6 + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-6

L-quinate + NAD⁺ → 3-dehydroquinate + NADH + H⁺

H₂O + NADP⁺ + 16-oxo-palmitate → 2 H⁺ + NADPH + hexadecanedioate

campesterol + NADP⁺ → crinosterol + NADPH + H⁺

(2E,6E)-farnesol + CTP → H⁺ + (2E,6E)-farnesyl phosphate + CDP

2 H₂O + 2 L-glutamine + 2 ATP + hydrogenobyrinate → 2 H⁺ + 2 L-glutamate + 2 phosphate + 2 ADP + hydrogenobyrinate a,c-diamide

H₂O + dihomo γ-linolenoyl-CoA → coenzyme A + H⁺ + di-homo-γ-linolenate

H₂O + trans-5-O-caffeoyl-D-quinate → L-quinate + H⁺ + trans-caffeate

1D-1-O-(indol-3-yl)acetyl-myo-inositol + H₂O → myo-inositol + H⁺ + (indol-3-yl)acetate

H₂O + NAD⁺ + D-glyceraldehyde 3-phosphate → 2 H⁺ + NADH + 3-phospho-D-glycerate

coenzyme A + 3-hydroxypimeloyl-CoA → 2 H⁺ + glutaryl-CoA + acetyl-CoA

3'-phosphoadenylyl-sulfate + dopamine → dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H⁺

orcinol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-methoxy-5-hydroxytoluene + H⁺

2-chloro-2-hydroxypropanoate → pyruvate + H⁺ + chloride

H₂O + β-nicotinate D-ribonucleotide → nicotinate + H⁺ + aldehydo-D-ribose 5-phosphate

H₂O + L-methionine-(S)-S-oxide + ATP → L-methionine-(S)-S-oxide + H⁺ + phosphate + ADP

soyasapogenol B + UDP-α-D-glucose → soyasapogenol B-3-O-β-D-glucoside + H⁺ + UDP

phloroglucinol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dihydroxyanisole + H⁺

tabtoxinine-β-lactam + L-threonine + ATP → β-tabtoxin + H⁺ + diphosphate + AMP

JI-20A + ATP → H⁺ + ADP + 3'-phospho-JI-20A

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate → 2 H₂O + 3-amino-4-hydroxybenzoate + H⁺ + phosphate

S-adenosyl-L-methionine + N-desmethyl-gliotoxin → S-adenosyl-L-homocysteine + H⁺ + gliotoxin

H₂O + benzaldehyde + oxygen → hydrogen peroxide + H⁺ + benzoate

NAD(P)+ + (S)-ureidoglycolate → NAD(P)H + H⁺ + N-carbamoyl-2-oxoglycine

2'-deamino-2'-hydroxyparomamine + UDP-α-D-kanosamine → H⁺ + kanamycin X + UDP

H₂O + 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate → 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + H⁺ + sulfate

3 S-adenosyl-L-methionine + glycine → 3 S-adenosyl-L-homocysteine + 3 H⁺ + glycine betaine

2 H₂O + dATP → 2 H⁺ + 2 phosphate + dAMP

2 methylphoracetophenone → 2 H⁺ + hydratedusnate

L-serine + ADP → 3-phospho-L-serine + H⁺ + AMP

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + S-adenosyl-L-methionine → 3 H⁺ + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + formate + 5'-deoxyadenosine + L-methionine + carbon monoxide

2-dehydro-3-deoxy-D-galactonate + ATP → 2-dehydro-3-deoxy-D-galactonate 6-phosphate + H⁺ + ADP

3 S-adenosyl-L-methionine + (S)-norlaudanosoline → 3 S-adenosyl-L-homocysteine + 3 H⁺ + (S)-reticuline

2 a peptidoglycan dimer (S. aureus) + 3 H₂O → 4 D-alanine + a peptidoglycan with D,D cross-link (S. aureus) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

2 glutathione + S-sulfo-L-cysteine → H⁺ + glutathione disulfide + L-cysteine + sulfite

S-adenosyl-L-methionine + cobalt-precorrin-5B → 2 H⁺ + S-adenosyl-L-homocysteine + cobalt-precorrin-6A

NAD⁺ + β-L-galactopyranose → L-galactono-1,4-lactone + NADH + H⁺

tetrahydromethanopterin + L-glutamate + ATP → tetrahydrosarcinapterin + H⁺ + phosphate + ADP

S-adenosyl-L-methionine + methanethiol → S-adenosyl-L-homocysteine + H⁺ + dimethyl sulfide

5-nitrosalicylate + oxygen → 4-nitro-6-oxohepta-2,4-dienedioate + H⁺

7(8),7'(8')-tetrahydroisojusticidin B + NAD⁺ → NADH + 7(8)-dihydroisojusticidin B + H⁺

H₂O + salicyl-6-hydroxy-2-cyclohexene-on-oyl → salicyl alcohol + H⁺ + 6-hydroxy-2-cyclohexen-one-carboxylate

L-aspartate + fumarate → H⁺ + succinate + 2-iminosuccinate

2 cob(I)alamin + NAD⁺ + H⁺ ← 2 cob(II)alamin + NADH

testosterone + NAD(P)+ → androst-4-ene-3,17-dione + NAD(P)H + H⁺

H₂O + 3-(hydroxyphosphinoyl)pyruvate + acetyl-CoA → coenzyme A + H⁺ + 2-(phosphonoylmethyl)malate

3'-phosphoadenylyl-sulfate + 4-methylphenol → adenosine 3',5'-bisphosphate + H⁺ + 4-methylphenyl sulfate

glucosyl-(heptosyl)₂-Kdo₂-lipid A + ATP → glucosyl-(heptosyl)₂-Kdo₂-lipid A-phosphate + H⁺ + ADP

H₂O + 4-aminobutanal + NAD⁺ → 2 H⁺ + 4-aminobutanoate + NADH

erythritol + ATP → D-erythritol 1-phosphate + H⁺ + ADP

H₂O + 4,4'-(1E)-prop-1-ene-1,2-diyldiphenol + oxygen → S-1-(4-hydroxyphenyl)-ethanol + H⁺ + 4-hydroxybenzoate

H₂O + fluoroacetyl-CoA → coenzyme A + fluoroacetate + H⁺

5-methoxybenzimidazole ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(5-methoxybenzimidazolyl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

4-hydroxypentanoyl-CoA + ATP → H⁺ + 4-(phosphooxy)pentanoyl-CoA + ADP

D-sedoheptulose 7-phosphate + ATP → D-sedoheptulose 1,7-bisphosphate + H⁺ + ADP

2 NAD(P)+ + H₂O + UDP-N-acetyl-α-D-galactosamine → 2 NAD(P)H + 3 H⁺ + UDP-N-acetyl-α-D-galactosaminouronate

α-D-galactosyl-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-di-trans,octa-cis-undecaprenol + UDP-α-D-galactose → β-D-galactosyl-(1→4)-α-D-galactosyl-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-di-trans,octa-cis-undecaprenol + H⁺ + UDP

O-succinyl-L-homoserine → 2 H⁺ + succinate + (2Z)-2-aminobut-2-enoate

5-amino-1-(β-D-ribosyl)imidazole + ATP → 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + H⁺ + ADP

nothofagin + UDP-α-D-glucose → 3',5'-di-C-glucosylphloretin + H⁺ + UDP

H₂O + CMP-5'-3-(N-acetyl-N-hydroxy)aminopropylphosphonate → CMP + H⁺ + FR-900098

cyanidin + UDP-α-D-glucose → H⁺ + cyanidin-3-O-β-D-glucoside + UDP

validone + ATP → validone 7-phosphate + H⁺ + ADP

H₂O + L-glucono-1,5-lactone → L-gluconate + H⁺

delphinidin 3,5-di-O-β-D-glucoside + UDP-α-D-glucose → H⁺ + delphinidin 3,3',5-tri-O-β-D-glucoside + UDP

β-nicotinate D-ribonucleotide + adenine → nicotinate + H⁺ + adenine ribotide phosphate

2 H₂O + dGTP → 2 H⁺ + 2 phosphate + dGMP

H₂O + N²-succinyl-L-glutamate 5-semialdehyde + NAD⁺ → 2 H⁺ + N²-succinylglutamate + NADH

coenzyme A + H₂O + 2-[(1R,6S)-1,6-dihydroxycyclohexa-2,4-dien-1-yl]acetyl-coA → H⁺ + acetyl-CoA + (3S)-hydroxyadipyl-CoA

cysteamine + oxygen → hypotaurine + H⁺

glycine + choloyl-CoA → coenzyme A + H⁺ + glycocholate

H₂O + dUTP → H⁺ + diphosphate + dUMP

H₂O + 3-sulfinopyruvate → pyruvate + H⁺ + sulfite

L-3-cyclohex-2'-enylalanine + chloroethylmalonyl-CoA + acetyl-CoA → 2 coenzyme A + salinosporamide A + H⁺ + CO₂

NAD⁺ + narcotine hemiacetal → NADH + H⁺ + noscapine

dTDP-β-L-rhamnose + spinosyn tricyclic macrolactone → H⁺ + rhamnosyl tricyclic spinosyn pseudoaglycone + dTDP

CDP-choline + GalNAc-GalNAc-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol → (Chol-P-GalNAc)-GalNAc-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol + CMP + H⁺

coenzyme A + H₂O + NAD⁺ + (3R)-hydroxy-nonanoyl-CoA + oxygen → hydrogen peroxide + NADH + H⁺ + 3-hydroxy-heptanoyl-CoA + acetyl-CoA

1-(2-amino-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP → deacetylmycothiol + H⁺ + diphosphate + AMP

hydroxymethylphosphonate + NADP⁺ → 2 H⁺ + NADPH + phosphonoformaldehyde

H₂O + 3-hydroxybenzaldehyde + NADP⁺ → 2 H⁺ + NADPH + 3-hydroxybenzoate

11-cis-retinyl palmitate + H₂O → 11-cis-retinol + palmitate + H⁺

S-adenosyl-L-methionine + 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 8,12-diethyl-3-vinylbacteriochlorophyllide d + H⁺

glucosyl-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + UDP-α-D-galactose → galactosyl-glucosyl-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + H⁺ + UDP

H₂O + simvastatin lactone → simvastatin acid + H⁺

FMNH₂ + dibenzothiophene-5-oxide + oxygen → FMN + H₂O + dibenzothiophene-5,5-dioxide + H⁺

1,2-dihydropyrimidine + N-methyl-Δ¹-pyrrolinium cation → H⁺ + 3,6-dihydronicotine

3-methyl-4-nitrocatechol + oxygen → 2-hydroxy-5-nitro-6-oxohepta-2,4-dienoate + H⁺

H₂O + L-phenylalanine + ATP → L-phenylalanine + H⁺ + phosphate + ADP

H₂O + NAD⁺ + grixazone A → 2 H⁺ + NADH + grixazone B

N-3-(R,R)-epoxysuccinamoyl-(S)-2,3-diaminopropanoate + L-valine + ATP → N-(R,R)-3-epoxysuccinamoyl-(S)-2,3-diaminopropanoyl-L-valine + H⁺ + phosphate + ADP

L-threonate + NAD⁺ → NADH + 2-dehydro-L-erythronate + H⁺

a reduced electron donor + 3,3',5,5'-tetraiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3,3',5'-triiodothyronamine

N-acetyl-β-D-mannosamine + ATP → 2 H⁺ + N-acetyl-D-mannosamine 6-phosphate + ADP

2,2-dichloroacetate + glutathione → H⁺ + S-(2-chlorocarboxymethyl)-glutathione + chloride

H₂O + (R)-3-((R)-3-hydroxybutanoyloxy)-butanoate → 2 (R)-3-hydroxybutanoate + H⁺

spermidine + acetyl-CoA → coenzyme A + N⁸-acetylspermidine + H⁺

2-oxoglutarate + oxygen + gibberellin A₈ → H₂O + H⁺ + succinate + gibberellin A₈-catabolite + CO₂

NAD(P)+ + oryzalexin D → NAD(P)H + H⁺ + oryzalexin A

sinapyl alcohol + UDP-α-D-glucose → syringin + H⁺ + UDP

5-chloro-3-fluorocatechol + oxygen → 2 H⁺ + 4-chloro-2-fluoromuconate

coenzyme A + (25R)-3α,7α-dihydroxy-5-β-cholestanate + ATP → H⁺ + (25R)-3α,7α-dihydroxy-5β-cholestanoyl-CoA + diphosphate + AMP

oxygen + trans-caffeate → 2 H⁺ + 3-(2-carboxyethenyl)-cis,cis-muconate

4-methylcatechol + oxygen → (2Z,4E)-2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + H⁺

H₂O + 4-methylumbelliferyl acetate → 4-methylumbelliferone + acetate + H⁺

acetyl-CoA + UDP-N-acetylbacillosamine → coenzyme A + H⁺ + UDP-N,N'-diacetylbacillosamine

2-hydroxy-6-oxo-nona-2,4-dienoate + H₂O → butanoate + H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate

2-hydroxyparaconate + oxygen → 2 H⁺ + itatartarate

2 S-adenosyl-L-methionine + a reduced electron donor + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 5'-deoxyadenosine + L-methionine

1D-chiro-inositol + UDP-α-D-galactose → H⁺ + fagopyritol A1 + UDP

agmatine + (E)-4-coumaroyl-CoA → coenzyme A + H⁺ + 4-coumaroylagmatine

H₂O + an acyl-CoA → a carboxylate + coenzyme A + H⁺

H₂O + versiconal hemiacetal acetate → acetate + H⁺ + versiconal

(+)-secoisolariciresinol monoglucoside + UDP-α-D-glucose → (+)-secoisolariciresinol diglucoside + H⁺ + UDP

L-glutamate + ATP + 4-aminobenzoate → N-(4-aminobenzoyl)-L-glutamate + H⁺ + diphosphate + AMP

5-O-β-mycaminosyltylonolide + dTDP-6-deoxy-α-D-allose → demethyllactenocin + H⁺ + dTDP

H₂O + β-D-galactofuranose + ATP → β-D-galactofuranose + H⁺ + phosphate + ADP

S-adenosyl-L-methionine + cephaeline → S-adenosyl-L-homocysteine + H⁺ + emetine

S-adenosyl-L-methionine + N-demethyllincomycin → S-adenosyl-L-homocysteine + H⁺ + lincomycin A

S-adenosyl-L-methionine + 4'-O-demethylrebeccamycin → S-adenosyl-L-homocysteine + H⁺ + rebeccamycin

S-adenosyl-L-methionine + 9-demethylpremithramycin A3 → S-adenosyl-L-homocysteine + H⁺ + premithramycin A3

H₂O + NAD⁺ + 3-formyl-4-hydroxybenzoate → 2 H⁺ + NADH + 4-hydroxyisophthalate

4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate → xanthurenate + H₂O + H⁺

(2S)-naringenin + 2-oxoglutarate + oxygen → H₂O + H⁺ + succinate + CO₂ + apigenin

S-adenosyl-L-methionine + genistein → S-adenosyl-L-homocysteine + H⁺ + biochanin-A

carbamoyl phosphate → cyanate + H⁺ + phosphate

5-amino-5-deoxy-3-dehydroshikimate → H₂O + H⁺ + 3-amino-5-hydroxybenzoate

ADP-α-D-glucose + sn-glycerol 3-phosphate → 2-O-(α-D-glucopyranosyl)-sn-glycerol 3-phosphate + H⁺ + ADP

2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate → 4-hydroxy-2-keto-5-methyl-6-oxo-3-hexenoate + H⁺

H₂O + NAD⁺ + 3-dimethylsulfoniopropionaldehyde → 2 H⁺ + dimethylsulfoniopropanoate + NADH

β-nicotinate D-ribonucleotide + 5-methoxybenzimidazole → nicotinate + 5-methoxybenzimidazole ribotide phosphate + H⁺

rhizocticin A + L-valine + ATP → rhizocticin B + H⁺ + phosphate + ADP

2'-deamino-2'-hydroxyneamine + UDP-α-D-kanosamine → H⁺ + kanamycin A + UDP

D-xylulose + ATP → H⁺ + ADP + D-xylulose 5-phosphate

H₂O + L-alanyl-γ-D-glutamyl-meso-diaminopimelate + ATP → L-alanyl-γ-D-glutamyl-meso-diaminopimelate + H⁺ + phosphate + ADP

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(β-D-ribofuranosyl)aminobenzene-5'-phosphate → 2 H⁺ + 7,8-dihydropterin-6-ylmethyl-4-(β-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphate

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-mannosaminuronate → N-acetyl-β-D-mannosaminuronyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

S-adenosyl-L-methionine + 24-methylidenelophenol → S-adenosyl-L-homocysteine + 24-ethylidenelophenol + H⁺

maltotriose + H₂O + ATP → maltotriose + H⁺ + phosphate + ADP

trichloroethanol + UDP-α-D-glucose → trichloroethanol glucoside + H⁺ + UDP

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine + ATP + D-aspartate → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-N-(β-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + H⁺ + phosphate + ADP

[(1R,2R,3S,4S)-4-{5-cyano-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,3-dihydroxycyclopentyl]methyl phosphate + L-aspartate + GTP → 2 H⁺ + succinylo-toyocamycin phosphate + phosphate + GDP

prenyl diphosphate + naringenin chalcone → desmethylxanthohumol + H⁺ + diphosphate

2 S-adenosyl-L-methionine + H₂O + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide e

H₂O + atrazine → hydroxyatrazine + H⁺ + chloride

L-proline + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-proline + H⁺ + diphosphate + AMP

H₂O + dGTP → H⁺ + triphosphate + 2'-deoxyguanosine

2-chloro-5-methyl-dienelactone + H₂O → 2-chloro-5-methyl-maleylacetate + H⁺

NADP⁺ + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester → 2 H⁺ + NADPH + 3,8-divinyl protochlorophyllide a

dihydrozeatin + UDP-α-D-glucose → H⁺ + dihydrozeatin-O-glucoside + UDP

2 S-adenosyl-L-methionine + norbaeocystin → 2 S-adenosyl-L-homocysteine + 2 H⁺ + psilocybin

3,3',5-triiodothyroacetate + UDP-α-D-glucuronate → H⁺ + triiodothyroacetate ether glucuronide + UDP

GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol → H⁺ + GDP + α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol

2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-α-D-mycaminose

2-S-cysteinyldopaquinone → 8-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate + H₂O + H⁺

4-aminobutanoate + L-histidine + ATP → homocarnosine + H⁺ + phosphate + ADP

2-oxoglutarate + oxygen + (2R,3S,4S)-leucodelphinidin → 2 H₂O + delphinidin + H⁺ + succinate + CO₂

L-gulono-1,4-lactone + oxygen → L-ascorbate + hydrogen peroxide + H⁺

1-O-sinapoyl-β-D-glucose + cyanidin 3-O-[2"-O-(2"'-O-(sinapoyl) xylosyl) 6"-O-(p-coumaroyl) glucoside] 5-O-[6""-O-(malonyl) glucoside → sinapate + H⁺ + cyanidin 3-O-[2"-O-(2"'-O-(sinapoyl) xylosyl) 6"-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6""-O-(malonyl) glucoside

gossypetin + UDP-α-D-glucose → H⁺ + UDP + gossypetin 7-O-glucoside

H₂O + 2-hydroxy-7-methyl-6-oxo-2,4-octadienoate → isobutanoate + 2-oxopent-4-enoate + H⁺

H₂O + enterobactin → N-(2,3-dihydroxybenzoyl)-L-serine trimer + H⁺

narbonolide + dTDP-D-desosamine → H⁺ + narbomycin + dTDP

S-adenosyl-L-methionine + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester → 2 H⁺ + 5'-deoxyadenosine + L-methionine + 3,8-divinyl protochlorophyllide a

H₂O + 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate → 6 H⁺ + 3-hydroxy-2-methylpyridine-4,5-dicarboxylate

(20S,22S,25S)-22,25-epoxyfurost-5-ene-3-β,26-diol + UDP-α-D-glucose → (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-β,26-diol 3-o-β-D-glucoside + H⁺ + UDP

coenzyme A + H₂O + NAD⁺ + (S)-methylmalonate-semialdehyde → propanoyl-CoA + NADH + H⁺ + hydrogencarbonate

octopamine → H₂O + H⁺ + 4-[(Z)-2-aminoethenyl]phenol

S-adenosyl-L-methionine + isoscopoletin → S-adenosyl-L-homocysteine + H⁺ + scoparone

FMNH₂ + dibenzothiophene + oxygen → FMN + H₂O + H⁺ + dibenzothiophene-5-oxide

S-adenosyl-L-methionine + nocardicin G → S-methyl-5'-thioadenosine + H⁺ + isonocardicin C

S-adenosyl-L-methionine + tryptamine → S-adenosyl-L-homocysteine + N-methyltryptamine + H⁺

S-adenosyl-L-methionine + glutathione → S-adenosyl-L-homocysteine + S-methylglutathione + H⁺

H₂O + 2''-O-acetyl-ADP-ribose → acetate + H⁺ + ADP-D-ribose

S-adenosyl-L-methionine + 3',4',5'-trimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,3',4',5'-tetramethylmyricetin

H₂O + 1,4-dihydroxy-2-naphthoyl-CoA → coenzyme A + 1,4-dihydroxy-2-naphthoate + H⁺

3'-phosphoadenylyl-sulfate + brassinolide → adenosine 3',5'-bisphosphate + H⁺ + brassinolide 22-O-sulfate

3,5-dichlorocatechol + oxygen → 2 H⁺ + 2,4-dichloro-cis,cis-muconate

α-D-Man-(1→2)-α-D-Man-(1→2)-[α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)]_n-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ATP → 3-O-phospho-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)]_n-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H⁺ + ADP

H₂O + 3''-O-acetyl-ADP-ribose → acetate + H⁺ + ADP-D-ribose

NAD⁺ + (1'S,5'R)-hydroxyaverantin → NADH + H⁺ + 5'-oxoaverantin

3 H₂O + 4 Fe³⁺ + S-sulfanylglutathione → 4 Fe²⁺ + 6 H⁺ + glutathione + sulfite

H₂O + (-)-methyl jasmonate → methanol + H⁺ + (-)-jasmonate

coenzyme A + H₂O + NAD⁺ + 3-hydroxy-heptanoyl-CoA + oxygen → hydrogen peroxide + NADH + 3-hydroxy-pentanoyl-CoA + H⁺ + acetyl-CoA

α-ribazole + adenosylcobinamide-GDP → H⁺ + adenosylcobalamin + GMP

H₂O + 2-hydroxy-5-nitro-6-oxohepta-2,4-dienoate → acetate + 2-hydroxy-5-nitropenta-2,4-dienoate + H⁺

(2R,3R)-3-methylglutamyl-5-semialdehyde-N⁶-lysine → H₂O + L-pyrrolysine + H⁺

a reduced electron donor + 3,3'-diiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3'-iodothyronamine

N²-acetyl-α-aminoadipate + ATP → N²acetyl-L-2-aminoadipate 6-phosphate + H⁺ + ADP

sulfoacetaldehyde + L-cysteine → H₂O + 2-(sulfomethyl)thiazolidine-4-carboxylate + H⁺

H₂O + formaldehyde + NAD⁺ → 2 H⁺ + NADH + formate

2-amino-4-[3-(2-amino-2-carboxylatoethyl)-6-oxocyclohexa-1,4-dien-1-yl]pentanedioate → H₂O + 6-(2-amino-2-carboxylatoethyl)-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate + H⁺

dehydrorabelomycin + oxygen → 3-(2-formyl-6-hydroxy-4-methylphenyl)-8-hydroxy-1,4-dioxonaphthalene-2-carboxylate + H⁺

FADH₂ + chloride + oxygen + tetracycline → 2 H₂O + FAD + H⁺ + 7-chlorotetracycline

H₂O + 3-hydroxy-4-methylbenzaldehyde + NADP⁺ → 2 H⁺ + NADPH + 3-hydroxy-4-methyl-benzoate

2,4,5-trihydroxytoluene + oxygen → 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate + H⁺

(E,E)-piperoyl-CoA + piperidine → coenzyme A + piperine + H⁺

H₂O + geranyl diphosphate → geranyl monophosphate + H⁺ + phosphate

NADP⁺ + gentisyl alcohol → NADPH + H⁺ + gentisaldehyde

dTDP-β-L-rhodosamine + aklavinone → H⁺ + aclacinomycin T + dTDP

mycophenolate + UDP-α-D-glucuronate → H⁺ + UDP + mycophenolic acid phenolic glucuronide

H₂O + NAD⁺ + hypoxanthine → xanthine + NADH + H⁺

H₂O + 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene → acetate + 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + H⁺

H₂O + 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one → 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + H⁺

ATP + β-D-fructofuranose → β-D-fructofuranose 1-phosphate + H⁺ + ADP

(-)-(αS,βR)-guaiacylglycerol-β-guaiacyl ether + NAD⁺ → NADH + (2R)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one + H⁺

Co²⁺ + H₂O + hydrogenobyrinate a,c-diamide + ATP → 3 H⁺ + phosphate + ADP + cob(II)yrinate a,c-diamide

H₂O + selenate + ATP → H⁺ + phosphate + selenate + ADP

2 an oxidized electron donor + 2 H₂O + 4,4'-diapolycopen-4,4'-dial → 2 a reduced electron donor + 2 H⁺ + 4,4'-diapolycopenedioate

D-serine → H₂O + H⁺ + 2-aminoprop-2-enoate

NADP⁺ + (3R)-3-hydroxypentanoyl-CoA → NADPH + 3-oxopentanoyl-CoA + H⁺

6-hydroxyhexan-6-olide → 6-oxohexanoate + H⁺

saturated CDP-archaeol + 1D-myo-inositol 3-monophosphate → saturated archaetidylinositol phosphate + CMP + H⁺

H₂O + glycerol 2-phosphate + ATP → glycerol 2-phosphate + H⁺ + phosphate + ADP

2 H₂O + dCTP → 2 H⁺ + 2 phosphate + dCMP

D-gluconate + H⁺ → D-gluconate + H⁺

H₂O + 3-hydroxy-5-methylbenzaldehyde + NADP⁺ → 2 H⁺ + NADPH + 3-hydroxy-5-methyl-benzoate

H₂O + phenylethyl acetate → acetate + 2-phenylethanol + H⁺

H₂O + S-adenosyl-L-methionine + (3¹R)-8,12-diethylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8,12-diethyl-7¹-hydroxybacteriochlorophyllide c

3-hydroxy-L-kynurenine + H₂O → 3-hydroxyanthranilate + H⁺ + L-alanine

H₂O + UDP-N,N'-diacetylbacillosamine → 2,4-diacetamido-2,4,6-trideoxy-α-D-mannopyranose + H⁺ + UDP

4-phospho-D-erythronate + NAD⁺ → NADH + 3-dehydro-4-phospho-D-erythronate + H⁺

4-(2-aminophenyl)-2,4-dioxobutanoate → H₂O + kynurenate + H⁺

an oxidized electron donor + H₂O + 3-dimethylselenopropionaldehyde → dimethylselenoniopropanoate + a reduced electron donor + H⁺

S-adenosyl-L-methionine + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester → H⁺ + 5'-deoxyadenosine + L-methionine + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester

(E)-2-(4-hydroxyphenyl)-N-(sulfonatooxy)ethenimidothioate → H⁺ + 4-hydroxybenzyl isothiocyanate + sulfate

(E)-4-coumaroyl-CoA + tyramine → coenzyme A + H⁺ + p-coumaroyltyramine

S-adenosyl-L-methionine + 8-demethyl-8-α-L-rhamnosyl-tetracenomycin C → S-adenosyl-L-homocysteine + H⁺ + 8-demethyl-8-(2-O-methyl-α-L-rhamnosyl)-tetracenomycin C

L-aspartate + oxygen → hydrogen peroxide + H⁺ + 2-iminosuccinate

(-)-medicarpin + UDP-α-D-glucose → (-)-medicarpin-3-O-glucoside + H⁺ + UDP

UDP-α-D-glucose + kaempferol → H⁺ + kaempferol 3-O-β-D-glucoside + UDP

H₂O + 3-hydroxypropanal + NAD⁺ → 2 H⁺ + 3-hydroxypropanoate + NADH

1-(β-D ribofuranosyl)nicotinamide + ATP → β-nicotinamide D-ribonucleotide + H⁺ + ADP

2 an oxidized electron donor + 18'-hydroxy-χ,χ-caroten-18-oate + H₂O → 2 a reduced electron donor + synechoxanthin + H⁺

H₂O + NADP⁺ + (S)-lactaldehyde → 2 H⁺ + NADPH + (S)-lactate

H⁺ + sulfate + ADP ← phosphate + adenosine 5'-phosphosulfate

demethylmacrocin + S-adenosyl-L-methionine → macrocin + S-adenosyl-L-homocysteine + H⁺

3-propylcatechol + oxygen → 2-hydroxy-6-oxo-nona-2,4-dienoate + H⁺

(N-acetylgalactosaminyl)₅-N,N'-diacetylbacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-α-D-glucose → (N-acetylgalactosaminyl)₂-(glucosyl)-(N-acetylgalactosaminyl)₃- N,N'-diacetylbacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + H⁺ + UDP

2,3,5-trihydroxytoluene + oxygen → 2,4,6-trioxoheptanoate + H⁺

2 N-hydroxy-N-succinyl-putrescine + ATP → pre-putrebactin + H⁺ + diphosphate + AMP

H₂O + NAD⁺ + 2-(glutathion-S-yl)-2-methylbut-3-enal → 2 H⁺ + NADH + 2-(glutathion-S-yl)-2-methylbut-3-enoate

α-D-glucosamine 1-phosphate + acetyl-CoA → coenzyme A + N-acetyl-α-D-glucosamine 1-phosphate + H⁺

UDP-α-D-glucose + leucodopachrome → H⁺ + UDP + cyclo-dopa 5-O-glucoside

GDP-β-L-gulose + phosphate → H⁺ + GDP + β-L-gulose 1-phosphate

2 (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate → 2 H₂O + 2 H⁺ + (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate

H₂O + 2,4-diacetylphloroglucinol → acetate + 2-acetylphloroglucinol + H⁺

S-adenosyl-L-methionine + lathosterol → 4α-methyl-5α-cholest-7-en-3β-ol + S-adenosyl-L-homocysteine + H⁺

(7S)-salutaridinol 7-O-acetate → acetate + thebaine + H⁺

NAD⁺ + (1'S,5'S)-hydroxyaverantin → NADH + H⁺ + 5'-oxoaverantin

H₂O + hydroxypyruvaldehyde phosphate + NAD⁺ → 2 H⁺ + 3-phosphooxypyruvate + NADH

H₂O + 4-trimethylammoniobutanal + NAD⁺ → 2 H⁺ + γ-butyrobetaine + NADH

GDP-α-D-mannose + 2-O-(α-D-glucopyranosyl)-3-phospho-D-glycerate → H⁺ + 2-[2-O-(α-D-mannopyranosyl)-(1→2)-α-D-glucopyranosyl]-3-phospho-D-glycerate + GDP

(4S)-2,3-dehydro-leucocyanidin → cyanidin + H₂O + H⁺

glycerophosphoglycerol + H₂O → glycerol + H⁺ + sn-glycerol 3-phosphate

an oxidized electron donor + H₂O + 4-methylphenol → 2 H⁺ + 4-hydroxybenzaldehyde + a reduced electron donor

UDP-α-D-glucose + quercetin-3-gentiobioside → H⁺ + quercetin-3-gentiotrioside + UDP

(3R,4R)-3,4-bis(4-hydroxy-3-methoxybenzyl)tetrahydro-2-furanol + NAD⁺ → NADH + (-)-matairesinol + H⁺

curcumin 4'-O-β-D-gentiobioside + UDP-α-D-glucose → curcumin 4'-O-β-D-gentiotrioside + H⁺ + UDP

4 Fe²⁺ + 6 H₂O + oxygen → 4 [FeO(OH)] monomer + 8 H⁺

S-(4-hydroxy-nonenal-3-yl)-L-cysteine + acetyl-CoA → coenzyme A + 4-hydroxy-2-nonenal-N-acetyl-L-cysteine + H⁺

H₂O + oxygen + (indol-3-yl)acetaldehyde → hydrogen peroxide + H⁺ + (indol-3-yl)acetate

H₂O + CDP-glycerol → 2 H⁺ + CMP + sn-glycerol 3-phosphate

curcumin monoglucoside + UDP-α-D-glucose → curcumin diglucoside + H⁺ + UDP

2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactosyl-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose → Glc-AATGal-PP-undecaprenol + H⁺ + UDP

coniferaldehyde + UDP-α-D-glucose → coniferaldehyde glucoside + H⁺ + UDP

13-cis-retinol + NAD⁺ → 13-cis-retinal + NADH + H⁺

hydrogencarbonate + cerotoyl-CoA + ATP → H⁺ + phosphate + 2-carboxy-cerotoyl-CoA + ADP

D-glyceraldehyde 3-phosphate → H⁺ + enolaldehyde + phosphate

protocatechuate + oxygen → (2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H⁺

H₂O + 5-oxo-2-furoyl-CoA → H⁺ + (2Z)-2-hydroxypent-2-enedioyl-CoA

L-tryptophan + oxygen → hydrogen peroxide + H⁺ + 2-imino-3-(indol-3-yl)propanoate

(S)-norcoclaurine + S-adenosyl-L-methionine → (S)-coclaurine + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + N1-hydroxy-roquefortine C → S-adenosyl-L-homocysteine + H⁺ + roquefortine F

pyridoxal + ATP → pyridoxal 5'-phosphate + H⁺ + ADP

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + H⁺ + ADP

H₂O + D-glucaro-1,5-lactone → H⁺ + D-glucarate

H₂O + octanoyl-CoA + isopenicillin N → coenzyme A + penicillin K + L-2-aminoadipate + H⁺

H₂O + (-)-medicarpin-3-O-glucoside-6''-malonate → malonate + (-)-medicarpin-3-O-glucoside + H⁺

H₂O + GTP → H⁺ + diphosphate + GMP

2 H₂O + N-methylhydantoin + ATP → 2 H⁺ + N-carbamoylsarcosine + phosphate + ADP

2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + oxygen → OH-DDVA meta-cleavage product + H⁺

S-adenosyl-L-methionine + (S)-norlaudanine → S-adenosyl-L-homocysteine + H⁺ + (S)-tetrahydropapaverine

H₂O + L-glutamine + ATP + nicotinate adenine dinucleotide → NAD⁺ + H⁺ + L-glutamate + diphosphate + AMP

S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine → S-adenosyl-L-homocysteine + dihydrochelirubine + H⁺

H₂O + choloyl-CoA → coenzyme A + H⁺ + cholate

H₂O + myristoyl-CoA → coenzyme A + myristate + H⁺

2 NAD⁺ + H₂O + UDP-N-acetyl-α-D-glucosamine → 2 NADH + 3 H⁺ + UDP-N-acetyl-α-D-glucosaminouronate

H₂O + 5-phospho-α-D-ribose 1,2-cyclic phosphate → D-ribofuranose 2,5-bisphosphate + H⁺

H₂O + sulfinylidenemethanethione → H⁺ + monothiocarbonate + S⁰

N-methylethanolamine phosphate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-dimethylethanolamine phosphate + H⁺

thiamine + ATP → thiamine diphosphate + H⁺ + AMP

H₂O + (2Z,4E)-2-amino-5-methyl-muconate semialdehyde + NAD⁺ → 2 H⁺ + NADH + (2Z,4E)-2-amino-5-methyl-muconate

a reduced electron donor + 3,5-diiodothyronine → an oxidized electron donor + H⁺ + iodide + 3-monoiodothyronine

S-adenosyl-L-methionine + geranyl diphosphate → S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate + H⁺

H₂O + cytidine 2',3'-cyclic monophosphate → cytidine 2'-monophosphate + H⁺

[(S)-1-aminoethyl]phosphonate + acetyl-CoA → coenzyme A + [(1S)-1-acetamidoethyl]phosphonate + H⁺

S-adenosyl-L-methionine + (-)-thujaplicatin → S-adenosyl-L-homocysteine + 5-O-methylthujaplicatin + H⁺

2-naphthol + UDP-α-D-glucose → H⁺ + 2-naphthol glucoside + UDP

3 H₂O + trimethylaminoacetone → 9 H⁺ + glycine betaine + CO₂

GDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose + H₂O → 2,4-diacetamido-2,4,6-trideoxy-α-D-mannopyranose + H⁺ + GDP

H₂O + monoglucosyl-enterobactin → monoglucosyl-(2,3-dihydroxybenzoylserine)₃ + H⁺

H₂O + (2E,4Z)-2-hydroxy-6-oxohepta-2,4-dienoate → acetate + 2-oxopent-4-enoate + H⁺

H₂O + gentisyl-CoA → coenzyme A + gentisate + H⁺

4-isopropylbenzyl alcohol + NAD⁺ → NADH + p-cumic aldehyde + H⁺

S-adenosyl-L-methionine + β-peltatin → S-adenosyl-L-homocysteine + β-peltatin-A methyl ether + H⁺

psilocybin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + aeruginascin + H⁺

H₂O + cobalt-precorrin-5A → acetaldehyde + H⁺ + cobalt-precorrin-5B

H₂O + sulfoacetaldehyde + NAD⁺ → 2 H⁺ + NADH + sulfoacetate

α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + UDP-α-D-galactofuranose → β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + H⁺ + UDP

H₂O + cis-vaccenyl acetate → acetate + cis-vaccenyl alcohol + H⁺

H₂O + (S)-5-hydroxyisourate → H⁺ + (S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline

NAD⁺ + 3-deacetyl-3-(1-hydroxyethyl)-bacteriochlorophyllide g → NADH + H⁺ + bacteriochlorophyllide b

S-adenosyl-L-methionine + 12-ethyl-8-propylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-propylbacteriochlorophyllide c + H⁺

hydroxyspirilloxanthin + S-adenosyl-L-methionine → spirilloxanthin + S-adenosyl-L-homocysteine + H⁺

NAD⁺ + (+)-trans-carveol → NADH + H⁺ + (+)-carvone

an oxidized electron donor + H₂O + indole-3-glycol aldehyde → a reduced electron donor + H⁺ + indole-3-glycolate

H₂O + 8-(methylsulfanyl)-2-oxooctanoate + acetyl-CoA → coenzyme A + 2-[(6'-methylsulfanyl)hexyl]malate + H⁺

S-adenosyl-L-methionine + demethylmenaquinol-10 → S-adenosyl-L-homocysteine + menaquinol-10 + H⁺

(3R)-vestitone + NADPH + H⁺ ← NADP⁺ + (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol

UDP-β-L-rhamnose + isovitexin 7-O-glucoside → H⁺ + UDP + isovitexin-7-O-glucosyl-2''O-rhamnoside

ATP + 2'-deoxyguanosine → H⁺ + ADP + dGMP

S-adenosyl-L-methionine + 5-O-methylthujaplicatin → S-adenosyl-L-homocysteine + O4,O5--dimethylthujaplicatin + H⁺

β-D-galactosyl-[1→3]-N-acetyl-β-D-glucosaminyl-[1→3]-α-D-galactosyl-[1→3]-N-acetyl-D-galactosamine + GDP-β-colitose → H⁺ + α-L-colitosyl-[1→2]-β-D-galactosyl-[1→3]-N-acetyl-β-D-glucosaminyl-[1→3]-α-D-galactosyl-[1→3]-N-acetyl-D-galactosamine + GDP

isovitexin + UDP-β-L-rhamnose → H⁺ + UDP + isovitexin 2''-O-rhamnoside

FADH₂ + 4-coumarate + oxygen → FAD + H₂O + H⁺ + trans-caffeate

2 H₂O + 2 NAD⁺ + bixin aldehyde → 2 NADH + 4 H⁺ + norbixin

S-adenosyl-L-methionine + δ-tocotrienol → S-adenosyl-L-homocysteine + H⁺ + β-tocotrienol

H₂O + glutarate semialdehyde + NADP⁺ → 2 H⁺ + glutarate + NADPH

H₂O + uridine 2'3'-cyclic monophosphate → uridine 2'-monophosphate + H⁺

(-)-dihydrocarveol + NAD⁺ → NADH + (+)-dihydrocarvone + H⁺

a reduced electron donor + 3',5'-diiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3'-iodothyronamine

H₂O + D-cystine + ATP → D-cystine + H⁺ + phosphate + ADP

S-adenosyl-L-methionine + 3,7,4'-trimethylquercetin 2'-O-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',4'-tetramethylquercetin 2'-O-β-D-glucoside

NAD(P)+ + oryzalexin A → NAD(P)H + H⁺ + oryzalexin C

NAD(P)+ + oryzalexin B → NAD(P)H + H⁺ + oryzalexin C

(E)-cinnamoyl-CoA + tyramine → coenzyme A + H⁺ + cinnamoyltyramine

dihydrosterigmatocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin + H⁺

L-N²-(2-carboxyethyl)arginine + ATP → deoxyamidinoproclavaminate + H⁺ + diphosphate + AMP

an oxidized electron donor + 4,4'-diapolycopen-4-al-4'-oate + H₂O → a reduced electron donor + H⁺ + 4,4'-diapolycopenedioate

(3-hydroxy-2-oxindol-3-yl)acetyl-L-aspartate + UDP-α-D-glucose → 3-(O-β-glucosyl)-(2-oxindol-3-yl)acetyl-L-aspartate + H⁺ + UDP

3 UDP-N-acetyl-α-D-galactosamine + N-acetyl-D-galactosaminyl-α-(1→4)-N-acetyl-D-galactosaminyl-α-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol → 3 H⁺ + 3 UDP + (N-acetylgalactosaminyl)₅-N,N'-diacetylbacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol

cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-β-D-glucose → H⁺ + 4-hydroxybenzoate + cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside)

FMNH₂ + methanesulfinate + oxygen → FMN + H₂O + methanesulfonate + H⁺

N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-galactosamine → N-acetyl-α-D-galactosaminyl-(1→6)-N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

3 L-(4-hydroxyphenyl)glycine + 5 ATP + H₂O + L-serine + L-arginine → 5 H⁺ + 5 diphosphate + 5 AMP + L-4-hydroxyphenylglycine-L-arginyl-D-4-hydroxyphenylglycine-L-seryl-L 4-hydroxyphenylglycine

2 juglone + oxygen → 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H⁺

H₂O + melatonin → acetate + H⁺ + 5-methoxytryptamine

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + sequoyitol

UDP-α-D-glucose + 6-hydroxyflavone → H⁺ + UDP + 6-O-β-D-glucosyl-6-hydroxyflavone

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + D-ononitol

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + L-bornesitol

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + D-bornesitol

H₂O + UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose → 2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose + H⁺ + UDP

D-gluconate + ATP → D-gluconate 6-phosphate + H⁺ + ADP

2 5'-dehydroinosine + oxygen → 2 9-riburonosylhypoxanthine + 2 H⁺

naringenin chalcone + UDP-α-D-glucose → chalcone 2'-O-glucoside + H⁺ + UDP

4-methylphenyl ribotide phosphate + adenosylcobinamide-GDP → 4-methylphenyl-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

2-hydroxyethylphosphonate + oxygen → (methyl)phosphonate + H⁺ + hydrogencarbonate

2 NAD⁺ + H₂O + 6,8-dihydroxypurine → 2 NADH + 2 H⁺ + urate

UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ATP + D-lysine → H⁺ + phosphate + ADP + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-N^ε-D-lysine

monoglucosyl-enterobactin + UDP-α-D-glucose → salmochelin S4 + H⁺ + UDP

H₂O + linoleoyl-CoA → coenzyme A + H⁺ + linoleate

NAD⁺ + cis-3-phenylcyclohexa-3,5-diene-1,2-diol → NADH + biphenyl-2,3-diol + H⁺

2 NADPH + 2,2,2-trichloroacetate + oxygen → 2 NADP⁺ + 2 H⁺ + 3 chloride + oxalate

FMNH₂ + 5-hydroxyadamantan-2-one + oxygen → FMN + H₂O + 1-hydroxy-4-oxahomoadamantan-5-one + H⁺

glycerophosphoserine + H₂O → H⁺ + L-serine + sn-glycerol 3-phosphate

2 S-adenosyl-L-methionine + sarcosine → 2 S-adenosyl-L-homocysteine + 2 H⁺ + glycine betaine

dTDP-β-L-rhamnose + β-D-glucosyl-(1,6)-α-D-glucosyl-(1,2)-β-D-glucuronate-(1,2)-α-D-mannosyl-(1,3)-β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol → β-L-rhamnosyl-(1,6)-β-D-glucosyl-(1,6)-α-D-glucosyl-(1,2)-β-D-glucuronate-(1,2)-α-D-mannosyl-(1,3)-β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol + H⁺ + dTDP

β-nicotinate D-ribonucleotide + 2-methyladenine → nicotinate + H⁺ + 2-methyladenine ribotide phosphate

hop-22(29)-ene + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + H⁺ + L-methionine + adenosyl hopane

an oxidized electron donor + 3,5,3'-triiodo-L-thyronine + H⁺ + iodide ← a reduced electron donor + L-thyroxine

(R)-4'-phosphopantothenate + L-cysteine + CTP → (R)-4'-phosphopantothenoyl-L-cysteine + CMP + H⁺ + diphosphate

kinetin + UDP-α-D-glucose → H⁺ + kinetin-9-N-glucoside + UDP

(4S)-perillyl alcohol + NAD⁺ → NADH + H⁺ + (4S)-perillyl aldehyde

S-adenosyl-L-methionine + 1'-hydroxy-1',2'-dihydro-β,ψ-caroten-4'-one → S-adenosyl-L-homocysteine + H⁺ + thiothece-474

2-hydroxy-2-methylpropanenitrile + UDP-α-D-glucose → linamarin + H⁺ + UDP

H₂O + cyclic ADP-ribose → H⁺ + ADP-D-ribose

NAD⁺ + (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA → NADH + H⁺ + (5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA

2 a peptidoglycan dimer (mycobacteria) + 4 H₂O → 4 D-alanine + a peptidoglycan with D,D cross-links (mycobacteria) + H⁺ + mono-trans,octa-cis-decaprenyl diphosphate

S-adenosyl-L-methionine + trans-anol → S-adenosyl-L-homocysteine + t-anethole + H⁺

3 2,3-dihydroxybenzoate + 3 glycine + 3 L-threonine + 6 ATP → 3 H₂O + 3 H⁺ + 6 diphosphate + 6 AMP + bacillibactin

H₂O + sinapaldehyde + NADP⁺ → 2 H⁺ + NADPH + sinapate

L-homocysteine → H⁺ + (2Z)-2-aminobut-2-enoate + hydrogen sulfide

H₂O + glucosyl-oleandomycin + ATP → H⁺ + glucosyl-oleandomycin + phosphate + ADP

trans-3-hydroxy-L-proline → H₂O + 1-pyrroline-2-carboxylate + H⁺

D-erythronate + NAD⁺ → NADH + 2-dehydro-D-erythronate + H⁺

H₂O + L-cystathionine → ammonia + 2-oxobutanoate + H⁺ + L-cysteine

3 oxygen + 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline 2,4-dicarboxylate → 2 H₂O + 2 hydrogen peroxide + pyrroloquinoline quinone + H⁺

(+)-sesaminol 2-O-β-D-gentiobioside + UDP-α-D-glucose → (+)-sesaminol 2-O-β-D-glucosyl (1->2)-O-[β-D-glucosyl (1->6)]-β-D-glucoside + H⁺ + UDP

S-adenosyl-L-methionine + carminomycin → S-adenosyl-L-homocysteine + H⁺ + daunorubicin

L-threonine → H₂O + H⁺ + (2Z)-2-aminobut-2-enoate

H₂O + aclacinomycin A → methanol + H⁺ + 15-demethoxy-aclacinomycin A

H₂O + 3-chlorocatechol + oxygen → 3 H⁺ + (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + chloride

H₂O + acetoacetyl-CoA → coenzyme A + H⁺ + acetoacetate

stevioside + UDP-α-D-glucose → rebaudioside A + H⁺ + UDP

L-thyroxine + UDP-α-D-glucuronate → H⁺ + L-thyroxine phenolic β-D-glucuronide + UDP

dichlorocarbene + H₂O → 2 H⁺ + 2 chloride + carbon monoxide

1-palmitoyl-2-linoleoyl-phosphatidylcholine + H₂O → 1-linoleoyl-sn-glycero-3-phosphocholine + palmitate + H⁺

S-adenosyl-L-methionine + 5-amino-6-(D-ribitylamino)uracil + L-tyrosine → 2 H⁺ + 2-iminoacetate + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 5'-deoxyadenosine + L-methionine

β-D-glucuronate + NAD⁺ → NADH + D-glucaro-1,5-lactone + H⁺

H₂O + 2,4,6-trioxohexanoate → acetylpyruvate + formate + H⁺

3-oxochenodeoxycholoyl-CoA + NAD⁺ → NADH + H⁺ + 7α-hydroxy-3-oxochol-4-en-24-oyl-CoA

curcumin 4'-O-β-D-gentiobiosyl 4''-O-β-D-glucoside + UDP-α-D-glucose → curcumin 4',4''-O-β-D-digentiobioside + H⁺ + UDP

H₂O + cetraxate benzyl ester → benzyl alcohol + H⁺ + cetraxate

H₂O + 3-chlorobenzoate → H⁺ + chloride + 3-hydroxybenzoate

H₂O + mannosylfructose-phosphate → mannosylfructose + H⁺ + phosphate

S-adenosyl-L-methionine + 3'-O-demethyl-staurosporine → S-adenosyl-L-homocysteine + H⁺ + staurosporine

S-adenosyl-L-methionine + 3,4-dihydroxymandelate → S-adenosyl-L-homocysteine + H⁺ + vanillyl mandelate

carbon tetrachloride + a reduced electron donor → 2 H⁺ + an oxidized electron donor + trichloromethyl radical + chloride

a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide → a mature peptidoglycan_(n) (meso-DAP containing) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

3 H⁺ + glutathione disulfide + selenite + AMP ← 2 glutathione + adenosine 5'-phosphoselenate

dehydroascorbate (bicyclic form) → 3 H⁺ + cyclic-2,3-O-oxalyl-L-threonate

3-amino-4-hydroxybenzaldehyde + acetyl-CoA → coenzyme A + H⁺ + 3-acetylamino-4-hydroxybenzaldehyde

(S)-malate + UDP-N-acetyl-α-D-glucosamine → (S)-malyl N-acetyl-α-D-glucosaminide + H⁺ + UDP

H₂O + (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene → (1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol + H⁺ + chloride

H₂O + succinate semialdehyde + NAD(P)+ → 2 H⁺ + NAD(P)H + succinate

6-chlorohydroxyquinol + oxygen → 2 H⁺ + 2-chloromaleylacetate

H₂O + CTP → H⁺ + phosphate + CDP

methylazoxymethanol + UDP-α-D-glucose → cycasin + H⁺ + UDP

H₂O + HAI-1 → H⁺ + N-(3-hydroxybutanoyl)-L-homoserine

NAD⁺ + L-threonine → 2 H⁺ + L-2-amino-3-oxobutanoate + NADH

a reduced electron donor + 3,3'-diiodothyronine → an oxidized electron donor + H⁺ + iodide + 3-monoiodothyronine

calycosin + UDP-α-D-glucose → calycosin 7-O-glucoside + H⁺ + UDP

H₂O + L-phenylalanine + oxygen → ammonia + hydrogen peroxide + 3-phenyl-2-oxopropanoate + H⁺

2-(R)-hydroxypropyl-CoM + NAD⁺ → NADH + 2-oxopropyl-CoM + H⁺

H₂O + S-(+)-3,6,8-trimethylallantoin → 1,6,8-trimethylallantoate + H⁺

H₂O + GTP → H⁺ + phosphate + GDP

2 H₂O + 2 N⁶-acetyl-N⁶-hydroxy-L-lysine + 4 ATP + citrate → 4 H⁺ + 4 phosphate + 4 ADP + aerobactin

undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine + UDP-N-acetyl-α-D-glucosamine → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine + H⁺ + UDP

kaempferol 3-O-β-gentiobioside + UDP-β-L-rhamnose → H⁺ + kaempferol-3-O-β-gentiobioside-7-O-α-L-rhamnoside + UDP

cis-3,4-dehydroadipyl-CoA → 2 H⁺ + trans-2,3-dehydroadipyl-coA

S-adenosyl-L-methionine + a reduced electron donor + L-tyrosine → 2 H⁺ + an oxidized electron donor + 2-iminoacetate + 5'-deoxyadenosine + L-methionine + 4-methylphenol

2 S-adenosyl-L-methionine + tricetin → 2 S-adenosyl-L-homocysteine + 2 H⁺ + tricin

H₂O + lanosteryl oleate → lanosterol + oleate + H⁺

kaempferol 3-O-β-D-galactoside + UDP-α-D-glucose → H⁺ + kaempferol 3-O-β-D-glucosylgalactoside + UDP

2,3,6-trihydroxypyridine → 6,3-dihydroxy-2-pyridinone + H⁺

kaempferol-3-O-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside + UDP-α-D-glucose → H⁺ + kaempferol-3-O-β-gentiobioside-7-O-α-L-rhamnoside + UDP

H₂O + NAD⁺ + 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate → 3-dehydroquinate + NADH + H⁺ + ammonium

S-adenosyl-L-methionine + resorcinol → S-adenosyl-L-homocysteine + 3-methoxyphenol + H⁺

H₂O + CMP-5'-phosphonoformate + 3-phospho-D-glycerate → CMP + 2-phosphono-formylglycerate + H⁺ + phosphate

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose → β-D-glucosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

S-adenosyl-L-methionine + kaempferol → S-adenosyl-L-homocysteine + kaempferide + H⁺

phenyl ribotide phosphate + adenosylcobinamide-GDP → phenyl-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

O-methyl-4-O-[α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + O-methyl-4-O-[2-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + H⁺

D-arabinono-1,4-lactone + H₂O → H⁺ + D-arabinonate

H₂O + 4,15-diacetylnivalenol → acetate + H⁺ + 4-acetylnivalenol

7-deoxyloganetin + UDP-α-D-glucose → 7-deoxyloganin + H⁺ + UDP

H₂O + acetyl-CoA + oxaloacetate → coenzyme A + H⁺ + citrate

(4S)-7-hydroxy-4-isoprenyl-7-methyl-2-oxo-oxepanone → (3S)-3-isopropenyl-6-oxoheptanoate + H⁺

UDP-N-acetyl-α-D-muramoyl-L-alanine + ATP + D-glutamate → H⁺ + phosphate + ADP + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate

NAD⁺ + ATP → NADP⁺ + H⁺ + ADP

H₂O + diethylphosphate → ethanol + H⁺ + ethylphosphate

(2Z,2E)-2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H₂O → 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H⁺

(R)-norlaudanosoline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (R)-N-methylnorlaudanosoline + H⁺

α-Kdo-(2→6)-lipid IV_A + ATP → 4-O-phospho-α-Kdo-(2→6)-lipid IV_A + H⁺ + ADP

H₂O + sulfinosuccinate → H⁺ + succinate + sulfite

H₂O + (4R,7S)-7-isopropyl-4-methyloxepan-2-one → H⁺ + (3R,6S)-6-hydroxy-3,7-dimethyloctanoate

H₂O + biochanin A-7-O-glucoside-6''-malonate → malonate + H⁺ + biochanin A-7-O-glucoside

pyruvic oxime + oxygen → pyruvate + H⁺ + nitrite

dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose + acetyl-CoA → coenzyme A + dTDP-3-acetamido-α-D-fucose + H⁺

H₂O + (2R,4S)-2, 4-diaminopentanoate + NAD⁺ → 2 H⁺ + ammonia + (2R)-2-amino-4-oxopentanoate + NADH

H₂O + 3,6-dihydroxypyridine-2,5-dione → 5-amino-2,4,5-trioxopentanoate + H⁺

4-methylbenzyl alcohol + NAD⁺ → NADH + 4-methylbenzaldehyde + H⁺

S-adenosyl-L-methionine + 8-demethyl-8-(methylamino)riboflavin → S-adenosyl-L-homocysteine + H⁺ + roseoflavin

FADH₂ + L-tyrosine + oxygen → FAD + H₂O + L-dopa + H⁺

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose → H⁺ + UDP + β-D-glucosyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

(E)-ω-(methylsulfanyl)butyl-thiohydroximate + UDP-α-D-glucose → 3-(methylsulfanyl)propyl-desulfoglucosinolate + H⁺ + UDP

isopentenyl diphosphate + di-trans,poly-cis-decaprenyl diphosphate → 5 H⁺ + di-trans,octa-cis-undecaprenyl diphosphate + diphosphate

β-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole → α-ribazole 5'-phosphate + nicotinate + H⁺

H₂O + NAD⁺ + (25R)-3α,7α-dihydroxy-5β-cholestan-26-al → 2 H⁺ + NADH + (25R)-3α,7α-dihydroxy-5-β-cholestanate

(S)-reticuline + oxygen → (S)-scoulerine + hydrogen peroxide + H⁺

H₂O + (2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + NAD⁺ → 2 H⁺ + NADH + (2Z,4E)-2-aminomuconate

(1R,2R)-cyclohexa-3,5-diene-1,2-diol + NADP⁺ → NADPH + catechol + H⁺

L-2,3-diaminopropanoate + fumarate + ATP → N-3-fumaroyl-L-2,3-diaminopropanoate + H⁺ + diphosphate + AMP

H₂O + L-glutamine + XMP + ATP → 2 H⁺ + L-glutamate + diphosphate + AMP + GMP

S-adenosyl-L-methionine + 1-O-caffeoyl-β-D-glucose → S-adenosyl-L-homocysteine + 1-O-feruloyl-β-D-glucose + H⁺

cis-zeatin + UDP-α-D-glucose → H⁺ + cis-zeatin-9-N-glucoside + UDP

D-alanyl-D-alanine + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysine + ATP → H⁺ + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine + phosphate + ADP

(20S)-protopanaxadiol + UDP-α-D-glucose → ginsenoside C-K + H⁺ + UDP

apigenin 7-O-β-D-glucoside + UDP-D-apiose → apigenin 7-O-[β-D-apiosyl-(1→2)-β-D-glucoside] + H⁺ + UDP

10 ATP + 3 L-threonine + 6 L-2,4-diaminobutanoate + L-leucine + 6-methyloctanoyl-CoA → 10 diphosphate + 10 AMP + 11 H⁺ + coenzyme A + polymyxin A

L-xylulose + ATP → H⁺ + ADP + L-xylulose 5-phosphate

2 3-[(8Z,11E,13Z)-pentadeca-8,11,13-trien-1-yl] )catechol + oxygen → 2 H⁺ + dimeric urushiol peroxide

delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-β-D-glucose → H⁺ + 4-hydroxybenzoate + delphinidin 3-O-rutinoside-7-O-glucoside

3 ATP + H₂O + L-2-aminoadipate + L-valine + L-cysteine → 3 H⁺ + 3 diphosphate + 3 AMP + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

3-methylgentisate + oxygen → (2E)-2-methyl-4,6-dioxohept-2-enedioate + H⁺

β-D-fructofuranose 6-phosphate + ATP → β-D-fructose 1,6-bisphosphate + H⁺ + ADP

serotonin + trans-caffeoyl-CoA → coenzyme A + H⁺ + caffeoylserotonin

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-N-(β-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-N-(β-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + H⁺ + diphosphate + AMP

NADPH + H⁺ + 3-oxo-(11Z)-eicos-11-enoyl-CoA ← NADP⁺ + 3R-hydroxy-(11Z)-eicos-11-enoyl-CoA

ammonium + L-aspartate + ATP → H⁺ + L-asparagine + phosphate + ADP

2 coenzyme A + 2 H₂O + 2 NAD⁺ + 2 oxygen + 10-trans-heptadecenoyl-CoA → 2 hydrogen peroxide + 2 NADH + 2 H⁺ + 2 acetyl-CoA + 6-trans-tridecenoyl-CoA

1D-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-α-D-galactose → H⁺ + 5-O-(indol-3-ylacetyl-myo-inositol) D-galactoside + UDP

S-adenosyl-L-methionine + 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H⁺

L-2-amino-5-phosphono-3-cis-pentenoate + L-arginine + ATP → rhizocticin A + H⁺ + phosphate + ADP

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + hydrogencarbonate + ATP → 2 H⁺ + N⁵-carboxyaminoimidazole ribonucleotide + phosphate + ADP

UDP-α-D-glucuronate + wogonin → H⁺ + UDP + wogonin 7-O-β-D-glucuronate

cyanidin + UDP-α-D-glucose → H⁺ + cyanidin 5-O-β-D-glucoside + UDP

ATP + bacimethrin → bacimethrin pyrophosphate + H⁺ + AMP

H₂O + NAD(P)+ + 1-propanal → 2 H⁺ + NAD(P)H + propanoate

H₂O + PAI-1-2 → H⁺ + N-(butyryl)-L-homoserine

NAD⁺ + (1R,2S)-3,6-dichloro-4-methylcyclohexa-3,5-diene-1,2-diol → NADH + H⁺ + 3,6-dichloro-4-methylcatechol

ammonium + L-aspartate + ATP → H⁺ + L-asparagine + diphosphate + AMP

S-adenosyl-L-methionine + selgin → S-adenosyl-L-homocysteine + tricin + H⁺

S-adenosyl-L-methionine + 4-demethylpremithracinone → S-adenosyl-L-homocysteine + H⁺ + premithracinone

(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine → H⁺ + 3-O-acetyl-4'-O-demethylpapaveroxine

oxygen + 2,3-dihydroxy-p-cumate → H⁺ + 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate

H₂O + cocaine → methanol + H⁺ + benzoylecgonine

(S)-demethyl-4-deoxygadusol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (S)-4-deoxygadusol + H⁺

S-adenosyl-L-methionine + quercetin → S-adenosyl-L-homocysteine + H⁺ + 3-O-methylquercetin

D-myo-inositol (1,3,4,6)-tetrakisphosphate + ATP → H⁺ + D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP

(+)-neodihydrocarveol + NAD⁺ → NADH + (+)-dihydrocarvone + H⁺

H₂O + NAD⁺ + (-)-dehydrodiconiferyl acid aldehyde → 2 H⁺ + NADH + (-)-dehydrodiconiferyl acid carboxylate

α-ribazole + ATP → α-ribazole 5'-phosphate + H⁺ + ADP

3,4-didehydrorhodopin + S-adenosyl-L-methionine → anhydrorhodovibrin + S-adenosyl-L-homocysteine + H⁺

2 NADP⁺ + (6E)-8-hydroxygeraniol → 2 NADPH + 2 H⁺ + (6E)-8-oxogeranial

ecdysone + ATP → ecdysone 22-phosphate + H⁺ + ADP

tomatidine + UDP-α-D-galactose → H⁺ + tomatidine galactoside + UDP

2-hydroxy-cyclohexane-1-carbonyl-CoA + NAD⁺ → 2-ketocyclohexane-1-carbonyl-CoA + NADH + H⁺

S-adenosyl-L-methionine + laricitrin → S-adenosyl-L-homocysteine + H⁺ + 3,3'-dimethylmyricetin

H₂O + (2Z,4E)-2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate → acetate + H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate

5-phospho-β-D-ribosylamine + glycine + ATP → N¹-(5-phospho-β-D-ribosyl)glycinamide + H⁺ + phosphate + ADP

a reduced electron donor + oxygen + γ-coniceine → an oxidized electron donor + H₂O + H⁺ + 5-hydroxy-γ-coniceine

2 a peptidoglycan dimer (mycobacteria) + 4 H₂O → 4 D-alanine + a peptidoglycan with L,D cross-links (mycobacteria) + H⁺ + mono-trans,octa-cis-decaprenyl diphosphate

2,2-dichloroacetate + NADPH + oxygen → 2 H⁺ + 2 chloride + NADP⁺ + oxalate

avenasterol → 2 H⁺ + 5-dehydroavenasterol

6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine → 3-methyl-6-methoxy-2-octaprenyl-1,4-benzoquinone + S-adenosyl-L-homocysteine + H⁺

H₂O + N-acetyl-DL-methionine + ATP → N-acetyl-DL-methionine + H⁺ + phosphate + ADP

UDP-β-L-rhamnose + β-chaconine → H⁺ + UDP + α-chaconine

S-adenosyl-L-methionine + 3-phenyl-2-oxopropanoate → S-adenosyl-L-homocysteine + H⁺ + (3S)-β-methyl-phenylpyruvate

3 N-hydroxy-N-succinylcadaverine + ATP → H₂O + desferrioxamine G₁ + H⁺ + diphosphate + AMP

S-adenosyl-L-methionine + nor-rubrofusarin → S-adenosyl-L-homocysteine + H⁺ + rubrofusarin

FMNH₂ + (+)-bornane-2,5-dione + oxygen → FMN + H₂O + (+)-5-oxo-1,2-campholide + H⁺

5-methoxybenzimidazole + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 5-methoxy-6-methylbenzimidazole + H⁺

NAD⁺ + 22-hydroxy-3-oxochol-4-en-24-oyl-CoA → NADH + H⁺ + 3,22-dioxochol-4-en-24-oyl-CoA

S-adenosyl-L-methionine + (-)-pluviatolide → S-adenosyl-L-homocysteine + (-)-bursehernin + H⁺

5-hydroxybenzimidazole ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(5-hydroxybenzimidazolyl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

3D-(3,5/4)-trihydroxycyclohexane-1,2-dione + H₂O → H⁺ + 5-dehydro-2-deoxy-D-gluconate

S-adenosyl-L-methionine + (-)-norephedrine → 2 H⁺ + S-adenosyl-L-homocysteine + (-)-ephedrine

S-adenosyl-L-methionine + isoshowacene → S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H⁺

2 an oxidized electron donor + 18-hydroxyrenierapurpurin + H₂O → 2 a reduced electron donor + χ,χ-caroten-18-oate + H⁺

L-dopa + betalamate → H₂O + H⁺ + dopaxanthin

S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone → S-adenosyl-L-homocysteine + H⁺ + 7,4'-dihydroxy, 8-methoxyflavone

H₂O + phosphonoacetate → acetate + H⁺ + phosphate

(+)-exo-5-hydroxycamphor + NAD⁺ → (+)-bornane-2,5-dione + NADH + H⁺

trichloroethanol + oxygen → H₂O + 2,2,2-trichloroacetate + H⁺

H₂O + trehalose-cis-keto-mono-mycolate + ATP → H⁺ + trehalose-cis-keto-mono-mycolate + phosphate + ADP

H₂O + dATP → H⁺ + diphosphate + dAMP

NAD⁺ + L-arginine → 4,5-dehydro-L-arginine + NADH + H⁺

NAD⁺ + 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxyhexanoyl)-CoA → NADH + H⁺ + 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3-oxohexanoyl)-CoA

caffealdehyde + oxygen → (2E,4Z,6E)-5-formyl-2-hydroxy-8-oxoocta-2,4,6-trienoate + H⁺

L-glutamate + ATP + tyramine → γ-glutamyltyramine + H⁺ + phosphate + ADP

H₂O + 2-pyrone-4,6-dicarboxylate → (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H⁺

3-(hydroxyphosphonoylmethyl)malate → H⁺ + deamino α-keto demethylphosphinothricin + CO₂

vanillate + L-glutamate + ATP → H⁺ + diphosphate + AMP + N-vanillate-L-glutamate

H₂O + phenylacetyl-CoA → coenzyme A + phenylacetate + H⁺

3-sulfanylpropanoate + oxygen → H⁺ + 3-sulfinopropionate

α-maltose + ATP → H⁺ + α-maltose 1-phosphate + ADP

H₂O + 1-O-alkyl-2-acetyl-sn-glycerol → 1-O-alkyl-sn-glycerol + acetate + H⁺

ammonium + XMP + ATP → 2 H⁺ + diphosphate + AMP + GMP

7,8-didemethyl-8-hydroxy-5-deazariboflavin + (2S)-lactyl-2-diphospho-5'-guanosine → oxidized coenzyme F₄₂₀-0 + H⁺ + GMP

a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate) tripeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate) tripeptide + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

H₂O + L-phenylalanine + NAD⁺ → NADH + 3-phenyl-2-oxopropanoate + H⁺ + ammonium

(S)-3-hydroxybutanoyl-CoA + H₂O → coenzyme A + (S)-3-hydroxybutanoate + H⁺

S-adenosyl-L-methionine + 8-hydroxy-salvigenin → S-adenosyl-L-homocysteine + H⁺ + gardenin B

(S)-coclaurine + S-adenosyl-L-methionine → (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine + H⁺

NAD⁺ + (3R)-hydroxy-5-trans-dodecenoyl-CoA → NADH + H⁺ + (5E)-3-oxo-dodec-5-enoyl-CoA

H₂O + 4-acetamidobutanal + NAD⁺ → 2 H⁺ + 4-acetamidobutanoate + NADH

17-α-hydroxypregnenolone + NAD⁺ → 17-α-hydroxyprogesterone + NADH + H⁺

D-threonate + ATP → 4-phospho-D-threonate + H⁺ + ADP

hydroxymethylene acetate → acetate + formaldehyde + H⁺

glycine + NAD⁺ + hydrogen sulfide → 2 H⁺ + 3 H₂O + nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate

S-adenosyl-L-methionine + reumycin → S-adenosyl-L-homocysteine + toxoflavin + H⁺

2,6-dioxo-6-phenylhexa-3-enoate + H₂O → 2-oxopent-4-enoate + H⁺ + benzoate

5-amino-2-oxopentanoate → H₂O + 1-pyrroline-2-carboxylate + H⁺

H₂O + 2-hydroxy-6-(2-carboxyphenyl)-6-oxo-2,4-hexadienoate → phthalate + (2E)-2-hydroxypenta-2,4-dienoate + H⁺

(S)-NADHX + ADP → NADH + H⁺ + phosphate + AMP

5-chloroprotocatechuate + oxygen → H⁺ + 6-chloro-2-hydroxy-4-carboxymuconate-6-semialdehyde

H₂O + PAI-1 → H⁺ + N-(3-oxododecanoyl)-L-homoserine

H₂O + (1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol → (1S,4S)-2,5-dichloro-2,5-cyclohexadiene-1,4-diol + H⁺ + chloride

thiamine + H₂O → 4-amino-2-methyl-5-pyrimidinemethanol + H⁺ + 5-(2-hydroxyethyl)-4-methylthiazole

3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD⁺ → NADH + H⁺ + 3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA

(S)-tetrahydroprotoberberine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine

1-phenyl-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione + UDP-α-D-glucose → 1-phenyl-3-(3-C-glucosyl-2,4,6-trihydroxyphenyl)propane-1,3-dione + H⁺ + UDP

S-adenosyl-L-methionine + mercaptohistidine → S-adenosyl-L-homocysteine + ovothiol + H⁺

H₂O + L-ornithine + ATP → L-ornithine + H⁺ + phosphate + ADP

H₂O + mono-trans,octa-cis-decaprenyl diphosphate → H⁺ + phosphate + trans,octacis-decaprenyl phosphate

porifersta-5,7-dienol + NADP⁺ → 7-dehydroporiferasterol + NADPH + H⁺

NAD⁺ + (1R,2S)-3,5-dichlorocyclohexa-3,5-diene-1,2-diol → NADH + H⁺ + 3,5-dichlorocatechol

H₂O + (2Z,2E)-2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate → salicylate + 2-oxopent-4-enoate + H⁺

(R)-1-amino-2-propanol O-2-phosphate + ATP + adenosylcobyrate → H⁺ + phosphate + ADP + adenosyl-cobinamide phosphate

soyasaponin III + UDP-β-L-rhamnose → soyasaponin I + H⁺ + UDP

D-myo-inositol (3,4,6)-trisphosphate + ATP → H⁺ + D-myo-inositol (1,3,4,6)-tetrakisphosphate + ADP

L-lysine + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ATP → H⁺ + phosphate + ADP + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysine

H₂O + S-adenosyl-L-methionine + 12-ethyl-8-propylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹-hydroxy-8-propylbacteriochlorophyllide c

S-adenosyl-L-methionine + (3¹R)-8,12-diethylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + (3¹R)-8,12-diethylbacteriochlorophyllide c + H⁺

D-sedoheptulose + ATP → D-sedoheptulose 1-phosphate + H⁺ + ADP

H₂O + 2,4,6-trioxoheptanoate → acetate + acetylpyruvate + H⁺

glucosyl-(heptosyl)₂-Kdo₂-lipid A-phosphate + ADP-L-glycero-β-D-manno-heptose → glucosyl-(heptosyl)₃-Kdo₂-lipid A-phosphate + H⁺ + ADP

glucoraphanin + oxygen → methanesulfonate + H⁺ + gluconapin

S-adenosyl-L-methionine + N⁶-dimethylallyladenine → S-methyl-5'-thioadenosine + discadenine + H⁺

tylosin + UDP-α-D-glucose → H⁺ + 2'-[O-(β-D-glucopyranosyl)]-tylosin + UDP

glutaryl-CoA → 2 H⁺ + crotonyl-CoA + CO₂

an oxidized electron donor + glycolaldehyde → glycolate + a reduced electron donor + H⁺

3-isopropylcatechol + oxygen → H⁺ + 2-hydroxy-7-methyl-6-oxo-2,4-octadienoate

4-deoxy-2-O-sulfo-β-L-erythro-hex-4-enopyranuronosyl-(1,4)-D-N-sulfoglucosamine 6-O-sulfate + H₂O → 4-deoxy-β-L-erythro-hex-4-enopyranuronosyl-(1,4)-D-N-sulfoglucosamine 6-O-sulfate + H⁺ + sulfate

2 S-adenosyl-L-methionine + a reduced electron donor + N-acetyldemethyl-L-phosphinothricin → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricin + 5'-deoxyadenosine + L-methionine

coenzyme A + [(1R)-4,5,5-trimethyl-2-oxocyclopent-3-enyl]acetate + ATP → [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H⁺ + diphosphate + AMP

H₂O + tetrathionate → H⁺ + sulfate + thiosulfate + S⁰

curcumin 4'-O-β-D-gentiotrioside + UDP-α-D-glucose → curcumin 4'-O-β-D-gentiotetraside + H⁺ + UDP

(R)-glycerate + ATP → H⁺ + 2-phospho-D-glycerate + ADP

H₂O + β-hexachlorocyclohexane → 2,3,4,5,6-pentachlorocyclohexanol + H⁺ + chloride

β-D-galactopyranose + NAD⁺ → D-galactono-1,4-lactone + NADH + H⁺

3 H₂O + enterobactin → 3 N-(2,3-dihydroxybenzoyl)-L-serine + 3 H⁺

CDP-choline + (Chol-P-GalNAc)-GalNAc-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol → (Chol-P-GalNAc)-(Chol-P-GalNAc)-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol + CMP + H⁺

S-adenosyl-L-methionine + precorrin-4 → S-adenosyl-L-homocysteine + precorrin-5 + H⁺

1-naphthol + UDP-α-D-glucose → H⁺ + 1-naphthol glucoside + UDP

H₂O + p-nitrophenyl-α-L-arabinofuranoside → 4-nitrophenol + α-L-arabinofuranose + H⁺

CDP-glycerol + Gro-P-ManNAc-GlcNAc-PP-undecaprenol → CMP + H⁺ + Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol

cytosinine + 3-methylarginine + ATP → H⁺ + phosphate + demethylarginomycin + ADP

2-amino-5-chlorophenol + oxygen → (2E,4E)-2-amino-5-chloro-6-oxohexa-2,4-dienoate + H⁺

dopamine + betalamate → H₂O + H⁺ + miraxanthin V

urolithin A + UDP-α-D-glucuronate → H⁺ + urolithin A 3-O-glucuronide + UDP

H₂O + α-D-ribose 1-(acetamidomethylphosphonate) 5-triphosphate → α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + H⁺ + diphosphate

S-adenosyl-L-methionine + N-acetyl-N6,O-didemethylpuromycin → S-adenosyl-L-homocysteine + H⁺ + N-acetyl-O-demethylpuromycin

3-chloro-D-alanine → H⁺ + 2-aminoprop-2-enoate + chloride

diaminobutyryl-citryl-ethanolamine + 2-oxoglutarate + ATP → α-ketoglutaryl-diaminobutyryl-citryl-ethanolamine + H⁺ + diphosphate + AMP

delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-β-D-glucose → H⁺ + 4-hydroxybenzoate + delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside)

H₂O + decanal + NAD⁺ → 2 H⁺ + NADH + decanoate

H₂O + 3-oxopropanoyl-CoA → coenzyme A + H⁺ + 3-oxopropanoate

2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-D-desosamine

H₂O + ATP + urea + CO₂ → 2 H⁺ + urea-1-carboxylate + phosphate + ADP

oxygen + 2,3-dihydroxy-4-toluate → 2-hydroxy-3-carboxy-6-oxo-hepta-2,4-dienoate + H⁺

luteolin 7-O-β-D-diglucuronide + UDP-α-D-glucuronate → luteolin 7-O-[β-D-glucosyluronate-(1,2)-β-D-glucosiduronate]-4'-O-β-D-glucosiduronate + H⁺ + UDP

L-aspartate 4-semialdehyde + pyruvate → H₂O + H⁺ + (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

L-galactono-1,4-lactone + oxygen → L-ascorbate + hydrogen peroxide + H⁺

S-adenosyl-L-methionine + 2-iodophenol → S-adenosyl-L-homocysteine + H⁺ + 2-iodophenol methyl ether

(1R,2S)-5-chloro-3-methylcyclohexa-3,5-diene-1,2-diol + NAD⁺ → NADH + H⁺ + 5-chloro-3-methylcatechol

H₂O + 2-ketocyclohexane-1-carbonyl-CoA → pimeloyl-CoA + H⁺

3-[(2-aminopentan-5-oylcarbamoyl)methyl]-3-hydroxybutanoate + ATP + citrate → H⁺ + staphyloferrin A + diphosphate + AMP

glutathione + monochlorobimane → H⁺ + (glutathion-S-yl)-bimane + chloride

H₂O + oxaloacetate 4-methyl ester → methanol + H⁺ + oxaloacetate

oxidized DCPIP + (1S,2S,4R)-limonene-1,2-diol → (1S,4R)-1-hydroxymenth-8-en-2-one + reduced DCPIP + H⁺

H₂O + 3-O-aceylpapaveroxine → acetate + H⁺ + narcotine hemiacetal

H₂O + (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate → H⁺ + fumarate + (2Z)-2-hydroxypenta-2,4-dienoate

4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine → 2 H⁺ + 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + squalene → S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H⁺

NADP⁺ + 18-hydroxyoleate → NADPH + H⁺ + 18-oxo-oleate

phenylacetyl-CoA + L-glutamine → coenzyme A + H⁺ + α-N-phenylacetyl-L-glutamine

UDP-N-acetyl-α-D-galactosamine + Gro-P-ManNAc-GlcNAc-PP-undecaprenol → UMP + H⁺ + GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol

myo-inositol + NAD⁺ → 1-keto-D-chiro-inositol + NADH + H⁺

tetrahydro-4-hydroxyphenylpyruvate + L-phenylalanine → tetrahydrotyrosine + 3-phenyl-2-oxopropanoate + H⁺

2-propenyl-thiohydroximate-O-sulfate → 2-(thiiran-2-yl)acetonitrile + H⁺ + sulfate

3-dehydro-L-erythronate + ATP → 3-dehydro-4-phospho-L-erythronate + H⁺ + ADP

H₂O + dUDP → H⁺ + phosphate + dUMP

(+)-taxifolin + S-adenosyl-L-methionine → (+)-3'-methyltaxifolin + S-adenosyl-L-homocysteine + H⁺

an oxidized electron donor + (4-hydroxyphenyl)acetate + H⁺ + chloride ← a reduced electron donor + 3-chloro-4-hydroxyphenylacetate

dTDP-viosamine + acetyl-CoA → coenzyme A + dTDP-N-acetylviosamine + H⁺

2 UDP-α-D-glucose + zeaxanthin → 2 H⁺ + 2 UDP + zeaxanthin bis(β-D-glucoside)

(2S)-2-hydroxypropyl-CoM + NAD⁺ → NADH + 2-oxopropyl-CoM + H⁺

H₂O + 4-(γ-L-glutamylamino)butanal + NAD(P)+ → 2 H⁺ + NAD(P)H + 4-(γ-L-glutamylamino)butanoate

3,4-dichloro-6-methylcatechol + oxygen → 2 H⁺ + 2,3-dichloro-5-methyl-muconate

coenzyme A + an oxidized ferredoxin [iron-sulfur] cluster + 3-methyl-2-oxobutanoate → a reduced ferredoxin [iron-sulfur] cluster + H⁺ + isobutanoyl-CoA + CO₂

H₂O + NAD⁺ + (S)-lactaldehyde → 2 H⁺ + NADH + (S)-lactate

3-chlorocatechol + oxygen → 5-chlorocarbonyl-2-hydroxy-penta-2,4-dienate + H⁺

(S)-2-amino-6-oxohexanoate + H₂O + NAD(P)+ → 2 H⁺ + NAD(P)H + L-2-aminoadipate

isopyridoxal + NAD⁺ → 5-pyridoxolactone + NADH + H⁺

H₂O + decanoyl-CoA → coenzyme A + decanoate + H⁺

an oxidized electron donor + H₂O + L-sorbosone 2,6-lactone → a reduced electron donor + 2-keto-L-gulonate + H⁺

2 hydrogen peroxide + Reactive Blue 5 → 2 H₂O + 2 H⁺ + phthalate + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2,2'-disulfonyl azobenzene

thymidine + ATP → H⁺ + ADP + dTMP

shikimate + NAD⁺ → 3-dehydroshikimate + NADH + H⁺

tributyrin + H₂O → 1,2-dibutyrin + butanoate + H⁺

3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA + NAD⁺ → NADH + 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + H⁺

2 ammonia + Ni²⁺ + precorrin-2 → 2 H₂O + H⁺ + Ni-sirohydrochlorin

littorine → H⁺ + (S)-atropine

FMNH₂ + 1-butanesulfonate + oxygen → 2 H⁺ + FMN + H₂O + butan-1-al + sulfite

H₂O + 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate → (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H⁺

pre-alcaligin + ATP → alcaligin + H⁺ + diphosphate + AMP

2 S-adenosyl-L-methionine + 2 a reduced electron donor + 12,18-didecarboxysiroheme → 2 an oxidized electron donor + 2 acetate + 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + Fe-coproporphyrin III

S-adenosyl-L-methionine + 3,7-dimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3'-trimethylquercetagetin

soyasapogenol B + UDP-α-D-glucose → soyasapogenol-B-23-O-β-D-glucoside + H⁺ + UDP

N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine → N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H⁺

2-chloro-2-(2,4-dichloro-5-oxofuran-2-yl)acetate → 2,5-dichloro-trans-dienelactone + H⁺ + chloride

2'-deoxyuridine + ATP → H⁺ + ADP + dUMP

H₂O + deoxylimonate → deoxylimononic acid D-ring-lactone + H⁺

H₂O + rutin → H⁺ + β-L-rhamnopyranose + quercetin-3-glucoside

2 Charged-LEU-tRNAs → 2 H⁺ + 2 LEU-tRNAs + cyclo(L-leucyl-L-leucyl)

L-glutamate + L-cysteine + ATP → H⁺ + phosphate + ADP + γ-L-glutamyl-L-cysteine

H₂O + N-(2,3-dihydroxybenzoyl)-L-serine trimer → N-(2,3-dihydroxybenzoyl)-L-serine + N-(2,3-dihydroxybenzoyl)-L-serine dimer + H⁺

2,6-dioxo-6-phenylhexa-3-enoate + H₂O → H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate + benzoate

erythromycin C + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + erythromycin A + H⁺

H₂O + glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose → glycoprotein-phospho-D-mannose + H⁺ + N-acetyl-β-D-glucosamine

2,5-dihydroxypyridine + oxygen → N-formylmaleamate + H⁺

6-methoxypodophyllotoxin + UDP-α-D-glucose → 6-methoxypodophyllotoxin 7-glucoside + H⁺ + UDP

phenylethanolamine + S-adenosyl-L-methionine → N-methylphenylethanolamine + S-adenosyl-L-homocysteine + H⁺

H₂O + 4-methylbenzaldehyde + NAD⁺ → 2 H⁺ + NADH + 4-methylbenzoate

2'-aminobiphenyl-2,3-diol + oxygen → H⁺ + (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate

sarcinaxanthin + UDP-α-D-glucose → sarcinaxanthin monoglucoside + H⁺ + UDP

stigmasterol + UDP-α-D-glucose → stigmasterol 3-O-β-D-glucoside + H⁺ + UDP

2-amino-2-deoxy-D-mannitol + NAD⁺ → (2R,3R,4S,5S)1,3,4,5-tetrahydroxy-6-oxohexan-2-aminium + NADH + H⁺

coenzyme A + H₂O + cyclohexane-1-carboxylate + ATP → 2 phosphate + cyclohexane-1-carbonyl-CoA + H⁺ + AMP

a reduced electron donor + 3,3',5'-triiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3',5'-diiodothyronamine

chavicol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + methylchavicol

H₂O + adenylylcoelenterazine disulfonate + oxygen → 2 H⁺ + coelenterazine disulfonate dioxetanone + AMP

5-hydroxybenzimidazole + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 5-methoxybenzimidazole + H⁺

H₂O + propanoyl-CoA + glyoxylate → coenzyme A + (2R,3S)-3-methylmalate + H⁺

H₂O + dADP → H⁺ + phosphate + dAMP

H₂O + (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + NAD⁺ → 2 H⁺ + 2-maleylacetate + NADH

D-xylono-1,4-lactone 5-phosphate + H₂O → 5-phospho-D-xylonate + H⁺

ATP + kanosamine → H⁺ + D-kanosamine 6-phosphate + ADP

N⁶-dimethylallyladenine + UDP-α-D-glucose → H⁺ + isopentenyladenine-9-N-glucoside + UDP

L-cystathionine → H⁺ + L-cysteine + (2Z)-2-aminobut-2-enoate

2',3,4,4',6'-pentahydroxychalcone + UDP-α-D-glucose → 2',3,4,4',6'-pentahydroxychalcone 4'-O-β-D-glucoside + H⁺ + UDP

UDP-α-D-glucose + genistin → H⁺ + genistin 7-gentiobioside + UDP

2 S-adenosyl-L-methionine + squalene → 2 S-adenosyl-L-homocysteine + 2 H⁺ + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene

α-D-glucopyranose + ATP → α-D-glucose 6-phosphate + H⁺ + ADP

S-adenosyl-L-methionine + demethylmenaquinol-11 → S-adenosyl-L-homocysteine + menaquinol-11 + H⁺

N¹-citryl-N³-decanoyl-N³-hydroxy-1,3-diaminopropane + L-2,4-diaminobutanoate + ATP → N⁵-2,4-diaminobutanoate-N¹-citryl-N³-decanoyl-N³-hydroxy-1,3-diaminopropane + H⁺ + diphosphate + AMP

GalNAc-P-Glc-GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + UDP-α-D-glucose → Glc-GalNAc-P-Glc-GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + H⁺ + UDP

γ-tomatine + UDP-α-D-glucose → H⁺ + β1-tomatine + UDP

L-homocysteine + S-methyl-L-methionine → 2 L-methionine + H⁺

ubiquinol-8 → 4 H⁺ + ubiquinone-8

H₂O + hypoxanthine → 2 H⁺ + xanthine

S-adenosyl-L-methionine + rhamnetin → S-adenosyl-L-homocysteine + H⁺ + 7,4'-dimethylquercetin

GDP-α-D-mannose + bis(myo-inositol)-1,3'-phosphate → H⁺ + GDP + 2-O-(β-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate

4-sulfocatechol + oxygen → 2 H⁺ + 3-sulfomuconate

N-acetylmuramate + ATP → N-acetyl-α-D-muramate 1-phosphate + H⁺ + ADP

2 S-adenosyl-L-methionine + H₂O + (3¹R)-8,12-diethylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + (3¹R)-8,12-diethylbacteriochlorophyllide e

H₂O + P¹,P⁴-bis(5'-guanosyl) tetraphosphate → 2 H⁺ + GTP + GMP

H₂O + (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate → 2 H⁺ + HCl + 2-maleylacetate

S-adenosyl-L-methionine + 3-demethylubiquinol-9 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-9

H₂O + (Z)-1-(L-cysteinyglycin-S-yl)-N-hydroxy-2-phenylethan-1-imine → L-seryl-glycine + H⁺ + (Z)-2-phenyl-1-thioacetohydroximate

3D-(3,5/4)-trihydroxycyclohexane-1,2-dione + H₂O → 5-deoxy-D-glucuronate + H⁺

S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde → S-adenosyl-L-homocysteine + vanillin + H⁺

H₂O + (2Z,4Z)-2-amino-5-chloro-6-oxohexa-2,4-dienoate + NAD⁺ → 2 H⁺ + NADH + (2Z,4Z)-2-amino-5-chlorohexa-2,4-dienedioate

H₂O + 4-sulfomuconolactone → 2 H⁺ + 2-maleylacetate + sulfite

(-)-maackiain + UDP-α-D-glucose → (-)-maackiain-3-O-glucoside + H⁺ + UDP

S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain → S-adenosyl-L-homocysteine + (+)-pisatin + H⁺

H₂O + S-methyl-L-methionine → L-homoserine + H⁺ + dimethyl sulfide

3 oxygen + 6-(2-amino-2-carboxylatoethyl)-7-hydroxy-8-oxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate → 2 H₂O + 2 hydrogen peroxide + 2 H⁺ + pyrroloquinoline quinone

eugenol O-β-D-xylopyranosyl-(1->6)-O-β-D-glucopyranoside + UDP-α-D-glucose → H⁺ + UDP + eugenol 2-O-β-D-glucopyranosyl-(1 -> 2)-[O-β-D-xylopyranosyl-(1 -> 6)]-O-β-D-glucopyranoside

unsaturated CDP-archaeol + L-serine → CMP + unsaturated archaetidylserine + H⁺

H₂O + L-canavanine → L-canaline + H⁺ + urea

H₂O + 5-phospho-α-D-ribose 1,2-cyclic phosphate → α-D-ribose 1,5-bisphosphate + H⁺

1-(3-aminopropyl)-pyrrolinium → 1,5-diazabicyclononane + H⁺

2 oxygen + H₂O + choline → 2 hydrogen peroxide + glycine betaine + H⁺

cis-dienelactone + H⁺ + chloride ← (+)-5-chloromuconolactone

H₂O + cocaine → H⁺ + benzoate + ecgonine methyl ester

NAD⁺ + 6-hydroxyhexanoate → 6-oxohexanoate + NADH + H⁺

H₂O + β-nicotinamide D-ribonucleotide → nicotinamide + H⁺ + aldehydo-D-ribose 5-phosphate

S-adenosyl-L-methionine + gentamicin A → S-adenosyl-L-homocysteine + H⁺ + gentamicin X2

a reduced electron donor + 3,3',5,5'-tetraiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3,3',5-triiodothyronamine

guaiacol O-β-D-xylopyranosyl-(1->6)-O-β-D-glucopyranoside + UDP-α-D-glucose → H⁺ + guaiacol 2-O-β-D-glucopyranosyl-(1 -> 2)-[O-β-D-xylopyranosyl-(1 -> 6)]-O-β-D-glucopyranoside + UDP

H₂O + betaine aldehyde + oxygen → glycine betaine + hydrogen peroxide + H⁺

S-adenosyl-L-methionine + cobalt-precorrin-2 → S-adenosyl-L-homocysteine + H⁺ + cobalt-precorrin-3

(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD⁺ → NADH + 3-methylcatechol + H⁺

xanthotoxol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + xanthotoxin

NADP⁺ + 3,6-dihydronicotine → NADPH + H⁺ + (S)-nicotine

2 S-adenosyl-L-methionine + H₂O + 12-ethyl-8-propylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + 12-ethyl-8-propylbacteriochlorophyllide e

FADH₂ + oxygen + 4-tyrosol → FAD + H₂O + H⁺ + 3-hydroxytyrosol

(+)-sesaminol + UDP-α-D-glucose → (+)-sesaminol 2-O-β-D-glucoside + H⁺ + UDP

thiamine + ATP → thiamine phosphate + H⁺ + ADP

scyllo-inosose + NAD⁺ → 3-dehydro scyllo-inosose + NADH + H⁺

N-[2-chloro-6-(4-chloro-1H-pyrrol-3-yl)phenyl]hydroxylamine + NAD(P)+ → NAD(P)H + H⁺ + 3-chloro-4-(3-chloro-2-nitrosophenyl)-1H-pyrrole

digitoxigenin + UDP-fucose → H⁺ + digitoxigenin 3-O-β-D-quinovoside + UDP

UDP-α-D-glucose + quercetin-3-gentiotrioside → H⁺ + quercetin-3-gentiotetraside + UDP

S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → S-adenosyl-L-homocysteine + dTDP-2,3,6-trideoxy-3-C-methyl-3-amino-4-dehydro-α-D-glucose + H⁺

pyruvate + hydrogencarbonate + ATP → H⁺ + phosphate + oxaloacetate + ADP

uridine + GTP → UMP + H⁺ + GDP

3 H₂O + 3 S⁰ → 2 H⁺ + 2 hydrogen sulfide + sulfite

(-)-5-oxo-1,2-campholide → [(1R)-4,5,5-trimethyl-2-oxocyclopent-3-enyl]acetate + H⁺

H₂O + all-trans-retinal + oxygen → hydrogen peroxide + all-trans-retinoate + H⁺

O-acetyl-L-serine + hydroxyurea → acetate + H⁺ + O-ureido-L-serine

(+)-5-oxo-1,2-campholide → [(1R)-4,5,5-trimethyl-2-oxocyclopent-3-enyl]acetate + H⁺

H₂O + S-sulfinatoglutathione → H⁺ + glutathione + sulfite

3 2,3-dihydroxybenzoate + 3 L-serine + 6 ATP → 3 H⁺ + 6 diphosphate + 6 AMP + enterobactin

β-alanine + (R)-pantoate + ATP → (R)-pantothenate + H⁺ + phosphate + ADP

H₂O + N-Formyl-L-kynurenine → formate + L-kynurenine + H⁺

H⁺ + aldehydo-D-ribose 5-phosphate + ATP ← diphosphate + ADP-D-ribose

H₂O + (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate + NAD⁺ → 2 H⁺ + 2-maleylacetate + NADH

H₂O + paraoxon → 2 H⁺ + diethylphosphate + 4-nitrophenol

ubiquinol-9 → 4 H⁺ + ubiquinone-9

UDP-α-D-glucose + sulfuretin → H⁺ + UDP + sulfuretin 6-glucoside

dTDP-4-dehydro-6-deoxy-α-D-glucopyranose → H₂O + dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H⁺

L-ornithine + acetyl-CoA → coenzyme A + N⁵-acetyl-L-ornithine + H⁺

S-adenosyl-L-methionine + dTDP-N-monodesmethyl-α-D-forosamine → S-adenosyl-L-homocysteine + dTDP-α-D-forosamine + H⁺

H₂O + α-D-ribose-1-[N-(phosphonomethyl)glycine] 5-triphosphate → α-D-ribose-1-[N-(phosphonomethyl)glycine] 5-phosphate + H⁺ + diphosphate

O-1,4-α-L-dihydrostreptosyl-streptidine 6-phosphate + CDP-N-methyl-L-glucosamine → dihydrostreptomycin 6-phosphate + H⁺ + CDP

daidzein + UDP-α-D-glucose → H⁺ + daidzin + UDP

7,8-dihydropteroate + L-glutamate + ATP → 7,8-dihydrofolate monoglutamate + H⁺ + phosphate + ADP

2,3-dihydroxybenzoate + oxygen → 2 H⁺ + 2-carboxy-cis,cis-muconate

S-adenosyl-L-methionine + 3,7-dimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,4'-trimethylquercetagetin

H₂O + L-2-amino-4-chloropent-4-enoate → 2-oxopent-4-enoate + H⁺ + ammonium + chloride

2,3-dihydroxybenzoate + oxygen → 3-carboxy-2-hydroxymuconate semialdehyde + H⁺

2 FADH₂ + 2,4,6-trichlorophenol + oxygen → 2 FAD + 3 H⁺ + H₂O + 2,6-dichlorohydroquinone + chloride

C33-phthiotriol A + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + C34-phthiocerol A + H⁺

GalNAc-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol + UDP-N-acetyl-α-D-galactosamine → GalNAc-GalNAc-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol + H⁺ + UDP

2 H⁺ + pyridin-1-ium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complex ← Ni²⁺ + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide

H₂O + (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate → formate + H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate

2-amino-4,6-dinitrotoluene + UDP-α-D-glucose → 2 H⁺ + 2-amino-4,6-dinitrotoluene glucoside + UDP

H₂O + 4-hydroxybenzaldehyde + NADP⁺ → 2 H⁺ + NADPH + 4-hydroxybenzoate

(O-carbamoyl)adenylate + kanamycin B → H⁺ + 6''-O-carbamoylkanamycin B + AMP

FMNH₂ + oxygen + 22-[(1R,3S)-5,9,10-trihydroxy-1-methyl-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate → FMN + H₂O + H⁺ + THN

5-chloro-3-oxoadipate → 2-maleylacetate + H⁺ + chloride

H₂O + DIMBOA-β-D-glucoside → H⁺ + β-D-glucopyranose + DIMBOA

salicyl alcohol + UDP-α-D-glucose → H⁺ + salicin + UDP

S-adenosyl-L-methionine + dehypoxanthine futalosine → H⁺ + 5'-deoxyadenosine + L-methionine + cyclic dehypoxanthine futalosine

H₂O + NAD(P)+ + 3,6-anhydro-α-L-galactopyranose → 2 H⁺ + NAD(P)H + 3,6-anhydro-L-galactonate

2 ATP + H₂O + ammonium + CO₂ → 2 ADP + 3 H⁺ + carbamoyl phosphate + phosphate

dihydroxyacetone + ATP → glycerone phosphate + H⁺ + ADP

7,8-dihydroneopterin 3'-triphosphate → H⁺ + (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

H₂O + (Z)-3-ureidoacrylate peracid → (Z)-3-peroxyaminoacrylate + H⁺ + carbamate

(Rib-ol)-P-Glc-AATGal-PP-undecaprenol + UDP-N-acetyl-α-D-galactosamine → GalNAc-(Rib-ol)-P-Glc-AATGal-PP-undecaprenol + H⁺ + UDP

H₂O + phosphonoformaldehyde + NADP⁺ → NADPH + H⁺ + phosphonoformate

2-amino-5-chlorophenol + oxygen → (2Z,4Z)-2-amino-5-chloro-6-oxohexa-2,4-dienoate + H⁺

S-adenosyl-L-methionine + genkwanin → S-adenosyl-L-homocysteine + H⁺ + apigenin-7,4'-dimethyl ether

H₂O + phytenal + NAD⁺ → 2 H⁺ + phytenate + NADH

3-amino-1-hydroxyacetone 1-phosphate + 1-deoxy-D-xylulose 5-phosphate → 2 H₂O + pyridoxine 5'-phosphate + H⁺ + phosphate

D-myo-inositol (1,4,5)-trisphosphate + ATP → H⁺ + D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP

γ-pentachlorocyclohexene → HCl + (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H⁺

4-tyrosol + UDP-α-D-glucose → H⁺ + salidroside + UDP

UDP-α-D-glucose + (R)-4-hydroxymandelonitrile → taxiphyllin + H⁺ + UDP

NAD⁺ + (1R,2S)-3,4,6-trichlorocyclohexa-3,5-diene-1,2-diol → 2 H⁺ + NADH + 3,4,6-trichlorocatechol

H₂O + cis-3,4-dehydroadipyl-CoA semialdehyde + NADP⁺ → 2 H⁺ + NADPH + cis-3,4-dehydroadipyl-CoA

FAD + H₂O + squalene + H⁺ ← FADH₂ + hydroxysqualene

H₂O + α-D-galactofuranose + ATP → α-D-galactofuranose + H⁺ + phosphate + ADP

H₂O + lovastatin lactone → lovastatin acid + H⁺

3-fluorocatechol + oxygen → 2 H⁺ + 2-fluoromuconate

NAD⁺ + chanoclavine-I → NADH + H⁺ + chanoclavine-I aldehyde

FMNH₂ + dimethyl sulfone + oxygen → 2 H⁺ + FMN + H₂O + methanesulfinate + formaldehyde

S-adenosyl-L-methionine + norajmaline → S-adenosyl-L-homocysteine + H⁺ + ajmaline

H₂O + isobutyl acetate → acetate + isobutanol + H⁺

2 H₂O + N-(2,3-dihydroxybenzoyl)-L-serine trimer → 2 H⁺ + 3 N-(2,3-dihydroxybenzoyl)-L-serine

bergaptol + S-adenosyl-L-methionine → bergapten + S-adenosyl-L-homocysteine + H⁺

an oxidized electron donor + H₂O + uracil → 2 H⁺ + a reduced electron donor + barbiturate

oleanolate 3-β-D-glucuronoside-28-glucoside + UDP-α-D-galactose → oleanolate 3-beta-D-glucuronoside-(3,1)-galactoside-28-glucoside + H⁺ + UDP

H₂O + NAD(P)+ + L-2-aminopropionaldehyde → 2 H⁺ + NAD(P)H + L-alanine

2 caldariellaquinol + 5 H⁺ + oxygen → 2 caldariellaquinone + 2 H₂O + 5 H⁺

H₂O + NAD⁺ + (indol-3-yl)acetaldehyde → 2 H⁺ + NADH + (indol-3-yl)acetate

delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + UDP-α-D-glucose → H⁺ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP

2-(formamido)-N¹-(5-phospho-β-D-ribosyl)acetamidine + ATP → 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + H⁺ + phosphate + ADP

NAD⁺ + (3R)-hydroxy, 6-cis-tridecenoyl-CoA → NADH + H⁺ + 6-cis, 3-oxo-tridecenoyl-CoA

a reduced electron donor + UDP-α-D-glucose + gibberellin A₃ → an oxidized electron donor + H⁺ + gibberellin 2-O-β-D-glucoside + UDP

S-adenosyl-L-methionine + 2-(all-trans-nonaprenyl)benzene-1,4-diol → S-adenosyl-L-homocysteine + 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinol + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + spermidine → S-methyl-5'-thioadenosine + N⁴-aminopropylspermidine + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + spermidine → S-methyl-5'-thioadenosine + spermine + H⁺

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP → 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + H⁺ + phosphate + ADP

H₂O + (4-hydroxyphenyl)acetaldehyde + NAD⁺ → 2 H⁺ + (4-hydroxyphenyl)acetate + NADH

3'-phosphoadenylyl-sulfate + L-thyroxine → adenosine 3',5'-bisphosphate + H⁺ + thyroxine sulfate

H₂O + 1-heptanal + oxygen → hydrogen peroxide + heptanoate + H⁺

H₂O + 2-arachidonoylglycerol → glycerol + H⁺ + arachidonate

β-D-ribosylnicotinate + ATP → 2 H⁺ + β-nicotinate D-ribonucleotide + ADP

S-adenosyl-L-methionine + 2-hexaprenyl-6-methoxyaminophenol → S-adenosyl-L-homocysteine + H⁺ + 2-hexaprenyl-3-methyl-6-methoxyaminophenol

7β-hydroxy-3-oxochol-24-oyl-CoA + NAD⁺ → NADH + H⁺ + 7β-hydroxy-3-oxochol-4-en-24-oyl-CoA

3'-phosphoadenylyl-sulfate + 5-(methylsulfanyl)pentyl-desulfoglucosinolate → adenosine 3',5'-bisphosphate + 5-(methylsulfanyl)pentyl-glucosinolate + H⁺

S-adenosyl-L-methionine + (R)-adrenaline → S-adenosyl-L-homocysteine + H⁺ + metanephrine

NADPH + H⁺ + 3-oxo-lesqueroloyl-CoA ← NADP⁺ + 3R-hydroxy-lesqueroloyl-CoA

(+)-sesaminol 2-O-β-D-gentiobioside + UDP-α-D-glucose → (+)-sesaminol 2-O-β-D-gentiotrioside + H⁺ + UDP

S-adenosyl-L-methionine + 3-(all-trans-nonaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 2-methoxy-6-(all-trans-nonaprenyl)phenol

NADP⁺ + (6E)-8-hydroxygeraniol → NADPH + H⁺ + (6E)-8-oxogeraniol

esculetin + UDP-α-D-glucose → H⁺ + cichoriin + UDP

H₂O + S-sulfanylglutathione + oxygen → 2 H⁺ + glutathione + sulfite

H₂O + (11Z,14Z,17Z)-icosatrienoyl-CoA → (11Z,14Z,17Z)-icosa-11,14,17-trienoate + coenzyme A + H⁺

dihydrosterculate → 2 H⁺ + sterculate

L-arginyl-4-hydroxy-5-phosphonopentanoate + L-valine + ATP → L-valyl-L-arginyl-4-hydroxy-5-phosphonopentanoate + H⁺ + phosphate + ADP

S-adenosyl-L-methionine + catechol → S-adenosyl-L-homocysteine + H⁺ + guaiacol

3-α-mycarosylerythronolide B + dTDP-D-desosamine → erythromycin D + H⁺ + dTDP

2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP → H⁺ + staphyloferrin B + diphosphate + AMP

S-adenosyl-L-methionine + 2'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone → S-adenosyl-L-homocysteine + 2',3'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone + H⁺

6-oxocamphor + H₂O → H⁺ + [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate

H₂O + 7,8-dihydroneopterin 3'-triphosphate → 2 H⁺ + acetaldehyde + 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate

myricetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + laricitrin

(-)-dehydrodiconiferyl alcohol + NAD⁺ → NADH + (-)-dehydrodiconiferyl aldehyde + H⁺

H₂O + S-adenosyl-L-methionine + 12-ethyl-8-isobutylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹-hydroxy-8-isobutylbacteriochlorophyllide c

2 NAD⁺ + H₂O + histidinol → 2 NADH + 3 H⁺ + L-histidine

12 a reduced ferredoxin [iron-sulfur] cluster + 40 H₂O + 40 ATP + N₂ → 12 an oxidized ferredoxin [iron-sulfur] cluster + 2 ammonia + 28 H⁺ + 3 H₂ + 40 phosphate + 40 ADP

H₂O + oxygen + 3-aci-nitropropanoate → hydrogen peroxide + H⁺ + 3-oxopropanoate + nitrite

N-dimethylethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + choline + H⁺

γ-L-glutamyl 5-phosphate → 5-oxo-L-proline + H⁺ + phosphate

β-D-fructofuranose 1-phosphate + ATP → β-D-fructose 1,6-bisphosphate + H⁺ + ADP

diphenyl ether 2,3-diol + oxygen → (2Z,4E)-2-hydroxy-6-oxo-6-phenoxyhexa-2,4-dienoate + H⁺

2 3,5-dihydroxy-1,4-naphthoquinol + oxygen → 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H₂O + 2 H⁺

gentisate + UDP-α-D-glucose → H⁺ + UDP + 2,5-dihydroxybenzoate 5-O-β-D-glucoside

mycothiol + monobromobimane → H⁺ + mycothiol-bimane conjugate + bromide

3'-phosphoadenylyl-sulfate + 6-(methylsulfanyl)hexyl-desulfoglucosinolate → adenosine 3',5'-bisphosphate + 6-(methylsulfanyl)hexyl-glucosinolate + H⁺

salmochelin S4 + Fe³⁺ → 6 H⁺ + Fe³⁺-[diglucosyl-enterobactin] complex

a reduced electron donor + hydroxymethylphosphonate → 5 H⁺ + an oxidized electron donor + phosphonoformaldehyde

trans-zeatin + UDP-α-D-glucose → H⁺ + trans-zeatin-9-N-glucoside + UDP

FMNH₂ + thymine + oxygen → FMN + H⁺ + (Z)-2-methylureidoacrylate peracid

campest-4-en-3β-ol + NAD⁺ → campest-4-en-3-one + NADH + H⁺

oxygen + 3-sulfocatechol → (2Z,4E)-2-hydroxy-6-oxo-6-sulfonatohexa-2,4-dienoate + H⁺

Ca²⁺ + H₂O + ATP → Ca²⁺ + H⁺ + phosphate + ADP

H₂O + monomethyl sulfate → methanol + H⁺ + sulfate

H₂O + aldehydo-D-xylose + NAD⁺ → 2 H⁺ + NADH + D-xylonate

NADH + ATP → NADPH + H⁺ + ADP

OH-DDVA meta-cleavage product + H₂O → 5-carboxyvanillate + 4-carboxy-2-hydroxypenta-2,4-dienoate + H⁺

soyasapogenol A + UDP-α-D-glucuronate → soyasapogenol A 3-O-β-glucuronate + H⁺ + UDP

H₂O + 2-hydroxy-7-methyl-6-oxo-2,4-octadienoate → isobutanoate + H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate

S-adenosyl-L-methionine + 12-demethyl-elloramycin → S-adenosyl-L-homocysteine + H⁺ + elloramycin

2 3-[4-amino-3-hydroxybutyl]-hydroxy-carbamoyl-propanoate + ATP → pre-alcaligin + H⁺ + diphosphate + AMP

UDP-α-D-glucose + geraniol → geranyl β-D-glucopyranoside + H⁺ + UDP

glycine + phenylacetyl-CoA → coenzyme A + phenylacetylglycine + H⁺

α-D-Kdo-(2→4)-α-D-Kdo-(2→6)-lipid A + ADP-L-glycero-β-D-manno-heptose → heptosyl-Kdo₂-lipid A + H⁺ + ADP

H₂O + IDP → H⁺ + phosphate + IMP

S-adenosyl-L-methionine + quercetin → S-adenosyl-L-homocysteine + H⁺ + isorhamnetin

H₂O + pheophytin a → phytol + H⁺ + pheophorbide a

UDP-β-L-rhamnose + vitexin → vitexin 2''-O-β-L-rhamnoside + H⁺ + UDP

H₂O + guanosine 2',3'-cyclic monophosphate → H⁺ + guanosine 2'-monophosphate

H₂O + guanosine 2',3'-cyclic monophosphate → H⁺ + guanosine 3'-monophosphate

digitoxigenin + UDP-α-D-glucose → H⁺ + 3-O-β-D-glucoside digitoxigenin + UDP

ATP + geraniol → geranyl monophosphate + H⁺ + ADP

H₂O + 4-pyridoxolactone → 4-pyridoxate + H⁺

ATP + D-glyceraldehyde → H⁺ + D-glyceraldehyde 3-phosphate + ADP

H₂O + 3-sulfino-L-alanine → H⁺ + L-alanine + sulfite

NADH + H⁺ + 3-oxo-(9Z)-hexadecenoyl-CoA ← NAD⁺ + (S)-3-hydroxy-(9Z)-hexadecenoyl-CoA

an oxidized electron donor + trichloroethene + H⁺ + chloride ← tetrachloroethene + a reduced electron donor

S-adenosyl-L-methionine + 2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol

H₂O + 2-chloro-N-(2,6-diethylphenyl)acetamide → 2-chloroacetate + H⁺ + 2,6-diethylaniline

S-adenosyl-L-methionine + sarcosine → S-adenosyl-L-homocysteine + N,N-dimethylglycine + H⁺

H₂O + methyl (indol-3-yl)acetate → methanol + H⁺ + (indol-3-yl)acetate

H₂O + 3-(4-hydroxyphenyl)pyruvate + acetyl-CoA → coenzyme A + 2-(4-hydroxybenzyl)-malate + H⁺

L-methionine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-methionine + H⁺ + diphosphate + AMP

S-adenosyl-L-methionine + chondrochloren A → S-adenosyl-L-homocysteine + H⁺ + chondrochloren B

3 H₂O + GTP → 2 H⁺ + 2 phosphate + 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

H₂O + 4-O-methylrhodomycinone D → methanol + H⁺ + 10-carboxy-13-deoxydaunorubicin

4-methylamino-4-de(dimethylamino)anhydrotetracycline + S-adenosyl-L-methionine → anhydrotetracycline + S-adenosyl-L-homocysteine + H⁺

O-methyl-4-O-[2,4-di-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + p-HBAD-II + H⁺

cis-3-hydroxy-L-proline → H₂O + 1-pyrroline-2-carboxylate + H⁺

oxidized coenzyme F₄₂₀-2 + L-glutamate + ATP → coenzyme α-F₄₂₀-3 + H⁺ + phosphate + ADP

2 an L-tyrosyl-[tRNAtyr] → 2 a tRNAtyr + 2 H⁺ + cyclo-(L-tyrosyl-L-tyrosyl)

tomatidine galactoside + UDP-α-D-glucose → H⁺ + γ-tomatine + UDP

S-adenosyl-L-methionine + griseophenone D → S-adenosyl-L-homocysteine + H⁺ + griseophenone C

caffealdehyde + oxygen → (2E,4Z,5E)-2-hydroxy-7-oxo-(2-oxoethylidene)hepta-2,5-dienoate + H⁺

2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate → 2-methyl-cis-dienelactone + H⁺ + chloride

UDP-α-D-glucose + 2'-hydroxy 3,7,4'-trimethylquercetin → H⁺ + 3,7,4'-trimethylquercetin 2'-O-β-D-glucoside + UDP

undecaprenyl-N-acetyl-α-D-glucosaminyl-pyrophosphate + UDP-N-acetyl-α-D-mannosaminuronate → N-acetyl-β-D-mannosaminuronyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

2 H₂O + 2 hydrogen peroxide + 4 Mn²⁺ + oxygen → 4 Mn^IVO₂ + 8 H⁺

4-hydroxylamino-2,6-dinitrotoluene + UDP-α-D-glucose → H⁺ + 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP

H₂O + 2-protocatechuoylphloroglucinolcarboxylate → protocatechuate + phloroglucinol carboxylate + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 5 H⁺ + NAD⁺ → 2 an oxidized ferredoxin [iron-sulfur] cluster + 4 H⁺ + NADH

H₂O + GTP → 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + H⁺ + diphosphate

2 H₂O + dichlorocarbene → 2 chloride + 3 H⁺ + formate

N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-α-D-glucose → α-D-glucosyl-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-di-trans,octa-cis-undecaprenol + H⁺ + UDP

H₂O + UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate + ATP → H⁺ + diphosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + AMP

2,2',3,3'-tetrahydroxybiphenyl + oxygen → (2Z,2E)-2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H⁺

H₂O + 5-formyl-tetrahydromethanopterin → tetrahydromethanopterin + formate + H⁺

(25S)-5-β-spirostan-3-β-ol + UDP-α-D-glucose → (25S)-5β-spirostan-3β-ol 3-O-β-D- glucoside + H⁺ + UDP

7(8)-dihydroisojusticidin B + NAD⁺ → NADH + isojusticidin B + H⁺

thiophosgene + hydrogen sulfide → 2 H⁺ + 2 chloride + carbon disulfide

3-methylcatechol + oxygen → (2Z,4E)-2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + H⁺

dihydrodemethylsterigmatocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + dihydrosterigmatocystin + H⁺

quercetin 3,3',7-trissulfate + 3'-phosphoadenylyl-sulfate → adenosine 3',5'-bisphosphate + H⁺ + quercetin 3, 3', 4', 7-tetrasulfate

UDP-β-L-rhamnose + kaempferol → kaempferol-3-O-α-L-rhamnopyranoside + H⁺ + UDP

S-adenosyl-L-methionine + demethylmenaquinol-13 → S-adenosyl-L-homocysteine + menaquinol-13 + H⁺

2 coenzyme A + 2 H₂O + 2 NAD⁺ + 2 oxygen + oleoyl-CoA → 2 hydrogen peroxide + 2 NADH + 2 H⁺ + 2 acetyl-CoA + (5Z)-tetradecenoyl-CoA

H₂O + NAD⁺ + phosphonate → NADH + H⁺ + phosphate

H₂O + trans-zeatin riboside triphosphate → 2 H⁺ + trans-zeatin riboside diphosphate + phosphate

S-adenosyl-L-methionine + 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde → S-adenosyl-L-homocysteine + H⁺ + 4-methoxy-2,2'-bipyrrole-5-carbaldehyde

1D-myo-inositol 3-monophosphate + ATP → 2 H⁺ + D-myo-inositol (3,4)-bisphosphate + ADP

H₂O + NAD(P)+ + 3,6-anhydro-L-galactofuranose → 2 H⁺ + NAD(P)H + 3,6-anhydro-L-galactonate

cyclohexane-1,2-dione + H₂O → 6-oxohexanoate + H⁺

H₂O + triglucosyl-enterobactin → triglucosyl-(2,3-dihydroxybenzoylserine)₃ + H⁺

CDP-ribitol + Gro-P-ManNAc-GlcNAc-PP-undecaprenol → CMP + Rib-ol-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + H⁺

1-hydroxy-2-naphthoate + oxygen → (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H⁺

coenzyme A + H⁺ + trihomocitrate ← H₂O + 2-oxopimelate + acetyl-CoA

NAD⁺ + L-lysine → 2 H⁺ + 1-piperideine-2-carboxylate + NADH + ammonium

zeaxanthin-β-D-glucoside + UDP-α-D-glucose → zeaxanthin bis(β-D-glucoside) + H⁺ + UDP

GTP + adenosylcobinamide → H⁺ + GDP + adenosyl-cobinamide phosphate

histamine + L-glutamate + ATP → N^α-γ-L-glutamylhistamine + H⁺ + phosphate + ADP

H₂O + pyruvate + acetyl-CoA → coenzyme A + H⁺ + (R)-citramalate

3'-phosphoadenylyl-sulfate + 8-(methylsulfanyl)octyl-desulfoglucosinolate → adenosine 3',5'-bisphosphate + 8-(methylsulfanyl)octyl-glucosinolate + H⁺

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine + lipid X → lipid A disaccharide (E. coli) + H⁺ + UDP

(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene → HCl + 1,2,4-trichlorobenzene + H⁺

pimeloyl-CoA + NAD⁺ → 6-carboxyhex-2-enoyl-CoA + NADH + H⁺

gallate + oxygen → 2 H⁺ + (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate

H₂O + NAD⁺ + (25S)-26-oxocholest-4-en-3-one → 2 H⁺ + NADH + (25S)-3-oxocholest-4-en-26-oate

H₂O + (2Z,2E)-2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate → salicylate + H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate

2 monodehydroascorbate radical + NADH → 2 L-ascorbate + NAD⁺ + H⁺

3 S-adenosyl-L-methionine + tricaffeoyl spermidine → 3 S-adenosyl-L-homocysteine + 3 H⁺ + triferuloyl spermidine

2 decanoyl-CoA + H₂O → 2 coenzyme A + (2R)-2-octyl-3-oxododecanoate + H⁺

L-tyrosine + betalamate → H₂O + H⁺ + portulacaxanthin II

glycine + oxygen → hydrogen peroxide + 2-iminoacetate + H⁺

3,5,3'-triiodo-L-thyronine + a reduced electron donor → an oxidized electron donor + H⁺ + iodide + 3,5-diiodothyronine

H₂O + dCTP → H⁺ + diphosphate + dCMP

2,2',3-trihydroxybiphenyl + oxygen → (2Z,2E)-2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H⁺

3-hydroxy-4-methyl-L-kynurenine + H₂O → 3-hydroxy-4-methylanthranilate + H⁺ + L-alanine

1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H₂O → 1-palmitoyl-sn-glycero-3-phosphocholine + palmitate + H⁺

an oxidized electron donor + chloroethene + H⁺ + chloride ← trans-1,2-dichloroethene + a reduced electron donor

(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene → 1,2,4-trichlorobenzene + H⁺ + chloride

arsenite + S-adenosyl-L-methionine → methylarsonate + S-adenosyl-L-homocysteine + H⁺

H₂O + N¹-acetyl-N²-formyl-5-methoxykynuramine → formate + H⁺ + N-acetyl-5-methoxykynurenamine

L-glutamine + phosphoribulosylformimino-AICAR-phosphate → D-erythro-imidazole-glycerol-phosphate + H⁺ + L-glutamate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

N-acetyl-α-D-glucosaminyl-(C55 ω-saturated dolichyl phosphate) + UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronate → 2,3-diacetamido-2,3-dideoxy-β-D-uronateglucosyl-(1→3)-N-acetyl-α-D-glucosaminyl-(C55 ω-saturated dolichyl phosphate) + H⁺ + UDP

oleandomycin + UDP-α-D-glucose → H⁺ + glucosyl-oleandomycin + UDP

FMNH₂ + oxygen + medermycin → FMN + H₂O + H⁺ + mederrhodin A

5-methylbenzimidazole ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(5-methylbenzimidazolyl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

L-leucine + demethylarginomycin + ATP → H⁺ + phosphate + L-leucyl-demethylarginomycin + ADP

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-mannosamine → ManNAc-GlcNAc-PP-undecaprenol + H⁺ + UDP

rhodovibrin → 2 H⁺ + hydroxyspirilloxanthin

H₂O + butanoyl-CoA + glyoxylate → coenzyme A + H⁺ + 3-ethylmalate

decaprenoxanthin monoglucoside + UDP-α-D-glucose → decaprenoxanthin diglucoside + H⁺ + UDP

GDP-α-D-glucose + 3-phospho-D-glycerate → H⁺ + 2-O-(α-D-glucopyranosyl)-3-phospho-D-glycerate + GDP

S-adenosyl-L-methionine + mycinamicin VI → S-adenosyl-L-homocysteine + H⁺ + mycinamicin III

H₂O + oxygen + S⁰ → 2 H⁺ + sulfite

S-adenosyl-L-methionine + (R)-noradrenaline → S-adenosyl-L-homocysteine + (R)-adrenaline + H⁺

2-oxoglutarate + oxygen + gibberellin A₅₁ → H₂O + H⁺ + succinate + gibberellin A₅₁-catabolite + CO₂

7-α-hydroxy-O-carbamoyl-deacetylcephalosporin C + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + cephamycin C + H⁺

H₂O + L,L-homocystine + ATP → L,L-homocystine + H⁺ + phosphate + ADP

H₂O + acetylpyruvate → acetate + pyruvate + H⁺

H₂O + UTP → UMP + H⁺ + diphosphate

NAD⁺ + UDP-α-D-glucose → NADH + H⁺ + UDP-3-dehydro-α-D-glucose

S-adenosyl-L-methionine + desmethyl-dehydro-dechlorogriseofulvin → S-adenosyl-L-homocysteine + H⁺ + dechloro-dehydrogriseofulvin

(20S)-ginsenoside Rg3 + UDP-α-D-glucose → ginsenoside Rd + H⁺ + UDP

H₂O + L-glutamine + ATP + cob(II)yrinate c-monoamide → H⁺ + L-glutamate + phosphate + ADP + cob(II)yrinate a,c-diamide

3'-phosphoadenylyl-sulfate + 3-(methylsulfanyl)propyl-desulfoglucosinolate → adenosine 3',5'-bisphosphate + glucoiberverin + H⁺

homogentisate + oxygen → 4-maleyl-acetoacetate + H⁺

S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline → S-adenosyl-L-homocysteine + 17-O-deacetylvindoline + H⁺

UDP-α-D-glucose + apigenin → H⁺ + UDP + vitexin

S-adenosyl-L-methionine + gentamicin C1a → S-adenosyl-L-homocysteine + H⁺ + gentamicin C2b

H₂O + (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD⁺ → protocatechuate + NADH + H⁺ + hydrogencarbonate

N-acetyl-α-D-galactosamine + ATP → N-acetyl-D-galactosamine 6-phosphate + H⁺ + ADP

3 H⁺ + 3 malonyl-CoA + H₂O + acetyl-CoA → 3 CO₂ + 4 coenzyme A + H₂O + orsellinate + H⁺

H₂O + 4-O-acetyl-UDP-N-acetylglucosamine → 4-O-acetyl-N-acetylmannosamine + H⁺ + UDP

1,4-α-D-glucooligosaccharide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units + H⁺

H₂O + all-trans-retinal + NAD⁺ → 2 H⁺ + NADH + all-trans-retinoate

(S)-NADPHX + ADP → NADPH + H⁺ + phosphate + AMP

UDP-α-D-glucose + quercetagetin → H⁺ + quercetagetin 7-O-glucoside + UDP

2 H₂O + 2-oxepin-2(3H)-ylideneacetyl-CoA + NADP⁺ → 2 H⁺ + 3-oxo-5,6-didehydrosuberyl-CoA + NADPH

2 5-aminolevulinate → 2 H₂O + porphobilinogen + H⁺

H₂O + ADP-5-ethyl-4-methylthiazole-2-carboxylate → H⁺ + 4-methyl-5-(2-phosphooxyethyl)thiazole + AMP + CO₂

(R)-mevalonate + ATP → (R)-mevalonate 3-phosphate + H⁺ + ADP

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone → S-adenosyl-L-homocysteine + H⁺ + gossypetin 3',8-dimethyl ether

FMNH₂ + 2-methylpropan-1-amine + oxygen → 2 H⁺ + FMN + H₂O + N-(2-methylpropyl)hydroxylamine

trans-4-hydroxy-L-proline → H₂O + H⁺ + (S)-1-pyrroline-5-carboxylate

C.p.450 + UDP-α-D-glucose → C.p.450 monoglucoside + H⁺ + UDP

H₂O + dITP → H⁺ + diphosphate + dIMP

curcumin diglucoside + UDP-α-D-glucose → curcumin 4'-O-β-D-gentiobiosyl 4''-O-β-D-glucoside + H⁺ + UDP

2-(2,4-dichloro-5-oxofuran-2-yl)propanoate → 2-chloro-5-methyl-dienelactone + H⁺ + chloride

UDP-α-D-glucuronate + β-D-glucosyl-(C55 ω-saturated dolichyl phosphate) → H⁺ + UDP + β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate)

myxol + GDP-β-L-fucose → H⁺ + GDP + myxol-2' fucoside

N⁶-dimethylallyladenine + UDP-α-D-glucose → H⁺ + isopentenyladenine-7-N-glucoside + UDP

cis-zeatin + UDP-α-D-glucose → H⁺ + cis-zeatin-7-N-glucoside + UDP

D-erythro-D-gluco-octose 8-phosphate + ATP → D-erythro-D-gluco-octose α-1,8-bisphosphate + H⁺ + ADP

oxidized coenzyme F₄₂₀-1 + L-glutamate + GTP → oxidized coenzyme F₄₂₀-2 + H⁺ + phosphate + GDP

H₂O + p-nitrophenyl-α-L-rhamnopyranoside → 4-nitrophenol + H⁺ + β-L-rhamnopyranose

neamine + UDP-α-D-glucose → H⁺ + 3''-deamino-3''-hydroxykanamycin B + UDP

H₂O + 4-hydroxybenzaldehyde + NAD(P)+ → 2 H⁺ + NAD(P)H + 4-hydroxybenzoate

2,6-dichloro-3-(glutathion-S-yl)-hydroquinone + glutathione → 2,6-dichlorohydroquinone + H⁺ + glutathione disulfide

adenosine pentaphosphate + H₂O → adenosine tetraphosphate + H⁺ + phosphate

H₂O + dioleoyl phosphatidate → oleate + H⁺ + 1-oleoyl-sn-glycerol 3-phosphate

H₂O + NAD⁺ + 1,10-dihydro-1,10-dihydroxyfluoren-9-one → 2 H⁺ + NADH + 3-2-carboxyphenylcatechol

sphingosine + ATP → sphingosine 1-phosphate + H⁺ + ADP

(1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol → 2 H⁺ + 2,5-dichlorophenol + chloride

H₂O + UDP → UMP + H⁺ + phosphate

2 octanoyl-CoA + H₂O → 2 coenzyme A + (2R)-2-hexyl-3-oxodecanoate + H⁺

H₂O + L-saccharopine + NAD⁺ → NADH + 2-oxoglutarate + H⁺ + L-lysine

2 H⁺ + H₂O + Fe³⁺-[salmochelin S2] complex → N-(2,3-dihydroxybenzoyl)-L-serine + H⁺ + Fe³⁺-[diglucosyl-(2,3-dihydroxybenzoylserine)₂] complex

H₂O + dTTP → H⁺ + phosphate + dTDP

H₂O + phloretin → phloretate + phloroglucinol + H⁺

6-hydroxytryprostatin B + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + tryprostatin A + H⁺

protopanaxatriol + UDP-α-D-glucose → H⁺ + UDP + ginsenoside Rh1

vancomycin aglycone + UDP-α-D-glucose → H⁺ + devancosaminyl-vancomycin + UDP

taurine + choloyl-CoA → coenzyme A + H⁺ + taurocholate

UDP-N-acetyl-α-D-glucosamine + 2-deoxystreptamine → 2'-N-acetylparomamine + H⁺ + UDP

H₂O + ATP → H⁺ + diphosphate + AMP

FMNH₂ + 5-deoxy-dihydrokalafungin + oxygen → FMN + H₂O + H⁺ + 22-[(1R,3S)-5,9,10-trihydroxy-1-methyl-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate

L-2-aminoadipate + acetyl-CoA → coenzyme A + N²-acetyl-α-aminoadipate + H⁺

β-D-galactopyranosyl-(1→3)-D-galactopyranose + H₂O → bacillithiol + H⁺ + (R)-lactate

3-hydroxypropanoate + NAD⁺ → NADH + H⁺ + 3-oxopropanoate

2-chloro-trans-dienelactone + H₂O → 2-chloromaleylacetate + H⁺

UDP-α-D-glucose + baicalein → H⁺ + UDP + baicalein 7-O-β-D-glucoside

8-oxo-dADP + H₂O → 8-oxo-dAMP + H⁺ + phosphate

H₂O + S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate → H⁺ + L-methionine + hydrogencarbonate + 6-amino-6-deoxyfutalosine

putrescine + L-glutamate + ATP → γ-glutamyl-L-putrescine + H⁺ + phosphate + ADP

L-valine + (-)-jasmonate + ATP → H⁺ + diphosphate + (-)-jasmonoyl-L-valine + AMP

fenclorim + glutathione → H⁺ + 4-(glutathion-S-yl)-fenclorim + chloride

L-glutamine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-glutamine + H⁺ + diphosphate + AMP

glucoiberin + oxygen → methanesulfonate + H⁺ + sinigrin

UDP-α-D-glucose + γ-solanine → 2 H⁺ + β-solanine + UDP

H₂O + NAD(P)+ + (indol-3-yl)acetaldehyde → 2 H⁺ + NAD(P)H + (indol-3-yl)acetate

H₂O + D-glucono-1,5-lactone → D-gluconate + H⁺

H₂O + S-adenosyl-L-methionine + magnesium-protoporphyrin IX 13-monomethyl ester → H⁺ + 5'-deoxyadenosine + L-methionine + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

sarcinaxanthin monoglucoside + UDP-α-D-glucose → sarcinaxanthin diglucoside + H⁺ + UDP

H₂O + 3,4-dihydroxyphenylacetyl-CoA → coenzyme A + 3,4-dihydroxyphenylacetate + H⁺

11 ATP + 2 N⁵-formyl-N⁵-hydroxy-L-ornithine + 2 L-threonine + 2 L-serine + L-tyrosine + L-lysine + L-glutamate + L-2,4-diaminobutanoate + L-arginine → 11 diphosphate + 11 AMP + 12 H⁺ + ferribactin + H₂O

O-acetyl-L-serine + hydrogen selenide → 2 H⁺ + acetate + L-selenocysteine

ethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-monomethylethanolamine + H⁺

H₂O + (S)-2-O-sulfonatolactate → H⁺ + (S)-lactate + sulfate

H₂O + bis(2-ethylhexyl)phthalate → 2-ethylhexyl phthalate + H⁺ + 2-ethylhexan-1-ol

glutathione + bromoacetate → H⁺ + S-(acet-2-yl)-glutathione + bromide

β-nicotinate D-ribonucleotide + 5-methylbenzimidazole → nicotinate + 5-methylbenzimidazole ribotide phosphate + H⁺

3'-phosphoadenylyl-sulfate + 7-(methylsulfanyl)heptyl-desulfoglucosinolate → adenosine 3',5'-bisphosphate + 7-(methylsulfanyl)heptyl-glucosinolate + H⁺

acetyl phosphate + H⁺ + sulfite ← sulfoacetaldehyde + phosphate

(S)-2,3-dihydrodipicolinate + NAD⁺ → NADH + H⁺ + dipicolinate

16 H₂O + 16 ATP + 8 a reduced ferredoxin [iron-sulfur] cluster + N₂ → 16 phosphate + 16 ADP + 2 ammonium + 6 H⁺ + 8 an oxidized ferredoxin [iron-sulfur] cluster + H₂

2 NAD(P)+ + dimeric 9-hydroxyrubrofusarin → 2 NAD(P)H + 2 H⁺ + aurofusarin

3-methylxanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + theobromine + H⁺

tabtoxinine-β-lactam + acetyl-CoA → coenzyme A + N-acetyl-tabtoxinine-β-lactam + H⁺

dichloromethane + a reduced electron donor → an oxidized electron donor + methyl chloride + H⁺ + chloride

H₂O + octadecanal → formate + H⁺ + heptadecane

NAD⁺ + 2-carboxymethyl-3-hydroxyphenylpropanoyl-CoA → NADH + H⁺ + benzoylsuccinyl-CoA

H₂O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD⁺ → NADH + 2-oxoglutarate + L-2,3-diaminopropanoate + H⁺

S-adenosyl-L-methionine + δ-tocopherol → S-adenosyl-L-homocysteine + H⁺ + β-tocopherol

S-adenosyl-L-methionine + a reduced electron donor + GTP → an oxidized electron donor + (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + H⁺ + 5'-deoxyadenosine + L-methionine

H₂O + 2,4-didehydro-3-deoxy-L-rhamnonate → pyruvate + H⁺ + (S)-lactate

an oxidized electron donor + H⁺ + 4-chlorophenol + chloride ← a reduced electron donor + 2,4-dichlorophenol

H₂O + (R)-S-lactoylglutathione → H⁺ + glutathione + (R)-lactate

H₂O + S-formylmycothiol → formate + mycothiol + H⁺

2 H₂O + fumonisin B₁ → 2 H⁺ + 2 propane-1,2,3-tricarboxylate + aminopentol

4-methylcatechol + oxygen → 2 H⁺ + 3-methyl-cis,cis-muconate

2 coenzyme A + 2 H₂O + 2 NAD⁺ + 2 oxygen + 10-cis-heptadecenoyl-CoA → 2 hydrogen peroxide + 2 NADH + 2 H⁺ + 2 acetyl-CoA + 6-cis-tridecenoyl-CoA

H₂O + 2,6-dihydroxypseudooxynicotine → 4-methylaminobutanoate + 2,6-dihydroxypyridine + H⁺

S-adenosyl-L-methionine + C30 botryococcene → S-adenosyl-L-homocysteine + isoshowacene + H⁺

H₂O + cyclic- 3,4-O-oxalyl-L-threonate → 4-O-oxalyl-L-threonate + H⁺

5-methoxy-6-methylbenzimidazole ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(5-methoxy-6-methylbenzimidazolyl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

H₂O + 13-sophorosyloxydocosanoate 6',6''-diacetate → acetate + 13-[O(2')-β-D-glucopyranosyl-β-D-glucopyranosyloxy]docosanoate O(6'')-acetate + H⁺

H₂O + dTDP → H⁺ + phosphate + dTMP

N-(3-aminopropyl)-N-hydroxyacetamide + ATP + citrate → (citryl)-N-(3-aminopropyl)-N-hydroxyacetamide + H⁺ + diphosphate + AMP

S-adenosyl-L-methionine + calycosin → S-adenosyl-L-homocysteine + 7-hydroxy-4'5'-dimethoxyisoflavone + H⁺

NAD⁺ + (3R,6R)-6-hydroxy-3-isopropenylheptanoate → (3R)-3-isopropenyl-6-oxoheptanoate + NADH + H⁺

H₂O + salmochelin S4 → salmochelin S2 + H⁺

2 S-adenosyl-L-methionine + a reduced electron donor + N-acetyldemethylphosphinothricin tripeptide → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricin tripeptide + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + (2S)-eriodictyol → (2S)-hesperetin + S-adenosyl-L-homocysteine + H⁺

salmochelin S4 + UDP-α-D-glucose → triglucosyl-enterobactin + H⁺ + UDP

H₂O + acetyl-CoA → coenzyme A + acetate + H⁺

2 NAD⁺ + H₂O + UDP-α-D-glucose → 2 NADH + 3 H⁺ + UDP-α-D-glucuronate

2 NAD(P)H + oxygen + Cr⁶⁺ → 2 NAD(P)+ + 2 H⁺ + Cr³⁺ + superoxide

methylarsonite + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + cacodylate

dTDP-L-rhodinose + aclacinomycin S → H⁺ + aclacinomycin N + dTDP

H₂O + 5,10-methenyltetrahydromethanopterin → 10-formyl-tetrahydromethanopterin + H⁺

S-adenosyl-L-methionine → S-methyl-5'-thioadenosine + 1-aminocyclopropane-1-carboxylate + H⁺

2-chloro-2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate → 5-chloro-2-methyl-dienelactone + H⁺ + chloride

an oxidized electron donor + H₂O + 8-demethyl-8-formylriboflavin 5'-phosphate → a reduced electron donor + 8-carboxy-8-demethylriboflavin 5'-phosphate + H⁺

H₂O + β-ketoisocaproate → acetate + isobutanoate + H⁺

roseoflavin + ATP → H⁺ + roseoflavin 5'-phosphate + ADP

(+)-isodihydrocarveol + NAD⁺ → NADH + H⁺ + (+)-isodihydrocarvone

sulfoquinovose + NAD⁺ → 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H⁺

L-cysteate → 2 H⁺ + 2-aminoprop-2-enoate + sulfite

sn-glycero-3-phosphocholine + H₂O → choline + H⁺ + sn-glycerol 3-phosphate

soyasapogenol E + UDP-α-D-glucose → soyasapogenol E-23-O-β-D-glucoside + H⁺ + UDP

ergosta-5,7-dienol + NADP⁺ → ergosterol + NADPH + H⁺

NAD⁺ + (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA → NADH + H⁺ + (6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA

13-hydroxydocosanoate + UDP-α-D-glucose → H⁺ + UDP + 13-β-D-glucosyloxydocosanoate

NAD⁺ + (S)-3-hydroxy-(9Z)-octadecenoyl-CoA → NADH + H⁺ + 3-oxo-(9Z)-octadecenoyl-CoA

2 an oxidized electron donor + 2 H₂O + 8',8-diapocarotene-8',8-dial → 2 a reduced electron donor + 2 H⁺ + crocetin

H₂O + aldehydo-D-galacturonate + NAD⁺ → 2 H⁺ + NADH + D-galactarate

5-hydroxyxanthotoxin + S-adenosyl-L-methionine → isopimpinellin + S-adenosyl-L-homocysteine + H⁺

2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-L-lysyl-(glycyl)₅-D-alanyl-D-alanine → a peptidoglycan dimer (S. aureus) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

H₂O + 7,8-dihydroneopterin 2',3'-cyclic phosphate → 7,8-dihydroneopterin 2'-phosphate + H⁺

4-chlorocatechol + oxygen → 2 H⁺ + 3-chloro-cis,cis-muconate

2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricyl-L-alanyl-L-leucine + a reduced electron donor → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricyl-L-alanyl-L-leucine + 5'-deoxyadenosine + L-methionine

(S)-scoulerine + S-adenosyl-L-methionine → (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H⁺

an oxidized electron donor + (5E)-3-amino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one → a reduced electron donor + (5E)-3-imino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one + H⁺

S-adenosyl-L-methionine + 3,7,4'-trimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,4'-tetramethylquercetagetin

UDP-α-D-glucose + cyanidin 3-O-(β-D-xylosyl-(1→2)-β-D-galactoside) → H⁺ + cyanidin 3-O-(6-O-β-D-glucosyl-2-O-β-D-xylosyl-β-D-galactoside) + UDP

hesperidin + H₂O → (2S)-hesperetin + rutinose + H⁺

H₂O + 7,8-dihydroneopterin 2',3'-cyclic phosphate → 7,8-dihydroneopterin 3'-phosphate + H⁺

H₂O + 12α-hydroxy-3-oxochol-4-en-24-oyl-CoA → coenzyme A + H⁺ + 12-α-hydroxy-3 oxochol-4-enoate

H₂O + 5'-O-phosphonoadenylyl-(3'→5')-adenosine → 2 AMP + H⁺

keto-D-tagatose + ATP → keto-D-tagatose 6-phosphate + H⁺ + ADP

β-nicotinate D-ribonucleotide + benzimidazole → nicotinate + benzimidazole ribotide phosphate + H⁺

2 GDP-α-D-rhamnose + (3S,3'S)-astaxanthin → 2 H⁺ + 2 GDP + astaxanthin dirhamnoside

streptidine 6-phosphate + dTDP-L-dihydrostreptose → O-1,4-α-L-dihydrostreptosyl-streptidine 6-phosphate + H⁺ + dTDP

nicotinate + H₂O + NADP⁺ → 6-hydroxynicotinate + NADPH + H⁺

trans-zeatin-O-glucoside + UDP-α-D-glucose → H⁺ + trans-zeatin-O-glucoside-7-N-glucoside + UDP

dihydrozeatin + UDP-α-D-glucose → H⁺ + dihydrozeatin-7-N-glucose + UDP

4,5-dehydro-L-arginine + indolmycenate + ATP → (2R,4E)-2-amino-5-({[(2S,3R)-2-hydroxy-3-(1H-indol-3-yl)butanamido]methanimidoyl}amino)pent-4-enoate + H⁺ + diphosphate + AMP

L-β-lysine + acetyl-CoA → coenzyme A + H⁺ + N6-acetyl-L-β-lysine

2-oxoglutarate + UDP-4-amino-D-fucose + ATP → H⁺ + phosphate + ADP + UDP-yelose

NAD⁺ + (S)-3-hydroxydecanoyl-CoA → NADH + H⁺ + 3-oxodecanoyl-CoA

NAD⁺ + (2R,3R)-3-methylornithinyl-N⁶-lysine → 2 H⁺ + L-pyrrolysine + NADH + ammonium

S-adenosyl-L-methionine + tricetin → S-adenosyl-L-homocysteine + H⁺ + selgin

Cu²⁺ + H₂O + ATP → Cu²⁺ + H⁺ + phosphate + ADP

an aminated amino group acceptor + furostanol-26-aldehyde → a deaminated amino group acceptor + H⁺ + 26-amino-furostanol

phytol + CTP → phytyl monophosphate + H⁺ + CDP

NAD⁺ + phthalate 3,4-cis-dihydrodiol → 3,4-dihydroxyphthalate + NADH + H⁺

oleanolate + UDP-α-D-glucose → H⁺ + oleanolate 3-O-β-D-glucoside + UDP

NAD⁺ + (24R,25R)-3α,7α,24-trihydroxy-5β-cholestanoyl CoA → NADH + H⁺ + 3α,7α-dihydroxy-24-oxo-5β-cholestanoyl CoA

S-adenosyl-L-methionine + dTDP-4-dehydro-2,6-dideoxy-α-D-allose → S-adenosyl-L-homocysteine + dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-L-allose + H⁺

FAD + H₂O → 2 H⁺ + FMN + AMP

H₂O + L-djenkolate + ATP → L-djenkolate + H⁺ + phosphate + ADP

NADP⁺ + 22-hydroxydocosanoate → NADPH + H⁺ + 22-oxo-docosanoate

H₂O + syringaldehyde + NAD⁺ → 2 H⁺ + syringate + NADH

2,3-dihydroxybenzoate + oxygen → 2 H⁺ + 2-carboxymuconate

3-dehydro scyllo-inosose + H₂O → 5-dehydro-L-gluconate + H⁺

S-adenosyl-L-methionine + trihydroxyferuloyl spermidine → S-adenosyl-L-homocysteine + H⁺ + dihydroxyferuloyl-sinapoyl spermidine

methylcob(III)alamin + tetrahymanol → 2-methyltetrahymanol + H⁺ + cob(II)alamin

S-adenosyl-L-methionine + coniferyl alcohol → S-adenosyl-L-homocysteine + coniferyl alcohol 9-methyl ester + H⁺

2-benzyl-3-hydroxybutanedioate + NAD⁺ → 2-benzyl-3-oxobutanedioate + NADH + H⁺

(R)-glycerate + ATP → H⁺ + 3-phospho-D-glycerate + ADP

putrescine + acetyl-CoA → coenzyme A + N-acetylputrescine + H⁺

(2S)-naringenin + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + ponciretin

(3aS)-jadomycin A + dTDP-β-L-digitoxose → H⁺ + (3aS)-jadomycin B + dTDP

H₂O + ADP → H⁺ + phosphate + AMP

S-adenosyl-L-methionine + demethylmenaquinol-4 → S-adenosyl-L-homocysteine + menaquinol-4 + H⁺

S-adenosyl-L-methionine + (S)-isoandrocymbine → S-adenosyl-L-homocysteine + H⁺ + O-methylandrocymbine

H₂O + 8-oxo-dGDP → H⁺ + phosphate + 8-oxo-dGMP

cis-geranyl-CoA + hydrogencarbonate + ATP → H⁺ + 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + phosphate + ADP

D-ornithine + ATP + citrate → H⁺ + 3-[(2-aminopentan-5-oylcarbamoyl)methyl]-3-hydroxybutanoate + diphosphate + AMP

oxygen + 2,3-dihydroxyindole → anthranilate + H⁺ + CO₂

ADP-α-D-glucose + D-Glucose → H⁺ + α,α-trehalose + ADP

myristoylated pyoverdine intermediate + H₂O → pyoverdine biosynthetic intermediate + myristate + H⁺

(R)-4'-phosphopantothenate + L-cysteine + ATP → (R)-4'-phosphopantothenoyl-L-cysteine + H⁺ + diphosphate + AMP

L-alanine + ATP + fumiquinazoline F-indoline-2',3'-diol → H₂O + H⁺ + diphosphate + AMP + fumiquinazoline A

NAD⁺ + cholate → NADH + H⁺ + 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate

H₂O + 3-hydroxypropanoyl-CoA → coenzyme A + 3-hydroxypropanoate + H⁺

UDP-N-acetyl-α-D-glucosamine + ATP → H⁺ + UDP-N-acetyl-α-D-glucosamine 3'-phosphate + ADP

(-)-secoisolariciresinol + NAD⁺ → NADH + (3R,4R)-3,4-bis(4-hydroxy-3-methoxybenzyl)tetrahydro-2-furanol + H⁺

prenyl diphosphate + phlorisovalerophenone → 4-prenylphlorisovalerophenone + H⁺ + diphosphate

S-adenosyl-L-methionine + 1-(3,4-dihydroxyphenyl)-5-hydroxy-3-decanone → S-adenosyl-L-homocysteine + 6-gingerol + H⁺

L-phenylalanine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-phenylalanine + H⁺ + diphosphate + AMP

2 Fe²⁺ + 4 H₂O + oxygen → 2 [FeO(OH)] monomer + 4 H⁺ + hydrogen peroxide

2,3-seco-dopa → H₂O + (4Z)-4-[(2E)-3-carboxylato-3-hydroxyprop-2-en-1-ylidene]-3,4-dihydro-2H-pyrrole-2-carboxylate + H⁺

(S)-3-hydroxy-isobutanoyl-CoA + H₂O → coenzyme A + H⁺ + (S)-3-hydroxy-isobutanoate

2 an oxidized electron donor + 2 H₂O + acetyl-CoA → 2 a reduced electron donor + coenzyme A + glyoxylate + H⁺

2 H₂O + CDP-glycerol → 2 H⁺ + cytidine + phosphate + sn-glycerol 3-phosphate

H₂O + UDP-α-D-kanosamine → H⁺ + UDP + kanosamine

H₂O + 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate → (1Z,3Z)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate + methanol + H⁺

NAD⁺ + (S)-3-hydroxytetradecanoyl-CoA → NADH + H⁺ + 3-oxo-myristoyl-CoA

H₂O + 3-oxo-myristoyl-CoA → coenzyme A + H⁺ + 3-oxo-myristate

D-myo-inositol (3,4,6)-trisphosphate + ATP → 2 H⁺ + D-myo-inositol (3,4,5,6)-tetrakisphosphate + ADP

glutathione + 2-bromo-3-(4-nitrophenyl)propanoate → H⁺ + 2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoate + bromide

NADP⁺ + 22-hydroxy-docosanoyl-CoA → NADPH + 22-oxo-docosanoyl-CoA + H⁺

2'-deoxyadenosine + hydroxyl radical → 2-oxo-2'-deoxyadenosine + H⁺

4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl--D-galactosamine 6-sulfate + H₂O → 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + H⁺ + sulfate

D-ribulose + ATP → D-ribulose 1-phosphate + H⁺ + ADP

sinapoyl-CoA + tyramine → coenzyme A + H⁺ + sinapoyltyramine

S-adenosyl-L-methionine + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin 3'-O-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,2',4'-pentamethylquercetagetin 3'-O-β-D-glucoside

4-hydroxy-L-threonine + ATP → 4-phosphooxy-L-threonine + H⁺ + ADP

NAD⁺ + 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a → NADH + H⁺ + bacteriochlorophyllide a

S-adenosyl 3-(methylsulfanyl)propylamine + cadaverine → S-methyl-5'-thioadenosine + aminopropylcadaverine + H⁺

3-[(2'-methylsulfanyl)ethyl]malate + NAD⁺ → NADH + H⁺ + 2-[2-(methylsulfanyl)ethyl]-3-oxobutanedioate

NADP⁺ + L-serine → 2 H⁺ + 2-aminomalonate semialdehyde + NADPH

propane-1,3-diamine + acetyl-CoA → coenzyme A + N-(3-aminopropyl)acetamide + H⁺

S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-α-L-rhamnosyl)-tetracenomycin C → S-adenosyl-L-homocysteine + H⁺ + 12-demethyl-elloramycin

carboxyphosphate + ammonium → 2 H⁺ + carbamate + phosphate

cefoperazone + H₂O + ATP → cefoperazone + H⁺ + phosphate + ADP

N-acetyl-L-aspartate + L-glutamate + ATP → N-acetyl-α-L-aspartyl-L-glutamate + H⁺ + phosphate + ADP

dTDP-β-L-rhamnose + K-252c → H⁺ + K252d + dTDP

H₂O + neocarratetraose 4-O-disulfate → neocarratetraose 4-O-sulfate + H⁺ + sulfate

H₂O + (Z)-2-methylureidoacrylate peracid → (Z)-2-methyl-peroxyaminoacrylate + H⁺ + carbamate

2 glutathione + L-dehydro-ascorbate → L-ascorbate + H⁺ + glutathione disulfide

α-D-ribofuranose + ATP → H⁺ + α-D-ribose 5-phosphate + ADP

(-)-cyclopenine → methyl isocyanate + H⁺ + viridicatin

phosphate + GDP-β-L-galactose → H⁺ + GDP + β-L-galactose 1-phosphate

S-adenosyl-L-methionine + 2-demethylmenaquinone-8 → menaquinone-8 + S-adenosyl-L-homocysteine + H⁺

(1R,2R,4S)-limonene-1,2-diol + NAD⁺ → (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H⁺

norbelladine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + H⁺

5-chlorocarbonyl-4-hydroxy-penta-2,4-dienate + H₂O → 2-maleylacetate + H⁺ + chloride

L-gluconate + NAD⁺ → 5-dehydro-L-gluconate + NADH + H⁺

L-ribulose + ATP → L-ribulose 5-phosphate + H⁺ + ADP

S-adenosyl-L-methionine + mycinamicin III → S-adenosyl-L-homocysteine + H⁺ + mycinamicin IV

2,4'-dihydroxyacetophenone + oxygen → 2 H⁺ + formate + 4-hydroxybenzoate

H₂O + 2-oxoethyl-CoM + NAD⁺ → 2 H⁺ + NADH + 2-carboxyethyl-CoM

FMNH₂ + (1S)-bornane-2,5-dione + oxygen → FMN + H₂O + (-)-5-oxo-1,2-campholide + H⁺

NADP⁺ + deoxycholate → NADPH + H⁺ + 3-dehydrodeoxycholate

H₂O + dGTP → H⁺ + diphosphate + dGMP

H₂O + dCDP → H⁺ + phosphate + dCMP

3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dimethoxytoluene + H⁺

L-serine → H₂O + H⁺ + 2-aminoprop-2-enoate

glycine + benzoyl-CoA → coenzyme A + hippurate + H⁺

H₂O + 6-(methylsulfanyl)-2-oxohexanoate + acetyl-CoA → coenzyme A + 2-[(4'-methylsulfanyl)butyl]malate + H⁺

luteolin + UDP-α-D-glucose → isoorientin + H⁺ + UDP

H₂O + NADP⁺ + D-glyceraldehyde 3-phosphate → 2 H⁺ + NADPH + 3-phospho-D-glycerate

5-chloro-5-deoxy-D-ribose + NAD⁺ → 5-chloro-5-deoxy-D-ribono-γ-lactone + NADH + H⁺

H⁺ + glutathione disulfide + sulfite + AMP ← 2 glutathione + adenosine 5'-phosphosulfate

benzyladenine + UDP-α-D-glucose → H⁺ + benzyladenine-7-N-glucoside + UDP

3'-hydroxy-N-methyl-(S)-coclaurine + S-adenosyl-L-methionine → (S)-reticuline + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 3-hexaprenyl-4-amino-5-hydroxybenzoate → S-adenosyl-L-homocysteine + H⁺ + 3-hexaprenyl-4-amino-5-methoxybenzoate

H₂O + S-adenosyl-L-methionine + precorrin-5 → acetate + S-adenosyl-L-homocysteine + precorrin-6A + H⁺

S-adenosyl-L-methionine + 8-hydroxy-7-methoxy-flavone → S-adenosyl-L-homocysteine + H⁺ + 7,8-dimethoxy-flavone

3-O-methylgallate + oxygen → 2-pyrone-4,6-dicarboxylate + methanol + H⁺

S-adenosyl-L-methionine + C34-phenolphthiotriol A → S-adenosyl-L-homocysteine + C35-phenolphthiocerol A + H⁺

N-acetyl-α-D-galactosaminyl-(1→6)-N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucuronate → β-D-glucuronosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→6)-N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

3-dehydroshikimate + NADP⁺ → NADPH + 3,5-didehydroshikimate + H⁺

H₂O + NAD(P)+ + 2,5-diaminohexanoate → NAD(P)H + 2-amino-5-oxohexanoate + H⁺ + ammonium

glycine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + sarcosine + H⁺

GDP-α-D-mannose + β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol → α-D-Man-(1→3)-β-D-Glc-(1→4)-α-D-Glc-1-diphospho-ditrans,octacis-undecaprenol + H⁺ + GDP

2 trans-4-hydroxy-L-proline + oxygen → 2 H₂O + 2 (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + 2 H⁺

2 NAD⁺ + GDP-α-D-mannose + H₂O → 2 NADH + 3 H⁺ + GDP-α-D-mannuronate

(-)-isodihydrocarveol + NAD⁺ → NADH + H⁺ + (-)-isodihydrocarvone

deacetylmycothiol + acetyl-CoA → coenzyme A + mycothiol + H⁺

S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-α-L-rhamnosyl)-tetracenomycin C → S-adenosyl-L-homocysteine + H⁺ + 8-demethyl-8-(2,3-O-dimethyl-α-L-rhamnosyl)-tetracenomycin C

H₂O + S-adenosyl-L-methionine + (3¹R)-8,12-diethyl-7¹-hydroxybacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8,12-diethyl-7¹,7¹-dihydroxybacteriochlorophyllide c

H₂O + 4-sulfophenyl acetate → acetate + 4-sulfophenol + H⁺

myo-inositol + UDP-α-D-galactose → H⁺ + galactinol + UDP

an oxidized electron donor + H₂O + 4-guanidinobutyraldehyde → 4-guanidinobutanoate + a reduced electron donor + H⁺

L-tyrosine + L-arginine + ATP → L-tyrosyl-L-arginine + H⁺ + diphosphate + AMP

tylactone + dTDP-α-D-mycaminose → 5-O-β-mycaminosyltylactone + H⁺ + dTDP

oxidized coenzyme F₄₂₀-0 + L-glutamate + GTP → oxidized coenzyme F₄₂₀-1 + H⁺ + phosphate + GDP

2-oleoylglycerol + CTP → H⁺ + 1-oleoyl-sn-glycerol 3-phosphate + CDP

5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + oxygen → 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H⁺

N³-decanoyl-N³-hydroxy-1,3-diaminopropane + ATP + citrate → N¹-citryl-N³-decanoyl-N³-hydroxy-1,3-diaminopropane + H⁺ + diphosphate + AMP

O-acetyl-L-homoserine + methanethiol → acetate + H⁺ + L-methionine

3'-phosphoadenylyl-sulfate + 4-(methylsulfanyl)butyl-desulfoglucosinolate → adenosine 3',5'-bisphosphate + 4-(methylsulfanyl)butyl-glucosinolate + H⁺

S-adenosyl-L-methionine + demethylmenaquinol-6 → S-adenosyl-L-homocysteine + menaquinol-6 + H⁺

trichloromethanethiol → H⁺ + thiophosgene + chloride

myricetin 3-O-β-D-glucoside + UDP-α-D-glucose → H⁺ + myricetin 3-O-gentiobioside + UDP

2 H⁺ + Ni-sirohydrochlorin ← Ni²⁺ + sirohydrochlorin

NAD⁺ + (+)-(αS,βS)-guaiacylglycerol-β-guaiacyl ether → NADH + (2S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one + H⁺

S-adenosyl-L-methionine + 3,7-dimethylquercetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,4'-trimethylquercetin

dihydroprecondylocarpine acetate (enamine form) → acetate + dehydrosecodine + H⁺

NAD⁺ + 5-chlorobenzoate-cis-3,4-diol → 5-chloroprotocatechuate + NADH + H⁺

H₂O + N-(2,3-dihydroxybenzoyl)-L-serine dimer → 2 N-(2,3-dihydroxybenzoyl)-L-serine + H⁺

quercetin 3-O-sophoroside + UDP-β-L-rhamnose → H⁺ + quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP

H₂O + iminodiacetate → 2 H⁺ + glycine + glyoxylate

1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate → 2-demethylmenaquinone-8 + H⁺ + diphosphate + CO₂

3β-hydroxy-9β-pimara-7,15-diene-19,6β-olide + NAD(P)+ → momilactone A + NAD(P)H + H⁺

N-hydroxyl-tryptamine → 2 H⁺ + (E)-(indol-3-yl)acetaldehyde oxime

2 ATP + H₂O + acetophenone + hydrogencarbonate → 2 H⁺ + 2 phosphate + 2 ADP + 3-oxo-3-phenylpropanoate

trans-permethrin + H₂O → (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxlate + H⁺

2 H₂O + limonin → 2 H⁺ + limonoate

H₂O + (3E,5Z)-tetradeca-3,5-dienoyl-CoA → coenzyme A + (3E,5Z)-tetradecadienoate + H⁺

(S)-scoulerine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (S)-2-methylscoulerine + H⁺

S-adenosyl-L-methionine + gentamicin C2 → S-adenosyl-L-homocysteine + H⁺ + gentamicin C1

S-adenosyl-L-methionine + D-histidine → S-methyl-5'-thioadenosine + (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H⁺

S-adenosyl-L-methionine + dTDP-β-L-4-epi-vancosamine → S-adenosyl-L-homocysteine + dTDP-β-L-evernosamine + H⁺

S-adenosyl-L-methionine + 2-demethylmenaquinone-9 → menaquinone-9 + S-adenosyl-L-homocysteine + H⁺

an oxidized electron donor + H₂O + 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate → an oxidized electron donor + 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + a reduced electron donor + H⁺

L-dopa + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-O-methyldopa

butein + UDP-α-D-glucose → butein 4'-β-D-glucoside + H⁺ + UDP

D-glycero-α-D-manno-heptose 7-phosphate + ATP → D-glycero-α-D-manno-heptose 1,7-bisphosphate + H⁺ + ADP

psilocin + ATP → psilocybin + H⁺ + ADP

3,5,7-trioxododecanoyl-CoA → coenzyme A + olivetolate + H⁺

H₂O + 4-O-oxalyl-L-threonate → L-threonate + H⁺ + oxalate

quercetin + UDP-β-L-rhamnose → H⁺ + quercetin 3-O-rhamnoside + UDP

L-2,3-diaminopropanoate + ATP + citrate → 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H⁺ + diphosphate + AMP

H₂O + 2-oxo-3-(5-oxofuran-2-ylidene)propanoate → H⁺ + 3-maleylpyruvate

2-hydroxy-dATP + H₂O → 2-hydroxy-dAMP + H⁺ + diphosphate

L-leucine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-leucine + H⁺ + diphosphate + AMP

dopaquinone → H⁺ + leucodopachrome

desferrioxamine G₁ + ATP → desferrioxamine E + H⁺ + diphosphate + AMP

H₂O + testololactone → testolate + H⁺

D-sorbitol 6-phosphate + NAD⁺ → NADH + β-D-fructofuranose 6-phosphate + H⁺

H₂O + oleoyl-CoA → coenzyme A + oleate + H⁺

dTDP-D-desosamine + protomycinolide IV → H⁺ + mycinamicin VIII + dTDP

O-citryl-ethanolamine + L-2,4-diaminobutanoate + ATP → diaminobutyryl-citryl-ethanolamine + H⁺ + diphosphate + AMP

FADH₂ + 2,5-dichloro-p-quinol + oxygen → 3 H⁺ + FAD + H₂O + 5-chlorohydroxyquinone + chloride

H₂O + atropine → tropine + tropate + H⁺

H₂O + 2-carboxy-L-xylonolactone → 2-carboxy-L-threo-pentonate + H⁺

H₂O + 2-hydroxy-2-methylpropanal + NAD⁺ → 2 H⁺ + NADH + 2-hydroxy-2-methylpropanoate

S-adenosyl-L-methionine + 1,6-didemethyltoxoflavin → S-adenosyl-L-homocysteine + 6-demethyltoxoflavin + H⁺

H₂O + 1-18:1-2-18:1-phosphatidylethanolamine → oleate + H⁺ + 1-(oleoyl)-sn-glycero-3-phosphoethanolamine

S-adenosyl-L-methionine + laricitrin → S-adenosyl-L-homocysteine + H⁺ + 3',4'-dimethylmyricetin

an oxidized electron donor + phenol + H⁺ + chloride ← a reduced electron donor + 2-chlorophenol

NAD⁺ + 1-deoxy-11β-hydroxypentalenate → NADH + H⁺ + 1-deoxy-11-oxopentalenate

H₂O + 2-nitroimidazole → H⁺ + 1,3-dihydro-2H-imidazol-2-one + nitrite

S-adenosyl-L-methionine + noraucuparin → S-adenosyl-L-homocysteine + aucuparin + H⁺

D-myo-inositol (1,4,5)-trisphosphate + ATP → 2 H⁺ + D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP

5-chlorocarbonyl-2-hydroxy-penta-2,4-dienate + H₂O → 2 H⁺ + (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + chloride

3'-phosphoadenylyl-sulfate + (22R,23R)-28-homobrassinolide → (22R,23R)-28-homobrassinolide 22-sulfate + adenosine 3',5'-bisphosphate + H⁺

3 cadaverine + 4 pyruvate → 3 H₂O + 4 L-alanine + 17-oxosparteine + H⁺

enterobactin + UDP-α-D-glucose → monoglucosyl-enterobactin + H⁺ + UDP

S-adenosyl-L-methionine + precorrin-3B → 2 H⁺ + S-adenosyl-L-homocysteine + precorrin-4

O-acetyl-L-serine + pyrazole → acetate + 3-(pyrazol-1-yl)-L-alanine + H⁺

kaempferide 3-O-glucoside + UDP-β-L-rhamnose → H⁺ + kaempferide 3-O-β-D-glucopyranosyl -(1->2)-O-α-L-rhamnoside + UDP

3,6,7-trimethylquercetagetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,4'-tetramethylquercetagetin

pyridoxine + UDP-α-D-glucose → 5'-O-β-D-glucosylpyridoxine + H⁺ + UDP

soyasapogenol E + UDP-α-D-glucuronate → soyasapogenol E 3-O-β-glucuronate + H⁺ + UDP

L-cysteine + oxygen → 3-sulfino-L-alanine + H⁺

glutathionylspermidine + glutathione + ATP → H⁺ + trypanothione + phosphate + ADP

(-)-catechin + S-adenosyl-L-methionine → (-)-3'-methylcatechin + S-adenosyl-L-homocysteine + H⁺

D-erythro-sphinganine + ATP → sphinganine 1-phosphate + H⁺ + ADP

H₂O + S-formylbacillithiol → bacillithiol + formate + H⁺

1D-myo-inositol 3-monophosphate + UDP-N-acetyl-α-D-glucosamine → 1-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + H⁺ + UDP

dopamine quinone + a reduced electron donor → an oxidized electron donor + H⁺ + 2-descarboxy-cyclo-dopa

S-adenosyl-L-methionine + 3-(all-trans-decaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 6-(all-trans-decaprenyl)-2-methoxy-phenol

L-serine + ATP → 3-phospho-L-serine + H⁺ + ADP

2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-D-ravidosamine

2 anthranilate + 3 ATP + L-tryptophan → 3 diphosphate + 3 AMP + H₂O + H⁺ + asperlicin D

2 anthranilate + 3 ATP + L-tryptophan → 3 diphosphate + 3 AMP + H₂O + H⁺ + asperlicin C

geranylgeraniol + ATP → H⁺ + all-trans-geranyl-geranyl monophosphate + ADP

S-adenosyl-L-methionine + columbamine → palmatine + S-adenosyl-L-homocysteine + H⁺

H₂O + 4-[(2-hydroxyethoxy)carbonyl]benzoate → terephthalate + ethylene glycol + H⁺

glycine + ATP + γ-L-glutamyl-L-cysteine → H⁺ + glutathione + phosphate + ADP

formononetin + UDP-α-D-glucose → H⁺ + ononin + UDP

NADP⁺ + lithocholate → 3-dehydrolithocholate + NADPH + H⁺

3 glycine + 3 N⁵-acetyl-N⁵-hydroxy-L-ornithine + 3 ATP + Fe³⁺ → 3 H₂O + 3 diphosphate + 3 AMP + 6 H⁺ + ferrichrome

1-hydroxychlorobactene + UDP-α-D-glucose → hydroxychlorobactene glucoside + H⁺ + UDP

UDP-α-D-glucose + N-(4-hydroxy-1H-indol-3-yl)formamide → H⁺ + 4-O-β-D-glucosyl-indol-3-yl formamide + UDP

1,3,6,8-naphthalenetetrol + oxygen → H₂O + H⁺ + flaviolin

H₂O + glucotropaeolin → 2-benzyl-thiohydroximate-O-sulfate + H⁺ + β-D-glucopyranose

D-glucaro-1,4-lactone → 5-dehydro-4-deoxy-D-glucarate + H⁺

bis(β-D-glucosyl) crocetin + UDP-α-D-glucose → H⁺ + β-D-gentiobiosyl β-D-glucosyl crocetin + UDP

1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione + UDP-α-D-glucose → 3-C-glucosyl-2,4,4',6-tetrahydroxydibenzoylmethane + H⁺ + UDP

2 ATP + anthranilate + S-adenosyl-L-methionine + L-phenylalanine → 2 H⁺ + 2 diphosphate + 2 AMP + S-adenosyl-L-homocysteine + cyclopeptine

paromamine + UDP-α-D-kanosamine → H⁺ + kanamycin C + UDP

FMNH₂ + EDTA + oxygen → FMN + H₂O + ethylenediaminetriacetate + glyoxylate + H⁺

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H₂O → 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H⁺ + phosphate

S-adenosyl-L-methionine + (-)-matairesinol → S-adenosyl-L-homocysteine + arctigenin + H⁺

GDP-2-acetamido-2-deoxy-β-mannuronate + 2,3-diacetamido-2,3-dideoxy-β-D-uronateglucosyl-(1→3)-N-acetyl-α-D-glucosaminyl-(C55 ω-saturated dolichyl phosphate) → H⁺ + GDP + 2-acetamido-2-deoxy-β-uronatemannosyl-(β1→4)-2,3-diacetamido-2,3-dideoxy-β-D-uronateglucosyl-(1→3)-N-acetyl-α-D-glucosaminyl-(C55 ω-saturated dolichyl phosphate)

oleanolate 3-beta-D-glucuronoside-(3,1)-galactoside-28-glucoside + UDP-α-D-glucose → oleanolate-3-beta-D-glucuronoside-(3,1)-galactoside-(4,1)-glucoside-28-glucoside + H⁺ + UDP

acetyl-CoA + L-methionine → coenzyme A + N-acetyl-L-methionine + H⁺

UDP-α-D-glucose + (S)-4-hydroxymandelonitrile → dhurrin + H⁺ + UDP

H₂O + cyclohexane-1-carbonyl-CoA → coenzyme A + cyclohexane-1-carboxylate + H⁺

N⁶-(D-fructosyl)-L-lysine + ATP → N⁶-(6-phospho-D-fructosyl)-L-lysine + H⁺ + ADP

demycosaminyl-candicidin III + GDP-mycosamine → H⁺ + candicidin III + GDP

ammonium + L-glutamate + ATP → H⁺ + L-glutamine + phosphate + ADP

3'-phosphoadenylyl-sulfate + estrone → estrone 3-sulfate + adenosine 3',5'-bisphosphate + H⁺

H₂O + (2E,4E)-2-amino-5-chloro-6-oxohexa-2,4-dienoate + NAD⁺ → 2 H⁺ + (2E,4E)-2-amino-5-chlorohexa-2,4-dienedioate + NADH

5-chloro-trans-dienelactone + H₂O → 5-chloromaleylacetate + H⁺

O-[5-(hydroxynitroso)-3-(oxidonitroso)-2-oxocyclohexylidenenitroso]oxidanidolate → O-[5-(oxidonitroso)-4-oxocyclohex-2-en-1-ylidenenitroso]oxidanidolate + H⁺ + nitrite

H₂O + 8-oxo-GDP → H⁺ + phosphate + 8-oxo-GMP

UDP-α-D-glucose + luteolin 7-O-β-D-glucoside → H⁺ + UDP + luteolin-7-O-gentiobioside

GDP-α-D-glucose + α-D-glucose 6-phosphate → H⁺ + α,α-trehalose 6-phosphate + GDP

H₂O + acetaldehyde + oxygen → acetate + hydrogen peroxide + H⁺

H₂O + NAD⁺ + (3S,5S)-3,5-diaminohexanoate → NADH + (S)-5-amino-3-oxohexanoate + H⁺ + ammonium

α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP-3-deoxy-β-D-manno-octulosonate → α-Kdo-(2->4)-α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP + H⁺

coenzyme A + H⁺ + cis-vaccenate + ATP → H⁺ + cis-vaccenoyl-CoA + diphosphate + AMP

NADPH + tetrahydrogeranylgeranyl bacteriopheophytin + H⁺ ← bacteriopheophytin a + NADP⁺

H₂O + parathion → 2 H⁺ + diethylthiophosphate + 4-nitrophenol

NAD(P)+ + dimeric 9-hydroxyrubrofusarin-fuscofusarin → NAD(P)H + H⁺ + aurofusarin

H₂O + oxythiamine → H⁺ + 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone

H₂O + oxygen + 3-sulfocatechol → 3 H⁺ + (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + sulfite

S-adenosyl-L-methionine + pilosin → S-adenosyl-L-homocysteine + H⁺ + nevadensin

solasodine + UDP-α-D-glucose → solasodine 3-O-β-D-glucoside + H⁺ + UDP

H₂O + fluoroacetaldehyde + NAD⁺ → 2 H⁺ + fluoroacetate + NADH

α-D-ribose-1-phosphate + ADP → α-D-ribose 1,5-bisphosphate + H⁺ + AMP

GDP-α-D-mannose + 2-O-(β-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate → H⁺ + 2-O-(β-D-mannosyl-(1→2)-O-β-D-mannosyl)-bis(-myo-inositol) 1,3'-phosphate + GDP

(3S,5R)-carbapenam → 2 H⁺ + (5R)-carbapen-2-em-3-carboxylate

N-demethylindolmycin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + indolmycin

3-O-methylgallate + oxygen → H⁺ + 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate

8-demethylnovobiocic acid + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + novobiocic acid + H⁺

S-adenosyl-L-methionine + patuletin → S-adenosyl-L-homocysteine + H⁺ + eupatolitin

kaempferol 3-O-β-D-glucoside + UDP-α-D-glucose → H⁺ + kaempferol 3-O-β-D-glucosyl-(1->2)-β-D-glucoside + UDP

L-homoserine → H₂O + H⁺ + (2Z)-2-aminobut-2-enoate

acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-idosamine → coenzyme A + H⁺ + UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-idopyranose

pre-putrebactin + ATP → putrebactin + H⁺ + diphosphate + AMP

H₂O + 3-hydroxy-4-methyl-D-kynurenine → 3-hydroxy-4-methylanthranilate + H⁺ + L-alanine

2-phenylethanol + UDP-α-D-glucose → H⁺ + 2-phenylethyl β-D-glucopyranoside + UDP

acetylacetone + oxygen → acetate + H⁺ + methylglyoxal

2 ATP + L-tryptophan + L-proline → 2 H⁺ + 2 phosphate + 2 ADP + brevianamide F

GDP-α-D-mannose + β-D-GlcA-(1→2)-α-D-Man-(1→3)-β-D-Glc-(1→4)-α-D-Glc-1-diphospho-ditrans,octacis-undecaprenol → D-Man-β-(1→4)-GlcA-β-(1→2)-D-Man-α-(1→3)-D-Glc-β-(1→4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol + H⁺ + GDP

pyrogallol + oxygen → 2 H⁺ + (2Z,4E)-2-hydroxyhexa-2,4-dienedioate

3'-phosphoadenylyl-sulfate + (22R,23R)-28-homocastasterone → (22R,23R)-28-homocastasterone 22-O-sulfate + adenosine 3',5'-bisphosphate + H⁺

2 H₂O + GTP → 2 H⁺ + 2 phosphate + GMP

oleanolate 3 β-D-glucuronoside + UDP-α-D-galactose → oleanolate 3-beta-D-glucuronoside-(3,1)-galactoside + H⁺ + UDP

Co²⁺ + precorrin-2 → 4 H⁺ + cobalt-precorrin-2

NAD⁺ + galactitol → NADH + keto-D-tagatose + H⁺

NAD⁺ + D-altritol → NADH + keto-D-tagatose + H⁺

H₂O + 3,4-dihydroxyphenylglycolaldehyde + NAD⁺ → 2 H⁺ + NADH + 3,4-dihydroxymandelate

soyasapogenol B + UDP-α-D-glucose → soyasapogenol B-22-O-β-D-glucoside + H⁺ + UDP

demethyllactenocin + dTDP-β-L-mycarose → demethylmacrocin + H⁺ + dTDP

4-hydroxybenzoate + UDP-α-D-glucose → 4-(β-D-glucosyloxy)benzoate + H⁺ + UDP

3-methylcrotonyl-CoA + hydrogencarbonate + ATP → H⁺ + 3-methylglutaconyl-CoA + phosphate + ADP

2'-deoxymugineate + 2-oxoglutarate + oxygen → 3-epihydroxy-2'-deoxymugineate + H⁺ + succinate + CO₂

FADH₂ + (3Z,5S,6E,8E,10E)-1-aminododeca-3,6,8,10-tetraen-5-ol + oxygen → FAD + H₂O + (1E,3S,4Z)-7-amino-1-{3-[(1E)-prop-1-en-1-yl]oxiran-2-yl}hepta-1,4-dien-3-ol + H⁺

H₂O + 3-hydroxypropanal + NAD(P)+ → 2 H⁺ + NAD(P)H + 3-hydroxypropanoate

H₂O + 8-oxo-GTP → H⁺ + diphosphate + 8-oxo-GMP

N¹-citryl-N³-dec-2-enoyl-N³-hydroxy-1,3-diaminopropane + L-2,4-diaminobutanoate + ATP → N⁵-2,4-diaminobutanoate-N¹-citryl-N³-dec-2-enoyl-N³-hydroxy-1,3-diaminopropane + H⁺ + diphosphate + AMP

H₂O + histidinal + NAD⁺ → 2 H⁺ + NADH + L-histidine

H₂O + L-methionine-(R)-S-oxide + ATP → L-methionine-(R)-S-oxide + H⁺ + phosphate + ADP

H₂O + (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate → 2-oxopent-4-enoate + H⁺ + succinate

L-idonate + NADP⁺ → 5-dehydro-D-gluconate + NADPH + H⁺

H₂O + (2E)-2-methyl-4,6-dioxohept-2-enedioate → citraconate + pyruvate + H⁺

UDP-α-D-glucose + kaempferol → H⁺ + kaempferol 7-O-glucoside + UDP

H₂O + protoheme + ATP → H⁺ + phosphate + protoheme + ADP

α-ribazole 5'-phosphate + adenosylcobinamide-GDP → adenosylcobalamin 5'-phosphate + H⁺ + GMP

(2E,6E)-farnesol + ATP → H⁺ + (2E,6E)-farnesyl phosphate + ADP

S-adenosyl-L-methionine + L-leucyl-demethylarginomycin → S-adenosyl-L-homocysteine + H⁺ + L-leucyl-arginomycin

S-adenosyl-L-methionine + 2-(2,4-dihydroxy-6-methylbenzoyl)benzene-1,3,5-triol → S-adenosyl-L-homocysteine + H⁺ + griseophenone D

ginsenoside C-K + UDP-α-D-glucose → ginsenoside F2 + H⁺ + UDP

S-adenosyl-L-methionine + (indol-3-yl)pyruvate → S-adenosyl-L-homocysteine + H⁺ + (R)-3-(indol-3-yl)-2-oxobutanoate

hydrogen peroxide + melatonin → 2 H⁺ + N¹-acetyl-N²-formyl-5-methoxykynuramine

2,4',5,7-tetrahydroxyisoflavanone + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + 2,5,7-trihydroxy-4'-methoxyisoflavanone

4-methylgentisate + oxygen → (2E)-3-methyl-4,6-dioxohept-2-enedioate + H⁺

NADPH + geranylgeranyl bacteriopheophytin + H⁺ ← dihydrogeranylgeranyl bacteriopheophytin + NADP⁺

H₂O + all-trans-retinyl palmitate → all-trans-retinol + palmitate + H⁺

dammarenediol II + UDP-α-D-glucose → (20S)-20-O-β-(D-glucosyl)-3-hydroxydammarene + H⁺ + UDP

erythromycin C + dTDP-L-megosamine → H⁺ + megalomicin A + dTDP

3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate

2 N-hydroxy-N-succinylcadaverine + N-hydroxy-N-acetylcadaverine + ATP → H₂O + desferrioxamine B + H⁺ + diphosphate + AMP

NAD⁺ + (S)-3-hydroxy-isobutanoate → NADH + H⁺ + (S)-methylmalonate-semialdehyde

L-2-amino-8-hydroxydecanoate + NADP⁺ → NADPH + L-2-amino-8-oxodecanoate + H⁺

H₂O + D-myo-inositol 1,2-cyclic phosphate → 1D-myo-inositol 1-monophosphate + H⁺

3,5,3'-triiodo-L-thyronine + UDP-α-D-glucuronate → H⁺ + 3,5,3'-triiodo-L-thyronine phenolic β-D-glucuronide + UDP

FADH₂ + 3,5,6-trichloro-2-pyridinol + oxygen → 2 H⁺ + FAD + H₂O + 3,6-dichloropyridine-2,5-dione + chloride

2 H₂O + D-glucurono-6,3-lactone + NAD⁺ → 3 H⁺ + NADH + D-glucarate

D-galactaro-1,4-lactone → 5-dehydro-4-deoxy-D-glucarate + H⁺

(2S)-3-sulfopropanediol + NADP⁺ → 1-hydroxy-2-oxo-3-sulfopropane + NADPH + H⁺

3'-dephospho-CoA + ATP → coenzyme A + H⁺ + ADP

β-alanine + (R)-pantoate + ATP → (R)-pantothenate + H⁺ + diphosphate + AMP

2,3,5,6-tetrachlorohydroquinone + NAD⁺ + H⁺ ← NADH + 2,3,5,6-tetrachloro-1,4-benzoquinone

1-deoxy-D-xylulose + ATP → H⁺ + ADP + 1-deoxy-D-xylulose 5-phosphate

NADP⁺ + (6E)-8-hydroxygeraniol → NADPH + H⁺ + (6E)-8-hydroxygeranial

O-acetyl-L-homoserine + L-cysteine → acetate + H⁺ + L-cystathionine

protopanaxatriol + UDP-α-D-glucose → ginsenoside F1 + H⁺ + UDP

2 a peptidoglycan dimer (E. faecium, tetrapeptide) + 3 H₂O → 4 D-alanine + a peptidoglycan tetramer with an L,D cross-link (Enterococcus faecium) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

4,5-seco-dopa → H₂O + H⁺ + betalamate

S-adenosyl-L-methionine + demethylphylloquinol → phylloquinol + S-adenosyl-L-homocysteine + H⁺

L-isoleucine + (-)-jasmonate + ATP → H⁺ + (+)-7-epi-jasmonoyl-L-isoleucine + diphosphate + AMP

a reduced electron donor + cadaverine + oxygen → an oxidized electron donor + H₂O + N-hydroxycadaverine + H⁺

H₂O + carbamoyl phosphate + kanamycin B + ATP → H⁺ + diphosphate + phosphate + 6''-O-carbamoylkanamycin B + AMP

H₂O + XTP → H⁺ + phosphate + XDP

2 H₂O + 2,3-epoxy-2,3-dihydrobenzoyl-CoA → formate + cis-3,4-dehydroadipyl-CoA semialdehyde + H⁺

3,4,6-trichlorocatechol + oxygen → 2,3,5-trichloro-cis,cis-muconate + H⁺

2-amino-5-oxohexanoate → H₂O + H⁺ + 1-pyrroline-2-methyl-5-carboxylate

L-tyrosine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-tyrosine + H⁺ + diphosphate + AMP

GDP-α-D-mannose + (R)-glycerate → H⁺ + 2-O-(α-D-mannosyl)-D-glycerate + GDP

2 H₂O + dUTP → 2 H⁺ + 2 phosphate + dUMP

glutathione + thiosulfate → H⁺ + S-sulfanylglutathione + sulfite

NAD⁺ + (-)-(αR,βR)-guaiacylglycerol-β-guaiacyl ether → NADH + (2R)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one + H⁺

H₂O + cyclic di-3',5'-adenylate → H⁺ + 5'-O-phosphonoadenylyl-(3'→5')-adenosine

(S)-dihydroorotate + NAD⁺ → orotate + NADH + H⁺

(R)-mevalonate 3-phosphate + ATP → (R)-3,5-bisphosphomevalonate + H⁺ + ADP

S-adenosyl-L-methionine + tyramine → S-adenosyl-L-homocysteine + N-methyltyramine + H⁺

L-glutamate + 4-hydroxybenzoate + ATP → H⁺ + diphosphate + AMP + N-(4-hydroxybenzoyl)-L-glutamate

3 ATP + anthranilate + L-tryptophan + L-alanine → 2 H⁺ + 3 diphosphate + 3 AMP + H₂O + fumiquinazoline F

N⁵-2,4-diaminobutanoate-N¹-citryl-N³-dec-2-enoyl-N³-hydroxy-1,3-diaminopropane + 2-oxoglutarate + ATP → baumannoferrin A + H⁺ + diphosphate + AMP

H₂O + methyl parathion → 2 H⁺ + 4-nitrophenol + dimethylthiophosphate

3-methylcatechol + oxygen → (2E,4Z)-2-hydroxy-6-oxohepta-2,4-dienoate + H⁺

ADP-α-D-glucose + α-D-glucose 6-phosphate → H⁺ + α,α-trehalose 6-phosphate + ADP

curcumin + UDP-α-D-glucose → curcumin monoglucoside + H⁺ + UDP

S-adenosyl-L-methionine + luteolin → S-adenosyl-L-homocysteine + H⁺ + chrysoeriol

S-adenosyl-L-methionine + cycloartenol → S-adenosyl-L-homocysteine + (24R)-24-methylcycloarta-25-en-3-β-ol + H⁺

H₂O + Fe³⁺-[diglucosyl-enterobactin] complex → H⁺ + Fe³⁺-[salmochelin S2] complex

β-D-glucose 6-phosphate + NADP⁺ → 6-phospho D-glucono-1,5-lactone + NADPH + H⁺

S-adenosyl-L-methionine + 2'-hydroxy 3,7,4'-trimethylquercetin → S-adenosyl-L-homocysteine + H⁺ + 2'-hydroxy 3,7,3',4'-tetramethylquercetin

β-D-fructofuranose 6-phosphate + ATP → β-D-fructose 2,6-bisphosphate + H⁺ + ADP

esculetin + UDP-α-D-glucose → H⁺ + esculin + UDP

inosine + ATP → H⁺ + IMP + ADP

UDP-α-D-glucose + betanidin → H⁺ + UDP + betanin

NADPH + S-adenosyl-L-methionine + L-tyrosine → 2-iminoacetate + NADP⁺ + H⁺ + 5'-deoxyadenosine + L-methionine + 4-methylphenol

H₂O + 7,8-dihydroneopterin 3'-triphosphate → 7,8-dihydroneopterin 3'-phosphate + H⁺ + diphosphate

3'-phosphoadenylyl-sulfate + NADPH → adenosine 3',5'-bisphosphate + NADP⁺ + H⁺ + sulfite

3'-phosphoadenylyl-sulfate + α,α-trehalose → 2-O-sulfo-α,α-trehalose + adenosine 3',5'-bisphosphate + H⁺

S-adenosyl-L-methionine + all trans-decaprenyl-2-methoxy-6-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol

H₂O + choline sulfate + ATP → choline sulfate + H⁺ + phosphate + ADP

S-adenosyl-L-methionine + 10-carboxy-3-deoxycarminomycin → S-adenosyl-L-homocysteine + H⁺ + 10-carboxy-13-deoxydaunorubicin

NAD⁺ + (1R,2S)-1,2-dihydronaphthalene-1,2-diol → naphthalene-1,2-diol + NADH + H⁺

methyl chloride + a reduced electron donor → an oxidized electron donor + methane + H⁺ + chloride

decaprenyl-diphospho-N-acetylmuramoyl-pentapeptide + UDP-N-acetyl-α-D-glucosamine → decaprenyl-pyrophosphoryl-(N-acetylglucosamine)-N-acetylmuramyl-(pentapeptide) + H⁺ + UDP

UDP-α-D-xylose + cyanidin-3-O-β-D-galactoside → H⁺ + cyanidin 3-O-(β-D-xylosyl-(1→2)-β-D-galactoside) + UDP

meso-diaminopimelate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ATP → H⁺ + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + phosphate + ADP

acetylcholine + H₂O → acetate + choline + H⁺

α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP-3-deoxy-β-D-manno-octulosonate → α-Kdo-(2->8)-α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP + H⁺

ginsenoside Rd + UDP-α-D-glucose → ginsenoside Rb1 + H⁺ + UDP

dehydroascorbate (bicyclic form) → 2,3-dioxo-L-gulonate + H⁺

dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose → maltol + H⁺ + dTDP

NAD⁺ + (25S)-26-hydroxycholest-4-en-3-one → NADH + H⁺ + (25S)-26-oxocholest-4-en-3-one

H₂O + dichloromethane → 2 H⁺ + 2 chloride + formaldehyde

2 ATP + L-tryptophan + L-histidine → 2 H⁺ + 2 diphosphate + 2 AMP + histidyltryptophyldiketopiperazine

L-cystathionine → L-homocysteine + H⁺ + 2-aminoprop-2-enoate

dTDP-β-D-oliose + premithramycin A1 → H⁺ + dTDP + premithramycin A2

H₂O + imidazole acetaldehyde + NAD⁺ → 2 H⁺ + 4-imidazoleacetate + NADH

gentisate + oxygen → H⁺ + 3-maleylpyruvate

NAD⁺ + 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA → NADH + H⁺ + (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA

S-adenosyl-L-methionine + 1-hydroxyglucobrassicin → S-adenosyl-L-homocysteine + H⁺ + neoglucobrassicin

2 H₂O + ATP → 2 H⁺ + 2 phosphate + AMP

H₂O + NADPH + magnesium-protoporphyrin IX 13-monomethyl ester → 3 H⁺ + NADP⁺ + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

19-O-β-glucopyranosyl-steviol + UDP-α-D-glucose → rubusoside + H⁺ + UDP

N¹-(5-phospho-β-D-ribosyl)glycinamide + formate + ATP → N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide + H⁺ + phosphate + ADP

L-isoleucine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-isoleucine + H⁺ + diphosphate + AMP

NAD⁺ + (-)-trans-isopiperitenol → (-)-isopiperitenone + NADH + H⁺

4-phospho-D-threonate + NAD⁺ → NADH + 3-dehydro-4-phospho-L-erythronate + H⁺

2'-deoxymugineate + 2-oxoglutarate + oxygen → mugineate + H⁺ + succinate + CO₂

H₂O + choline sulfate → choline + H⁺ + sulfate

2-exo-hydroxy-1,8-cineole + NAD⁺ → 6-oxo-1,8-cineole + NADH + H⁺

H₂O + cyclohexane-1,3-dione → 5-oxohexanoate + H⁺

3-methylcatechol + oxygen → 2-hydroxy-6-oxohepta-2,4-dienoate + H⁺

(+)-5-chloromuconolactone → trans-dienelactone + H⁺ + chloride

zeaxanthin + UDP-α-D-glucose → zeaxanthin-β-D-glucoside + H⁺ + UDP

NAD⁺ + pyridoxal → 4-pyridoxolactone + NADH + H⁺

(S)-reticuline → 2 H⁺ + 1,2-dehydroreticuline

ATP + adenosylcobinamide → H⁺ + ADP + adenosyl-cobinamide phosphate

3-methylbenzyl alcohol + NAD⁺ → NADH + 3-methylbenzaldehyde + H⁺

trans-dienelactone + H₂O → 2-maleylacetate + H⁺

L-glutamate + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-glutamate + H⁺ + diphosphate + AMP

L-cysteine → H⁺ + 2-aminoprop-2-enoate + hydrogen sulfide

5-hydroxy-CTP + H₂O → 5-hydroxy-CMP + H⁺ + diphosphate

H₂O + L-glutamine + ATP + UTP → 2 H⁺ + L-glutamate + phosphate + ADP + CTP

oxygen + dihydrosorgoleone → H₂O + H⁺ + sorgoleone

D-myo-inositol (3,4,5,6)-tetrakisphosphate + ATP → 2 H⁺ + D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP

xanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-methylxanthine + H⁺

S-adenosyl-L-methionine + 3,7,3'-trimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,3'-tetramethylquercetagetin

glycerol + ATP → glycerol 2-phosphate + H⁺ + ADP

GDP-α-D-mannose + α-D-mannosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol → α-D-mannosyl-(1→3)-α-D-mannosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + GDP

UDP-α-D-xylose + pelargonidin-3-O-β-D-glucoside → H⁺ + pelargonidin 3-O-β-D-sambubioside + UDP

H₂O + 4-hydroxybenzoate 1-phenylethylidene → H⁺ + acetophenone hydrazone + 4-hydroxybenzoate

H₂O + L-lysine + ATP → H⁺ + L-lysine + phosphate + ADP

lipid IV_A + CMP-8-amino-3,8-dideoxy-α-D-manno-octulosonate → α-Kdo8N-(2→6)-lipid IV_A + CMP + H⁺

D-galactono-1,4-lactone + H₂O → D-galactonate + H⁺

L-aspartate + O-ureido-L-homoserine + ATP → H⁺ + diphosphate + AMP + canavaninosuccinate

apo-4'-lycopenal + H₂O + NAD(P)+ → NADPH + H⁺ + apo-4'-lycopenoate

a reduced electron donor + 3,3',5'-triiodo-L-thyronine → an oxidized electron donor + H⁺ + iodide + 3',5'-diiodothyronine

H₂O + N⁵-phospho-L-glutamine → phosphoramidate + H⁺ + L-glutamate

2 S-adenosyl-L-methionine + H₂O + 12-ethyl-8-isobutylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + 12-ethyl-8-isobutylbacteriochlorophyllide e

2 S-adenosyl-L-methionine + 3-(aminomethyl)indole → 2 S-adenosyl-L-homocysteine + 2 H⁺ + gramine

ppGpp + H₂O → H⁺ + diphosphate + GDP

S-adenosyl-L-methionine + rhamnetin → S-adenosyl-L-homocysteine + H⁺ + 7,3'-dimethylquercetin

NAD⁺ + 12-α-hydroxy-3 oxochol-4-enoate → 12-α-hydroxy-3 oxochola-4,6-dienoate + NADH + H⁺

H₂O + 12α-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA → coenzyme A + 12-α-hydroxy-3 oxochola-4,6-dienoate + H⁺

L-aspartate + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-aspartate + H⁺ + diphosphate + AMP

H₂O + malonyldaidzin → malonate + H⁺ + daidzin

L-ornithine + succinyl-CoA → coenzyme A + N²-succinyl-L-ornithine + H⁺

tylactone + dTDP-D-desosamine → 20-deoxo-20-dihydro-12,13-deepoxyrosamicin + H⁺ + dTDP

2-keto-D-gluconate + ATP → 2-dehydro-6-phospho-D-gluconate + H⁺ + ADP

5-S-cysteinyldopaquinone → 7-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate + H₂O + H⁺

2 monodehydroascorbate radical + NADPH → 2 L-ascorbate + 3 H⁺ + NADP⁺

acetyl-CoA + GDP-4-amino-4,6-dideoxy-α-D-N-acetylglucosamine → GDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose + coenzyme A + H⁺

H₂O + 3-sulfino-L-alanine + NAD⁺ → L-cysteate + NADH + H⁺

quercetin + UDP-α-D-glucose → H⁺ + quercetin 7-O-glucoside + UDP

H₂O + 4-aminoimidazole → 3,5-dihydro-4H-imidazol-4-one + H⁺ + ammonium

2 UDP-α-D-glucose + delphinidin 3-O-(6''-O-malonyl)-β-glucoside → 2 H⁺ + 2 UDP + ternatin C5

(4R)-7-hydroxy-4-isoprenyl-7-methyl-2-oxo-oxepanone → (3R)-3-isopropenyl-6-oxoheptanoate + H⁺

2 FADH₂ + 2,6-dichlorohydroquinone + oxygen → 2 FAD + 2 H⁺ + H₂O + 6-chlorohydroxyquinol + chloride

S-adenosyl-L-methionine + (S)-corytuberine → S-adenosyl-L-homocysteine + H⁺ + (S)-magnoflorine

2-(dihydroxymethyl)furan + oxygen → hydrogen peroxide + 2-furoate + H⁺

S-adenosyl-L-methionine + N-acetyl-serotonin → S-adenosyl-L-homocysteine + H⁺ + melatonin

H₂O + S-formylglutathione → formate + H⁺ + glutathione

2-epi-5-epi-valiolone + NAD⁺ → NADH + desmethyl gadusol + H⁺

S-adenosyl-L-methionine + 17-O-acetylnorajmaline → S-adenosyl-L-homocysteine + H⁺ + 17-O-acetylajmaline

S-adenosyl-L-methionine + isoorientin → isoscoparine + S-adenosyl-L-homocysteine + H⁺

H₂O + 4-chlorobenzoate → H⁺ + 4-hydroxybenzoate + chloride

UDP-α-D-glucose + betanidin → H⁺ + UDP + gomphrenin I

L-aspartate 4-semialdehyde + pyruvate → 2 H₂O + (S)-2,3-dihydrodipicolinate + H⁺

2-dehydro-3-deoxy-D-gluconate + ATP → 2-dehydro-3-deoxy-D-gluconate 6-phosphate + H⁺ + ADP

H₂O + 4-hydroxy-3-methylbenzaldehyde + NADP⁺ → 2 H⁺ + NADPH + 4-hydroxy-3-methylbenzoate

3 trans,octacis-decaprenylphospho-β-D-arabinofuranose + an oxidized electron donor + [β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→6)]₁₄-β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)--L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol → 3 trans,octacis-decaprenyl phosphate + 4 H⁺ + a reduced electron donor + mycobacterial arabinogalactan primed with arabinofuran

H₂O + 3'-amino-3'-deoxyATP → 2 H⁺ + diphosphate + 3'-amino-3'-deoxyAMP

H₂O + (-)-dehydrodiconiferyl aldehyde + NAD⁺ → 2 H⁺ + NADH + (-)-dehydrodiconiferyl acid

2 H₂O + acetyl-CoA → 5 H⁺ + coenzyme A + glyoxylate

3'-phosphoadenylyl-sulfate + quercetin → adenosine 3',5'-bisphosphate + quercetin 3-sulfate + H⁺

2 a reduced electron donor + perchlorate → 2 an oxidized electron donor + 2 H₂O + H⁺ + chlorite

NAD⁺ + (1R,2S)-3,4-dichloro-6-methylcyclohexa-3,5-diene-1,2-diol → NADH + H⁺ + 3,4-dichloro-6-methylcatechol

S-adenosyl-L-methionine + L-histidine → S-methyl-5'-thioadenosine + (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H⁺

macrocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + tylosin

nicotinamide + α-D-ribose-1-phosphate + H⁺ ← 1-(β-D ribofuranosyl)nicotinamide + phosphate

2 2-nitropropane + oxygen → 2 acetone + 2 H⁺ + 2 nitrite

ADP-α-D-glucose + (R)-glycerate → H⁺ + 2-O-(α-D-glucopyranosyl)-D-glycerate + ADP

H₂O + deoxycholoyl-CoA → coenzyme A + H⁺ + deoxycholate

S-adenosyl-L-methionine + 3,4-dihydroxyphenylacetate → S-adenosyl-L-homocysteine + H⁺ + homovanillate

H₂O + (R)-N-formyl-β-hydroxy-L-kynurenine → (R)-β-hydroxy-L-kynurenine + formate + H⁺

S-adenosyl-L-methionine + dTDP-4-dehydro-β-L-rhamnose → S-adenosyl-L-homocysteine + dTDP-4-dehydro-5-methyl-β-L-rhamnose + H⁺

2 H₂O + 5-oxo-L-proline + ATP → H⁺ + L-glutamate + phosphate + ADP

S-adenosyl-L-methionine + L-selenocysteine → S-adenosyl-L-homocysteine + H⁺ + Se-methyl-L-selenocysteine

S-adenosyl-L-methionine + 16-hydroxytabersonine → S-adenosyl-L-homocysteine + 16-methoxytabersonine + H⁺

(R)-pantothenate + ATP → (R)-4'-phosphopantothenate + H⁺ + ADP

ferribactin + NADP⁺ + oxygen → pyoverdine I + H₂O + NADPH + H⁺

ethyl-2-methylacetoacetate + NADPH + H⁺ ← ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP⁺

cytidine + GTP → CMP + H⁺ + GDP

H₂O + carbamoyl phosphate + tobramycin + ATP → H⁺ + diphosphate + phosphate + nebramycin 5' + AMP

prunin + UDP-β-L-rhamnose → H⁺ + naringin + UDP

S-adenosyl-L-methionine + L-glutamate + oxygen + gentamicin A2 → hydrogen peroxide + S-adenosyl-L-homocysteine + 2-oxoglutarate + H⁺ + gentamicin A

(1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol → 2 H⁺ + HCl + 2,5-dichlorophenol

glycine + (S)-4-deoxygadusol + ATP → 2 H⁺ + mycosporine glycine + phosphate + ADP

S-adenosyl-L-methionine + 2-methoxy-6-all trans-nonaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol

neamine + UDP-α-D-kanosamine → H⁺ + kanamycin B + UDP

benzimidazole ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(benzimidazolyl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

methylcob(III)alamin + hopan-22-ol → H⁺ + 2-methyldiplopterol + cob(II)alamin

2-oxoglutarate + oxygen + (2R,3S,4S)-leucopelargonidin → 2 H⁺ + H₂O + (4S)-2,3-dehydroleucopelargonidin + succinate + CO₂

H₂O + 1,3,7-trimethyl-5-hydroxyisourate → H⁺ + 3,6,8-trimethyl-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline

β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine + UDP-α-D-galactose → α-D-galactosyl-(1,3)-β-D-galactosyl-(1,4)-N-acetyl-D-glucosamine + H⁺ + UDP

1,2-dipalmitoylglycerol + CDP-choline → 1,2-dipalmitoyl-sn-glycero-3-phosphocholine + CMP + H⁺

3 an oxidized electron donor + FMN + H₂O + L-glutamate + oxygen → 3 a reduced electron donor + 8-amino-8-demethylriboflavin 5'-phosphate + 2-oxoglutarate + H⁺ + CO₂

ADP-α-D-glucose + α-D-glucopyranose 1-phosphate → H⁺ + α-maltose 1-phosphate + ADP

quercetin + UDP-α-D-galactose → H⁺ + quercetin 3-galactoside + UDP

S-adenosyl-L-methionine + daidzein → S-adenosyl-L-homocysteine + isoformononetin + H⁺

S-adenosyl-L-methionine + welwitindolinone C isothiocyanate → S-adenosyl-L-homocysteine + H⁺ + N-methylwelwitindolinone C isothiocyanate

cyclohexanol + NAD⁺ → cyclohexanone + NADH + H⁺

NAD⁺ + (1R,2S)-3,4-dichlorocyclohexa-3,5-diene-1,2-diol → NADH + H⁺ + 4,5-dichlorobenzene-1,2-diol

sterigmatocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin + H⁺

H₂O + dIDP → H⁺ + phosphate + dIMP

serotonin + acetyl-CoA → coenzyme A + H⁺ + N-acetyl-serotonin

cholesterol + UDP-α-D-glucose → cholesteryl-α-D-glucoside + H⁺ + UDP

1D-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-β-L-arabinopyranose → (indol-3-yl)acetyl-myo-inositol L-arabinoside + H⁺ + UDP

L-glutamate + 5,6,7,8-tetrahydrofolate + ATP → 2 H⁺ + tetrahydrofolate-L-glutamate + phosphate + ADP

2 isonicotinate acyl radical + NADH + NAD⁺ → 2 isonicotinate acyl-NADH adduct + H⁺

NAD(P)+ + glutamate-4-semialdehyde → NAD(P)H + H⁺ + L-glutamate

ethylamine + L-glutamate + ATP → γ-glutamyl-ethylamide + H⁺ + phosphate + ADP

acetyl-CoA + deacetylcolchicine → coenzyme A + H⁺ + (S)-colchicine

H₂O + luteolin 7-O-β-D-glucuronide → β-D-glucuronate + H⁺ + luteolin

acetyl-CoA + hydrogencarbonate + ATP → H⁺ + malonyl-CoA + phosphate + ADP

ammonium + ATP + UTP → 2 H⁺ + phosphate + ADP + CTP

L-arabinono-1,4-lactone + H₂O → H⁺ + L-arabinonate

2-hydroxylamino-4,6-dinitrotoluene + UDP-α-D-glucose → H⁺ + 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP

(E)-ω-(methylsulfanyl)pentyl-thiohydroximate + UDP-α-D-glucose → 4-(methylsulfanyl)butyl-desulfoglucosinolate + H⁺ + UDP

2-cis,4-trans-xanthoxin + NAD⁺ → NADH + H⁺ + (+)-cis-abscisic aldehyde

S-adenosyl-L-methionine + cobalt-precorrin-6B → S-adenosyl-L-homocysteine + H⁺ + cobalt-precorrin-7

dimethylselenoniopropanoate → acrylate + dimethyl selenide + H⁺

1-phenyl-3-(3-C-glucosyl-2,4,6-trihydroxyphenyl)propane-1,3-dione → H₂O + 6-C-glucosyl chrysin + H⁺

H₂O + L-aspartate 4-semialdehyde + NAD⁺ → 2 H⁺ + NADH + L-aspartate

S-adenosyl-L-methionine + N-acetyl-O-demethylpuromycin → S-adenosyl-L-homocysteine + H⁺ + N-acetylpuromycin

androsterone + NAD(P)+ → 5α-androstane-3,17-dione + NAD(P)H + H⁺

H₂O + P¹,P⁴-bis(5'-adenosyl) tetraphosphate → 2 H⁺ + 2 ADP

acetoacetyl-CoA + L-isoleucine + ATP → coenzyme A + tenuazonic acid + H⁺ + diphosphate + AMP

S-adenosyl-L-methionine + paraxanthine → S-adenosyl-L-homocysteine + caffeine + H⁺

α-D-Man-(1→3)-β-D-Glc-(1→4)-α-D-Glc-1-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucuronate → β-D-GlcA-(1→2)-α-D-Man-(1→3)-β-D-Glc-(1→4)-α-D-Glc-1-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

3'-phosphoadenylyl-sulfate + ω-hydroxy-β-dihydromenaquinone-9 → adenosine 3',5'-bisphosphate + ω-sulfo-β-dihydromenaquinone-9 + H⁺

H₂O + 3-methylbenzaldehyde + NAD⁺ → 2 H⁺ + NADH + 3-methylbenzoate

(2S)-naringenin + S-adenosyl-L-methionine → (2S)-sakuranetin + S-adenosyl-L-homocysteine + H⁺

an oxidized electron donor + H⁺ + 3-chlorophenol + chloride ← a reduced electron donor + 2,3-dichlorophenol

H₂O + S-succinylglutathione → H⁺ + glutathione + succinate

H₂O + 6-deoxy-6-sulfo-D-glucono-1,5-lactone → 6-deoxy-6-sulfo-D-gluconate + H⁺

H₂O + a reduced electron donor + ground state firefly oxyluciferin → an oxidized electron donor + thioglycolate + 2-cyano-6-hydroxybenzothiazole + H⁺

L-tryptophan + oxygen → α,β-didehydrotryptophan + hydrogen peroxide + H⁺

daphnetin + UDP-α-D-glucose → 4-O- β -D-glucosyl-daphnetin + H⁺ + UDP

D-erythrose 4-phosphate + H₂O + NAD⁺ → 2 H⁺ + 4-phospho-D-erythronate + NADH

dihydrozeatin + UDP-α-D-glucose → H⁺ + dihydrozeatin-9-N-glucoside + UDP

H₂O + 2-keto-6-acetamidocaproate + NAD⁺ → 5-acetamidovalerate + NADH + H⁺ + CO₂

2-amino-6-[1-hydroxyethyl]-7-methyl-7,8-dihydropterin + ATP → [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate + H⁺ + AMP

L-alaninol + NAD(P)+ → NAD(P)H + L-2-aminopropionaldehyde + H⁺

(E)-ω-(methylsulfanyl)heptyl-thiohydroximate + UDP-α-D-glucose → 6-(methylsulfanyl)hexyl-desulfoglucosinolate + H⁺ + UDP

2 S-adenosyl-L-methionine + S-demethyl-thiocoraline dithiol → 2 S-adenosyl-L-homocysteine + 2 H⁺ + thiocoraline dithiol

51 trans,octacis-decaprenylphospho-β-D-arabinofuranose + mycobacterial arabinogalactan primed with arabinofuran → 51 H⁺ + 51 trans,octacis-decaprenyl phosphate + mycobacterial arabinogalactan containing linear arabinofuran

D-myo-inositol (1,3,4)-trisphosphate + ATP → 2 H⁺ + D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP

3,4-dihydroxyphenylacetate + oxygen → 2-hydroxy-5-carboxymethylmuconate semialdehyde + H⁺

apigenin 7-O-β-D-glucoside + UDP-β-L-rhamnose → H⁺ + UDP + apigenin 7-O-neohesperidoside

H₂O + 3,6-dichloropyridine-2,5-dione → 3-chloro-6-hydroxypyridine-2,5-dione + H⁺ + chloride

H₂O + sn-glycero-3-phospho-1-inositol → myo-inositol + H⁺ + sn-glycerol 3-phosphate

NAD⁺ + 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxyoctanoyl)-CoA → NADH + H⁺ + 3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3-oxooctanoyl)-CoA

rubusoside + UDP-α-D-glucose → stevioside + H⁺ + UDP

H₂O + ferric coprogen + ATP → H⁺ + phosphate + ferric coprogen + ADP

β-D-GlcA-(1→2)-α-D-Man-(1→3)-β-D-Glc-(1→4)-α-D-Glc-1-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose → α-D-glucosyl-(1,2)-β-D-glucuronate-(1,2)-α-D-mannosyl-(1,3)-β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol + H⁺ + UDP

2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + L-2,3-diaminopropanoate + ATP → 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + H⁺ + diphosphate + AMP

(E)-ω-(methylsulfanyl)nonyl-thiohydroximate + UDP-α-D-glucose → 8-(methylsulfanyl)octyl-desulfoglucosinolate + H⁺ + UDP

10-formyl-tetrahydrofolate mono-L-glutamate + UDP-4-amino-4-deoxy-β-L-arabinopyranose → UDP-4-deoxy-4-formamido-β-L-arabinopyranose + H⁺ + 5,6,7,8-tetrahydrofolate

castasterone + UDP-α-D-glucose → castasterone-23-O-glucoside + H⁺ + UDP

H₂O + cinnamaldehyde + oxygen → hydrogen peroxide + trans-cinnamate + H⁺

NADH + H⁺ + 3-oxo-(11Z)-octadecenoyl-CoA ← NAD⁺ + (S)-3-hydroxy-(11Z)-octadecenoyl-CoA

(R)-demethyl-4-deoxygadusol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (R)-4-deoxygadusol + H⁺

FADH₂ + phenol + oxygen → FAD + H₂O + catechol + H⁺

S-adenosyl-L-methionine + trans-resveratrol → S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene + H⁺

2 FMNH₂ + 2 oxygen + dimethyl sulfone → 2 FMN + 2 H₂O + 3 H⁺ + formaldehyde + methanesulfonate

an oxidized electron donor + 4,4'-diapolycopene-4-al + H₂O → 4,4'-diapolycopene-4-oate + a reduced electron donor + H⁺

(S)-2-amino-6-oxohexanoate + H₂O + NAD⁺ → 2 H⁺ + NADH + L-2-aminoadipate

N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-galactosamine → N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

H₂O + abieta-7,13-diene-18-al + NAD⁺ → 2 H⁺ + NADH + abieta-7,13-diene-18-oate

phloretin + UDP-α-D-glucose → nothofagin + H⁺ + UDP

coprogen + Fe³⁺ → 3 H⁺ + ferric coprogen

H₂O + 2-sulfinoacetaldehyde → acetaldehyde + H⁺ + sulfite

H₂O + 2-hydroxy-5-carboxymethylmuconate semialdehyde + NAD⁺ → 2 H⁺ + 5-carboxymethyl-2-hydroxymuconate + NADH

L-homocysteine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + L-methionine

2 N⁵-formyl-N⁵-hydroxy-L-ornithine + 2 L-threonine + 2 L-serine + L-tyrosine + L-lysine + L-glutamate + L-2,4-diaminobutanoate + L-arginine → 12 H₂O + ferribactin + H⁺

H₂O + P¹,P⁵-bis(5'-adenosyl) pentaphosphate → adenosine tetraphosphate + H⁺ + AMP

H₂O + NAD⁺ + 5-hydroxyindole acetaldehyde → 2 H⁺ + NADH + 5-hydroxyindole acetate

N⁴-(β-N-acetyl-D-glucosaminyl)-L-asparagine + H₂O → N-acetyl-β-glucosaminylamine + H⁺ + L-aspartate

coenzyme A + palmitoleate + H⁺ + ATP → H⁺ + palmitoleoyl-CoA + diphosphate + AMP

(1R,2S)-1,3,4,6-tetrachlorocyclohexa-3,5-diene-1,2-diol → 2 H⁺ + 3,4,6-trichlorocatechol + chloride

H₂O + rifampicin + ATP → 2 H⁺ + phosphate + 21-phosphorifampicin + AMP

H₂O + 3-maleylpyruvate → pyruvate + H⁺ + fumarate

H₂O + 3-maleylpyruvate → pyruvate + H⁺ + maleate

acetyl-CoA + N6,N6,O-tridemethylpuromycin → coenzyme A + H⁺ + N-acetyl-N6,N6,O-tridemethylpuromycin

S-adenosyl-L-methionine + showacene → S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H⁺

H₂O + oxygen + (+)-cis-abscisic aldehyde → hydrogen peroxide + H⁺ + 2-cis-abscisate

NADP⁺ + versicolorin B → NADPH + H⁺ + versicolorin A

S-adenosyl-L-methionine + 3-hydroxy-5-methyl-L-tyrosine → S-adenosyl-L-homocysteine + H⁺ + 4O,5-dimethyl,3-hydroxy L-tyrosine

H₂O + NADP⁺ + 18-oxo-oleate → 2 H⁺ + NADPH + α,ω-9Z-octadecenedioate

H₂O + CDP-choline → 2 H⁺ + phosphocholine + CMP

H₂O + O-succinyl-L-homoserine → 2-oxobutanoate + H⁺ + ammonium + succinate

pretetramide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 6-methylpretetramide + H⁺

2-amino-5-methylphenol + oxygen → (2Z,4E)-2-amino-5-methyl-muconate semialdehyde + H⁺

carbamoyl phosphate + L-2,3-diaminopropanoate → β-ureidoalanine + H⁺ + phosphate

NADH + H⁺ + 3-oxo-(7Z)-tetradecenoyl-CoA ← NAD⁺ + (S)-3-hydroxy-(7Z)-tetradecenoyl-CoA

H₂O + NAD⁺ + 3-methoxy-4-hydroxyphenylglycolaldehyde → 2 H⁺ + NADH + vanillyl mandelate

S-adenosyl-L-methionine + nocardicin F → S-methyl-5'-thioadenosine + H⁺ + isonocardicin B

5-chloro-5-deoxy-D-ribono-γ-lactone + H₂O → 5-chloro-5-deoxy-D-ribonate + H⁺

naphthalene-1,2-diol + oxygen → 2-hydroxychromene-2-carboxylate + H⁺

H₂O + ergosteryl oleate → ergosterol + oleate + H⁺

5-aminolevulinyl-CoA → 2,5-piperidinedione + coenzyme A + H⁺

2 S-adenosyl-L-methionine + uroporphyrinogen-III → 2 S-adenosyl-L-homocysteine + precorrin-2 + H⁺

3,4-dichlorobenzoate-cis-4,5-diol → 5-chloroprotocatechuate + H⁺ + chloride

H₂O + UTP → H⁺ + phosphate + UDP

S-adenosyl-L-methionine + eugenol → S-adenosyl-L-homocysteine + methyleugenol + H⁺

S-adenosyl-L-methionine + apigenin → S-adenosyl-L-homocysteine + H⁺ + acacetin

H₂O + 9-(methylsulfanyl)-2-oxononanoate + acetyl-CoA → coenzyme A + 2-[(7'-methylsulfanyl)heptyl]malate + H⁺

7-methylxanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + theobromine + H⁺

gallate + oxygen → H₂O + 2-pyrone-4,6-dicarboxylate + H⁺

N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose → β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

methylsalicylate O-β-D-xylopyranosyl-(1->6)-O-β-D-glucopyranoside + UDP-α-D-glucose → methylsalicylate 2-O-β-D-glucopyranosyl-(1 -> 2)-[O-β-D-xylopyranosyl-(1 -> 6)]-O-β-D-glucopyranoside + H⁺ + UDP

2 NAD⁺ + H₂O + trimethylaminoacetone + oxygen → 2 NADH + 3 H⁺ + glycine betaine + CO₂

H₂O + m⁷GTP → N⁷-methylguanosine 5'-phosphate + H⁺ + diphosphate

carnosine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + anserine

2 3-amino-4-hydroxybenzaldehyde + 2 oxygen + N-acetyl-L-cysteine → 3 H₂O + formate + H⁺ + grixazone A

L-phenylalanine + (-)-jasmonate + ATP → H⁺ + (-)-jasmonoyl-L-phenylalanine + diphosphate + AMP

O-acetyl-L-homoserine + serinol → acetate + dihydrorhizobitoxine + H⁺

H₂O + arsenite + ATP → arsenite + H⁺ + phosphate + ADP

(+)-dihydrokaempferol + 2-oxoglutarate + oxygen → H₂O + H⁺ + succinate + CO₂ + kaempferol

paromamine + UDP-α-D-xylose → H⁺ + gentamicin A2 + UDP

ribostamycin + UDP-N-acetyl-α-D-glucosamine → 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H⁺ + UDP

N-acetyl-tunicaminyl-uracil + UDP-N-acetyl-α-D-glucosamine → N-acetyl-D-glucosaminyl-N-acetyl-tunicaminyl-uracil + H⁺ + UDP

riboflavin + CTP → FMN + H⁺ + CDP

H₂O + stipitatonate → stipitatate + H⁺ + CO₂

S-adenosyl-L-methionine + DIBOA-β-D-glucoside → S-adenosyl-L-homocysteine + 4-O-methyl-DIBOA-glucoside + H⁺

S-adenosyl-L-methionine + N^α,N^α-dimethyl-L-histidine → S-adenosyl-L-homocysteine + H⁺ + hercynine

2 GDP-α-D-mannose + bis(myo-inositol)-1,3'-phosphate → 2 H⁺ + 2 GDP + 2-O-(β-D-mannosyl-(1→2)-O-β-D-mannosyl)-bis(-myo-inositol) 1,3'-phosphate

oxidized DCPIP + (-)-trans-carveol → reduced DCPIP + H⁺ + (-)-carvone

FADH₂ + (4-hydroxyphenyl)acetate + oxygen → FAD + H₂O + 3,4-dihydroxyphenylacetate + H⁺

[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA → Δ^2,5-3,4,4-trimethylpimeloyl-CoA + H⁺

ammonium + adenosine 5'-phosphosulfate → 2 H⁺ + adenosine 5'-phosphoramidate + sulfate

paromamine + UDP-α-D-glucose → H⁺ + 3''-deamino-3''-hydroxykanamycin C + UDP

N-acetyl-β-D-glucosamine + ATP → N-acetyl-D-glucosamine-6-phosphate + H⁺ + ADP

2-oxoglutarate + L-arginine + oxygen → H₂O + guanidinium + H⁺ + (S)-1-pyrroline-5-carboxylate + succinate + CO₂

an oxidized electron donor + (S)-tetrahydropapaverine → a reduced electron donor + H⁺ + dihydropapaverine

H₂O + NAD⁺ + L-leucine → NADH + 4-methyl-2-oxopentanoate + H⁺ + ammonium

H₂O + N-3-fumaroyl-L-2,3-diaminopropanoate + L-glutamine + ATP → N-3-fumaramoyl-L-2,3-diaminopropanoate + H⁺ + L-glutamate + diphosphate + AMP

H₂O + di-trans,octa-cis-undecaprenyl diphosphate → H⁺ + phosphate + di-trans,octa-cis-undecaprenyl phosphate

S-adenosyl-L-methionine + 4-hydroxyglucobrassicin → S-adenosyl-L-homocysteine + H⁺ + 4-methoxyglucobrassicin

3-chlorobenzyl alcohol + NAD⁺ → NADH + 3-chlorobenzaldehyde + H⁺

(20S)-protopanaxadiol + UDP-α-D-glucose → (20S)-ginsenoside Rh2 + H⁺ + UDP

S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine → S-adenosyl-L-homocysteine + dihydromacarpine + H⁺

H₂O + isopyridoxal + NAD⁺ → 2 H⁺ + 5-pyridoxate + NADH

H₂O + 2-formylaminobenzaldehyde → O-aminobenzaldehyde + formate + H⁺

S-adenosyl-L-methionine + (-)-5'-demethylyatein → S-adenosyl-L-homocysteine + (-)-yatein + H⁺

NAD(P)+ + oryzalexin D → NAD(P)H + H⁺ + oryzalexin B

methylmercury + glutathione → H⁺ + methylmercury-S-glutatione

H₂O + glyoxylate + oxygen → hydrogen peroxide + H⁺ + oxalate

taurine + chenodeoxycholoyl-CoA → coenzyme A + H⁺ + taurochenodeoxycholate

S-adenosyl-L-methionine + 12-ethyl-8-isobutylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-isobutylbacteriochlorophyllide c + H⁺

acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-α-D-glucuronate → coenzyme A + H⁺ + UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronate

mogrol + UDP-α-D-glucose → mogroside IE + H⁺ + UDP

S-adenosyl-L-methionine + dTDP-viosamine + a reduced electron donor → an oxidized electron donor + dTDP-3-dehydro-4,6-deoxy-α-D-glucose + H⁺ + ammonium + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + welwitindolinone B isothiocyanate → S-adenosyl-L-homocysteine + H⁺ + N-methylwelwitindolinone B isothiocyanate

S-(hydroxymethyl)mycothiol + NAD⁺ → S-formylmycothiol + NADH + H⁺

S-adenosyl-L-methionine + glandicoline B → S-adenosyl-L-homocysteine + H⁺ + meleagrin

3-chloro-6-fluorocatechol + oxygen → 4-chloro-2-fluoromuconate + H⁺

L-alanyl-γ-D-glutamyl-meso-diaminopimelate + UDP-N-acetyl-α-D-muramate + ATP → H⁺ + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + phosphate + ADP

H₂O + isatin → isatinate + H⁺

H₂O + N-acetyl-β-D-glucosamine + oxygen → N-acetyl-D-glucosaminate + hydrogen peroxide + H⁺

2 ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-β-D-glucosaminyl)-(1,4)-]-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine → a peptidoglycan dimer (meso-diaminopimelate containing) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

a reduced electron donor + L-selenocysteine → an oxidized electron donor + H⁺ + L-alanine + selenide

galactosyl-(glucosyl)₂-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + UDP-α-D-glucose → H⁺ + galactosyl-(glucosyl)₃-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + UDP

2 H₂O + an oxidized electron donor + phenylacetyl-CoA → 3 H⁺ + coenzyme A + a reduced electron donor + phenylglyoxylate

H₂O + XTP → H⁺ + diphosphate + XMP

(4R)-perillyl alcohol + NAD⁺ → NADH + H⁺ + (4R)-perillyl aldehyde

H₂O + NAD⁺ + salicylaldehyde → 2 H⁺ + salicylate + NADH

2 H₂O + 3 oxygen + 5-hydroxymethylfurfural → 2 H⁺ + 3 hydrogen peroxide + furan-2,5-dicarboxylate

dTDP-β-L-rhamnose + ginsenoside Rh1 → H⁺ + dTDP + ginsenoside Rg2

S-adenosyl-L-methionine + fusarubinaldehyde → S-adenosyl-L-homocysteine + H⁺ + 8-O-methylfusarubinaldehyde

H₂O + tert-butyl formate → tert-butyl alcohol + formate + H⁺

2 H₂O + NAD⁺ + (S)-1-pyrroline-5-carboxylate → NADH + H⁺ + L-glutamate

2 L-serine + 3 methylglutaconyl hydroxy ornithine + 3 ATP + glycine + Fe³⁺ → 3 H₂O + 3 H⁺ + 3 diphosphate + 3 AMP + ferrichrome A

H₂O + 4-hydroxybenzoyl-CoA → coenzyme A + H⁺ + 4-hydroxybenzoate

glycine + chenodeoxycholoyl-CoA → coenzyme A + H⁺ + glycochenodeoxycholate

demethylspheroidene + S-adenosyl-L-methionine → spheroidene + S-adenosyl-L-homocysteine + H⁺

5-(methylsulfinyl)pentyl-glucosinolate + oxygen → methanesulfonate + H⁺ + 4-pentenyl-glucosinolate

collinusin + NAD⁺ → NADH + justicidin B + H⁺

coenzyme A + H₂O + crotonyl-CoA → 2 H⁺ + 2 acetyl-CoA

S-adenosyl-L-methionine + daidzein → S-adenosyl-L-homocysteine + H⁺ + formononetin

3-chloro-2-methyl-dienelactone + H₂O → 3 H⁺ + 3-chloro-2-methyl-maleylacetate

2 ATP + anthranilate + L-tryptophan → 2 phosphate + 2 ADP + H⁺ + (R)-benzodiazepinedione

3-(hydroxymethyl)-5-methylphenol + NAD⁺ → 3-hydroxy-5-methylbenzaldehyde + NADH + H⁺

NAD⁺ + D-arabinitol → NADH + D-xylulose + H⁺

3-hydroxybenzyl alcohol + NADP⁺ → 3-hydroxybenzaldehyde + NADPH + H⁺

3-phospho-D-glyceroyl-phosphate → H⁺ + 2,3-diphospho-D-glycerate

α-D-galactosamine-1-phosphate + acetyl-CoA → coenzyme A + N-acetyl-α-D-galactosamine 1-phosphate + H⁺

S-adenosyl-L-methionine + 3-(aminomethyl)indole → S-adenosyl-L-homocysteine + H⁺ + (1H-indol-3-yl)-N-methylmethanamine

cis-zeatin + UDP-α-D-glucose → H⁺ + cis-zeatin-O-glucoside + UDP

H₂O + α, α'-trehalose 6-α-mycolate + ATP → H⁺ + α, α'-trehalose 6-α-mycolate + phosphate + ADP

diaminobutyryl-citryl-ethanolamino-α-ketoglutarate + 2-oxoglutarate + ATP → H⁺ + achromobactin + diphosphate + AMP

H₂O + 3-chloro-6-hydroxypyridine-2,5-dione → 3,6-dihydroxypyridine-2,5-dione + H⁺ + chloride

7-mercaptoheptanoylthreonine + ATP → coenzyme B + H⁺ + ADP

S-adenosyl-L-methionine + dopamine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxytyramine

theobromine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + caffeine + H⁺

S-adenosyl-L-methionine + γ-tocotrienol → S-adenosyl-L-homocysteine + H⁺ + α-tocotrienol

4-coumarate + UDP-α-D-glucose → 4-O-β-D-glucosyl-4-hydroxycinnamate + H⁺ + UDP

H₂O + VAI-1 → H⁺ + N-(3-oxohexanoyl)-L-homoserine

3 H₂O + 7,8-dihydromonapterin triphosphate → 2 H⁺ + 3 phosphate + 7,8-dihydromonapterin

2 N^ω-hydroxy-L-arginine + 2 oxygen + NADPH → 2 H₂O + 2 L-citrulline + 2 nitric oxide + NADP⁺ + H⁺

NAD⁺ + fucoxanthinol → NADH + H⁺ + amarouciaxanthin A

1-aminocyclopropane-1-carboxylate → H⁺ + (2Z)-2-aminobut-2-enoate

1-oleoyl-sn-glycerol + H₂O → oleate + glycerol + H⁺

steviol + UDP-α-D-glucose → steviolmonoside + H⁺ + UDP

H₂O + palmitoyl-CoA → coenzyme A + palmitate + H⁺

ADP-L-glycero-β-D-manno-heptose + galactosyl-(glucosyl)₃-(heptosyl)₃-Kdo₂-lipid A-bisphosphate → H⁺ + core oligosaccharide-lipid A (E. coli K-12 core type) (no GlcNAc) + ADP

H₂O + ureidomalonate → malonate + H⁺ + urea

S-adenosyl-L-methionine + 3-(all-trans-heptaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 2-methoxy-6-(all-trans-heptaprenyl)phenol

H₂O + (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate → 2 H⁺ + 2-maleylacetate + chloride

NAD⁺ + (3R)-hydroxy- 5-cis, 7-trans-tetradecadienoyl-CoA → NADH + H⁺ + 5-cis, 7-trans-3-oxo-tetradecadienoyl-CoA

S-adenosyl-L-methionine + cobalt-sirohydrochlorin → S-adenosyl-L-homocysteine + H⁺ + cobalt-factor III

O-carbamoyl-deacetylcephalosporin C + H₂O → 2 H⁺ + 7-α-hydroxy-O-carbamoyl-deacetylcephalosporin C

S-adenosyl-L-methionine + 3,7-dimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3'-trimethylmyricetin

β-D-fructofuranose 6-phosphate + UDP-α-D-glucose → H⁺ + sucrose 6^F-phosphate + UDP

S-adenosyl-L-methionine + (4'R)-10',11'-dihydroxy-5'-azaspiro[cyclohexane-1,2'-tricyclo[6.3.1.04,ï¿½ï¿½]dodecane]-'(12'),2,5,8',10'-pentaen-4-one → S-adenosyl-L-homocysteine + H⁺ + crotonosine

a reduced electron donor + oxygen + adonixanthin → 2 H⁺ + an oxidized electron donor + H₂O + (3S,3'S)-astaxanthin

(3,5-dihydroxyphenyl)acetyl-CoA + oxygen → coenzyme A + H⁺ + 2-(3,5-dihydroxyphenyl)-2-oxoacetate

brassicasterol + UDP-α-D-glucose → brassicasterol 3-O-β-D-glucoside + H⁺ + UDP

D-sedoheptulose + ATP → D-sedoheptulose 7-phosphate + H⁺ + ADP

H₂O + 2,5-dioxopentanoate + NADP⁺ → 2 H⁺ + NADPH + 2-oxoglutarate

ubiquinol-10 → 4 H⁺ + ubiquinone-10

(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine → (S)-tetrahydropalmatine + S-adenosyl-L-homocysteine + H⁺

3'-phosphoadenylyl-sulfate + desulfoglucobrassicin → adenosine 3',5'-bisphosphate + H⁺ + glucobrassicin

2,5-dichloro-trans-dienelactone + H₂O → 2,5-dichloromaleylacetate + H⁺

(+)-secoisolariciresinol + UDP-α-D-glucose → (+)-secoisolariciresinol monoglucoside + H⁺ + UDP

H₂O + prop-2-ynal + NAD⁺ → 2 H⁺ + propynoate + NADH

H₂O + glyoxal + oxygen → hydrogen peroxide + glyoxylate + H⁺

2 ATP + anthranilate + S-adenosyl-L-methionine + O-methyl-L-tyrosine → 2 H⁺ + 2 diphosphate + 2 AMP + S-adenosyl-L-homocysteine + 4'-methoxycyclopeptine

H₂O + ITP → H⁺ + phosphate + IDP

3,5,3'-triiodo-L-thyronine + a reduced electron donor → an oxidized electron donor + H⁺ + iodide + 3,3'-diiodothyronine

H₂O + 5-(methylsulfanyl)-2-oxopentanoate + acetyl-CoA → coenzyme A + 2-[(3'-methylsulfanyl)propyl]malate + H⁺

4-methylene-L-glutamate + ammonium + ATP → 4-methylene-L-glutamine + H⁺ + diphosphate + AMP

H₂O + nitroethane + oxygen → hydrogen peroxide + acetaldehyde + H⁺ + nitrite

N¹-citryl-N⁶-acetyl-N⁶-hydroxy-L-lysine + N⁶-acetyl-N⁶-hydroxy-L-lysine + ATP → aerobactin + H⁺ + diphosphate + AMP

H₂O + glycerol 1,2-cyclic phosphate → H⁺ + sn-glycerol 3-phosphate

3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine → 3-methoxy-5-methyl-1-naphthoate + S-adenosyl-L-homocysteine + H⁺

H₂O + S-adenosyl-L-methionine → S-methyl-5'-thioadenosine + L-homoserine + H⁺

xanthine + H₂O → H⁺ + 5-ureidoimidazole-4-carboxylate

H₂O + vanillin + NAD⁺ → 2 H⁺ + vanillate + NADH

a reduced electron donor + 3,3',5'-triiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3,3'-diiodothyronamine

sinapaldehyde + UDP-α-D-glucose → sinapaldehyde glucoside + H⁺ + UDP

NADH + H⁺ + 3-oxo-(5Z)-dodecenoyl-CoA ← NAD⁺ + (S)-3-hydroxy-(5Z)-dodecenoyl-CoA

S-adenosyl-L-methionine + 5-pentadecatrienyl resorcinol → S-adenosyl-L-homocysteine + H⁺ + 5-pentadecatrienyl resorcinol-3-methyl ether

H₂O + 1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate → 2 H⁺ + phosphate + phytate

H₂O + ATP + Na⁺ → H⁺ + phosphate + ADP + Na⁺

2 H₂O + dimethylsulfoniopropioyl-CoA → 2 H⁺ + coenzyme A + 3-hydroxypropanoate + dimethyl sulfide

a reduced electron donor + 3,3',5-triiodothyronamine → an oxidized electron donor + H⁺ + iodide + 3,3'-diiodothyronamine

(R)-norcoclaurine + S-adenosyl-L-methionine → (R)-coclaurine + S-adenosyl-L-homocysteine + H⁺

FADH₂ + styrene + oxygen → FAD + H₂O + H⁺ + (S)-2-phenyloxirane

H₂O + stearoyl-CoA → coenzyme A + stearate + H⁺

H₂O + dGDP → H⁺ + phosphate + dGMP

ginsenoside F1 + UDP-α-D-glucose → H⁺ + UDP + ginsenoside Rg1

L-aspartate + IMP + GTP → 2 H⁺ + adenylo-succinate + phosphate + GDP

S-adenosyl-L-methionine + (2S)-eriodictyol → S-adenosyl-L-homocysteine + homoeriodictyol + H⁺

malonyl-CoA + phosphate + ADP → 2 H⁺ + pimeloyl-CoA + hydrogencarbonate + ATP

H₂O + S-(5-hydroxy-2-furoyl)-CoA → 2-oxoglutaryl-CoA + H⁺

H₂O + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-al + NAD⁺ → 2 H⁺ + NADH + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate

3'-phosphoadenylyl-sulfate + quercetin 3-sulfate → quercetin-3,4'-bissulfate + adenosine 3',5'-bisphosphate + H⁺

S-adenosyl-L-methionine + 5-hydroxy-coniferaldehyde → S-adenosyl-L-homocysteine + sinapaldehyde + H⁺

GDP-α-D-glucose + H₂O → H⁺ + β-D-glucopyranose + GDP

3 H₂O + GTP → 2 H⁺ + 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + diphosphate

S-adenosyl-L-methionine + (S)-laudanine → S-adenosyl-L-homocysteine + H⁺ + (S)-laudanosine

protocatechuate + oxygen → 2 H⁺ + 3-carboxy-cis,cis-muconate

2 NADH + 2 H⁺ + methyl red ← 2 NAD⁺ + anthranilate + N,N-dimethyl-1,4-phenylenediamine

H₂O + N-formylmaleamate → maleamate + formate + H⁺

H₂O + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-glutamine + ATP → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine + H⁺ + L-glutamate + phosphate + ADP

S-adenosyl-L-methionine + 2-methoxy-6-all trans-heptaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol

H₂O + (2Z,4E)-2-hydroxy-6-oxo-6-sulfonatohexa-2,4-dienoate → 2 H⁺ + (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + sulfite

2-chloro-2-(4-chloro-5-oxo-2H-furan-2-yl)acetate → 2-chloro-trans-dienelactone + H⁺ + chloride

H₂O + α-D-ribose-1-(methyl)phosphonate-5-triphosphate → α-D-ribose-1-methylphosphonate 5-phosphate + H⁺ + diphosphate

di-trans,octa-cis-undecaprenol + ATP → H⁺ + ADP + di-trans,octa-cis-undecaprenyl phosphate

4-hydroxytryptamine + ATP → norbaeocystin + H⁺ + ADP

H₂O + 3,4,15-triacetylnivalenol → acetate + 4,15-diacetylnivalenol + H⁺

core oligosaccharide-lipid A (E. coli K-12 core type) (no GlcNAc) + UDP-N-acetyl-α-D-glucosamine → H⁺ + core oligosaccharide-lipid A (E. coli K-12 core type) + UDP

riboflavin + ATP → FMN + H⁺ + ADP

β-D-glucosyl crocetin + UDP-α-D-glucose → H⁺ + β-D-gentiobiosyl crocetin + UDP

2-methylpropane-1,2-diol + NAD⁺ → NADH + 2-hydroxy-2-methylpropanal + H⁺

S-adenosyl-L-methionine + 6-O-demethylfusarubinaldehyde → S-adenosyl-L-homocysteine + H⁺ + fusarubinaldehyde

H₂O + ITP → H⁺ + diphosphate + IMP

S-adenosyl-L-methionine + coniine → S-adenosyl-L-homocysteine + H⁺ + methylconiine

(2-amino-1-hydroxyethyl)phosphonate + oxygen → 2 H⁺ + glycine + phosphate

H₂O + NAD⁺ + methylglyoxal → 2 H⁺ + NADH + pyruvate

NAD⁺ + (3S,6Z,9Z,12Z,15Z,18Z)-3-hydroxytetracosapentaenoyl-CoA → NADH + H⁺ + (6Z,9Z,12Z,15Z,18Z)-3-oxotetracosapentaenoyl-CoA

H₂O + 4-hydroxybenzyl isothiocyanate → 4-hydroxybenzyl alcohol + thiocyanate + H⁺

H₂O + ellagic acid → H⁺ + 3,4,8,9,10-pentahydroxy-6-oxobenzo[c]chromene-1-carboxylate

2 H⁺ + 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate ← H₂O + (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate

H₂O + 3-methylbutyl acetate → acetate + 3-methylbutanol + H⁺

2 myristoyl-CoA + H₂O → 2 coenzyme A + (2R)-2-dodecyl-3-oxohexadecanoate + H⁺

S-(hydroxymethyl)bacillithiol + NAD⁺ → S-formylbacillithiol + NADH + H⁺

2 H₂O + trans-cinnamate + NAD⁺ → 2 H⁺ + acetate + NADH + benzoate

H₂O + NADP⁺ + magnesium-protoporphyrin IX 13-monomethyl ester → NADPH + H⁺ + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

H₂O + NAD(P)+ + 3,4-dihydroxybenzaldehyde → 2 H⁺ + protocatechuate + NAD(P)H

S-adenosyl-L-methionine + 2-methyl-6-phytyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + 2,3-dimethyl-6-phytyl-1,4-benzoquinol + H⁺

4-(1-methyl-5-hydroxy-2-pyrrolidinyl)-3-oxobutanoate methyl ester → H₂O + methyl ecgonone + H⁺

H₂O + dihydrocoumarin → H⁺ + melilotate

L-phosphinothricin + acetyl-CoA → coenzyme A + N-acetylphosphinothricin + H⁺

kaempferide 3-O-β-D-glucopyranosyl -(1->2)-O-α-L-rhamnoside + UDP-α-D-glucose → H⁺ + kaempferide triglycoside + UDP

S-adenosyl-L-methionine + trichosetin → S-adenosyl-L-homocysteine + H⁺ + equisetin

H₂O + GTP → 7,8-dihydroneopterin 3'-triphosphate + formate + H⁺

podophyllotoxin + UDP-α-D-glucose → podophyllotoxin 7-glucoside + H⁺ + UDP

H₂O + indole-3-carbinonium ion → H⁺ + indole-3-carbinol

H₂O + L-aspartate + L-glutamine + ATP → H⁺ + L-glutamate + L-asparagine + diphosphate + AMP

H₂O + adenosine tetraphosphate → 2 H⁺ + phosphate + ATP

3'-phosphoadenylyl-sulfate + 5-hydroxytryptophol → adenosine 3',5'-bisphosphate + H⁺ + 5-hydroxytryptophol sulfate

3-chloro-5-fluorocatechol + oxygen → 2 H⁺ + 2-chloro-4-fluoromuconate

cis-dienelactone + H₂O → 2-maleylacetate + H⁺

agmatine + S-adenosyl 3-(methylsulfanyl)propylamine → S-methyl-5'-thioadenosine + N¹-(3-aminopropyl)agmatine + H⁺

H₂O + ATP + methyl-β-D-galactoside → H⁺ + phosphate + ADP + methyl-β-D-galactoside

2,2-dichloroacetate + NADP⁺ + H⁺ + chloride ← trichloroethene + NADPH + oxygen

L-erythrulose + ATP → L-erythrulose 1-phosphate + H⁺ + ADP

H₂O + ground state fungal oxyluciferin → pyruvate + H⁺ + trans-caffeate

S-adenosyl-L-methionine + esculetin → S-adenosyl-L-homocysteine + H⁺ + scopoletin

S-adenosyl-L-methionine + 3',4',5'-trimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 7,3',4',5'-tetramethylmyricetin

H₂O + 2'-hydroxybiphenyl-2-sulfinate → 2-hydroxybiphenyl + H⁺ + sulfite

H₂O + 4-nitrophenyl phosphate → 4-nitrophenol + H⁺ + phosphate

a nascent peptidoglycan with D,D cross-links (meso-diaminopimelate containing) → di-trans,octa-cis-undecaprenyl diphosphate + a mature peptidoglycan with D,D cross-links (meso-diaminopimelate containing) + H⁺

H₂O + 17-O-acetylajmaline → acetate + H⁺ + ajmaline

a reduced electron donor + 3,3',5'-triiodo-L-thyronine → an oxidized electron donor + H⁺ + iodide + 3,3'-diiodothyronine

H₂O + 3,15-acetyldeoxynivalenol → acetate + H⁺ + 15-acetyldeoxynivalenol

NAD⁺ + 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol → NADH + H⁺ + 2-(glutathion-S-yl)-2-methylbut-3-enal

UDP-N-acetyl-α-D-galactosamine + Glc-GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol → UMP + H⁺ + GalNAc-P-Glc-GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol

3 trans-feruloyl-CoA + spermidine → 3 coenzyme A + 3 H⁺ + triferuloyl spermidine

S-adenosyl-L-methionine + demethylmenaquinol-9 → S-adenosyl-L-homocysteine + menaquinol-9 + H⁺

17β-estradiol + UDP-α-D-glucuronate → 17β-estradiol 17-glucosiduronate + H⁺ + UDP

α-D-glucosyl-(1,2)-β-D-glucuronate-(1,2)-α-D-mannosyl-(1,3)-β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol + UDP-α-D-glucose → β-D-glucosyl-(1,6)-α-D-glucosyl-(1,2)-β-D-glucuronate-(1,2)-α-D-mannosyl-(1,3)-β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol + H⁺ + UDP

H₂O + 17-O-acetylnorajmaline → acetate + H⁺ + norajmaline

28 UDP-α-D-galactofuranose + β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol → 28 H⁺ + 28 UDP + [β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→6)]₁₄-β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)--L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol

2,2',3-trihydroxydiphenyl-ether + oxygen → 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H⁺

questin + NADPH + H⁺ + oxygen → demethylsulochrin + NADP⁺ + H⁺

4 H₂O + 4 L-glutamine + 4 ATP + adenosyl-cob(III)yrinate a,c-diamide → 4 H⁺ + 4 L-glutamate + 4 phosphate + 4 ADP + adenosylcobyrate

NADP⁺ + ascladiol → NADPH + H⁺ + patulin

3 S-adenosyl-L-methionine → 3 S-methyl-5'-thioadenosine + 3 H⁺ + L-nicotianamine

6-hydroxymellein + S-adenosyl-L-methionine → 6-methoxymellein + S-adenosyl-L-homocysteine + H⁺

N3-methylcytosine + 2-oxoglutarate + oxygen → formaldehyde + H⁺ + succinate + cytosine + CO₂

H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-2-(4-hydroxyphenyl)ethan-1-imine → (Z)-N-hydroxy-2-(4-hydroxyphenyl)acetimidothioate + pyruvate + H⁺ + ammonium

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H⁺ ← NAD(P)+ + 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one

desmethyl gadusol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + gadusol + H⁺

5'-demethoxy-6-methoxypodophyllotoxin + UDP-α-D-glucose → 5'-demethoxy-6-methoxypodophyllotoxin 7-glucoside + H⁺ + UDP

NADPH + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester → 3 H⁺ + NADP⁺ + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester

curcumin monoglucoside + UDP-α-D-glucose → curcumin 4'-O-β-D-gentiobioside + H⁺ + UDP

H₂O + (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate → anthranilate + (2E)-2-hydroxypenta-2,4-dienoate + H⁺

L-alanine + UDP-N-acetyl-α-D-muramate + ATP → H⁺ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanine + ADP

S-adenosyl-L-methionine + γ-tocopherol → S-adenosyl-L-homocysteine + H⁺ + α-tocopherol

ergosterol + UDP-α-D-glucose → ergosterol 3-O-β-D-glucoside + H⁺ + UDP

episterol → 2 H⁺ + ergosta-5,7,24(28)-trien-3β-ol

7-methylxanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + paraxanthine + H⁺

H₂O + 3,4-dihydroxybenzaldehyde + oxygen → protocatechuate + hydrogen peroxide + H⁺

3'-phosphoadenylyl-sulfate + desulfoglucotropaeolin → adenosine 3',5'-bisphosphate + H⁺ + glucotropaeolin

S-adenosyl-L-methionine + 8,12-diethyl-3-vinylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H⁺

2,3-dihydroxy-trans-cinnamate + oxygen → H⁺ + (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate

D-myo-inositol (3,6)-bisphosphate + ATP → D-myo-inositol (3,4,6)-trisphosphate + H⁺ + ADP

α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + 5-phospho-α-D-ribose 1,2-cyclic phosphate + H⁺ + 5'-deoxyadenosine + L-methionine + N-methylacetamide

3 (E)-4-coumaroyl-CoA + spermidine → 3 coenzyme A + 3 H⁺ + tricoumaroyl spermidine

H₂O + chlorophyll a → phytol + H⁺ + chlorophyllide a

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose → α-D-galactosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

H₂O + 3-aminopropanal + NAD(P)+ → 2 H⁺ + β-alanine + NAD(P)H

2-aminophenol + oxygen → (2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + H⁺

S-adenosyl-L-methionine + 7-O-methylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 7,4'-dimethylmyricetin

UDP-β-L-rhamnose + γ-chaconine → H⁺ + UDP + β-chaconine

H₂O + 2,4-dinitrocyclohexan-1-one → 4,6-dinitrohexanoate + H⁺

H₂O + amino-parathion → diethylthiophosphate + 4-aminophenol + H⁺

2 H₂O + acetone + ATP + CO₂ → 2 phosphate + 3 H⁺ + acetoacetate + AMP

H₂O + 2,4-dinitroanisole → 2,4-dinitrophenol + methanol + H⁺

H₂O + ε-rhodomycinone → 15-demethoxy-ε-rhodomycinone + methanol + H⁺

unsaturated CDP-archaeol + 1D-myo-inositol 3-monophosphate → unsaturated archaetidylinositol phosphate + CMP + H⁺

GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + UDP-α-D-glucose → H⁺ + Glc-GalNAc-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + UDP

H₂O + (+)-7-epi-jasmonoyl-CoA → coenzyme A + H⁺ + (+)-7-epi-jasmonate

(S)-coclaurine + NADP⁺ → 2 H⁺ + NADPH + (4'R)-11'-hydroxy-10'-methoxy-5'-azaspiro[cyclohexane-1,2'-tricyclo[6.3.1.04,ï¿½ï¿½]dodecane]-'(12'),2,5,8',10'-pentaen-4-one

tert-butoxymethanol + NAD⁺ → NADH + tert-butyl formate + H⁺

decaprenoxanthin + UDP-α-D-glucose → decaprenoxanthin monoglucoside + H⁺ + UDP

H₂O + aspirin → salicylate + acetate + H⁺

S-adenosyl-L-methionine + L-tyrosine → S-adenosyl-L-homocysteine + H⁺ + 3-methyl-L-tyrosine

L-valine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-valine + H⁺ + diphosphate + AMP

2 S-adenosyl-L-methionine + trans-resveratrol → 2 S-adenosyl-L-homocysteine + 2 H⁺ + pterostilbene

poly(ribitol phosphate) + ATP + D-alanine → O-D-alanyl-poly(ribitol phosphate) + H⁺ + diphosphate + AMP

GDP-4-dehydro-α-D-rhamnose + L-glutamate → H₂O + 2-oxoglutarate + H⁺ + 2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol]

H₂O + glucoiberin + oxygen → methanesulfonate + H⁺ + 3-hydroxypropyl-glucosinolate

NAD⁺ + (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol → NADH + H⁺ + 3-chlorocatechol

H₂O + sirohydrochlorin + L-glutamine + ATP → H⁺ + L-glutamate + phosphate + siroamide + ADP

H₂O + (S)-(+)-allantoin → H⁺ + allantoate

3'-phosphoadenylyl-sulfate + isorhamnetin → adenosine 3',5'-bisphosphate + H⁺ + isorhamnetin 3-sulfate

2 H₂O + CTP → 2 H⁺ + 2 phosphate + CMP

2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone + glutathione → 2,3,6-trichlorohydroquinone + H⁺ + glutathione disulfide

H₂O + UDP-N-acetyl-α-D-glucosamine → N-acetyl-α-D-mannosamine + H⁺ + UDP

5-(dihydroxymethyl)furan-2-carboxylate + oxygen → hydrogen peroxide + furan-2,5-dicarboxylate + H⁺

hederagenin + UDP-α-D-glucose → H⁺ + hederagenin-3-O-β-D-glucoside + UDP

cholesterol + UDP-α-D-glucose → cholesteryl-β-D-glucoside + H⁺ + UDP

NAD⁺ + 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a → NADH + H⁺ + 3-acetyl-3-devinylchlorophyllide a

NAD⁺ + choloyl-CoA → 3-oxocholoyl-CoA + NADH + H⁺

NAD⁺ + (3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA → NADH + H⁺ + 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA

3 S-adenosyl-L-methionine + tricetin → 3 S-adenosyl-L-homocysteine + 3 H⁺ + 3',4',5'-O-trimethyltricetin

acetyl-andilesin A → acetate + H⁺ + andilesin B

S-adenosyl-L-methionine + patuletin → S-adenosyl-L-homocysteine + H⁺ + quercetagetin 3',6-dimethyl ether

S-adenosyl-L-methionine + (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine → S-adenosyl-L-homocysteine + deacetoxyvindoline + H⁺

S-adenosyl-L-methionine + furfuryl thiol → S-adenosyl-L-homocysteine + H⁺ + furfuryl methyl sulfide

dimethylsulfoniopropanoate → acrylate + H⁺ + dimethyl sulfide

UDP-β-L-rhamnose + luteolin 7-O-β-D-glucoside → H⁺ + luteolin 7-O-neohesperidoside + UDP

3 coenzyme A + H₂O + Δ^2,5-3,4,4-trimethylpimeloyl-CoA → 3 acetyl-CoA + H⁺ + isobutanoyl-CoA

NAD⁺ + (S)-ureidoglycolate → NADH + H⁺ + N-carbamoyl-2-oxoglycine

chloroform + a reduced electron donor → an oxidized electron donor + dichloromethane + H⁺ + chloride

H₂O + 4-oxo-4-(pyridin-3-yl)butanal + NADP⁺ → 2 H⁺ + 4-oxo-4-(3-pyridyl)-butanoate + NADPH

alizarin + UDP-α-D-glucose → 1-hydroxy-2-(β-D-glucosyloxy)-9,10- anthraquinone + H⁺ + UDP

1D-myo-inositol 3-monophosphate + CDP-1L-myo-inositol → CMP + H⁺ + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate

1-hydroxyneurosporene + S-adenosyl-L-methionine → methoxyneurosporene + S-adenosyl-L-homocysteine + H⁺

N-demethylgalanthamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + galanthamine + H⁺

H₂O + salicyl-CoA → coenzyme A + salicylate + H⁺

H₂O + L-glutamate-5-semialdehyde + NAD⁺ → 2 H⁺ + NADH + L-glutamate

S-adenosyl-L-methionine + ladanein → S-adenosyl-L-homocysteine + H⁺ + salvigenin

2-mercaptosuccinate + oxygen → H⁺ + sulfinosuccinate

NAD⁺ + L-serine → 2-aminomalonate semialdehyde + NADH + H⁺

N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-α-D-galactose → α-D-galactosyl-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-di-trans,octa-cis-undecaprenol + H⁺ + UDP

progesterone + NADPH + H⁺ ← 5-β-pregnan-3,20 dione + NADP⁺

H₂O + nonane-4,6-dione → pentan-2-one + butanoate + H⁺

H₂O + sn-glycero-3-phospho-1-inositol → 1D-myo-inositol 1-monophosphate + glycerol + H⁺

D-erythrulose + ATP → D-erythrulose 4-phosphate + H⁺ + ADP

UDP-α-D-glucose + solanidine → H⁺ + UDP + γ-chaconine

N-monomethylethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-dimethylethanolamine + H⁺

3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxy-coumarin + ATP → 8-demethylnovobiocic acid + H⁺ + diphosphate + AMP

H₂O + 1-naphthaldehyde + oxygen → 1-naphthoate + hydrogen peroxide + H⁺

NADP⁺ + 16-hydroxypalmitate → NADPH + H⁺ + 16-oxo-palmitate

H₂O + propanoyl-CoA → coenzyme A + propanoate + H⁺

3,6-dichloro-3a-methyl-dihydro-3H-furo[3,2-b]furan-2,5-dione → 2 H⁺ + 2-chloro-3-methyl-dienelactone + chloride

triglucosyl-enterobactin + Fe³⁺ → 6 H⁺ + ferric–[triglucosyl-enterobactin] complex

2-amino-4-hydroxy-5-phosphonopentanoate + L-arginine + ATP → L-arginyl-4-hydroxy-5-phosphonopentanoate + H⁺ + phosphate + ADP

pre-bisucaberin + ATP → bisucaberin + H⁺ + diphosphate + AMP

UDP-α-D-glucuronate + cyclo-dopa 5-O-glucoside → H⁺ + UDP + cyclo-dopa glucuronosyl glucoside

S-adenosyl-L-methionine + desmethyl-dehydro-griseofulvin → S-adenosyl-L-homocysteine + H⁺ + dehydrogriseofulvin

choline + ATP → phosphocholine + H⁺ + ADP

CDP-ribitol + Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol → CMP + Rib-ol-P-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + H⁺

H₂O + 3-acetyl T-2 toxin → acetate + H⁺ + T-2 toxin

an oxidized electron donor + carlactone + oxygen → carlactone carboxylate + a reduced electron donor + H⁺

H₂O + UDP-N-acetyl-tunicaminyl-uracil → N-acetyl-tunicaminyl-uracil + H⁺ + UDP

H₂O + succinate semialdehyde + NAD⁺ → 2 H⁺ + NADH + succinate

monodeglucosyl des-acyl avenacin A + UDP-α-D-glucose → des-acyl avenacin A + H⁺ + UDP

L-cystine → S-sulfanyl-L-cysteine + H⁺ + 2-aminoprop-2-enoate

cis-tuberonic acid + UDP-α-D-glucose → cis-tuberonic acid glucoside + H⁺ + UDP

H₂O + (1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol → HCl + (1S,4S)-2,5-dichloro-2,5-cyclohexadiene-1,4-diol + H⁺

H₂O + carbamoyl phosphate + kanamycin A + ATP → H⁺ + diphosphate + phosphate + 6''-O-carbamoylkanamycin A + AMP

cis-p-coumarate + UDP-α-D-glucose → 4'-O-β-D-glucosyl-cis-p-coumarate + H⁺ + UDP

pinosylvin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + pinosylvin monomethylether + H⁺

H₂O + O-sinapoylcholine → choline + sinapate + H⁺

H₂O + malonyl-CoA + L-glutamine + ATP → malonamoyl-CoA + H⁺ + L-glutamate + diphosphate + AMP

β-D-glucopyranose + ADP → β-D-glucose 6-phosphate + H⁺ + AMP

H₂O + (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + NAD⁺ → 2 H⁺ + NADH + (2Z,4E)-2-hydroxyhexa-2,4-dienedioate

H₂O + S-adenosyl-L-methionine + 12-ethyl-7¹-hydroxy-8-isobutylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹,7¹-dihydroxy-8-isobutylbacteriochlorophyllide c

UDP-α-D-glucose + 3,6,7,4'-tetramethylquercetagetin → H⁺ + 3,6,7,4'-tetramethylquercetagetin 3'-O-β-D-glucoside + UDP

baeocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + psilocybin + H⁺

α-D-glucopyranosyl-diphosphoundecaprenol + UDP-α-D-glucose → β-D-glucosyl-(1,4)-α-D-glucosyl-diphosphoundecaprenol + H⁺ + UDP

H₂O + geranial + oxygen → hydrogen peroxide + H⁺ + geranate

H₂O + acetaminophen → acetate + 4-aminophenol + H⁺

3,5-dihydroxyanisole + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dimethoxyphenol + H⁺

an oxidized electron donor + 4,4'-diapolycopen-4,4'-dial + H₂O → 4,4'-diapolycopen-4-al-4'-oate + a reduced electron donor + H⁺

fusicocca-1,10(14)-diene-3,8β,16-triol + S-adenosyl-L-methionine → fusicocca-1,10(14)-diene-16-(hydroxymethyl)-3,8β-diol + S-adenosyl-L-homocysteine + H⁺

H₂O + NADP⁺ + L-malic semialdehyde → 2 H⁺ + NADPH + (S)-malate

β-nicotinate D-ribonucleotide + phenol → nicotinate + phenyl ribotide phosphate + H⁺

2 decaprenyl-pyrophosphoryl-(N-acetylglucosamine)-N-acetylmuramyl-(pentapeptide) → a peptidoglycan dimer (mycobacteria) + H⁺ + mono-trans,octa-cis-decaprenyl diphosphate

H₂O + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} → CMP + (S)-2-hydroxypropylphosphonate + H⁺

S-adenosyl-L-methionine + quercetagetin → S-adenosyl-L-homocysteine + H⁺ + patuletin

serotonin + trans-feruloyl-CoA → coenzyme A + H⁺ + feruloylserotonin

sn-glycero-3-phosphoethanolamine + H₂O → ethanolamine + H⁺ + sn-glycerol 3-phosphate

H₂O + N⁵-(cytidine 5'-diphosphoramidyl)-L-glutamine → H⁺ + L-glutamate + cytidine 5'-diphosphoramidate

S-adenosyl-L-methionine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil → 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H⁺ + ammonium + 5'-deoxyadenosine + L-methionine

coniferyl alcohol + UDP-α-D-glucose → H⁺ + coniferin + UDP

2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-N-(β-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine → a peptidoglycan dimer (E. faeciums) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

H₂O + 3,15-acetyldeoxynivalenol → acetate + H⁺ + 3-acetyldeoxynivalenol

H₂O + (4S,7R)-4-isopropenyl-7-methyloxepan-2-one → H⁺ + (3S,6R)-6-hydroxy-3-isopropenyl-heptanoate

(E)-cinnamoyl-CoA + serotonin → coenzyme A + H⁺ + cinnamoylserotonin

3-hydroxyanthranilate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate + H⁺

ADP-L-glycero-β-D-manno-heptose + galactosyl-(glucosyl)₃-(heptosyl)₃-Kdo₂-lipid A-bisphosphate → H⁺ + core oligosaccharide-lipid A (E. coli K-12 core type) + ADP

(E)-ω-(methylsulfanyl)hexyl-thiohydroximate + UDP-α-D-glucose → 5-(methylsulfanyl)pentyl-desulfoglucosinolate + H⁺ + UDP

UDP-α-D-glucose + 3,7,4'-trimethylquercetagetin → H⁺ + 3,7,4'-trimethylquercetagetin 3'-O-β-D-glucoside + UDP

(20S)-ginsenoside Rh2 + UDP-α-D-glucose → ginsenoside F2 + H⁺ + UDP

S-adenosyl-L-methionine + (1H-indol-3-yl)-N-methylmethanamine → S-adenosyl-L-homocysteine + H⁺ + gramine

S-adenosyl-L-methionine + (-)-vestitol → S-adenosyl-L-homocysteine + (-)-sativan + H⁺

NAD⁺ + ATP → NADH + H⁺ + 3'-keto-3'-dehydroATP

H₂O + trehalose-cis-methoxy-mono-mycolate + ATP → H⁺ + trehalose-cis-methoxy-mono-mycolate + phosphate + ADP

S-adenosyl 3-(methylsulfanyl)propylamine + norspermine → S-methyl-5'-thioadenosine + caldopentamine + H⁺

L-thyroxine + UDP-α-D-glucuronate → H⁺ + L-thyroxine acyl β-D-glucuronide + UDP

α-ketoglutaryl-diaminobutyryl-citryl-ethanolamine + 2-oxoglutarate + ATP → H⁺ + achromobactin + diphosphate + AMP

(R,S)-tetrahydrobenzylisoquinoline + S-adenosyl-L-methionine → N-methyl-(R,S)-tetrahydrobenzylisoquinoline + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 7-O-methylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7-dimethylmyricetin

isoliquiritigenin + UDP-α-D-glucose → isoliquiritigenin 4'-glucoside + H⁺ + UDP

S-adenosyl-L-methionine + 3-O-methylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7-dimethylmyricetin

2-hydroxyethyl-CoM + NAD⁺ → NADH + 2-oxoethyl-CoM + H⁺

H₂O + glutathione + methylacrylyl-CoA → coenzyme A + H⁺ + 2-(glutathion-S-yl)-2-carboxypropane

H₂O + lanthionine + ATP → lanthionine + H⁺ + phosphate + ADP

trichloroethene + oxygen → 2,2,2-trichloroacetate + H⁺

2,4-dibromo-6-(2,4-dibromo-6-hydroxyphenoxy)phenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol + H⁺

2 ATP + L-phenylalanine + L-serine → 2 H⁺ + 2 phosphate + 2 ADP + cyclo(L-phenylalanyl-L-seryl)

2'-deoxyadenosine + ATP → H⁺ + dAMP + ADP

O-demethylpuromycin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + puromycin + H⁺

dTDP-L-ristosamine + K-252c → H⁺ + holyrine A + dTDP

S-adenosyl-L-methionine + nocardicin E → S-methyl-5'-thioadenosine + H⁺ + isonocardicin A

2 hexadeca-4,7,10,13-tetraene-1-oyl-CoA + H₂O → 2 coenzyme A + (6Z,9Z,12Z,15Z)-3-oxo-2-[(2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl]octadeca-6,9,12,15-tetraenoate + H⁺

S-adenosyl-L-methionine + 3,6,7,4'-tetramethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,3',4'-pentamethylquercetagetin

L-glutamine + D-glyceraldehyde 3-phosphate + aldehydo-D-ribose 5-phosphate → 3 H₂O + pyridoxal 5'-phosphate + H⁺ + L-glutamate + phosphate

a nascent peptidoglycan with L,D cross links (meso-diaminopimelate containing) → a mature peptidoglycan with L,D cross-links (meso-diaminopimelate containing) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

H₂O + cyanuric acid → 1-carboxybiuret + H⁺

L-serine + diphosphate → 3-phospho-L-serine + H⁺ + phosphate

H₂O + prenyl diphosphate → H⁺ + phosphate + prenyl phosphate

protocatechuate + oxygen → (2E,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H⁺

H₂O + phosphonoacetaldehyde + NAD⁺ → 2 H⁺ + NADH + phosphonoacetate

L-lysine + ATP + (3R)-3-methyl-D-ornithine → H⁺ + phosphate + (2R,3R)-3-methylornithinyl-N⁶-lysine + ADP

benzyladenine + UDP-α-D-glucose → H⁺ + benzyladenine-9-N-glucoside + UDP

NAD(P)+ + dimeric rubrofusarin-9-hydroxyrubrofusarin → NAD(P)H + H⁺ + fuscofusarin

cytidine + ATP → CMP + H⁺ + ADP

S-adenosyl-L-methionine + C36-phenolphthiotriol A → S-adenosyl-L-homocysteine + C37-phenolphthiocerol A + H⁺

H₂O + NAD(P)+ + (S)-1-pyrroline-5-carboxylate → NAD(P)H + H⁺ + L-glutamate

L-selenocystathionine → 2 H⁺ + seleno-L-homocysteine + 2-aminoprop-2-enoate

H₂O + 1-(oleoyl)-sn-glycero-3-phosphoethanolamine → sn-glycero-3-phosphoethanolamine + oleate + H⁺

S-adenosyl-L-methionine + N,N-dimethylglycine → glycine betaine + S-adenosyl-L-homocysteine + H⁺

intermediate IV → akuammicine + formate + H⁺

H₂O + chenodeoxycholoyl-CoA → H⁺ + coenzyme A + chenodeoxycholate

ginsenoside F2 + UDP-α-D-glucose → ginsenoside Rd + H⁺ + UDP

N-acetyl-β-D-glucosamine + UDP-α-D-galactose → β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine + H⁺ + UDP

6-demethylsterigmatocystin + S-adenosyl-L-methionine → sterigmatocystin + S-adenosyl-L-homocysteine + H⁺

FMNH₂ + isethionate + oxygen → 2 H⁺ + FMN + H₂O + glycolaldehyde + sulfite

1-hydroxy-2-phosphorylethylphosphonate + NAD⁺ → 2 H⁺ + NADH + 1-oxo-2-phosphorylethylphosphonate

H₂O + geranyl acetate → acetate + H⁺ + geraniol

H₂O + 3-hydroxybenzoyl-CoA → coenzyme A + H⁺ + 3-hydroxybenzoate

2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose

H₂O + NAD(P)+ + iso-arabidopaldehyde → 2 H⁺ + NAD(P)H + iso-arabidopate

D-ribulose 5-phosphate + L-tryptophan → hydroxyacetone + H₂O + formaldehyde + H⁺ + phosphate + (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate

S-adenosyl-L-methionine + scutellarein 7-methyl ether → S-adenosyl-L-homocysteine + cirsimaritin + H⁺

2-oxoglutarate + oxygen + gibberellin A₃₄ → H₂O + H⁺ + succinate + gibberellin A₃₄-catabolite + CO₂

quercetin + UDP-α-D-glucose → H⁺ + quercetin-3-glucoside + UDP

5-aminolevulinyl-CoA → 2-amino-3-hydroxycyclopent-2-enone + coenzyme A + H⁺

H₂O + p-cumic aldehyde + NAD⁺ → 2 H⁺ + NADH + p-cumate

S-adenosyl-L-methionine + tetracenomycin B3 → S-adenosyl-L-homocysteine + H⁺ + tetracenomycin E

trichloromethyl radical + a reduced electron donor → 2 H⁺ + an oxidized electron donor + dichlorocarbene + chloride

afrormosin + UDP-α-D-glucose → afrormosin-7-O-glucoside + H⁺ + UDP

M-antigen (variant) monomer undecaprenyl diphosphate + core oligosaccharide-lipid A (E. coli K-12 core type) (no GlcNAc) → M_LPS + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

UDP-α-D-glucose + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin → H⁺ + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin 3'-O-β-D-glucoside + UDP

geranyl β-D-glucopyranoside + UDP-α-D-xylose → geranyl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside + H⁺ + UDP

steviolbioside + UDP-α-D-glucose → rebaudioside B + H⁺ + UDP

(+)-neoisodihydrocarveol + NAD⁺ → NADH + H⁺ + (+)-isodihydrocarvone

3 trans,octacis-decaprenylphospho-β-D-arabinofuranose + [β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→6)]₁₄-β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)--L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol → 3 trans,octacis-decaprenyl phosphate + 6 H⁺ + mycobacterial arabinogalactan primed with arabinofuran

N-3-fumaramoyl-L-2,3-diaminopropanoate + L-leucine + ATP → dapdiamide C + H⁺ + phosphate + ADP

coenzyme A + H₂O + NAD⁺ + (3R)-hydroxy-undecanoyl-CoA + oxygen → hydrogen peroxide + NADH + H⁺ + (3R)-hydroxy-nonanoyl-CoA + acetyl-CoA

4'-apo-β-carotenal + H₂O + NAD⁺ → 2 H⁺ + NADH + neurosporaxanthin

GDP-α-D-mannose + N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol → α-D-mannosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + GDP

4-(β-D-ribofuranosyl)hydroxybenzene 5'-phosphate + L-aspartate + ATP → 2 H⁺ + 4-(β-D-ribofuranosyl)-N-succinylaminobenzene 5'-phosphate + phosphate + ADP

S-adenosyl-L-methionine + 6-O-methyl-N-deacetylisoipecoside aglycon → S-adenosyl-L-homocysteine + H⁺ + 6,7-O,O-dimethyl-N-deacetylisoipecoside aglycon

acetyl-CoA + kanamycin B → coenzyme A + N6'-acetylkanamycin-B + H⁺

4 Mn⁺³ + 6 H₂O + oxygen → 12 H⁺ + 4 Mn^IVO₂

S-adenosyl-L-methionine + L-histidine → S-adenosyl-L-homocysteine + H⁺ + N^α-methyl-L-histidine

steviolmonoside + UDP-α-D-glucose → steviolbioside + H⁺ + UDP

anthranilate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + N-methylanthranilate

3,6-dichloro-4-methylcatechol + oxygen → 2 H⁺ + 2,5-dichloro-3-methyl-muconate

2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine + ATP → H⁺ + phosphate + ADP + UDP-solosamine

S-adenosyl-L-methionine + 3,7-dimethylquercetagetin → S-adenosyl-L-homocysteine + 3,6,7-trimethylquercetagetin + H⁺

2 H₂O + 2 L-glutamine + 2 ATP + cobyrinate → 2 L-glutamate + 2 phosphate + 2 ADP + 3 H⁺ + cob(II)yrinate a,c-diamide

benzyl alcohol + H⁺ + 6-hydroxy-2-cyclohexen-one-carboxylate ← H₂O + benzyl-6-hydroxy-2-cyclohexene-on-oyl

H₂O + 3-sulfinopropanoyl-CoA → propanoyl-CoA + H⁺ + sulfite

FMNH₂ + 3-(N-morpholino)propanesulfonate + oxygen → 2 H⁺ + FMN + H₂O + 3-(N-morpholino)propanal + sulfite

hydrogen peroxide + dehydroascorbate (bicyclic form) → 3 H⁺ + L-threonate + oxalate

H₂O + deethylsimazine → N-ethylammeline + H⁺ + chloride

H₂O + 3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP⁺ → 2 H⁺ + 3-oxo-5,6-didehydrosuberyl-CoA + NADPH

S-adenosyl-L-methionine + 2-sulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA → S-adenosyl-L-homocysteine + H⁺ + 2-methylsulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA

2 H₂O + UTP → 2 H⁺ + 2 phosphate + UMP

icosatetraenoate → 2 H⁺ + (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate

validamine 7-phosphate + GDP-valienol → validoxylamine A 7'-phosphate + H⁺ + GDP

FMNH₂ + adamantanone + oxygen → FMN + H₂O + 4-oxahomoadamantan-5-one + H⁺

2-chloro-3-methyl-dienelactone + H₂O → 2-chloro-3-methyl-maleylacetate + H⁺

H₂O + 3,4-dihydroxyphenylacetaldehyde + NAD⁺ → 2 H⁺ + NADH + 3,4-dihydroxyphenylacetate

H₂O + 4-chlorobenzoyl-coA → H⁺ + 4-hydroxybenzoyl-CoA + chloride

prenyl diphosphate + phlormethylbutanophenone → 4-prenylphlormethylbutanophenone + H⁺ + diphosphate

autoinducer 2 + ATP → H⁺ + (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione + ADP

trans-3'-hydroxycotinine + UDP-α-D-glucuronate → H⁺ + trans-3-hydroxycotinine-glucuronide + UDP

H₂O + rutin → rutinose + H⁺ + quercetin

UDP-α-D-glucose + apigeninidin → H⁺ + apigeninidin 5-O-glucoside + UDP

N¹-(3,4-dihydroxybenzoyl)-N⁸-citryl-spermidine + spermidine + ATP → N¹-(3,4-dihydroxybenzoyl)-N⁸,N'⁸-citryl-bis(spermidine) + H⁺ + diphosphate + AMP

4,5-dichlorobenzene-1,2-diol + oxygen → 2 H⁺ + 2,3-dichloro-cis,cis-muconate

α-D-ribose-1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + methane + 5-phospho-α-D-ribose 1,2-cyclic phosphate + H⁺ + 5'-deoxyadenosine + L-methionine

2 an oxidized electron donor + H₂O + nornicotine → 2 a reduced electron donor + H⁺ + norcotinine

N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose → H⁺ + β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + UDP

S-adenosyl-L-methionine + 27-O-demethyl-rifamycin SV → S-adenosyl-L-homocysteine + H⁺ + rifamycin SV

(R)-prunasin + UDP-α-D-glucose → (R)-amygdalin + H⁺ + UDP

S-adenosyl-L-methionine + thiobenzoate → S-adenosyl-L-homocysteine + H⁺ + (S)-methyl thiobenzoate

(2E)-3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD⁺ → NADH + 2,3-dihydroxy-trans-cinnamate + H⁺

H₂O + ε-caprolactone → H⁺ + 6-hydroxyhexanoate

H₂O + thiamine triphosphate → thiamine diphosphate + H⁺ + phosphate

(R)-norreticuline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (R)-N-methylnorreticuline + H⁺

myo-inositol + ATP → 2 H⁺ + 1D-myo-inositol 3-monophosphate + ADP

2 K⁺ + 3 Na⁺ + H₂O + ATP → 2 K⁺ + 3 Na⁺ + H⁺ + phosphate + ADP

2 S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin → 2 S-adenosyl-L-homocysteine + 2 H⁺ + roseoflavin

2 L-dehydro-ascorbate + oxygen → 2 cyclic-2,3-O-oxalyl-L-threonate + 2 H⁺

S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + plastoquinol-9 + H⁺

enterobactin + Fe³⁺ → 6 H⁺ + ferric-enterobactin complex

N-acetyl-α-D-galactosamine + ATP → N-acetyl-α-D-galactosamine 1-phosphate + H⁺ + ADP

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ATP + D-aspartate → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-N-(β-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + H⁺ + phosphate + ADP

L-glutamate + ATP + citrate → β-citryl-L-glutamate + H⁺ + phosphate + ADP

4-phosphooxy-L-threonine + NAD⁺ → 2 H⁺ + NADH + (2S)-2-amino-3-oxo-4-phosphooxybutanoate

1'-hydroxy-γ-carotene + H₂O → 2 H⁺ + plectaniaxanthin

NAD⁺ + (3S,6R)-6-hydroxy-3-isopropenyl-heptanoate → (3S)-3-isopropenyl-6-oxoheptanoate + NADH + H⁺

β-alanine + ATP + γ-L-glutamyl-L-cysteine → H⁺ + homoglutathione + phosphate + ADP

N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-α-D-galactosamine → N-acetyl-D-galactosaminyl-α-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + H⁺ + UDP

H₂O + 3'-phosphoadenylyl-sulfate → 2 H⁺ + adenosine 3',5'-bisphosphate + sulfate

4-O-(α-L-rhamnopyranosyl)-hydroxybenzoate methyl ester + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + p-HBAD-I + H⁺

oleanolate + UDP-α-D-glucuronate → oleanolate 3 β-D-glucuronoside + H⁺ + UDP

3-oxocholoyl-CoA + NAD⁺ → 7α,12α-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H⁺

an oxidized electron donor + propane-1,3-diamine → 2 H⁺ + pyrazolidine + a reduced electron donor

4-amino-2,6-dinitrotoluene + UDP-α-D-glucose → 2 H⁺ + 4-amino-2,6-dinitrotoluene glucoside + UDP

(R)-1-aminopropan-2-ol + ATP + adenosylcobyrate → H⁺ + phosphate + ADP + adenosylcobinamide

3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate

L-pipecolate + oxygen → hydrogen peroxide + 1-piperideine 6-carboxylate + H⁺

N-3-fumaramoyl-L-2,3-diaminopropanoate + L-valine + ATP → dapdiamide A + H⁺ + phosphate + ADP

2 L-glutamate + 2 ATP + N-acetyl-L-aspartate → 2 H⁺ + 2 phosphate + 2 ADP + N-acetyl-α-L-aspartyl-L-glutamyl-L-glutamate

hydrogen cyanide + thiosulfate → 2 H⁺ + thiocyanate + sulfite

α-Kdo8N-(2→6)-lipid IV_A + ATP → 4-O-phospho-α-Kdo8N-(2→6)-lipid IV_A + H⁺ + ADP

2 S-adenosyl-L-methionine + scutellarein 7-methyl ether → 2 S-adenosyl-L-homocysteine + 2 H⁺ + salvigenin

NADP⁺ + L-allo-threonine → L-2-amino-3-oxobutanoate + NADPH + H⁺

3-(methylsulfanyl)propanoate + H⁺ + 5-methyltetrahydropteroyl mono-L-glutamate ← dimethylsulfoniopropanoate + 5,6,7,8-tetrahydrofolate

2 ATP + S-adenosyl-L-methionine + (S)-1-pyrroline-5-carboxylate + L-arginine → 2 H⁺ + 2 diphosphate + 2 AMP + H₂O + S-adenosyl-L-homocysteine + peramine

NADP⁺ + H⁺ + Hg⁰ ← Hg²⁺ + NADPH

S-adenosyl-L-methionine + 7'-O-demethylcephaeline → S-adenosyl-L-homocysteine + H⁺ + cephaeline

hydroquinone + UDP-α-D-glucose → arbutin + H⁺ + UDP

H₂O + 4,4'-diaponeurosporenal + NAD⁺ → NADH + 4,4'-diaponeurosporenoate + H⁺

(6S)-hydroxyhyoscyamine + 2-oxoglutarate + oxygen → H₂O + scopolamine + H⁺ + succinate + CO₂

an oxidized electron donor + L-homoserine + ammonium → L-canaline + a reduced electron donor + H⁺

H₂O + (glutathion-S-yl)-bimane + ATP → H⁺ + (glutathion-S-yl)-bimane + phosphate + ADP

dTDP-β-L-rhamnose + 8-demethyltetracenomycin C → H⁺ + 8-demethyl-8-α-L-rhamnosyl-tetracenomycin C + dTDP

9-N-hydroxy-L-tryptophan + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 9-N-methoxy-tryptophan

S-adenosyl-L-methionine + mono(methylsulfanyl)gliotoxin → S-adenosyl-L-homocysteine + H⁺ + bis(methylsulfanyl)gliotoxin

2-hydroxylamino-4,6-dinitrotoluene + UDP-α-D-glucose → H⁺ + 2-hydroxylamino-4,6-dinitrotoluene-C3-glucoside + UDP

dTDP-L-olivose + oleandolide → H⁺ + L-olivosyl-oleandolide + dTDP

saturated CDP-archaeol + L-serine → CMP + saturated archaetidylserine + H⁺

spermidine + N-citryl-spermidine + ATP → N⁸,N'⁸-citryl-bis(spermidine) + H⁺ + diphosphate + AMP

H₂O + trehalose-trans-methoxy-mono-mycolate + ATP → H⁺ + trehalose-trans-methoxy-mono-mycolate + phosphate + ADP

trans-zeatin + UDP-α-D-glucose → H⁺ + trans-zeatin-7-N-glucoside + UDP

benzoyl-CoA + N-debenzoyl-(3'-RS)-taxol → coenzyme A + taxol + H⁺

coenzyme A + H⁺ + dihomocitrate ← H₂O + 2-oxoadipate + acetyl-CoA

H₂O + 1-18:1-2-16:0-monogalactosyldiacylglycerol → sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H⁺

xanthohumol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 4-O-methylxanthohumol + H⁺

H₂O + 2,4-dinitrophenyl-S-glutathione + ATP → H⁺ + 2,4-dinitrophenyl-S-glutathione + phosphate + ADP

dTDP-D-mycarose + premithramycin A2 → H⁺ + dTDP + 9-demethylpremithramycin A3

dTDP-α-D-forosamine + 2',3',4'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone → spinosyn A + H⁺ + dTDP

H₂O + glycolaldehyde + NAD⁺ → 2 H⁺ + glycolate + NADH

NAD⁺ + 10-hydroxy-α-humulene → NADH + H⁺ + zerumbone

H₂O + myosin light-chain phosphate → 2 H⁺ + phosphate + a [myosin light-chain] L-serine

2 FMNH₂ + dibenzothiophene-5,5-dioxide + oxygen → 2 FMN + 3 H⁺ + H₂O + 2'-hydroxybiphenyl-2-sulfinate

H₂O + (2E)-hexadecenal + NAD⁺ → 2 H⁺ + (2E)-hexadecenoate + NADH

D-erythritol 1-phosphate + NADP⁺ → D-erythrulose 1-phosphate + NADPH + H⁺

chlorohydroquinone + oxygen → 2 H⁺ + 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienate

S-adenosyl-L-methionine + 5-hydroxy-desmethylanthrotainin → S-adenosyl-L-homocysteine + H⁺ + 5-hydroxyanthrotainin

demethyllactenocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + lactenocin + H⁺

H₂O + (E)-1-(L-cystein-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine → pyruvate + H⁺ + ammonium + (E)-2-(1H-indol-3-yl)-1-thioacetohydroximate

S-adenosyl-L-methionine + 3'-O-demethyl-4'-N-demethyl-staurosporine → S-adenosyl-L-homocysteine + H⁺ + 3'-O-demethyl-staurosporine

(citryl)-N-(3-aminopropyl)-N-hydroxyacetamide + N-(3-aminopropyl)-N-hydroxyacetamide + ATP → schizokinen + H⁺ + diphosphate + AMP

D-glyceraldehyde 3-phosphate + L-arginine → L-N²-(2-carboxyethyl)arginine + H⁺ + phosphate

demethyldecarbamoyl novobiocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + decarbamoylnovobiocin + H⁺

H₂O + (E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine → L-seryl-glycine + H⁺ + (E)-2-(1H-indol-3-yl)-1-thioacetohydroximate

H₂O + 3-β-hydroxyandrost-5-en-17-one 3-sulfate → 3 H⁺ + 3-β-hydroxyandrost-5-en-17-one + sulfate

streptomycin + ATP → streptomycin 6-phosphate + H⁺ + ADP

2 oxygen + H₂O + adenosine → 2 hydrogen peroxide + H⁺ + adenin-9-yl riburonosate

a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

catechol + oxygen → 2 H⁺ + cis,cis-muconate

L-lysine + ATP + (indol-3-yl)acetate → N⁶-[(Indole-3-yl)acetyl]-L-lysine + H⁺ + phosphate + ADP

medicagenate + UDP-α-D-glucose → H⁺ + medicagenate-28-O-β-D-glucoside + UDP

UDP-α-D-glucuronate + cytosine → cytosyl-β-D-glucuronate + H⁺ + UDP

H₂O + (S)-3-hydroxy-3-methylglutaryl-CoA → coenzyme A + 3-hydroxy-3-methylglutarate + H⁺

H₂O + benzoyl-CoA → coenzyme A + H⁺ + benzoate

H₂O + β-D-ribopyranose + ATP → β-D-ribopyranose + H⁺ + phosphate + ADP

L-glutamate + ATP + benzoate → H⁺ + diphosphate + AMP + N-benzoyl-L-glutamate

2-propenyl-thiohydroximate-O-sulfate → H⁺ + allyl isothiocyanate + sulfate

UDP-α-D-glucose + 2'-hydroxy 3,7,3',4'-tetramethylquercetin → H⁺ + 3,7,3',4'-tetramethylquercetin 2'-O-β-D-glucoside + UDP

H₂O + L-4-hydroxyglutamate semialdehyde + NAD⁺ → 2 H⁺ + NADH + erythro-4-hydroxy-L-glutamate

H₂O + NADH → 2 H⁺ + reduced β-nicotinamide D-ribonucleotide + AMP

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + L-glutamate → 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 2-oxoglutarate + ammonium

zymosterol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + fecosterol + H⁺

S-adenosyl-L-methionine + demethylmenaquinol-7 → S-adenosyl-L-homocysteine + menaquinol-7 + H⁺

3-chloro-5-methylcatechol + oxygen → 2 H⁺ + 2-chloro-4-methyl-cis,cis-muconate

H₂O + 7-(methylsulfanyl)-2-oxoheptanoate + acetyl-CoA → coenzyme A + 2-[(5'-methylsulfanyl)pentyl]malate + H⁺

(S)-lactate + GTP → (2S)-2-phospholactate + H⁺ + GDP

NADH + H⁺ + 3-oxo-(7Z)-hexadecenoyl-CoA ← NAD⁺ + (S)-3-hydroxy-(7Z)-hexadecenoyl-CoA

3 trans-caffeoyl-CoA + spermidine → 3 coenzyme A + 3 H⁺ + tricaffeoyl spermidine

D-erythronate + ATP → 4-phospho-D-erythronate + H⁺ + ADP

1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate → 2-demethylmenaquinone-7 + H⁺ + diphosphate + CO₂

H₂O + S-adenosyl-L-methionine + (3¹R)-8-ethyl-7¹-12-methylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8-ethyl-7¹,7¹-dihydroxy-12-methylbacteriochlorophyllide c

3 S-adenosyl-L-methionine + H₂O + magnesium-protoporphyrin IX 13-monomethyl ester → 3 5'-deoxyadenosine + 3 L-methionine + 4 H⁺ + 3,8-divinyl protochlorophyllide a

H₂O + ethyl acetate → acetate + ethanol + H⁺

luteolin 7-O-β-D-glucuronide + UDP-α-D-glucuronate → luteolin 7-O-β-D-diglucuronide + H⁺ + UDP

S-adenosyl-L-methionine + L-leucyl-demethyl-blasticidin S → S-adenosyl-L-homocysteine + H⁺ + L-leucyl-blasticidin S

H₂O + oxaloacetate → acetate + H⁺ + oxalate

quercetin + UDP-α-D-glucose → H⁺ + quercetin 4'-O-glucoside + UDP

NADPH + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester → 3 H⁺ + NADP⁺ + 3,8-divinyl protochlorophyllide a

S-adenosyl-L-methionine + 3-demethylubiquinol-8 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-8

pinocembrin chalcone → (2S)-pinocembrin + H⁺

H₂O + 4-oxo-4-sulfanylbutanoate → H⁺ + succinate + hydrogen sulfide

NAD⁺ + chenodeoxycholoyl-CoA → 3-oxochenodeoxycholoyl-CoA + NADH + H⁺

UDP-α-D-glucose + 7-hydroxyflavone → H⁺ + UDP + 7-O-β-D-glucosyl-7-hydroxyflavone

NADP⁺ + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester → NADPH + H⁺ + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester

N³-dec-2-enoyl-N³-hydroxy-1,3-diaminopropane + ATP + citrate → N¹-citryl-N³-dec-2-enoyl-N³-hydroxy-1,3-diaminopropane + H⁺ + diphosphate + AMP

3,5-dioxodecanoyl-CoA → coenzyme A + H⁺ + triketide pyrone

3'-phosphoadenylyl-sulfate + castasterone → adenosine 3',5'-bisphosphate + H⁺ + castasterone 22-O-sulfate

acetyl-CoA + (S)-azetidine-2-carboxylate → coenzyme A + H⁺ + (2S)-1-acetylazetidine-2-carboxylate

β-nicotinate D-ribonucleotide + 4-methylphenol → nicotinate + 4-methylphenyl ribotide phosphate + H⁺

S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene → S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H⁺

NADP⁺ + isoepoxydon → NADPH + H⁺ + phyllostine

S-adenosyl-L-methionine + triostin A → S-adenosyl-L-homocysteine + echinomycin + H⁺

S-adenosyl-L-methionine + licodione → S-adenosyl-L-homocysteine + 2'-O-methyllicodione + H⁺

biphenyl-2,3-diol + oxygen → 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H⁺

(-)-dehydrodiconiferyl acid + NAD⁺ → NADH + H⁺ + (-)-dehydrodiconiferyl acid aldehyde

H₂O + NAD(P)+ + arabidopaldehyde → 2 H⁺ + NAD(P)H + arabidopate

5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline + NAD⁺ → 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H⁺

an oxidized electron donor + H⁺ + iodide + 3,3',5'-triiodo-L-thyronine ← a reduced electron donor + L-thyroxine

(-)-neodihydrocarveol + NAD⁺ → NADH + (-)-dihydrocarvone + H⁺

dTDP-6-deoxy-α-D-allose + mycinamicin VII → H⁺ + mycinamicin VI + dTDP

kinetin + UDP-α-D-glucose → H⁺ + kinetin-7-N-glucoside + UDP

β-alanine + L-histidine + ATP → carnosine + H⁺ + phosphate + ADP

H₂O + 4-guanidinobutyraldehyde + NAD⁺ → 2 H⁺ + 4-guanidinobutanoate + NADH

H₂O + D-xylono-1,5-lactone → D-xylonate + H⁺

salicylate + UDP-α-D-glucose → H⁺ + UDP + salicylate 2-O-β-D-glucoside

di-homo-γ-linolenate → 2 H⁺ + arachidonate

digitoxigenin + UDP-fucose → H⁺ + digiproside + UDP

undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-L-lysyl- D-alanine + UDP-N-acetyl-α-D-glucosamine → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine + H⁺ + UDP

S-adenosyl-L-methionine + rhamnetin → S-adenosyl-L-homocysteine + H⁺ + 3,7-dimethylquercetin

H₂O + L-glutamine + ATP + cobyrinate → H⁺ + L-glutamate + phosphate + ADP + cob(II)yrinate c-monoamide

(O-carbamoyl)adenylate + kanamycin A → H⁺ + 6''-O-carbamoylkanamycin A + AMP

actinomycin D + H₂O → actinomyc-D monolactone + H⁺

ATP + L-fuculose → H⁺ + ADP + L-fuculose 1-phosphate

phytosphingosine + ATP → phytosphingosine 1-phosphate + H⁺ + ADP

histamine + S-adenosyl-L-methionine → N^τ-methylhistamine + S-adenosyl-L-homocysteine + H⁺

dTDP-L-daunosamine + ε-rhodomycinone → rhodomycinone D + H⁺ + dTDP

N-acetyl-D-galactosaminyl-α-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-α-D-galactosamine → N-acetyl-D-galactosaminyl-α-(1→4)-N-acetyl-D-galactosaminyl-α-(1→3)-N,N'-diacetyl-α-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol + H⁺ + UDP

2 ATP + ammonium + hydrogencarbonate → 2 H⁺ + 2 ADP + carbamoyl phosphate + phosphate

a reduced electron donor + 3',5'-diiodothyronine → an oxidized electron donor + H⁺ + iodide + 3'-monoiodothyronine

acetyl-CoA + GDP-D-glucosamine → GDP-N-acetyl-D-glucosamine + coenzyme A + H⁺

11-hydroxyvittatine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + hemanthamine + H⁺

NAD(P)H + 4-nitrocatechol + oxygen → H₂O + 2-hydroxy-1,4-benzoquinone + NAD(P)+ + H⁺ + nitrite

S-adenosyl-L-methionine + 8-hydroxykaempferol → S-adenosyl-L-homocysteine + H⁺ + 8-methoxykaempferol

H₂O + 1-(5-phospho-β-D-ribosyl)-ATP → H⁺ + 1-(5-phospho-β-D-ribosyl)-AMP + diphosphate

H₂O + 4-fumaryl-acetoacetate → H⁺ + acetoacetate + fumarate

2-oxoglutarate + UDP-4-amino-4-deoxy-β-L-arabinopyranose + ATP → H⁺ + phosphate + UDP-aravonose + ADP

cephalosporin C + H₂O → acetate + H⁺ + deacetylcephalosporin C

H₂O + 2-butyloctyl sulfate → H⁺ + sulfate + 2-butyl-1-octanol

4 H₂O + 5 S⁰ + oxygen → 2 hydrogen sulfide + 3 H⁺ + sulfite + thiosulfate

FADH₂ + 2-methylpropan-1-amine + oxygen → 2 H⁺ + FAD + H₂O + N-(2-methylpropyl)hydroxylamine

pppGpp + H₂O → ppGpp + H⁺ + phosphate

H₂O + Fe³⁺-[monoglucosyl-enterobactin] complex → H⁺ + Fe³⁺-[monoglucosyl-(2,3-dihydroxybenzoylserine)₃] complex

H₂O + CDP → CMP + H⁺ + phosphate

H₂O + icosanoyl-CoA → coenzyme A + arachidate + H⁺

(2-aminoethyl)phosphonate + acetyl-CoA → 2 H⁺ + coenzyme A + (2-acetamidoethyl)phosphonate

3,5-dimethoxyphenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 1,3,5-trimethoxybenzene + H⁺

S-adenosyl-L-methionine + (-)-matairesinol → S-adenosyl-L-homocysteine + isoarctigenin + H⁺

isourolithin A + UDP-α-D-glucuronate → H⁺ + isourolithin A 3-O-glucuronide + UDP

H₂O + 8-oxo-dGTP → H⁺ + diphosphate + 8-oxo-dGMP

2,3-dihydroxy-4-methoxybenzoate + oxygen → 2-hydroxy-3-carboxy-6-methoxy-hexa-2,4-dienoate + H⁺

UDP-α-D-glucuronate + α-D-galacturonosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate) → H⁺ + UDP + β-D-glucuronosyl-(1→4)-α-D-galacturonosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate)

S-adenosyl-L-methionine + dithiolgliotoxin → S-adenosyl-L-homocysteine + H⁺ + mono(methylsulfanyl)gliotoxin

S-adenosyl-L-methionine + cirsiliol → S-adenosyl-L-homocysteine + H⁺ + cirsilineol

NAD⁺ + (1R,2S)-4,6-dichloro-3-methylcyclohexa-3,5-diene-1,2-diol → NADH + H⁺ + 4,6-dichloro-3-methylcatechol

18'-hydroxy-χ,χ-caroten-18-oate + H₂O → 5 H⁺ + synechoxanthin

NAD⁺ + (-)-borneol → NADH + H⁺ + (-)-camphor

1D-chiro-inositol + UDP-α-D-galactose → H⁺ + fagopyritol B1 + UDP

a reduced electron donor + thiosulfate → an oxidized electron donor + H⁺ + sulfite + hydrogen sulfide

pelargonidin + UDP-α-D-glucose → H⁺ + pelargonidin-3-O-β-D-glucoside + UDP

lactenocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + desmycosin + H⁺

octyl α-D-glucopyranoside + UDP-α-D-galactofuranose → octyl β-1,6-D-galactofuranosyl-α-D-glucopyranoside + H⁺ + UDP

solasodine + UDP-α-D-galactose → H⁺ + solasodine 3-O-β-D-galactoside + UDP

UDP-α-D-glucose + vitexin → vitexin 2''-O-β-D-glucoside + H⁺ + UDP

β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + UDP-α-D-galactofuranose → β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + H⁺ + UDP

isopropylamine + L-glutamate + ATP → γ-glutamyl-isopropylamide + H⁺ + phosphate + ADP

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil → 2 H₂O + 6,7-dimethyl-8-(1-D-ribityl)lumazine + H⁺ + phosphate

a reduced electron donor + 3'-iodothyronamine → an oxidized electron donor + H⁺ + thyronamine + iodide

H₂O + hypotaurine + NAD⁺ → taurine + NADH + H⁺

anthranilate + FADH₂ + oxygen → FAD + H₂O + 3-hydroxyanthranilate + H⁺

H₂O + lauroyl-CoA → coenzyme A + laurate + H⁺

L-tryptophan + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-tryptophan + H⁺ + diphosphate + AMP

protocatechuate + oxygen → 4-carboxy-2-hydroxymuconate-6-semialdehyde + H⁺

H₂O + (E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-2-(4-hydroxyphenyl)ethan-1-imine → L-seryl-glycine + (Z)-N-hydroxy-2-(4-hydroxyphenyl)acetimidothioate + H⁺

H₂O + urea-1-carboxylate → 2 carbamate + H⁺

3-[(2R)-3,5-dioxo-4-[(2E.4S,6S,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate → sch210972 + H⁺

1-amino-1-deoxy-scyllo-inositol + ATP → H⁺ + ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate

GDP-6-deoxy-α-D-altrose + sordaricin → 4'-O-demethylsordarin + H⁺ + GDP

H₂O + formononetin-7-O-glucoside-6''-malonate → malonate + H⁺ + ononin

(1S,2S,4R)-limonene-1,2-diol + NAD⁺ → (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H⁺

β-D-glucuronosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→6)-N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucuronate → H⁺ + β-D-glucuronosyl-(1→4)-β-D-glucuronosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→6)-N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol + UDP

S-adenosyl-L-methionine + cycloartenol → S-adenosyl-L-homocysteine + H⁺ + 24-methylenecycloartanol

2-hydroxy-3-carboxy-4,5-cyclopropylhex-5-enoate → 2 H⁺ + 2-oxo-3-carboxy-4,5-cyclopropylhex-5-enoate

pyridoxine + ATP → pyridoxine 5'-phosphate + H⁺ + ADP

dTDP-β-L-vancosamine + devancosaminyl-vancomycin → H⁺ + vancomycin + dTDP

S-adenosyl-L-methionine + 3,7,3',5'-tetramethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',4',5'-pentamethylmyricetin

novobiocic acid + dTDP-4-O-demethyl-β-L-noviose → demethyldecarbamoyl novobiocin + H⁺ + dTDP

2 NAD⁺ + H₂O + UDP-N-acetyl-α-D-mannosamine → 2 NADH + 3 H⁺ + UDP-N-acetyl-α-D-mannosaminuronate

4-(4-hydroxy-3-methoxyphenyl)-tetrahydro-3H-furo[3,4-c]furan-1-one + H₂O → 5-(4-hydroxy-3-methoxyphenyl)-4-(hydroxymethyl)oxolane-3-carboxylate + H⁺

3-chlorobenzoate-cis-3,4-diol → protocatechuate + H⁺ + chloride

(20S)-ginsenoside Rh2 + UDP-α-D-glucose → (20S)-ginsenoside Rg3 + H⁺ + UDP

H₂O + 2-oxohexa-4,5-cyclopropyl-5-enoate + acetyl-CoA → coenzyme A + 3-hydroxy-3-carboxy-4,5-cyclopropylhex-5-enoate + H⁺

3,4-dihydroxybenzaldehyde + tyramine → H₂O + norcraugsodine + H⁺

oxygen + hydroxyquinol → 2 H⁺ + 2-maleylacetate

S-adenosyl-L-methionine + gossypetin → S-adenosyl-L-homocysteine + H⁺ + 3,3',4',5,7-pentahydroxy-8-methoxyflavone

3'-phosphoadenylyl-sulfate + quercetin 3-sulfate → quercetin-3,3'-bissulfate + adenosine 3',5'-bisphosphate + H⁺

2 H₂O + acryloyl-CoA → coenzyme A + 3-hydroxypropanoate + H⁺

4-phospho-D-erythronate + NAD⁺ → NADH + (3R)-3-hydroxy-2-oxo-4 phosphooxybutanoate + H⁺

H₂O + (-)-maackiain-3-O-glucoside-6''-malonate → malonate + (-)-maackiain-3-O-glucoside + H⁺

FMNH₂ + oxygen + uracil → FMN + H⁺ + (Z)-3-ureidoacrylate peracid

5-(hydroxymethyl)-2-methylphenol + NAD⁺ → 3-hydroxy-4-methylbenzaldehyde + NADH + H⁺

guanosine + ATP → H⁺ + ADP + GMP

esculetin + UDP-α-D-glucose → 4-O-β-D-glucosyl-esculetin + H⁺ + UDP

5-(2-hydroxyethyl)-4-methylthiazole + ATP → H⁺ + 4-methyl-5-(2-phosphooxyethyl)thiazole + ADP

erythromycin D + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + erythromycin B + H⁺

spermine + acetyl-CoA → coenzyme A + N¹-acetylspermine + H⁺

Mg²⁺ + H₂O + protoporphyrin IX + ATP → 3 H⁺ + phosphate + ADP + Mg-protoporphyrin

3,5,3'-triiodo-L-thyronine + UDP-α-D-glucuronate → H⁺ + 3,5,3'-triiodo-L-thyronine acyl β-D-glucuronide + UDP

6-aminopenicillanate + phenylacetyl-CoA → coenzyme A + penicillin G + H⁺

1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione + UDP-α-D-glucose → 1-(3,4-dihydroxyphenyl)-3-(3-C-glucosyl-2,4,6-trihydroxyphenyl)propane-1,3-dione + H⁺ + UDP

dihydrostreptomycin 6-phosphate → 2 H⁺ + streptomycin 6-phosphate

UDP-α-D-glucose + (R)-3,4-dihydroxymandelonitrile → H⁺ + UDP + 3,4-dihydroxymandelonitrile β-D-glucoside

phytol + NAD⁺ → NADH + phytenal + H⁺

H₂O + (2E,6E)-farnesal + NAD⁺ → 2 H⁺ + NADH + (2E,6E)-farnesoate

H₂O + (4,5-dihydro-5-oxofuran-2-yl)-acetate → H⁺ + 3-oxoadipate

S-adenosyl-L-methionine + quercetagetin 7-O-glucoside → S-adenosyl-L-homocysteine + H⁺ + patulitrin

H₂O + meso-diaminopimelate + ATP → H⁺ + meso-diaminopimelate + phosphate + ADP

3β-hydroxy-β-cyclocitral + UDP-α-D-glucose → picrocrocin + H⁺ + UDP

2 H⁺ + (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate ← H₂O + isopentenyl diphosphate

acetyl-CoA + dTDP-4-amino-4,6-dideoxy-α-D-galactose → coenzyme A + dTDP-4-acetamido-4,6-dideoxy-α-D-galactose + H⁺

H₂O + dihydrophloroglucinol → 3-hydroxy-5-oxohexanoate + H⁺

NAD(P)H + H⁺ + (11Z,14Z,17Z)-3-oxoicosatrienoyl-CoA ← NAD(P)+ + (3R,11Z,14Z,17Z)-3-hydroxyicosatrienoyl-CoA

7,8-dihydroxykynurenate + oxygen → 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate + H⁺

S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate → S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate + H⁺

β-nicotinate D-ribonucleotide + 5-hydroxybenzimidazole → nicotinate + 5-hydroxybenzimidazole ribotide phosphate + H⁺

β-D-glucopyranose + ATP → β-D-glucose 6-phosphate + H⁺ + ADP

esculetin + UDP-α-D-glucose → 3-O-β-D-glucosyl-esculetin + H⁺ + UDP

oxidized DCPIP + (4S,6S)-cis-carveol → reduced DCPIP + H⁺ + (+)-carvone

(±)-pavine + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + N-methylpavine

2-methyl-3-pentyl-1H-pyrrole + 4-methoxy-2,2'-bipyrrole-5-carbaldehyde + ATP → H⁺ + phosphate + prodigiosin + ADP

dihydrozeatin-9-N-glucoside + UDP-α-D-glucose → H⁺ + dihydrozeatin-9-N-glucoside-O-glucoside + UDP

UDP-α-D-glucose + (-)-menthol → H⁺ + (-)-menthyl O-β-D-glucoside + UDP

dTDP-2-deoxy-β-L-fucose + aclacinomycin T → H⁺ + aclacinomycin S + dTDP

NADP⁺ + (6E)-8-hydroxygeranial → NADPH + (6E)-8-oxogeranial + H⁺

NADP⁺ + (6E)-8-oxogeraniol → NADPH + (6E)-8-oxogeranial + H⁺

9-mercaptodethiobiotin → 2 H⁺ + biotin

trans-tuberonic acid + UDP-α-D-glucose → trans-tuberonic acid glucoside + H⁺ + UDP

2 H₂O + 2 S-adenosyl-L-methionine + 12,18-didecarboxysiroheme → 2 propanoate + 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + pre-heme d₁

glucosyl-(heptosyl)₃-Kdo₂-lipid A-phosphate + ATP → glucosyl-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + H⁺ + ADP

H₂O + 4-(6-hydroxy-pyridin-3-yl)-4-oxobutanal + NADP⁺ → 2 H⁺ + 6-hydroxy-3-succinoyl-pyridine + NADPH

(3-aminopropyl)phosphonate + acetyl-CoA → coenzyme A + (2-acetamidopropyl)phosphonate + H⁺

H₂O + 3-phosphonopyruvate + acetyl-CoA → coenzyme A + (R)-2-(phosphomethyl)malate + H⁺

UDP-α-D-glucose + indoxyl → indican + H⁺ + UDP

H₂O + NAD(P)+ + (2R,4S)-2, 4-diaminopentanoate → (2R)-2-amino-4-oxopentanoate + NAD(P)H + H⁺ + ammonium

UDP-α-D-glucose + patuletin → H⁺ + patulitrin + UDP

S-adenosyl-L-methionine + deacetylisoipecoside → S-adenosyl-L-homocysteine + H⁺ + 6-O-methyl-N-deacetylisoipecoside

S-adenosyl-L-methionine + 1,6-didemethyltoxoflavin → S-adenosyl-L-homocysteine + reumycin + H⁺

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + oxygen → formate + 3-(methylsulfanyl)propanoate + H⁺ + carbon monoxide

S-adenosyl-L-methionine + gentamicin X2 → S-adenosyl-L-homocysteine + H⁺ + G-418

S-adenosyl-L-methionine + 2-deoxy-scyllo-inosamine → 3-amino-2,3-dideoxy-scyllo-inosose + H⁺ + 5'-deoxyadenosine + L-methionine

NADP⁺ + (-)-trans-carveol → NADPH + H⁺ + (-)-carvone

H₂O + (S)-methylmalonyl-CoA → coenzyme A + methylmalonate + H⁺

2 a peptidoglycan dimer (E. faeciums) + 3 H₂O → 4 D-alanine + a peptidoglycan tetramer with a D,D cross-link (Enterococcus faecium) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

L-threonine + ATP → L-threonine 3-O-phosphate + H⁺ + ADP

H₂O + NADP⁺ + gentisaldehyde → 2 H⁺ + NADPH + gentisate

H₂O + L-glutamine + ATP → 2 H⁺ + N⁵-phospho-L-glutamine + phosphate + AMP

7-chloro-L-tryptophan + oxygen → hydrogen peroxide + H⁺ + 3-(7-chloroindol-3-yl)-2-iminopropanoate

NAD(P)+ + β-D-glucopyranose → NAD(P)H + D-glucono-1,5-lactone + H⁺

2 L-glutamine + acetyl-CoA → coenzyme A + H₂O + H⁺ + N-acetyl-L-glutaminyl-L-glutamine

H₂O + 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate → 2-oxopent-4-enoate + H⁺ + benzoate

H₂O + 5,10-methenyltetrahydrofolate mono-L-glutamate → H⁺ + (6S)-5-formyl-tetrahydrofolate mono-L-glutamate

FMNH₂ + ethylenediaminetriacetate + oxygen → FMN + H₂O + ethylenediamine-N,N'-diacetate + glyoxylate + H⁺

proansamycin X → 2 H⁺ + 34α-deoxy-rifamycin W

S-adenosyl-L-methionine + tricin → S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin + H⁺

H₂O + phorbol 12,13-dibutanoate → phorbol 13-butanoate + butanoate + H⁺

FADH₂ + (1E,3S,4Z)-7-amino-1-{3-[(1E)-prop-1-en-1-yl]oxiran-2-yl}hepta-1,4-dien-3-ol + oxygen → FAD + H₂O + (1S,2Z)-5-amino-1-(3-{3-[(1E)-prop-1-en-1-yl]oxiran-2-yl}oxiran-2-yl)pent-2-en-1-ol + H⁺

S-adenosyl-L-methionine + 5-hydroxyferulate → S-adenosyl-L-homocysteine + sinapate + H⁺

adenine ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(adenin-9-yl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

H₂O + NADP⁺ + 22-oxo-docosanoate → 2 H⁺ + NADPH + docosanedioate

α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose → α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-N-acetyl-α-D-galactosaminyldiphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

2-[4-(methylsulfanyl)butyl]-thiohydroximate-O-sulfate → 5-(methylsulfanyl)pentanenitrile + H⁺ + sulfate + S⁰

H₂O + (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA → coenzyme A + (7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentenoate + H⁺

5-(methylsulfanyl)-α-D-ribose + ATP → S-methyl-5-thio-α-D-ribose 1-phosphate + H⁺ + ADP

H₂O + trans-zeatin riboside diphosphate → trans-zeatin riboside monophosphate + H⁺ + phosphate

H₂O + dodecanal + NAD⁺ → 2 H⁺ + NADH + laurate

H₂O + palmitaldehyde + NAD⁺ → 2 H⁺ + NADH + palmitate

7(8),7'(8')-tetrahydrojusticidin B + NAD⁺ → NADH + collinusin + H⁺

D-myo-inositol (1,3,4)-trisphosphate + ATP → H⁺ + D-myo-inositol (1,3,4,6)-tetrakisphosphate + ADP

H₂O + NAD⁺ + 3-oxo-24-ethyl-26-al-cholest-4-ene → 2 H⁺ + NADH + 3-oxo-24-ethyl-cholest-4-en-26-oate

H₂O + (5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA → (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + coenzyme A + H⁺

NAD(P)+ + choloyl-CoA → 3-oxocholoyl-CoA + NAD(P)H + H⁺

alliin → H⁺ + allylsulfenate + 2-aminoprop-2-enoate

UDP-α-D-glucose + wogonin → H⁺ + UDP + wogonin 7-O-β-D-glucoside

H₂O + D-firefly luciferyl-CoA → coenzyme A + D-firefly luciferin + H⁺

S-adenosyl-L-methionine + precorrin-2 → S-adenosyl-L-homocysteine + precorrin-3A + H⁺

H₂O + diisopropyl fluorophosphate → 2 H⁺ + diisopropyl phosphate + fluoride

3-hydroxybenzyl alcohol + NAD⁺ → 3-hydroxybenzaldehyde + NADH + H⁺

O-acetyl-L-serine + uracil → acetate + L-willardiine + H⁺

GDP-α-D-mannose + 3-phospho-D-glycerate → H⁺ + 2-O-(α-D-mannosyl)-3-phospho-D-glycerate + GDP

2 S-adenosyl-L-methionine + precorrin-6B → 2 S-adenosyl-L-homocysteine + 2 H⁺ + precorrin-8x + CO₂

an oxidized electron donor + H₂O + indole-3-glyoxal → a reduced electron donor + H⁺ + indole-3-glyoxylate

pantetheine + ATP → 4'-phosphopantetheine + H⁺ + ADP

(2S)-methylsuccinyl-CoA → 2 H⁺ + 2-methylfumaryl-CoA

NAD(P)+ + 2-deoxy-scyllo-inosamine → NAD(P)H + 3-amino-2,3-dideoxy-scyllo-inosose + H⁺

D-ribulose 5-phosphate + L-tyrosine → hydroxyacetone + H₂O + formaldehyde + H⁺ + phosphate + (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate

(2S)-naringenin + UDP-α-D-glucose → prunin + H⁺ + UDP

H⁺ + aldehydo-D-ribose 5-phosphate + ADP ← phosphate + ADP-D-ribose

5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + oxygen → 2 H⁺ + 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone

S-adenosyl-L-methionine + emodin → questin + S-adenosyl-L-homocysteine + H⁺

a reduced electron donor + 3-iodothyronamine → an oxidized electron donor + H⁺ + thyronamine + iodide

(L-seryl)adenylate + mycosporine glycine → 3 H⁺ + shinorine + AMP

FADH₂ + resorcinol + oxygen → FAD + H₂O + H⁺ + hydroxyquinol

S-adenosyl-L-methionine + 13-dihydrocarminomycin → S-adenosyl-L-homocysteine + H⁺ + 13-dihydrodaunorubicin

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + oxygen → (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1 (10),2-dien-4-oate + H⁺

2'-deoxycytidine + ATP → H⁺ + ADP + dCMP

O-methyl-4-O-[2-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + O-methyl-4-O-[2,4-di-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + H⁺

S-adenosyl-L-methionine + cirsimaritin → S-adenosyl-L-homocysteine + H⁺ + salvigenin

(O-carbamoyl)adenylate + tobramycin → H⁺ + nebramycin 5' + AMP

(+)-sesaminol 2-O-β-D-glucoside + UDP-α-D-glucose → (+)-sesaminol 2-O-β-D-gentiobioside + H⁺ + UDP

(+)-dihydrocarveol + NAD⁺ → NADH + (-)-dihydrocarvone + H⁺

a reduced electron donor + trithionate → an oxidized electron donor + H⁺ + sulfite + thiosulfate

H₂O + P¹,P³-bis(5'-adenosyl) triphosphate → 2 H⁺ + ADP + AMP

S-adenosyl-L-methionine + N^α-methyl-L-histidine → S-adenosyl-L-homocysteine + H⁺ + N^α,N^α-dimethyl-L-histidine

3-keto-L-gulonate + ATP → 3-keto-L-gulonate 6-phosphate + H⁺ + ADP

5-nitrosalicylate + oxygen → H⁺ + nitrite + 2-oxo-3-(5-oxofuran-2-ylidene)propanoate

UDP-α-D-glucose + (-)-epicatechin → (-)-epicatechin-3'-O-glucoside + H⁺ + UDP

H₂O + all-trans-retinyl palmitate → 11-cis-retinol + palmitate + H⁺

H₂O + (4R,7R)-4-isopropenyl-7-methyloxepan-2-one → H⁺ + (3R,6R)-6-hydroxy-3-isopropenylheptanoate

H₂O + (2E,6E)-farnesyl diphosphate → H⁺ + (2E,6E)-farnesyl phosphate + phosphate

2-hydroxy-6-oxo-nona-2,4-dienoate + H₂O → 2-oxopent-4-enoate + butanoate + H⁺

3-methoxytyramine + betalamate → H₂O + H⁺ + betaxanthin

L-arabino-1,4-lactone 5-phosphate + H₂O → 5-phospho-L-arabinate + H⁺

2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine → 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + S-adenosyl-L-homocysteine + H⁺

tetraiodothyroacetate + UDP-α-D-glucuronate → H⁺ + tetraiodothyroacetate ether glucuronide + UDP

digiproside + UDP-α-D-glucose → H⁺ + glucodigifucoside + UDP

H₂O + 4-methyl-3-oxoadipate-enol-lactone → H⁺ + 4-methyl-3-oxoadipate

H₂O + dUTP → H⁺ + phosphate + dUDP

3'-phosphoadenylyl-sulfate + 3,5,3'-triiodo-L-thyronine → adenosine 3',5'-bisphosphate + H⁺ + triiodothyronine sulfate

2-propenyl-thiohydroximate-O-sulfate → 3-butenylnitrile + H⁺ + sulfate + S⁰

S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 2-methoxy-6-(all-trans-octaprenyl)phenol

S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose → S-adenosyl-L-homocysteine + dTDP-N-monodesmethyl-α-D-forosamine + H⁺

L-glutamate + UDP-N-acetyl-α-D-muramoyl-L-alanine + ATP → H⁺ + phosphate + ADP + UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate

6-oxohexanoate + H₂O + NADP⁺ → 2 H⁺ + adipate + NADPH

D-myo-inositol (3,4)-bisphosphate + ATP → 2 H⁺ + D-myo-inositol (3,4,6)-trisphosphate + ADP

NAD(P)+ + 4-hydroxy-2,2'-bipyrrole-5-methanol → NAD(P)H + H⁺ + 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde

H₂O + glyoxal → glycolate + H⁺

L-alanine + (-)-jasmonate + ATP → (+)-7-epi-jasmonoyl-L-alanine + H⁺ + diphosphate + AMP

2 H₂O + 2 L-glutamine + 2 ATP + Ni-sirohydrochlorin → 2 H⁺ + 2 L-glutamate + 2 phosphate + 2 ADP + Ni-sirohydrochlorin a,c-diamide

coenzyme A + (L-firefly luciferyl)adenylate → H⁺ + L-firefly luciferyl-CoA + AMP

H₂O + D-carnitinyl-CoA → coenzyme A + D-carnitine + H⁺

dihydroconiferyl alcohol + UDP-α-D-glucose → dihydroconiferyl alcohol glucoside + H⁺ + UDP

S-adenosyl-L-methionine + β-D-glucuronosyl-(1→4)-α-D-galacturonosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate) → S-adenosyl-L-homocysteine + H⁺ + methyl-O-4-β-D-glucuronosyl-(1→4)-α-D-galacturonosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate)

methylamine + L-glutamate + ATP → H⁺ + phosphate + ADP + N⁵-methyl-L-glutamine

oleanolate 3-beta-D-glucuronoside-(3,1)-galactoside + UDP-α-D-glucose → oleanolate-3-beta-D-glucuronoside-(3,1)-galactoside-(4,1)-glucoside + H⁺ + UDP

allopregnanolone + NAD⁺ → NADH + H⁺ + 5-α-pregnane-3,20-dione

H₂O + neocarrabiose sulfate → neocarrabiose + H⁺ + sulfate

(S)-reticuline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + (S)-laudanine

sitosterol + UDP-α-D-glucose → β-sitosterol 3-O-β-D-glucoside + H⁺ + UDP

an oxidized electron donor + (S)-nicotine → N-methylmyosmine + a reduced electron donor + H⁺

NAD⁺ + 3-oxo-24-ethyl-26-hydroxy-cholest-4-ene → NADH + 3-oxo-24-ethyl-26-al-cholest-4-ene + H⁺

2 monodehydroascorbate radical → L-ascorbate + L-dehydro-ascorbate + H⁺

uroporphyrinogen-I → 4 H⁺ + 4 CO₂ + coproporphyrinogen I

NAD⁺ + (3R)-hydroxy, 4-trans-undecenoyl-CoA → NADH + H⁺ + 4-trans-3-oxo-undecenoyl-CoA

norbaeocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + baeocystin + H⁺

FMNH₂ + methanesulfonate + oxygen → 2 H⁺ + FMN + H₂O + formaldehyde + sulfite

H₂O + pravastatin lactone → pravastatin acid + H⁺

2-methyladenine ribotide phosphate + adenosylcobinamide-GDP → Coα-[α-(2-methyladenin-9-yl)]-Coβ-adenosylcobamide 5'-phosphate + H⁺ + GMP

5-(dihydroxymethyl)furan-2-carbaldehyde + oxygen → hydrogen peroxide + 5-formylfuran-2-carboxylate + H⁺

H₂O + 3-oxo-24-(isopropanoyl)-cholest-4,24-dien-26-oyl-CoA → 2 H⁺ + propanoyl-CoA + 3,24-dioxo-cholest-4-en-26-oate

a reduced electron donor + 3,3'-diiodothyronine → an oxidized electron donor + H⁺ + iodide + 3'-monoiodothyronine

FMNH₂ + 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + oxygen → FMN + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H₂O + H⁺

H₂O + L-rhamnono-1,4-lactone → L-rhamnonate + H⁺

dTDP-α-D-olivose + premithracinone → H⁺ + dTDP + premithramycin A1

H₂O + NAD⁺ + L-lysine → (S)-2-amino-6-oxohexanoate + NADH + H⁺ + ammonium

S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H⁺

dehypoxanthine futalosine → 2 H⁺ + cyclic dehypoxanthine futalosine

valienone + ATP → valienone 7-phosphate + H⁺ + ADP

glycerone phosphate + L-aspartate + oxygen → 2 H₂O + quinolinate + hydrogen peroxide + H⁺ + phosphate

2 H⁺ + Fe-coproporphyrin III ← Fe²⁺ + coproporphyrin III

H₂O + phosphate + ATP → 2 phosphate + H⁺ + ADP

(S)-NADHX + ATP → NADH + H⁺ + phosphate + ADP

O-acetyl-L-serine + uracil → acetate + L-isowillardiine + H⁺

Glc-AATGal-PP-undecaprenol + CDP-ribitol → (Rib-ol)-P-Glc-AATGal-PP-undecaprenol + CMP + H⁺

α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + ADP-L-glycero-β-D-manno-heptose → heptosyl-Kdo₂-lipid IV_A + H⁺ + ADP

H₂O + AAI-1 → H⁺ + N-(3-oxooctanoyl)-L-homoserine

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD⁺ → 2,3-dihydroxybenzoate + NADH + H⁺

NAD⁺ + (25R)-5β-cholestane-3α,7α,26-triol → NADH + H⁺ + (25R)-3α,7α-dihydroxy-5β-cholestan-26-al

(-)-neoisodihydrocarveol + NAD⁺ → NADH + H⁺ + (-)-isodihydrocarvone

S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-α-D-glucose → S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + H⁺

pseudouridine + ATP → pseudouridine 5'-phosphate + H⁺ + ADP

dTDP-D-desosamine + 10-deoxymethynolide → H⁺ + 10-deoxymethymycin + dTDP

H₂O + 3-fumarylpyruvate → pyruvate + H⁺ + fumarate

H₂O + benzaldehyde + NADP⁺ → 2 H⁺ + NADPH + benzoate

2-deoxystreptamine + UDP-α-D-glucose → 2'-deamino-2'-hydroxyparomamine + H⁺ + UDP

S-adenosyl-L-methionine + 2',7-dihydroxy-4',5'-dimethoxyisoflavone → S-adenosyl-L-homocysteine + 7-hydroxy-2',4',5'-trimethoxyisoflavone + H⁺

4,6-dichloro-3-methylcatechol + oxygen → 2 H⁺ + 3,5-dichloro-2-methyl-muconate

FADH₂ + 2,4,5-trichlorophenol + oxygen → FAD + 2,5-dichloro-p-quinone + H₂O + H⁺ + chloride

H₂O + glutarate semialdehyde + NAD⁺ → 2 H⁺ + glutarate + NADH

2,4-dibromo-6-(2,4-dibromo-6-hydroxyphenoxy)phenol → H⁺ + bromide + spongiadioxin C

5-chlorohydroxyquinol → 2 H⁺ + 2-hydroxy-1,4-benzoquinone + chloride

guanidinoacetate + S-adenosyl-L-methionine → creatine + S-adenosyl-L-homocysteine + H⁺

3-[(2R)-3,5-dioxo-4-[(2E.4S,6S,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate → sch210971 + H⁺

3 S-adenosyl-L-methionine + L-histidine → 3 S-adenosyl-L-homocysteine + 3 H⁺ + hercynine

2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate → 2-chloro-trans-dienelactone + H⁺ + chloride

[(R)-1-aminoethyl]phosphonate + acetyl-CoA → coenzyme A + [(1R)-1-acetamidoethyl]phosphonate + H⁺

D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + ATP → N¹-amidinostreptamine 6-phosphate + H⁺ + ADP

3,5,7-trioxododecanoyl-CoA → coenzyme A + H⁺ + tetraketide pyrone

2 H₂O + 4-hydroxyacetophenone + ATP + CO₂ → 2 phosphate + 3 H⁺ + 4-hydroxybenzoyl-acetate + AMP

L-dopa + oxygen → 2,3-seco-dopa + H⁺

L-dopa + oxygen → 4,5-seco-dopa + H⁺

2-hydroxyethylphosphonate + oxygen → formate + hydroxymethylphosphonate + H⁺

peonidin + UDP-α-D-glucose → H⁺ + peonidin-3-O-β-D-glucoside + UDP

N^ω-hydroxy-L-arginine → H₂O + guanidinium + H⁺ + (S)-1-pyrroline-5-carboxylate

H₂O + chlorzoxazone → 2-amino-5-chlorophenyl carbonate + H⁺

(R)-mandelonitrile + UDP-α-D-glucose → (R)-prunasin + H⁺ + UDP

oxidized DCPIP + (1R,2R,4S)-limonene-1,2-diol → (1R,4S)-1-hydroxymenth-8-en-2-one + reduced DCPIP + H⁺

2 H₂O + dTTP → 2 H⁺ + 2 phosphate + dTMP

S-adenosyl-L-methionine + trans-caffeoyl-CoA → S-adenosyl-L-homocysteine + H⁺ + trans-feruloyl-CoA

(3S)-3-hydroxy-L-arginine → H₂O + guanidinium + H⁺ + (S)-1-pyrroline-5-carboxylate

β-alanine + (R)-4-phosphopantoate + ATP → (R)-4'-phosphopantothenate + H⁺ + diphosphate + AMP

FAD + (R)-β-hydroxy-L-kynurenine + H₂O → FADH₂ + (2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-hydroxypropanoate + H⁺

D-xylono-1,4-lactone + H₂O → D-xylonate + H⁺

UDP-α-D-glucose + pelargonidin-3-O-rutinoside → H⁺ + pelargonidin-3-O-rutinoside-5-O-β-D-glucoside + UDP

2 NAD⁺ + H₂O + (2R)-3-sulfopropanediol → 2 NADH + 3 H⁺ + (2R)-3-sulfolactate

S-adenosyl-L-methionine + 3,4-dihydroxyphenylglycol → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxyphenylglycol

curcumin 4'-O-β-D-gentiobioside + UDP-α-D-glucose → curcumin 4'-O-β-D-gentiobiosyl 4''-O-β-D-glucoside + H⁺ + UDP

S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene → S-adenosyl-L-homocysteine + pterostilbene + H⁺

H₂O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine → 2 H⁺ + UMP + lipid X

2,3-seco-dopa → H₂O + muscaflavin + H⁺

apigenin 7-O-β-D-glucoside + UDP-α-D-glucose → H⁺ + UDP + apigenin-7-O-gentiobioside

2 Fe²⁺ + 2 H₂O + hydrogen peroxide → 2 [FeO(OH)] monomer + 4 H⁺

oxidized DCPIP + (-)-cis-carveol → reduced DCPIP + H⁺ + (-)-carvone

H₂O + 3-ureidoacrylate → aminoacrylate + H⁺ + carbamate

H₂O + 4-nitrobenzaldehyde + NAD⁺ → 2 H⁺ + NADH + 4-nitrobenzoate

H₂O + N⁵-phenyl-L-glutamine → aniline + H⁺ + L-glutamate

H₂O + 5'-dehydroadenosine + oxygen → hydrogen peroxide + H⁺ + adenin-9-yl riburonosate

serotonin + (E)-4-coumaroyl-CoA → coenzyme A + H⁺ + p-coumaroylserotonin

H₂O + succinyl-CoA → coenzyme A + H⁺ + succinate

7-deoxyloganetate + UDP-α-D-glucose → 7-deoxyloganate + H⁺ + UDP

hesperitin-7-O-β-D-glucoside + UDP-β-L-rhamnose → neohesperidin + H⁺ + UDP

naringenin chalcone + UDP-α-D-glucose → 2',4,4',6'-tetrahydroxychalcone 4'-O-β-D-glucoside + H⁺ + UDP

H₂O + N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide + L-glutamine + ATP → 2-(formamido)-N¹-(5-phospho-β-D-ribosyl)acetamidine + H⁺ + L-glutamate + phosphate + ADP

H₂O + ATP + guanine → H⁺ + phosphate + ADP + guanine

H₂O + 2-oxoglutaryl-CoA → coenzyme A + 2-oxoglutarate + H⁺

2 N-hydroxy-N-succinylcadaverine + ATP → pre-bisucaberin + H⁺ + diphosphate + AMP

H₂O + aclacinomycin T → methanol + H⁺ + 15-demethoxyaclacinomycin T

H₂O + S-(2-chlorocarboxymethyl)-glutathione → glyoxylate + H⁺ + glutathione + chloride

S-adenosyl-L-methionine + isoeugenol → S-adenosyl-L-homocysteine + H⁺ + isomethyleugenol

a reduced electron donor + oxygen + cis-4-hydroxy-D-proline → 2 H₂O + an oxidized electron donor + H⁺ + 1-pyrroline-4-hydroxy-2-carboxylate

2,3-diketo-5-methylthio-1-phosphopentane → 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl 1-phosphate + H⁺

S-adenosyl-L-methionine + 31-O-desmethylFK-506 → S-adenosyl-L-homocysteine + H⁺ + FK-506

NAD(P)H + 3-(4-hydroxyphenyl)pyruvate + H⁺ ← NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate

urolithin B + UDP-α-D-glucuronate → H⁺ + urolithin B 3-O-glucuronide + UDP

2 oxygen + thiamine + H₂O → 2 hydrogen peroxide + H⁺ + thiamine acetate

hydroxylamine + oxygen → H₂O + H⁺ + nitrite

diaminobutyryl-citryl-ethanolamine + 2-oxoglutarate + ATP → diaminobutyryl-citryl-ethanolamino-α-ketoglutarate + H⁺ + diphosphate + AMP

O-phosphoethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-methylethanolamine phosphate + H⁺

S-adenosyl-L-methionine + 5-hydroxymethylcytosine → S-adenosyl-L-homocysteine + H⁺ + bacimethrin

pppGpp + H₂O → H⁺ + diphosphate + GTP

a reduced electron donor + 27-O-demethyl-25-O-deacetyl-rifamycin S → an oxidized electron donor + H⁺ + 27-O-demethyl-25-O-deacetyl-rifamycin SV

2 S-adenosyl-L-methionine + C30 botryococcene → 2 S-adenosyl-L-homocysteine + 2 H⁺ + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene

H₂O + NAD⁺ → 2 H⁺ + β-nicotinamide D-ribonucleotide + AMP

H₂O + UDP-N-acetyl-α-D-glucosamine → N-acetyl-β-D-mannosamine + H⁺ + UDP

L-alanine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-L-alanine + H⁺ + diphosphate + AMP

β-D-galacturonate + NAD⁺ → NADH + D-galactaro-1,5-lactone + H⁺

sn-glycero-3-phosphocholine + H₂O → phosphocholine + glycerol + H⁺

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal + NADP⁺ → NADPH + 2-pyrone-4,6-dicarboxylate + H⁺

2,4',5,7-tetrahydroxyisoflavanone → H₂O + genistein + H⁺

H₂O + 2-pyrone-4,6-dicarboxylate → (1Z,3Z)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate + H⁺

NAD⁺ + 2-dehydro-3-deoxy-L-rhamnonate → NADH + 2,4-didehydro-3-deoxy-L-rhamnonate + H⁺

coenzyme A + (salicyl)adenylate → H⁺ + salicyl-CoA + AMP

H₂O + 2-oleoylglycerol → oleate + glycerol + H⁺

H₂O + L-saccharopine + NAD⁺ → (S)-2-amino-6-oxohexanoate + NADH + H⁺ + L-glutamate

2-oxoglutarate + oxygen + gibberellin A₂₉ → H₂O + H⁺ + succinate + gibberellin A₂₉-catabolite + CO₂

vomilenine + UDP-α-D-glucose → H⁺ + raucaffricine + UDP

(S)-norlaudanosoline + S-adenosyl-L-methionine → 6-O-methylnorlaudanosoline + S-adenosyl-L-homocysteine + H⁺

H₂O + NAD(P)+ + 2,5-dioxopentanoate → 2 H⁺ + NAD(P)H + 2-oxoglutarate

H₂O + (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate → 2-oxopent-4-enoate + formate + H⁺

S-adenosyl-L-methionine + dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose → S-adenosyl-L-homocysteine + dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + H⁺

4-methyl-5-nitrocatechol + NAD(P)H + oxygen → H₂O + 2-hydroxy-5-methylquinone + NAD(P)+ + H⁺ + nitrite

methylcob(III)alamin + bacteriohopanetetrol → H⁺ + 2-methylbacteriohopanetetrol + cob(II)alamin

H₂O + pyrithiamine → 2 H⁺ + 4-amino-2-methyl-5-pyrimidinemethanol + 2-(2-methylpyridin-3-yl)ethanol

H₂O + 1-octanal + NAD⁺ → 2 H⁺ + NADH + octanoate

H₂O + methyl acetate → acetate + methanol + H⁺

(2Z,2E)-2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H₂O → 2,3-dihydroxybenzoate + H⁺ + (2Z)-2-hydroxypenta-2,4-dienoate

S-adenosyl-L-methionine + 3,5-dihydroxybiphenyl → S-adenosyl-L-homocysteine + 3-hydroxy-5-methoxybiphenyl + H⁺

7,8-diaminopelargonate + ATP + CO₂ → 3 H⁺ + dethiobiotin + phosphate + ADP

S-adenosyl-L-methionine + N-acetyl-N6,N6,O-tridemethylpuromycin → S-adenosyl-L-homocysteine + H⁺ + N-acetyl-N6,O-didemethylpuromycin

γ-hexachlorocyclohexane → γ-pentachlorocyclohexene + H⁺ + chloride

NAD⁺ + chenodeoxycholate → 7-oxolithocholate + NADH + H⁺

α-D-glucose 6-phosphate + UDP-α-D-glucose → H⁺ + α,α-trehalose 6-phosphate + UDP

H₂O + palmitoleoyl-CoA → coenzyme A + palmitoleate + H⁺

H₂O + uridine 2'3'-cyclic monophosphate → H⁺ + uridine 3'-monophosphate

S-adenosyl-L-methionine + 3,7,4'-trimethylquercetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',4'-tetramethylquercetin

S-adenosyl-L-methionine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene → S-adenosyl-L-homocysteine + C33 botryococcene + H⁺

6-chloro-2-hydroxy-4-carboxymuconate-6-semialdehyde → 2-pyrone-4,6-dicarboxylate + H⁺ + chloride

S-adenosyl-L-methionine + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,2',4'-pentamethylquercetagetin

a reduced electron donor + oxygen + echinenone → 2 H⁺ + an oxidized electron donor + H₂O + canthaxanthin

H₂O + dTTP → H⁺ + diphosphate + dTMP

(25R)-5β-cholestane-3α,7α,12α,26-tetraol + NAD⁺ → (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-al + NADH + H⁺

9-mercaptodethiobiotin + S-adenosyl-L-methionine → biotin + H⁺ + 5'-deoxyadenosine + L-methionine

loganetin + UDP-α-D-glucose → loganin + H⁺ + UDP

S-adenosyl-L-methionine + 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol

H₂O + isopenicillin N + phenylacetyl-CoA → coenzyme A + penicillin G + L-2-aminoadipate + H⁺

6-deoxy-6-sulfo-D-fructose + ATP → 6-deoxy-6-sulfo-D-fructose 1-phosphate + H⁺ + ADP

2 an oxidized ferredoxin [iron-sulfur] cluster + 1'-hydroxy-γ-carotene → 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + myxocoxanthin

maltotetraose + H₂O + ATP → maltotetraose + H⁺ + phosphate + ADP

desmethylxanthohumol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + xanthohumol + H⁺

H₂O + S-adenosyl-L-methionine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8-ethyl-7¹-12-methylbacteriochlorophyllide c

2-chloro-2-(2-chloro-5-oxofuran-2-yl)acetate → 5-chloro-trans-dienelactone + H⁺ + chloride

S-adenosyl-L-methionine + m7G(5')pppAm → S-adenosyl-L-homocysteine + m7G(5')pppm6Am + H⁺

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + S-adenosyl-L-methionine + a reduced electron donor → 2 H⁺ + an oxidized electron donor + 5-hydroxybenzimidazole + formate + ammonium + 5'-deoxyadenosine + L-methionine + phosphate

delphinidin-3-O-(6''-O-malonyl)-β-glucoside-3'-O-β-glucoside + UDP-α-D-glucose → 2 H⁺ + ternatin C5 + UDP

H₂O + 6-acetyl-D-glucose → acetate + H⁺ + β-D-glucopyranose

H₂O + 13-[O(2')-β-D-glucopyranosyl-β-D-glucopyranosyloxy]docosanoate O(6'')-acetate → acetate + sophorosyloxydocosanoate + H⁺

3,5-dihydroxy-1,4-naphthoquinol + H₂O + oxygen → 2 H⁺ + 2,3-dihydroxybenzoate + pyruvate

NAD⁺ + (R)-3-hydroxyoctanoyl-CoA → NADH + H⁺ + 3-oxooctanoyl-CoA

S-adenosyl-L-methionine + esculetin → S-adenosyl-L-homocysteine + H⁺ + isoscopoletin

2-amino-3-carboxymuconate-6-semialdehyde → H₂O + quinolinate + H⁺

UDP-α-D-glucose + 13-β-D-glucosyloxydocosanoate → sophorosyloxydocosanoate + H⁺ + UDP

H₂O + dCTP → H⁺ + phosphate + dCDP

S-1-(4-hydroxyphenyl)-ethanol + NAD⁺ → NADH + H⁺ + 4-hydroxyacetophenone

H₂O + O-orsellinate depside → 2 orsellinate + H⁺

(E)-ω-(methylsulfanyl)octyl-thiohydroximate + UDP-α-D-glucose → 7-(methylsulfanyl)heptyl-desulfoglucosinolate + H⁺ + UDP

salicylate + oxygen → 2-oxohepta--3,5-dienedioate + H⁺

α-D-ribofuranose + ATP → H⁺ + aldehydo-D-ribose 5-phosphate + ADP

H₂O + 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD⁺ → 2 H⁺ + 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH

L-methionine → methanethiol + H⁺ + (2Z)-2-aminobut-2-enoate

(3S)-β-arginine + cytosinine + ATP → H⁺ + phosphate + demethylblasticidin S + ADP

β-D-gentiobiosyl β-D-glucosyl crocetin + UDP-α-D-glucose → H⁺ + crocin + UDP

2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactose + ATP → H⁺ + phosphate + UDP-yelosamine + ADP

isovitexin + UDP-α-D-glucose → isovitexin 2''-O-β-D-glucoside + H⁺ + UDP

S-adenosyl-L-methionine + (R)-noradrenaline → S-adenosyl-L-homocysteine + H⁺ + normetanephrine

UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine + acetyl-CoA → coenzyme A + H⁺ + UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose

H₂O + 3-phenyl-2-oxopropanoate + acetyl-CoA → coenzyme A + 2-benzyl-2-hydroxybutanedioate + H⁺

2,5-dichloro-3-oxoadipate → 5-chloromaleylacetate + H⁺ + chloride

2-coumarate + UDP-α-D-glucose → trans-β-D-glucosyl-2-hydroxycinnamate + H⁺ + UDP

D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP → 2 H⁺ + D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP

lipid A disaccharide (E. coli) + ATP → H⁺ + lipid IV_A + ADP

S-adenosyl-L-methionine + putrescine → N-methylputrescine + S-adenosyl-L-homocysteine + H⁺

5-chloro-2-methyl-dienelactone + H₂O → 5-chloro-2-methyl-maleylacetate + H⁺

H₂O + NAD⁺ + (R)-lactaldehyde → 2 H⁺ + NADH + (R)-lactate

NAD⁺ + 3-dehydrodeoxycholate → NADH + H⁺ + 12-α-hydroxy-3 oxochol-4-enoate

quercetin 3-O-rhamnoside + UDP-β-L-rhamnose → quercetin-3-rhamnoside-7-rhamnoside + H⁺ + UDP

demethyl-L-phosphinothricin + acetyl-CoA → coenzyme A + H⁺ + N-acetyldemethyl-L-phosphinothricin

ATP + β-D-fructofuranose → β-D-fructofuranose 6-phosphate + H⁺ + ADP

D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP → 2 H⁺ + D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP

H₂O + S-adenosyl-L-methionine → adenosine + H⁺ + L-methionine

3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate

S-adenosyl-L-methionine + demethylmenaquinol-8 → S-adenosyl-L-homocysteine + menaquinol-8 + H⁺

NAD(P)+ + 7-hydroxy-pre-bikaverin → 3 H⁺ + NAD(P)H + 7,10-diketo-pre-bikaverin

S-adenosyl-L-methionine + 3-demethylubiquinol-7 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-7

L-leucine + demethylblasticidin S + ATP → H⁺ + phosphate + L-leucyl-demethyl-blasticidin S + ADP

H₂O + (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1 (10),2-dien-4-oate → (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H⁺

Mg²⁺ + H₂O + ATP → Mg²⁺ + H⁺ + phosphate + ADP

2-amino-2-deoxy-D-gluconate → (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H₂O + H⁺

S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine → S-adenosyl-L-homocysteine + H⁺ + 3-O-aceylpapaveroxine

1,2-dihydroxyethylphosphonate + ATP → 1-hydroxy-2-phosphorylethylphosphonate + H⁺ + ADP

H₂O + cyclic ADP-ribose → 3 H⁺ + 1-(5-phospho-β-D-ribosyl)-AMP

H₂O + 3-(glutathion-S-yl)-3-methylhexan-1-ol + ATP → H⁺ + 3-(glutathion-S-yl)-3-methylhexan-1-ol + phosphate + ADP

an oxidized electron donor + H₂O + D-glyceraldehyde → (R)-glycerate + a reduced electron donor + H⁺

galactosyl-glucosyl-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + UDP-α-D-glucose → galactosyl-(glucosyl)₂-(heptosyl)₃-Kdo₂-lipid A-bisphosphate + H⁺ + UDP

ATP + D-serine + D-alanine → D-alanyl-D-serine + H⁺ + phosphate + ADP

H₂O + rhodomycinone D → methanol + H⁺ + 10-carboxy-3-deoxycarminomycin

dTDP-D-desosamine + L-oleandrosyl-oleandolide → H⁺ + oleandomycin + dTDP

heptosyl-Kdo₂-lipid A + ADP-L-glycero-β-D-manno-heptose → (heptosyl)₂-Kdo₂-lipid A + H⁺ + ADP

2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate → 2-methyl-trans-dienelactone + H⁺ + chloride

Fe²⁺ + siroamide → 2 H⁺ + siroheme amide

NAD⁺ + 3-hydroxy-3-phenylpropanoyl-CoA → NADH + H⁺ + 3-oxo-3-phenylpropanoyl-CoA

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-L-lysyl-D-alanine + ATP + D-aspartate → ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-N-(β-D-asparatyl)-L-lysyl-D-alanine + H⁺ + phosphate + ADP

(2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-hydroxypropanoate + NAD⁺ → NADH + (2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-oxopropanoate + H⁺

1,1'-bis-valienamine + UDP-α-D-glucose → validienamycin + H⁺ + UDP

L-anticapsin + L-alanine + ATP → H⁺ + phosphate + ADP + bacilysin

trans-zeatin + UDP-α-D-glucose → H⁺ + trans-zeatin-O-glucoside + UDP

H₂O + GDP → H⁺ + phosphate + GMP

inosine + oxygen → H₂O + 9-riburonosylhypoxanthine + H⁺

S-adenosyl-L-methionine + precorrin-7 → 2 H⁺ + S-adenosyl-L-homocysteine + precorrin-8x

S-adenosyl-L-methionine + TRIBOA-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + DIMBOA-β-D-glucoside

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + (indol-3-yl)pyruvate → 2 a reduced ferredoxin [iron-sulfur] cluster + (indol-3 yl)acetyl-CoA + H⁺ + CO₂

2 oxygen + 4 Mn²⁺ + 4 H₂O → 4 Mn^IVO₂ + 8 H⁺

taurine + 2-oxoglutarate + oxygen → 2-aminoacetaldehyde + H⁺ + succinate + sulfite + CO₂

UDP-α-D-xylose + cyanidin-3-O-β-D-glucoside → H⁺ + cyanidin 3-O-β-D-sambubioside + UDP

ManNAc-GlcNAc-PP-undecaprenol + CDP-glycerol → CMP + H⁺ + Gro-P-ManNAc-GlcNAc-PP-undecaprenol

GDP-α-D-mannose + H₂O → 2 H⁺ + GMP + α-D-mannose 1-phosphate

(1S,2S)-3-phenoxycyclohexa-3,5-diene-1,2-diol + NAD⁺ → NADH + diphenyl ether 2,3-diol + H⁺

(20S)-17,20-dihydroxypregn-4-en-3-one + NAD⁺ → 17-α-hydroxyprogesterone + NADH + H⁺

emodin dianthrone + a reduced electron donor + oxygen → 2 H₂O + 2 H⁺ + an oxidized electron donor + protohypericin

S-adenosyl-L-methionine + desoxyhemigossypol → S-adenosyl-L-homocysteine + H⁺ + desoxyhemigossypol-6-methyl ether

6-O-methylnorlaudanosoline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + (S)-norreticuline

1,5-anhydro-D-glucitol + NAD⁺ → NADH + 1,5-anhydro-D-fructose + H⁺

ethanolamine + ATP → O-phosphoethanolamine + H⁺ + ADP

(3R)-3-hydroxybutanoyl-CoA + H₂O → coenzyme A + (R)-3-hydroxybutanoate + H⁺

fluoroacetate + H₂O → glycolate + H⁺ + fluoride

NAD⁺ + L-dihydroanticapsin → NADH + L-anticapsin + H⁺

H₂O + CTP → CMP + H⁺ + diphosphate

2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-isoglutaminyl-N-(β-D-asparaginyl)-L-lysyl-D-alanine → a peptidoglycan dimer (E. faecium, tetrapeptide) + di-trans,octa-cis-undecaprenyl diphosphate + H⁺

H₂O + (5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA → H⁺ + (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA

H₂O + 22-oxo-docosanoyl-CoA + NADP⁺ → 2 H⁺ + NADPH + 22-carboxy-docosanoyl-CoA

S-adenosyl-L-methionine + rhamnosyl tetracyclic spinosyn pseudoaglycone → S-adenosyl-L-homocysteine + 2'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone + H⁺

dTDP-α-D-olivose + 3A-deolivosylpremithramycin B → H⁺ + dTDP + premithramycin B

H₂O + selenite + ATP → H⁺ + phosphate + selenite + ADP

(2S,5S)-5-carboxymethyl proline + ATP → (3S,5S)-carbapenam-3-carboxylate + H⁺ + diphosphate + AMP

daphnetin + UDP-α-D-glucose → 3-O-β-D-glucosyl-daphnetin + H⁺ + UDP

UDP-α-D-glucuronate + β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate) → H⁺ + UDP + β-D-glucuronosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate)

(-)-4'-methoxycyclopenine → methyl isocyanate + H⁺ + 4'-methoxyviridicatin

7-mercaptoheptanoate + L-threonine + ATP → 7-mercaptoheptanoylthreonine + H⁺ + phosphate + ADP

α-D-ribose-1-phosphate + ATP → α-D-ribose 1,5-bisphosphate + H⁺ + ADP

4 GDP-α-D-mannose + α-D-mannosyl-(1→3)-α-D-mannosyl-(1→3)-α-D-mannosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol → 4 H⁺ + 4 GDP + α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)-α-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol

L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine + UDP-N-acetyl-α-D-muramate + ATP → H⁺ + UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine + phosphate + ADP

UDP-α-D-galactose + solanidine → H⁺ + UDP + γ-solanine

scopoletin + UDP-α-D-glucose → scopolin + H⁺ + UDP

(-)-exo-3-hydroxycamphor + NAD⁺ → (1S)-bornane-2,5-dione + NADH + H⁺

UDP-α-D-xylose + β1-tomatine → H⁺ + α-tomatine + UDP

H₂O + UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-gulopyranose → 2,4-diacetamido-2,4,6-trideoxy-β-L-gulopyranose + H⁺ + UDP

S-adenosyl 3-(methylsulfanyl)propylamine + N⁴-aminopropylspermidine → S-methyl-5'-thioadenosine + N⁴-bis(aminopropyl)spermidine + H⁺

5-phospho-α-D-ribose 1-diphosphate + H₂O → α-D-ribose 1,5-bisphosphate + H⁺ + phosphate

ATP + cytidine 5'-diphosphoramidate → H⁺ + ADP + cytidine 3'-phospho-5'-diphosphoramidate

3'-phosphoadenylyl-sulfate + O-galactosylsphingosine → psychosine sulfate + adenosine 3',5'-bisphosphate + H⁺

N³-oct-2-enoyl-N³-hydroxy-1,3-diaminopropane + N¹-citryl-N³-oct-2-enoyl-N³-hydroxy-1,3-diaminopropane + ATP → acinetoferrin + H⁺ + diphosphate + AMP

H₂O + NAD⁺ + L-isoleucine → NADH + (S)-3-methyl-2-oxopentanoate + H⁺ + ammonium

L-tyrosine → phenol + H⁺ + 2-aminoprop-2-enoate

methylparaben + dTDP-β-L-rhamnose → 4-O-(α-L-rhamnopyranosyl)-hydroxybenzoate methyl ester + H⁺ + dTDP

N-acetyl-β-D-glucosamine + ATP → N-acetyl-α-D-glucosamine 1-phosphate + H⁺ + ADP

H₂O + 4-(methylsulfanyl)-2-oxobutanoate + acetyl-CoA → coenzyme A + 2-[(2'-methylsulfanyl)ethyl]malate + H⁺

H₂O + 6-phospho D-glucono-1,5-lactone → D-gluconate 6-phosphate + H⁺

a reduced electron donor + 3-monoiodothyronine → an oxidized electron donor + H⁺ + L-thyronine + iodide

H₂O + (S)-malyl-CoA → coenzyme A + (S)-malate + H⁺

glycine + ATP + (indol-3-yl)acetate → (indol-3-yl)acetyl-glycine + H⁺ + diphosphate + AMP

2-chloro-cis-dienelactone + H₂O → 2-chloromaleylacetate + H⁺

2 L-tyrosinal → H₂O + (2S)-2-[(E)-[(2S)-2-amino-3-(4-hydroxyphenyl)propylidene]amino]-3-(4-hydroxyphenyl)propanal + H⁺

(Z)-3-peroxyaminoacrylate + a reduced electron donor → an oxidized electron donor + H₂O + aminoacrylate + H⁺

(1R,2S)-cyclohexa-3,5-diene-1,2-diol + NAD⁺ → NADH + catechol + H⁺

H₂O + succinate semialdehyde + NADP⁺ → 2 H⁺ + NADPH + succinate

a reduced electron donor + 3'-monoiodothyronine → an oxidized electron donor + H⁺ + L-thyronine + iodide

adenosine + ATP → H⁺ + ADP + AMP

S-adenosyl-L-methionine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide c + H⁺

H₂O + cytidine 2',3'-cyclic monophosphate → H⁺ + cytidine-3'-monophosphate

brassinolide + UDP-α-D-glucose → brassinolide-23-O-glucoside + H⁺ + UDP

18-hydroxyrenierapurpurin + H₂O → 5 H⁺ + χ,χ-caroten-18-oate

4 an oxidized electron donor + 2-amino-3-[(2,5-dihydroxyphenyl)sulfanyl]propanoate + L-cysteine → 4 a reduced electron donor + H₂O + L-firefly luciferin + H⁺ + CO₂

H₂O + P¹,P⁵-bis(5'-adenosyl) pentaphosphate → 2 H⁺ + ADP + ATP

D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP → H⁺ + phytate + ADP

UDP-N-acetyl-α-D-glucosaminouronate + NAD⁺ → NADH + H⁺ + UDP-2-acetamido-2-deoxy-α-D-ribo-hex-3-uluronate

H₂O + dGTP → H⁺ + phosphate + dGDP

H₂O + trehalose-trans-keto-mono-mycolate + ATP → H⁺ + trehalose-trans-keto-mono-mycolate + phosphate + ADP

NAD(P)+ + phenylmethanesulfenate → NAD(P)H + (Z)-phenylmethanethial S-oxide + H⁺

2 H₂O + 2 cob(II)alamin + NAD⁺ + H⁺ ← 2 aquacobalamin + NADH

H₂O + glorin → ethanol + H⁺ + N-propanoyl-γ-L-glutamyl-L-orornithine-δ-lactam

3-C-glucosyl-2,4,4',6-tetrahydroxydibenzoylmethane + UDP-α-D-glucose → 3,5-di-C-glucosyl-2,4,4',6-tetrahydroxydibenzoylmethane + H⁺ + UDP

χ,χ-caroten-18-oate + H₂O → 2 H⁺ + 18'-hydroxy-χ,χ-caroten-18-oate

NAD⁺ + 7α-hydroxycholesterol → NADH + H⁺ + 7α-hydroxycholest-4-en-3-one

a reduced electron donor + chlorate → an oxidized electron donor + H₂O + H⁺ + chlorite

(R)-pantoate + ATP → (R)-4-phosphopantoate + H⁺ + ADP

NADPH + dihydrogeranylgeranyl bacteriopheophytin + H⁺ ← tetrahydrogeranylgeranyl bacteriopheophytin + NADP⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + coenzyme M + coenzyme B ← 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H₂ + CoB-CoM heterodisulfide

H₂O + malonylgenistin → malonate + H⁺ + genistin

H₂O + 5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate → 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + H⁺ + phosphate

2 ATP + H₂O + N¹-citryl-N⁶-acetyl-N⁶-hydroxy-L-lysine + N⁶-acetyl-N⁶-hydroxy-L-lysine → 2 H⁺ + 2 phosphate + 2 ADP + aerobactin

H₂O + core oligosaccharide-lipid A (E. coli K-12 core type) + ATP → H⁺ + core oligosaccharide-lipid A (E. coli K-12 core type) + phosphate + ADP

NAD(P)+ + 9-fluorenol → NAD(P)H + H⁺ + 9-fluorenone

daphnetin + UDP-α-D-glucose → H⁺ + daphnin + UDP

an oxidized electron donor + chloroethene + H⁺ + chloride ← 1,1,-dichloroethene + a reduced electron donor

3'-phosphoadenylyl-sulfate + indoxyl → adenosine 3',5'-bisphosphate + H⁺ + indoxyl sulfate

4-amino-3-hydroxybenzoate + oxygen → (2Z,4Z)-2-amino-5-formylhexa-2,4-dienedioate + H⁺

H₂O + juvenile hormone III → juvenile hormone III acid + methanol + H⁺

H₂O + 1,2-dichloroethane → 2-chloroethanol + H⁺ + chloride

4-amino-4-de(dimethylamino)anhydrotetracycline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline + H⁺

oxygen + hydroxyquinol → 2 H⁺ + 3-hydroxy-cis,cis-muconate

3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate

oleate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + dihydrosterculate

O-acetyl-L-serine + ethanethiol → S-ethyl-L-cysteine + acetate + H⁺

Fosmidomycin + H⁺ → Fosmidomycin + H⁺

β-amyrin + 3 Reduced NADPH-hemoprotein reductase + 3 oxygen → oleanolate + 3 Oxidized NADPH-hemoprotein reductase + 4 H₂O + H⁺

betulinic aldehyde + Reduced NADPH-hemoprotein reductase + oxygen → betulinate + Oxidized NADPH-hemoprotein reductase + H₂O + H⁺

gentisate + H⁺ → gentisate + H⁺

ATP + 2-phospho-D-glycerate → ADP + 2,3-diphospho-D-glycerate + H⁺

ATP + amicoumacin B → ADP + amicoumacin B 2-phosphate + H⁺

ATP + L-arginine + H₂O → ADP + phosphate + L-arginine + H⁺

D-glyceraldehyde 3-phosphate + arsenate + NAD⁺ → 1-arseno-3-phosphoglycerate + NADH + H⁺

solanidine + NAD⁺ → solanid-4-en-3-one + NADH + H⁺

9-cis-retinal + NAD⁺ + H₂O → 9-cis-retinoate + NADH + 2 H⁺

bis-noryangonin + 2 S-adenosyl-L-methionine → yangonin + 2 S-adenosyl-L-homocysteine + H⁺

(E)-5,6-dihydro-4-hydroxy-6-(styryl)pyran-2-one + S-adenosyl-L-methionine → (R)-(+)-kavain + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + protostreptovaricin I → S-adenosyl-L-homocysteine + protostreptovaricin II + H⁺

chlorpyrifos + H₂O → 3,5,6-trichloro-2-pyridinol + diethylthiophosphate + H⁺

30-hydroxytriacontanoyl-CoA + phytosphingosine → N-(30-hydroxytriacontanoyl)-phytosphingosine + coenzyme A + H⁺

ATP + L-aspartate + H₂O → ADP + L-aspartate + phosphate + H⁺

ATP + putrescine + H₂O → ADP + putrescine + phosphate + H⁺

1-methyl-2-oxoimidazolidine-4-carboxylate + H₂O → (2S)-2-(carboxyamino)-3-(methylamino)propanoate + H⁺

2 GDP-α-D-mannose + [α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)]_n-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol → α-D-Man-(1→2)-α-D-Man-(1→2)-[α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)]_n-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + 2 GDP + 2 H⁺

18-oxo-oleate + NADP⁺ + H₂O → α,ω-9Z-octadecenedioate + NADPH + 2 H⁺

acetyl-CoA + spermidine → N¹-acetylspermidine + H⁺ + coenzyme A

Ni²⁺ + ATP + H₂O → Ni²⁺ + ADP + phosphate + H⁺

prostaglandin F_2α + NAD⁺ → 15-dehydroprostaglandin F_2α + NADH + H⁺

D-glycero-D-manno-heptose 7-phosphate + ATP → H⁺ + D-glycero-β-D-manno-heptose 1,7-bisphosphate + ADP

α,α-trehalose + H₂O + ATP → α,α-trehalose + phosphate + ADP + H⁺

2-ethylhexyl sulfate + oxygen + 2-oxoglutarate → 2-ethylhexanal + succinate + CO₂ + sulfate + H⁺

ATP + L-cysteine + H₂O → ADP + L-cysteine + phosphate + H⁺

4-amino-4-deoxyprephenate + NAD⁺ → 3-(4-aminophenyl)pyruvate + CO₂ + NADH + H⁺

hydrogen acetylphosphonate + L-alanine → [(S)-1-aminoethyl]phosphonate + pyruvate + H⁺

D-glucosamine + ATP → D-glucosamine 6-phosphate + ADP + H⁺

p-nitrophenyl-β-D-glucopyranoside + H₂O → 4-nitrophenol + D-glucopyranose + H⁺

UDP-α-D-glucose + (R)-2-hydroxy-3-methybutanenitrile → epiheterodendrin + UDP + H⁺

L-gulopyranose + NAD⁺ → L-gulono-1,4-lactone + NADH + H⁺

D-glucopyranose + ADP → D-glucopyranose 6-phosphate + AMP + H⁺

lignoceroyl-CoA + phytosphingosine → N-(lignoceroyl)-phytosphingosine + coenzyme A + H⁺

diazinon + H₂O → 2-isopropyl-6-methylpyrimidin-4-ol + diethylthiophosphate + H⁺

ATP + H₂O + L-tyrosine → ADP + phosphate + L-tyrosine + H⁺

UDP-α-D-glucose + 4-hydroxy-3-(hydroxymethyl)-2-butenenitrile → sutherlandin + UDP + H⁺

(S)-3-hydroxydodecanoyl-CoA + NAD⁺ → 3-oxododecanoyl-CoA + NADH + H⁺

aloesone + D-glucopyranose → aloesin + H₂O + H⁺

oxidized factor 420-2 + L-glutamate + GTP → oxidized factor 420-3 + GDP + phosphate + H⁺

(R)-(1-hydroxyethyl)phosphonate + oxygen → acetate + phosphate + 2 H⁺

UDP-α-D-glucose + methylsalicylate → methylsalicylate-2-O-β-D-glucoside + UDP + H⁺

pyridoxine + S-adenosyl-L-methionine → ginkgotoxin + S-adenosyl-L-homocysteine + H⁺

isethionate → acetaldehyde + sulfite + H⁺

3'-phosphoadenylyl-sulfate + 3-β-hydroxyandrost-5-en-17-one → adenosine 3',5'-bisphosphate + 3-β-hydroxyandrost-5-en-17-one 3-sulfate + H⁺

[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-Gro-P-Gro-P-β-D-ManNAc-(1→4)-α-D-GlcNAc-P-peptidoglycan + n H₂O → [(2-GlcNAc)-Rib-ol-P]n-Gro-P-Gro-P-β-D-ManNAc-(1→4)-α-D-GlcNAc-PP-peptidoglycan + n D-alanine + n H⁺

biochanin A-7-O-glucoside + H₂O → biochanin-A + D-glucopyranose + H⁺

Fe³⁺ + ATP + H₂O → Fe³⁺ + ADP + phosphate + H⁺

octyl sulfate + oxygen + 2-oxoglutarate → 1-octanal + succinate + CO₂ + sulfate + H⁺

D-xylopyranose + NAD(P)⁺ → D-xylono-1,5-lactone + NAD(P)H + H⁺

4-nitrophenyl palmitate + H₂O → 4-nitrophenol + palmitate + 2 H⁺

ATP + H₂O + D-xylose → ADP + phosphate + H⁺ + D-xylose

S-adenosyl-L-methionine + prostreptovaricin → S-adenosyl-L-homocysteine + 3-methylprostreptovaricin + H⁺

uracil + oxygen + FMNH₂ → (Z)-3-ureidoacrylate + FMN-N⁵-oxide + 2 H⁺

Zn²⁺ + ATP + H₂O → Zn²⁺ + ADP + phosphate + H⁺

solasodine + NADP⁺ → solasod-4-en-3-one + NADPH + H⁺

2 oxygen + Latia luciferin + a reduced unknown two electron carrier → Latia oxyluciferin + formate + CO₂ + H₂O + an oxidized unknown electron carrier + H⁺ + hν

genistin + H₂O → genistein + D-glucopyranose + H⁺

ATP + molybdate + H₂O → ADP + phosphate + molybdate + H⁺

O-[3-nitro-5-(oxidonitroso)-4-oxocyclohex-2-en-1-ylidenenitroso]oxidanidolate + an oxidized factor 420 + H⁺ ← 2,4,6-trinitrophenol + a reduced factor 420

α-acetyldigitoxin + H₂O → digitoxin + acetate + H⁺

glycine betaine + ATP + H₂O → glycine betaine + phosphate + H⁺ + ADP

D-selenomethionine + ATP + H₂O → D-selenomethionine + ADP + phosphate + H⁺

ATP + [6-O-phospho-α-glucan] + H₂O → 3-O-phospho-[6-O-phospho-α-glucan] + AMP + phosphate + 2 H⁺

2,6-dichlorohydroquinone + oxygen + FADH₂ → 2-chloro-6-hydroxy-1,4-benzoquinone + H₂O + chloride + FAD + H⁺

cyanidin 3-O-(6-O-β-D-glucosyl-2-O-β-D-xylosyl-β-D-galactoside) + 1-O-(4-coumaroyl)-β-D-glucose → cyanidin O-O-[6-O-(6-O-4-hydroxycinnamoyl-β-D-glucosyl)-2-O-β-D-xylosyl-β-D-galactoside] + D-glucopyranose + H⁺

arachidoyl-CoA + sphinganine → N-(arachidoyl)-sphinganine + coenzyme A + H⁺

3-all trans-hexaprenyl-4,5-dihydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-all trans-hexaprenyl-4-hydroxy-5-methoxybenzoate

S-adenosyl-L-methionine + 2',3'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone → S-adenosyl-L-homocysteine + 2',3',4'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone + H⁺

hydroquinone + oxygen → (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H⁺

N⁶-acetyl-N⁶-hydroxy-L-lysine + ATP + citrate → N¹-citryl-N⁶-acetyl-N⁶-hydroxy-L-lysine + H⁺ + diphosphate + AMP

H₂O + L-cysteate → pyruvate + H⁺ + ammonium + sulfite

7-carboxy-7-deazaguanine + ammonium + ATP → H₂O + preQ₀ + H⁺ + phosphate + ADP

ammonium + ATP + nicotinate adenine dinucleotide → NAD⁺ + H⁺ + diphosphate + AMP

rifamycin W → 2 H⁺ + rifamycin W hemiacetal

N⁴-acetylcytidine + H₂O → cytidine + acetate + H⁺

lignoceroyl-CoA + sphinganine → N-(tetracosanoyl)-sphinganine + coenzyme A + H⁺

oxidized factor 420-0 + FMN + H⁺ ← dehydro factor 420-0 + FMNH₂

2-methylbutanoyl-CoA + H₂O → 2-methylbutanoate + coenzyme A + H⁺

D-glucurono-6,3-lactone + H₂O → D-glucopyranuronate + H⁺

nonyl sulfate + oxygen + 2-oxoglutarate → 1-nonanal + succinate + CO₂ + sulfate + H⁺

2-hydroxy-dADP + H₂O → 2-hydroxy-dAMP + phosphate + H⁺

2-chloroacetate + H₂O → glycolate + H⁺ + chloride

2 S-adenosyl-L-methionine + H₂O + 3-(4-hydroxyphenyl)pyruvate + 5-amino-6-(D-ribitylamino)uracil → 2 5'-deoxyadenosine + 2 L-methionine + 3 H⁺ + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + ammonium + oxalate

H₂O + NAD⁺ + L-alanine → NADH + pyruvate + H⁺ + ammonium

(2R)-3-sulfolactate → pyruvate + H⁺ + sulfite

methylmalonate semialdehyde + coenzyme A + NAD⁺ + H₂O → propanoyl-CoA + hydrogencarbonate + NADH + H⁺

D-apionolactone + H₂O → D-apionate + H⁺

β-D-glucopyranosyl abscisate + H₂O → 2-cis-abscisate + D-glucopyranose + H⁺

CMP-N-acetyl-β-neuraminate + SSEA-3 → SSEA-4 + CMP + H⁺

H₂O + purine + NAD⁺ → 2 H⁺ + 8-hydroxypurine + NADH

S-sulfanylglutathione + oxygen → H⁺ + S-sulfinatoglutathione

H₂O + D-Glucurono-6,2-lactone → D-glucopyranuronate + H⁺

feruloylacetyl-CoA + H₂O → feruloyl diketide + coenzyme A + H⁺

S-adenosyl-L-methionine + demethyldeoxyspectinabilin → S-adenosyl-L-homocysteine + deoxyspectinabilin + H⁺

1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-biphosphate + H₂O → 1-stearoyl-2-arachidonoyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺

UDP-α-D-glucose + MMFT-5 → MMFT-6 + UDP + H⁺

UDP-α-D-glucose + (digitoxigenin-3β-yl)-β-D-quinovoside → glucodigitoxigenin 3-O-β-D-quinovoside + UDP + H⁺

sucrose + H⁺ → sucrose + H⁺

6-(hydroxymethyl)-7,8-dihydropterin + ATP → (7,8-dihydropterin-6-yl)methyl diphosphate + H⁺ + AMP

H₂O + 3-methyl-2-oxobutanoate + acetyl-CoA → coenzyme A + (2S)-2-isopropylmalate + H⁺

H₂O + cyclic-AMP → H⁺ + AMP

H₂O + cyclic-GMP → H⁺ + GMP

D-ribulose 5-phosphate → 1-deoxy-L-glycero-tetrulose 4-phosphate + formate + H⁺

(R)-lactate + 2 oxidized c-type cytochrome → pyruvate + 2 reduced c-type cytochrome + 2 H⁺

ATP + a 1-phosphatidyl-1D-myo-inositol 3-phosphate → H+ + ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate

5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate + 3 H2O → 4-(methylsulfanyl)-2-oxobutanoate + formate + 6 H+ + phosphate

2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine → 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone + H+ + S-adenosyl-L-homocysteine

3-methyl-2-oxobutanoate + acetyl-CoA + H2O → (2R,3S)-3-isopropylmalate + coenzyme A + H+

3-methyl-2-oxobutanoate + acetyl-CoA + H2O → coenzyme A + H+ + (2R,3S)-3-isopropylmalate

3',5'-Cyclic dAMP + H2O → dAMP + H+

cyclic-IMP + H2O → H+ + IMP

cyclic 3',5'-cytidine monophosphate + H2O → CMP + H+

ADP + 3 H+ + phosphate → ATP + 2 H+ + H2O

H2O + (indol-3-yl)acetaldehyde + NADP+ → 2 H+ + (indol-3-yl)acetate + NADPH

7,8-dihydroneopterin 3'-triphosphate + 3 H2O → 7,8-dihydroneopterin + 2 H+ + 3 phosphate

H₂O + diphosphate → 2 phosphate + H⁺

NADP+ + zymosterol intermediate 1c → CO2 + H+ + NADPH + zymosterone

cerotoyl-CoA + D-erythro-sphinganine → ceramide-1 (C26) + coenzyme A + H+

cerotoyl-CoA + phytosphingosine → N-(hexacosanoyl)-phytosphingosine + coenzyme A + H+

D-arabinose + NADP+ → D-arabinono-1,4-lactone + H+ + NADPH

D-arabinose + NAD+ → D-arabinono-1,4-lactone + H+ + NADH

D-sorbitol + NAD+ → D-Fructose + H+ + NADH

beta-D-mannosyldiacetylchitobiosyldiphosphodolichol + GDP-α-D-mannose → α-D-mannosyl-β-D-mannosyldiacetylchitobiosyldiphosphodolichol + GDP + H+

a CDP-diacylglycerol + phosphatidylglycerol → H+ + CMP + cardiolipin

H2O + octanoyl-CoA → coenzyme A + H+ + octanoate

4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol + NAD+ → 3-dehydro-4-methylzymosterol + CO2 + H+ + NADH

ATP + D-ribose 5-phosphate → AMP + H+ + 5-phospho-α-D-ribose 1-diphosphate

chitin + H2O → acetate + chitosan + H+

UDP-N-acetyl-α-D-glucosamine → chitin + H+ + UDP

CDP-ethanolamine + a diglyceride → H+ + CMP + phosphatidylethanolamine

8 coenzyme A + 8 H2O + 8 NAD+ + 6 oxygen + 9-octadecynoyl-CoA → 9 acetyl-CoA + 8 H+ + 6 hydrogen peroxide + 8 NADH

CDP-choline + a diglyceride → H+ + CMP + a phosphatidylcholine

ATP + 2'-deoxyribose → ADP + H+ + 2-Deoxy-D-ribose 5-phosphate

5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate + 3 H2O → 6 H+ + D-myo-inositol 1,3,4,5,6-pentakisphosphate + 3 phosphate

2-(3-Carboxy-3-aminopropyl)-L-histidine + S-adenosyl-L-methionine → 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H+ + S-adenosyl-L-homocysteine

CTP + dolichol → CDP + dolichyl phosphate + H+

dolichyl D-mannosyl phosphate → dolichyl phosphate + H+ + mannan

formaldehyde + glutathione + NAD+ → H+ + NADH + S-formylglutathione

D-glucopyranose 6-phosphate + NADP+ → 6-phospho D-glucono-1,5-lactone + H+ + NADPH

H2O + 1-acylglycerophosphocholine → H+ + sn-glycero-3-phosphocholine + fatty acid

H2O + phosphatidylethanolamine → H+ + fatty acid + 1-acylglycerophosphoethanolamine

H2O + 1-acylglycerophosphoethanolamine → H+ + sn-glycero-3-phosphoethanolamine + fatty acid

H2O + phosphatidyl-L-serine → H+ + fatty acid + 1-acylglycerophosphoserine

H2O + 1-acylglycerophosphoserine → H+ + glycerophosphoserine + fatty acid

H2O + a 1-phosphatidyl-1D-myo-inositol → H+ + fatty acid + 2-lysophosphatidyl-D-myo-inositol

H2O + 2-lysophosphatidyl-D-myo-inositol → H+ + sn-glycero-3-phospho-1-inositol + fatty acid

H2O + a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate → H+ + D-myo-inositol (1,4,5)-trisphosphate + a diglyceride

H2O + sn-glycero-3-phosphocholine → choline + glycerol 2-phosphate + H+

dihydrolipoylprotein + NAD+ → H+ + lipoylprotein + NADH

ATP + D-Glucose → ADP + D-glucopyranose 6-phosphate + H+

ATP + D-mannopyranose → ADP + α-D-mannopyranose 6-phosphate + H+

ATP + a 1-phosphatidyl-1D-myo-inositol → H+ + ADP + a 1-phosphatidyl-1D-myo-inositol 4-phosphate

myo-inositol + a CDP-diacylglycerol → H+ + CMP + a 1-phosphatidyl-1D-myo-inositol

ATP + a 1-phosphatidyl-1D-myo-inositol 4-phosphate → ADP + H+ + a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

L-Glucitol + NAD+ → H+ + L-sorbose + NADH

(R)-mevalonate + CTP → (R)-5-phosphomevalonate + CDP + H+

(R)-mevalonate + GTP → (R)-5-phosphomevalonate + GDP + H+

(R)-mevalonate + UTP → (R)-5-phosphomevalonate + H+ + UDP

L-serine + a CDP-diacylglycerol → H+ + CMP + phosphatidyl-L-serine

3'-phosphoadenylyl-sulfate + Thioredoxin → adenosine 3',5'-bisphosphate + 2 H+ + sulfite + thioredoxin disulfide

H2O + a phosphatidylcholine → choline + H+ + phosphatidate

S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine → H+ + S-adenosyl-L-homocysteine + a phosphatidylcholine

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine → H+ + S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ATP + CO2 + H2O → ADP + H+ + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

S-adenosyl-L-methionine + phosphatidylethanolamine → H+ + S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

glycerol 2-phosphate + a CDP-diacylglycerol → H+ + CMP + 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate

ATP + a 1-phosphatidyl-1D-myo-inositol → H+ + ADP + a 1-phosphatidyl-1D-myo-inositol 3-phosphate

ATP + L-proline + tRNA(Pro) → AMP + diphosphate + H+ + Pro-tRNA(Pro)

ATP + D-ribose → ADP + H+ + D-ribose 5-phosphate

ATP + D-glucosamine → ADP + α-D-glucosamine 6-phosphate + H+

L-histidine + S-adenosyl-L-methionine → H+ + Nπ-methyl-L-histidine + S-adenosyl-L-homocysteine

2 H2O + thiamine diphosphate → H+ + 2 phosphate + thiamine

ATP + hydrogencarbonate + urea → ADP + H+ + phosphate + urea-1-carboxylate

ATP + H2O + taurocholate → ADP + H+ + phosphate + taurocholate

H2O + a triglyceride → H+ + fatty acid + a diglyceride

β-D-Glc-(1→6)-β-D-Glc-(1→6)-β-D-Glc-(1→4)-6-O-acetyl-β-D-Glc-(1→4)-β-D-Glc-(1→3)-α-D-Gal-diphosphoundecaprenol + UDP-α-D-glucose → β-D-Glc-(1→3)-β-D-Glc-(1→6)-β-D-Glc-(1→6)-β-D-Glc-(1→4)-6-O-acetyl-β-D-Glc-(1→4)-β-D-Glc-(1→3)-α-D-Gal-diphosphoundecaprenol + UDP + H⁺

UDP-α-D-glucose → 1,3-β-D-glucan + H⁺ + UDP

UDP-α-D-glucose → (1→6)-β-D-glucan + H⁺ + UDP

D-glucopyranose 6-phosphate + UDP-α-D-glucose → α,α-trehalose 6-phosphate + H⁺ + UDP

H₂O + UDP-α-D-glucose → glycogen + H⁺ + UDP

10-formyl-tetrahydrofolate mono-L-glutamate + Met-tRNA(Met) → fMet-tRNA(fMet) + H+ + 5,6,7,8-tetrahydrofolate

ATP + a 1-phosphatidyl-1D-myo-inositol → H+ + ADP + a 1-phosphatidyl-1D-myo-inositol 4-phosphate

ATP + a 1-phosphatidyl-1D-myo-inositol 4-phosphate → H+ + ADP + a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

H2O + butanoyl-CoA → coenzyme A + H+ + butanoate

H2O + hexanoyl-CoA → coenzyme A + H+ + hexanoate

GTP + H2O → cyclic-GMP + diphosphate + H+

H2O + NAD+ + dodecanal → 2 H+ + NADH + decanoate

H2O + episteryl palmitoleate → H+ + palmitoleate + episterol

ergosteryl palmitoleate + H2O → ergosterol + H+ + palmitoleate

H2O + a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate → D-myo-inositol (1,4,5)-trisphosphate + H+ + a diglyceride

H2O + phosphatidylglycerol → H+ + glycerol 2-phosphate + a diglyceride

H2O + 1-acylglycerophosphocholine → H+ + sn-glycero-3-phosphocholine + fatty acid

H2O + a phosphatidylcholine → H+ + 1-acylglycerophosphocholine + fatty acid

NAD+ + (3R)-hydroxydecanoyl-CoA → 3-oxodecanoyl-CoA + H+ + NADH

NAD+ + (R)-3-hydroxylauroyl-CoA → 3-oxododecanoyl-CoA + H+ + NADH

NAD+ + (3R)-3-hydroxyoctadecanoyl-CoA → 3-oxooctadecanoyl-CoA + H+ + NADH

NAD+ + (S)-3-hydroxyhexacosanoyl-CoA → 3-oxo-cerotoyl-CoA + H+ + NADH

NAD+ + (R)-3-hydroxyicosanoyl-CoA → H+ + 3-oxoicosanoyl-CoA + NADH

NAD+ + (3R)-3-hydroxy-behenoyl-CoA → H+ + 3-oxo-behenoyl-CoA + NADH

NAD+ + (3R)-3-hydroxy-lignoceroyl-CoA → H+ + 3-oxo-lignoceroyl-CoA + NADH

NAD+ + (R)-3-hydroxy-cis-hexadec-9-enoyl-CoA → H+ + 3-oxo-(9Z)-hexadecenoyl-CoA + NADH

NAD+ + (R)-3-hydroxy-cis-tetradec-7-enoyl-CoA → H+ + 3-oxo-(7Z)-tetradecenoyl-CoA + NADH

NAD+ + (R)-3-hydroxy-cis-dodec-5-enoyl-CoA → H+ + 3-oxo-(5Z)-dodecenoyl-CoA + NADH

NAD+ + (R)-3-hydroxy-cis-octadec-9-enoyl-CoA → H+ + 3-oxo-(9Z)-octadecenoyl-CoA + NADH

NAD+ + (R)-3-hydroxy-cis-hexadec-7-enoyl-CoA → H+ + 3-oxo-(7Z)-hexadecenoyl-CoA + NADH

NAD+ + (R)-3-hydroxy-cis-tetradec-5-enoyl-CoA → H+ + 3-oxo-(5Z)-tetradecenoyl-CoA + NADH

H2O + episteryl oleate → H+ + oleate + episterol

H2O + fecosteryl palmitoleate → fecosterol + H+ + palmitoleate

H2O + fecosteryl oleate → fecosterol + H+ + oleate

H2O + lanosteryl palmitoleate → H+ + palmitoleate + lanosterol

H2O + zymosteryl palmitoleate → H+ + zymosterol + palmitoleate

H2O + zymosteryl oleate → H+ + zymosterol + oleate

H2O + zymosteryl palmitoleate → H+ + zymosterol + palmitoleate

H2O + zymosteryl oleate → H+ + zymosterol + oleate

CTP + a diglyceride → H+ + CDP + phosphatidate

H2O + cardiolipin → H+ + monolysocardiolipin + fatty acid

H2O + a phosphatidylcholine → H+ + 1-acylglycerophosphocholine + fatty acid

H2O + 1,2-diacylglycerol 3-diphosphate → phosphate + H+ + phosphatidate

H2O + 1,2-diacylglycerol 3-diphosphate → H+ + phosphate + phosphatidate

H2O + a diglyceride → H+ + fatty acid + a 1-monoglyceride

H2O + a diglyceride → H+ + a 1-monoglyceride + fatty acid

H2O + a 1-monoglyceride → H+ + glycerol + fatty acid

H2O + a phosphatidylcholine → H+ + fatty acid + 1-acylglycerophosphocholine

H2O + phosphatidylethanolamine → H+ + fatty acid + 1-acylglycerophosphoethanolamine

5,10-methenyltetrahydrofolate mono-L-glutamate + N1-(5-phospho-β-D-ribosyl)glycinamide + H2O → N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + 2 H+ + 5,6,7,8-tetrahydrofolate

ATP + N-[(R)-pantothenoyl]-L-cysteine → ADP + H+ + (R)-4'-phosphopantothenoyl-L-cysteine

H2O + ADP-D-ribose → AMP + 2 H+ + D-ribose 5-phosphate

Reversible reaction (1182)

trans-5-O-(4-coumaroyl)-D-quinate + NADPH + H⁺ + oxygen ↔ H₂O + NADP⁺ + trans-5-O-caffeoyl-D-quinate

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + 2-oxoglutarate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + succinyl-CoA + CO₂

H⁺ + sulfate + ATP ↔ diphosphate + adenosine 5'-phosphosulfate

2-chloro-cis,cis-muconate + H⁺ ↔ (+)-5-chloromuconolactone

campesterol + NADPH + H⁺ + oxygen ↔ H₂O + (22α)-hydroxy-campesterol + NADP⁺

(S)-N-methylcoclaurine + NADPH + H⁺ + oxygen ↔ H₂O + 3'-hydroxy-N-methyl-(S)-coclaurine + NADP⁺

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose ↔ β-D-galactosyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

2 H⁺ + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO₂

NAD⁺ + UDP-N-acetyl-α-D-glucosamine ↔ NADH + UDP-2-deoxy-2-acetamido-3-dehydro-α-D-glucopyranose + H⁺

NADP⁺ + keto-L-sorbose ↔ 5-dehydro-D-fructose + NADPH + H⁺

orsellinate + H⁺ ↔ orcinol + CO₂

H₂O + 3-phosphonopyruvate ↔ pyruvate + H⁺ + phosphate

3-[(7'-methylsulfanyl)heptyl]malate + NAD⁺ ↔ NADH + 3-carboxy-10-(methylsulfanyl)-2-oxodecanoate + H⁺

2 glutathione + 2,3,6-trichlorohydroquinone ↔ 2,6-dichlorohydroquinone + H⁺ + glutathione disulfide + chloride

NADP⁺ + 4,5β-dihydrocortisone ↔ NADPH + H⁺ + cortisone

(3R)-vestitone + NADP⁺ ↔ NADPH + 2-hydroxyformononetin + H⁺

streptothricin F + acetyl-CoA ↔ coenzyme A + N^β-acetylstreptothricin F + H⁺

L-idonate + NADP⁺ ↔ NADPH + 2-keto-L-gulonate + H⁺

precorrin-2 + NAD⁺ ↔ 2 H⁺ + NADH + sirohydrochlorin

12α-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH + H⁺ ↔ 12α-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD⁺

FADH₂ + NAD⁺ ↔ 2 H⁺ + FAD + NADH

H₂O + 7,8-dihydro-8-oxoguanine + H⁺ ↔ urate + ammonium

1-chloro-4-nitrosobenzene + NADPH + H⁺ ↔ 1-chloro-4-hydroxylaminobenzene + NADP⁺

2 H⁺ + FAD + glutaryl-CoA ↔ FADH₂ + crotonyl-CoA + CO₂

2'-deoxyguanosine + UTP ↔ H⁺ + dGMP + UDP

coenzyme A + NADP⁺ + 3-oxopropanoate ↔ NADPH + H⁺ + malonyl-CoA

aldehydo-L-galactonate + H⁺ ↔ L-galactono-1,4-lactone + H₂O

H⁺ + L-arginine ↔ agmatine + CO₂

H₂O + blasticidin S + H⁺ ↔ deaminohydroxyblasticidin S + ammonium

NADPH + H⁺ + geranylgeranyl chlorophyll a ↔ NADP⁺ + dihydrogeranylgeranyl chlorophyll a

pregnan-21-ol + NAD⁺ ↔ pregnan-21-al + NADH + H⁺

H₂O + ATP ↔ H⁺ + phosphate + ADP

dihydrophloroglucinol + NADP⁺ ↔ NADPH + phloroglucinol + H⁺

H₂O + carbonyl sulfide ↔ H⁺ + monothiocarbonate

2-oxoglutarate + L,L-diaminopimelate ↔ H₂O + (S)-2,3,4,5-tetrahydrodipicolinate + H⁺ + L-glutamate

H₂O + 1-heptanal ↔ hexane + formate + H⁺

2'-deoxycytidine + UTP ↔ H⁺ + UDP + dCMP

cycloeucalenone + NADPH + H⁺ ↔ cycloeucalenol + NADP⁺

4-sulfobenzyl alcohol + NAD⁺ ↔ 4-sulfobenzaldehyde + NADH + H⁺

(R)-pantoate + NAD⁺ ↔ (R)-4-dehydropantoate + NADH + H⁺

NAD⁺ + 3-ethylmalate ↔ NADH + 3-ethyl-2-oxosuccinate + H⁺

α-D-Man-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)-D-Man + UDP-N-acetyl-α-D-glucosamine ↔ α-D-Man-(1→3)-[α-D-GlcNAc-(1→2)]-α-D-Man-(1→2)-α-D-Man-(1→2)-D-Man + H⁺ + UDP

1-carboxyvinyl carboxyphosphonate + H⁺ ↔ 3-(hydroxyphosphinoyl)pyruvate + CO₂

5α-cholesta-8-en-3-one + NADPH + H⁺ ↔ zymostenol + NADP⁺

an oxidized electron donor + H₂O + arsenite ↔ a reduced electron donor + H⁺ + arsenate

FAD + H₂O + H⁺ + deoxycholate ↔ FADH₂ + cholate

H⁺ + UDP-α-D-galacturonate ↔ UDP-β-L-arabinopyranose + CO₂

NAD⁺ + 3-methoxy-4-hydroxyphenylglycol ↔ NADH + 3-methoxy-4-hydroxyphenylglycolaldehyde + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + NAD(P)+ + H⁺ ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + NAD(P)H

2-hydroxychalcone + pyruvate + H⁺ ↔ 3-(2-hydroxyphenyl)-1-phenylpentane-1,4-dione + CO₂

NAD(P)+ + (2R)-2,3-dihydroxy-3-methylbutanoate ↔ NAD(P)H + H⁺ + (S)-2-acetolactate

NAD(P)+ + L-idonate ↔ 5-dehydro-D-gluconate + NAD(P)H + H⁺

ATP + adenosine 5'-phosphosulfate ↔ 3'-phosphoadenylyl-sulfate + H⁺ + ADP

NADP⁺ + galactitol ↔ NADPH + β-D-galactopyranose + H⁺

α-D-mannopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-β-D-galactopyranosyl-diphospholipid + CDP-α-abequose ↔ α-D-abequopyranosyl-(1→3)-α-D-mannopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-β-D-galactopyranosyl-diphospholipid + H⁺ + CDP

H₂O + P¹,P⁶-bis(5'-adenosyl) hexaphosphate ↔ 2 H⁺ + 2 ATP

2 Fe²⁺ + NAD⁺ + H⁺ ↔ 2 Fe³⁺ + NADH

C31-phthiotriol + S-adenosyl-L-methionine ↔ S-adenosyl-L-homocysteine + C32-phthiocerol A + H⁺

3-(2,3-dihydroxyphenyl)propanoate + oxygen ↔ (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H⁺

a reduced electron donor + NADP⁺ ↔ an oxidized electron donor + H⁺ + 1,2-dihydro-β-NADP

4-coumaroyl-3',4'-dihydroxyphenyllactate + NADPH + H⁺ + oxygen ↔ H₂O + rosmarinate + NADP⁺

succinyl-CoA + L-arginine ↔ coenzyme A + N²-succinyl-L-arginine + H⁺

H⁺ + a [myosin light-chain] L-serine + ATP ↔ myosin light-chain phosphate + ADP

NADP⁺ + D-arabinitol ↔ NADPH + D-xylulose + H⁺

H₂O + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate ↔ H⁺ + phosphate + 1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

H₂O + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate ↔ H⁺ + phosphate + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate

castasterone + NADPH + H⁺ + oxygen ↔ H₂O + brassinolide + NADP⁺

H₂ + NAD(P)+ ↔ NAD(P)H + H⁺

H₂O + NAD⁺ ↔ nicotinamide + H⁺ + ADP-D-ribose

3-phospho-D-glyceroyl-phosphate + α-D-glucopyranose 1-phosphate ↔ α-glucose 1,6-bisphosphate + H⁺ + 3-phospho-D-glycerate

2 H⁺ + 6-deoxotyphasterol + oxygen ↔ H₂O + 6-deoxocastasterone

(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP⁺ ↔ (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH + H⁺

H⁺ + dTTP + α-D-galactose 1-phosphate ↔ dTDP-α-D-galactose + diphosphate

NADP⁺ + UDP-β-L-rhamnose ↔ NADPH + UDP-4-dehydro-6-deoxy-α-D-glucose + H⁺

NADH + 3-phenylpropanoate + H⁺ + oxygen ↔ NAD⁺ + 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate

2 cob(I)yrinate a,c-diamide + 3 H⁺ + FMN ↔ 2 cob(II)yrinate a,c-diamide + FMNH₂

NAD⁺ + S-(hydroxymethyl)glutathione ↔ NADH + H⁺ + S-formylglutathione

H₂O + 5,6-dihydrothymine ↔ H⁺ + 3-(carbamoylamino)-2-methylpropanoate

NADPH + 1-oleoyl-2-lyso-glycerone phosphate + H⁺ ↔ NADP⁺ + 1-oleoyl-sn-glycerol 3-phosphate

2 H⁺ + an oxidized electron donor + sulfite + AMP ↔ a reduced electron donor + adenosine 5'-phosphosulfate

trans-5-O-(4-coumaroyl)shikimate + NADPH + H⁺ + oxygen ↔ H₂O + NADP⁺ + 5-O-caffeoylshikimate

D-myo-inositol (4,5)-bisphosphate + ATP ↔ D-myo-inositol (1,4,5)-trisphosphate + H⁺ + ADP

pregnan-21-ol + NADP⁺ ↔ pregnan-21-al + NADPH + H⁺

(5Z)-(15S)-11-α-hydroxy-9,15-dioxoprostanoate + NAD(P)+ ↔ 15-dehydro-prostaglandin E₂ + NAD(P)H + H⁺

12α-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H⁺ ↔ 12α-hydroxy-3-oxocholan-24-oyl-CoA + NAD⁺

NAD⁺ + H⁺ ↔ NADH

(13E)-(15S)-11-α,15-dihydroxy-9-oxoprost-13-enoate + NADP⁺ ↔ NADPH + (13E)-11-α-hydroxy-9,15-dioxoprost-13-enoate + H⁺

FAD + 2,5-dichloro-p-quinol + H⁺ ↔ FADH₂ + 2,5-dichloro-p-quinone

H₂O + (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + H⁺ ↔ L-4-hydroxyglutamate semialdehyde

NAD(P)+ + 16-α-hydroxysteroid ↔ NAD(P)H + 16-oxosteroid + H⁺

coenzyme A + an oxidized ferredoxin [iron-sulfur] cluster + pyruvate ↔ a reduced ferredoxin [iron-sulfur] cluster + H⁺ + acetyl-CoA + CO₂

H⁺ + CTP + α-D-glucopyranose 1-phosphate ↔ diphosphate + CDP-α-D-glucose

(R)-mandelate + NAD⁺ ↔ NADH + phenylglyoxylate + H⁺

D-glucaro-1,4-lactone + H₂O ↔ H⁺ + D-glucarate

H₂O + 3-aminopropanal + NAD⁺ ↔ 2 H⁺ + β-alanine + NADH

2 H₂O + 1-piperideine 6-carboxylate + NAD⁺ ↔ NADH + L-2-aminoadipate + H⁺

(S)-1-phenylethanol + NAD⁺ ↔ NADH + H⁺ + acetophenone

propan-2-ol + NADP⁺ ↔ NADPH + acetone + H⁺

2 Fe³⁺ + H₂O + sulfite ↔ 2 Fe²⁺ + 2 H⁺ + sulfate

2 NADH + 2 H⁺ + 2 oxygen + canthaxanthin ↔ 2 H₂O + 2 NAD⁺ + 2,2'-dihydroxycanthaxanthin

H₂ + NAD⁺ ↔ NADH + H⁺

pyruvate + phosphate + ATP ↔ phosphoenolpyruvate + H⁺ + diphosphate + AMP

2 FMNH₂ + 2 oxygen + EDTA ↔ 2 FMN + 2 H₂O + 2 glyoxylate + 2 H⁺ + ethylenediamine-N,N'-diacetate

NAD⁺ + galactitol ↔ NADH + H⁺ + keto-L-tagatose

1,2-propanediol 1-phosphate + NAD⁺ ↔ hydroxyacetone phosphate + NADH + H⁺

(R)-2-hydroxyglutaryl-CoA ↔ 4 H⁺ + H₂O + (E)-glutaconyl-CoA

dTDP-β-L-rhamnose + NADP⁺ ↔ NADPH + dTDP-4-dehydro-β-L-rhamnose + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + norspermidine ↔ S-methyl-5'-thioadenosine + H⁺ + norspermine

2 UDP-α-D-galactofuranose + α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol ↔ 2 H⁺ + 2 UDP + β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol

3-α-hydroxy-5-β-androstane-17-one + NAD⁺ ↔ 5-β-androstane-3,17-dione + NADH + H⁺

5 H⁺ + phosphoenolpyruvate + α-D-mannopyranose 6-phosphate ↔ 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate

α-D-galacturonate 1-phosphate + H⁺ + UTP ↔ diphosphate + UDP-α-D-galacturonate

2 NADH + 2 H⁺ + 2 oxygen + adonixanthin ↔ 2 H₂O + 2 NAD⁺ + 2,3,2',3'-tetrahydroxy-β,β-caroten-4-one

hydrogencarbonate ↔ H⁺ + carbonate

NAD⁺ + 5,6-dihydrothymine ↔ thymine + NADH + H⁺

NADP⁺ + cholate ↔ NADPH + H⁺ + 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate

H₂O + N⁶-(Δ²-isopentenyl)-adenosine 5'-triphosphate ↔ 2 H⁺ + N⁶-(Δ²-isopentenyl)-adenosine 5'-diphosphate + phosphate

NADP⁺ + chenodeoxycholate ↔ NADPH + H⁺ + 7α-hydroxy-3-oxo-5β-cholanate

sucrose + UDP-α-D-galactose ↔ H⁺ + loliose + UDP

H₂O + dimethylsulfonio-2-hydroxybutanoate ↔ 4 H⁺ + dimethylsulfoniopropanoate + CO₂

a reduced electron donor + NADP⁺ ↔ an oxidized electron donor + H⁺ + 1,6-dihydro-β-NADP

NAD⁺ + (2E,6E)-farnesol ↔ NADH + (2E,6E)-farnesal + H⁺

NAD⁺ + D-mannitol ↔ NADH + aldehydo-D-mannose + H⁺

3'-phosphoadenylyl-sulfate + 24-epicathasterone ↔ 24-epicathasterone-22-O-sulfate + adenosine 3',5'-bisphosphate + H⁺

H₂O + lauroyl-CoA + oxaloacetate ↔ coenzyme A + H⁺ + (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate

(S)-2-aminobutanoate + decanoyl-CoA + H⁺ ↔ coenzyme A + (S)-3-aminotridecan-4-one + CO₂

NADPH + H⁺ + sinapoyl-CoA ↔ coenzyme A + sinapaldehyde + NADP⁺

NAD(P)+ + (S)-malate ↔ NAD(P)H + H⁺ + oxaloacetate

L-carnitine + NAD⁺ ↔ 3-dehydrocarnitine + NADH + H⁺

carbonic acid ↔ H⁺ + hydrogencarbonate

carbamoyl phosphate + putrescine ↔ N-carbamoylputrescine + H⁺ + phosphate

H₂O + NAD(P)+ + L-glutamate ↔ NAD(P)H + 2-oxoglutarate + H⁺ + ammonium

2-hydroxyeriodictyol ↔ 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione + H⁺

12 H⁺ + 4 (R)-methylmalonyl-CoA + 8 NADPH + icosanoyl-CoA ↔ 4 coenzyme A + 4 H₂O + 4 CO₂ + 8 NADP⁺ + C32 mycocerosyl-CoA

ammonia + H⁺ ↔ ammonium

spermidine + glutathione + ATP ↔ H⁺ + glutathionylspermidine + phosphate + ADP

NAD(P)+ + 23,24-dihydrocucurbitacin B ↔ NAD(P)H + cucurbitacin B + H⁺

α-D-xylopyranose + NAD⁺ ↔ D-xylono-1,5-lactone + NADH + H⁺

H₂O + acetyl-CoA + trans-homoaconitate ↔ coenzyme A + pentane-1,3,4,5-tetracarboxylate + H⁺

scopoletin ↔ 2 H⁺ + ayapin

2 ATP + H₂O + L-glutamine + hydrogencarbonate ↔ 2 H⁺ + 2 ADP + carbamoyl phosphate + L-glutamate + phosphate

dTDP-L-pneumose + NADP⁺ ↔ NADPH + dTDP-4-dehydro-β-L-rhamnose + H⁺

(S)-2-amino-6-oxohexanoate ↔ H₂O + 1-piperideine 6-carboxylate + H⁺

NADP⁺ + ecgonine methyl ester ↔ 2 H⁺ + methyl ecgonone + NADPH

7-epicholate + NADP⁺ ↔ NADPH + H⁺ + 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate

NADP⁺ + 3,8-divinyl chlorophyllide a ↔ NADPH + H⁺ + 3,8-divinyl protochlorophyllide a

NADP⁺ + protochlorophyllide a ↔ NADPH + H⁺ + 3,8-divinyl protochlorophyllide a

acetyl-CoA + L-2,4-diaminobutanoate ↔ coenzyme A + (2S)-4-acetamido-2-aminobutanoate + H⁺

an oxidized electron donor + H₂O + S-sulfo-L-cysteine + glutathione ↔ a reduced electron donor + H⁺ + (glutathion-S-yl)-L-cysteine + sulfate

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂ ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺

(R)-3-hydroxybutanoate + NAD⁺ ↔ NADH + H⁺ + acetoacetate

D-mannitol 1-phosphate + NAD⁺ ↔ NADH + β-D-fructofuranose 6-phosphate + H⁺

H₂O + L-galactono-1,5-lactone ↔ aldehydo-L-galactonate + H⁺

H₂O + 5,6-dihydrouracil ↔ H⁺ + 3-ureidopropanoate

(R,S)-2,3-butanediol + NAD⁺ ↔ (R)-acetoin + NADH + H⁺

H₂O + lauroyl-CoA + 2-oxoglutarate ↔ coenzyme A + H⁺ + 3-hydroxytetradecane-1,3,4-tricarboxylate

4-coumaroyl-4'-hydroxyphenyllactate + NADPH + H⁺ + oxygen ↔ H₂O + 4-coumaroyl-3',4'-dihydroxyphenyllactate + NADP⁺

prostaglandin F_2α + NADP⁺ ↔ prostaglandin E₂ + NADPH + H⁺

unsaturated CDP-archaeol + sn-glycerol 1-phosphate ↔ archaetidylglycerol phosphate + CMP + H⁺

14 NADPH + 21 H⁺ + 7 (R)-methylmalonyl-CoA + palmitoyl-CoA ↔ 14 NADP⁺ + 7 coenzyme A + 7 H₂O + 7 CO₂ + C37-phthioceranyl-CoA

(2R)-2,3-dihydroxy-3-methylbutanoate + NADP⁺ ↔ NADPH + H⁺ + (S)-2-acetolactate

FADH₂ + NAD(P)+ ↔ 2 H⁺ + FAD + NAD(P)H

2 H⁺ + hexane-6-ol-1,3,4,6-tetracarboxylate ↔ H₂O + hexane-1,3,4,6-tetracarboxylate

ADP-α-D-glucose + H₂O ↔ 2 H⁺ + AMP + α-D-glucopyranose 1-phosphate

NAD⁺ + sn-glycerol 3-phosphate ↔ glycerone phosphate + NADH + H⁺

NADP⁺ + 3-methyloxindole ↔ NADPH + H⁺ + 3-methyleneoxindole

H₂O + L-kynurenine ↔ anthranilate + H⁺ + L-alanine

H⁺ + 2-chloro-4-methyl-cis,cis-muconate ↔ 2-chloro-4-methyl-cis-dienelactone

β-L-arabinose 1-phosphate + H⁺ + UTP ↔ diphosphate + UDP-β-L-arabinopyranose

2,5-dichloro-3-methyl-muconolactone ↔ 2,5-dichloro-3-methyl-muconate + H⁺

NADP⁺ + D-pinitol ↔ 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H⁺

keto-D-tagatose + ATP ↔ D-tagatofuranose 6-phosphate + H⁺ + ADP

(S)-propane-1,2-diol + NAD⁺ ↔ NADH + H⁺ + (S)-lactaldehyde

3'-phosphoadenylyl-sulfate + glycolithocholate ↔ adenosine 3',5'-bisphosphate + H⁺ + glycolithocholate 3-sulfate

glycerol + ATP ↔ H⁺ + ADP + sn-glycerol 3-phosphate

D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP ↔ 2 H⁺ + D-myo-inositol (1,2,4,5,6)-pentakisphosphate + ADP

NAD(P)H + 5-guanidino-2-oxopentanoate + H⁺ + ammonium ↔ H₂O + NAD(P)+ + L-arginine

NADPH + sophoradiol + H⁺ + oxygen ↔ H₂O + soyasapogenol B + NADP⁺

3 N-hydroxy-N-succinylcadaverine + ATP ↔ H₂O + desferrioxamine G₁ + H⁺ + phosphate + ADP

10 malonyl-CoA + 9 H⁺ ↔ 10 coenzyme A + 10 CO₂ + 2 H₂O + tetracenomycin F2

D-arabitol 5-phosphate + NAD⁺ ↔ D-ribulose 5-phosphate + NADH + H⁺

H⁺ + ADP + ATP ↔ P¹,P⁴-bis(5'-adenosyl) tetraphosphate + phosphate

5α-cholesta-7,24-dien-3β-ol + NADPH + H⁺ ↔ lathosterol + NADP⁺

D-ornithine + L-lysine + ATP ↔ H⁺ + phosphate + ε-(D-ornithyl)-L-lysine + ADP

creatine + ATP ↔ N^ω-phosphocreatine + H⁺ + ADP

NADP⁺ + (R)-2-hydroxybutanoate ↔ NADPH + 2-oxobutanoate + H⁺

uracil 5-carboxylate + H⁺ ↔ uracil + CO₂

N-acetyl-L-ornithine + carbamoyl phosphate ↔ N-acetyl-L-citrulline + H⁺ + phosphate

L-asparagine ↔ H₂O + 3-cyano-L-alanine + H⁺

2 NADPH + 5 malonyl-CoA + 6 H⁺ + acetyl-CoA ↔ 2 NADP⁺ + 3 H₂O + 5 CO₂ + 6 coenzyme A + 2-hydroxy-5-methyl-1-naphthoate

2 H⁺ + NADH + oxygen + phenazine-1-carboxylate ↔ H₂O + phenazin-1-ol + NAD⁺ + CO₂

NADPH + β-amyrin + H⁺ + oxygen ↔ H₂O + 24-hydroxy-β-amyrin + NADP⁺

NAD⁺ + 4-hydroxybutanoate ↔ succinate semialdehyde + NADH + H⁺

L-threonate + NAD⁺ ↔ NADH + 3-dehydro-D-erythronate + H⁺

(R)-2-methylpyrrolidine + NADP⁺ ↔ NADPH + 2-methyl-1-pyrroline + H⁺

(E)-4-phenylbut-3-en-2-one + pyruvate + H⁺ ↔ (R)-phenylhexane-2,5-dione + CO₂

2 NAD⁺ + (-)-secoisolariciresinol ↔ 2 NADH + 2 H⁺ + (-)-matairesinol

24-epi-campesterol + NADP⁺ ↔ NADPH + brassicasterol + H⁺

UDP-N-acetyl-D-galactosamine 4-sulfate + 3'-phosphoadenylyl-sulfate ↔ UDP-N-acetyl-D-galactosamine 4,6-bissulfate + adenosine 3',5'-bisphosphate + H⁺

riboflavin + H₂O + H⁺ ↔ lumichrome + D-ribitol

(R)-glycerate + NAD(P)+ ↔ hydroxypyruvate + NAD(P)H + H⁺

H₂O + NAD(P)+ + nitrous oxide ↔ 2 nitric oxide + NAD(P)H + H⁺

2 NAD⁺ + H₂O + 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol ↔ 2 NADH + 3 H⁺ + 2-(glutathion-S-yl)-2-methylbut-3-enoate

NAD(P)+ + xylitol ↔ NAD(P)H + aldehydo-D-xylose + H⁺

NAD⁺ + chenodeoxycholate ↔ NADH + H⁺ + 7α-hydroxy-3-oxo-5β-cholanate

H⁺ + (R)-lactate ↔ H₂O + methylglyoxal

S-adenosyl-L-methionine + uroporphyrinogen-III ↔ S-adenosyl-L-homocysteine + precorrin-1 + H⁺

2 H⁺ + (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-(9,11,14)-trienoate ↔ H₂O + (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate

pyridoxamine + ATP ↔ pyridoxamine 5'-phosphate + H⁺ + ADP

15S-hydroxypentaenoate + NAD(P)+ ↔ NAD(P)H + H⁺ + 15-KETE

NAD⁺ + deoxycholate ↔ NADH + H⁺ + 3-dehydrodeoxycholate

desmosterol + NADPH + H⁺ ↔ cholesterol + NADP⁺

5,6-dihydrouracil + NADP⁺ ↔ NADPH + H⁺ + uracil

H₂O + betaine aldehyde + NAD⁺ ↔ 2 H⁺ + glycine betaine + NADH

2 H⁺ + 3 malonyl-CoA + hexanoyl-CoA ↔ 3 CO₂ + 4 coenzyme A + tetraketide pyrone

all-trans-retinol + NADP⁺ ↔ NADPH + all-trans-retinal + H⁺

H₂O + ATP + sn-glycerol 3-phosphate ↔ H⁺ + phosphate + ADP + sn-glycerol 3-phosphate

2-methyl-butan-2,3-diol + NAD⁺ ↔ NADH + H⁺ + methylacetoin

NAD⁺ + nerol ↔ NADH + H⁺ + neral

NAD⁺ + (11Z)-(S)-3-hydroxyhexadec-11-enoyl-CoA ↔ NADH + H⁺ + (11Z)-3-oxo-hexadecenoyl-CoA

H₂O + NAD⁺ + L-serine ↔ hydroxypyruvate + NADH + H⁺ + ammonium

17-α-hydroxypregnenolone + NAD⁺ ↔ pregn-5-ene-3,20-dione-17-ol + NADH + H⁺

poly (glycerol phosphate) + UDP-α-D-glucose ↔ o-(α-D-glucosyl)-polyglycerol phosphate + H⁺ + UDP

(2R)-2,3-dihydroxy-3-methylbutanoate + NAD⁺ ↔ NADH + H⁺ + (S)-2-acetolactate

H₂O + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA ↔ coenzyme A + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H⁺

4-amino-2-methyl-5-pyrimidinemethanol + ATP ↔ 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H⁺ + ADP

2 NADP⁺ + (-)-epiafzelechin ↔ 2 NADPH + 3 H⁺ + pelargonidin

9-cis-retinol + NAD⁺ ↔ 9-cis-retinal + NADH + H⁺

sucrose + UDP-α-D-galactose ↔ 6^F-α-D-galactosylsucrose + H⁺ + UDP

hydroxyacetone + NADP⁺ ↔ NADPH + H⁺ + methylglyoxal

NADP⁺ + D-arabinitol ↔ NADPH + D-ribulose + H⁺

S-adenosyl-L-methionine + isovaleryl-CoA ↔ N-isovaleryl-L-homoserine lactone + coenzyme A + S-methyl-5'-thioadenosine + H⁺

H₂O + NADP⁺ + D-glyceraldehyde ↔ 2 H⁺ + (R)-glycerate + NADPH

(S)-3-hydroxybutanoyl-CoA + NAD⁺ ↔ NADH + acetoacetyl-CoA + H⁺

meso-tartrate + NAD⁺ ↔ dihydroxyfumarate + NADH + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine ↔ norspermidine + S-methyl-5'-thioadenosine + H⁺

H⁺ + 4-chloro-2-methyl-cis,cis-muconate ↔ 2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate

4 H⁺ + 4 malonyl-CoA ↔ 3 coenzyme A + 4 CO₂ + H₂O + (3,5-dihydroxyphenyl)acetyl-CoA

NAD⁺ + 4-ethylguaiacol ↔ NADH + H⁺ + 4-vinylguaiacol

2 H⁺ + fumarate ↔ succinate

choline + NADP⁺ ↔ NADPH + betaine aldehyde + H⁺

H₂O + geranial + NAD⁺ ↔ 2 H⁺ + NADH + geranate

(R,S)-2,3-butanediol + NAD⁺ ↔ (S)-acetoin + NADH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 7¹-hydroxychlorophyll a ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + chlorophyll a

H₂O + NAD(P)+ + L-aspartate ↔ NAD(P)H + H⁺ + ammonium + oxaloacetate

D-dopachrome + H⁺ ↔ 5,6-dihydroxyindole + CO₂

thymidine + ADP ↔ H⁺ + AMP + dTMP

5-dehydro-D-gluconate + NADP⁺ ↔ NADPH + 2,5-didehydro-D-gluconate + H⁺

H₂O + betaine aldehyde + NADP⁺ ↔ 2 H⁺ + glycine betaine + NADPH

2 H₂O + an oxidized electron donor + coenzyme A + 2-[(1R,6S)-1,6-dihydroxycyclohexa-2,4-dien-1-yl]acetyl-coA ↔ a reduced electron donor + H⁺ + acetyl-CoA + (3S)-hydroxyadipyl-CoA

2 H⁺ + 3-decaprenyl-4-hydroxybenzoate + oxygen ↔ 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + H₂O

NAD(P)H + 4α-hydroxymethyl-4β-methyl-5α-cholest-7-en-3β-ol + H⁺ + oxygen ↔ 2 H₂O + 3β-hydroxy-4β-methyl-5α-cholest-7-ene-4α-carbaldehyde + NAD(P)+

taurocyamine + ATP ↔ 2 H⁺ + N^ω-phosphotaurocyamine + ADP

sucrose + ATP ↔ H⁺ + sucrose 6^G-phosphate + ADP

NADP⁺ + coformycin ↔ 2 H⁺ + 8-oxocoformycin + NADPH

H₂O + NADP⁺ + meso-diaminopimelate ↔ NADPH + L-α-amino-ε-keto-pimelate + H⁺ + ammonium

D-hamamelose + ATP ↔ D-hamamelose 2'-phosphate + H⁺ + ADP

gentisate + H⁺ ↔ hydroquinone + CO₂

2 H⁺ + oxygen + gibberellin A₁₂ ↔ H₂O + gibberellin A₅₃

scyllo-inositol + NAD⁺ ↔ scyllo-inosose + NADH + H⁺

L-citrulline + L-aspartate + ATP ↔ L-arginino-succinate + H⁺ + diphosphate + AMP

(2R)-3-sulfolactate + NAD⁺ ↔ 3-sulfopyruvate + NADH + H⁺

coenzyme A + H₂O ↔ 2 H⁺ + 4'-phosphopantetheine + adenosine 3',5'-bisphosphate

H₂O + 18-oxo-oleoyl-CoA + NADP⁺ ↔ 2 H⁺ + NADPH + ω-carboxy-(9Z)-octadec-9-enoyl-CoA

dihydrolipoamide + NAD⁺ ↔ lipoamide + NADH + H⁺

O-succinyl-L-homoserine + hydrogen sulfide ↔ L-homocysteine + H⁺ + succinate

D-lombricine + ATP ↔ N^ω-phospho-D-lombricine + H⁺ + ADP

a reduced electron donor + sarcosine + H⁺ + phosphate ↔ an oxidized electron donor + acetyl phosphate + H₂O + methylamine

GDP-α-D-mannose + 1-phosphatidyl-myo-inositol ↔ 1-phosphatidyl-myo-inositol 2-mannose + H⁺ + GDP

2 H₂O + 1-pyrroline + NAD⁺ ↔ 2 H⁺ + 4-aminobutanoate + NADH

indole-3-glycolate ↔ 2 H⁺ + indole-3-glyoxylate

4 H⁺ + L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate ↔ L-methionine + tetrahydropteroyl tri-L-glutamate

diphosphoundecaprenyl-[GlcNAc-MurNAc-pentapeptide]_n + ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-β-D-glucosaminyl)-(1,4)-]-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H⁺ ↔ diphosphoundecaprenyl-[GlcNAc-MurNAc-pentapeptide]_n+1 + di-trans,octa-cis-undecaprenyl diphosphate

H₂O + 3-hydroxy-3-methyl-butanal + NAD⁺ ↔ 2 H⁺ + NADH + 3-hydroxy-3-methylbutanoate

2-methyl-butane-1,2-diol + NAD⁺ ↔ NADH + 2-hydroxy-2-methyl-butanal + H⁺

an oxidized electron donor + coenzyme A + phenylglyoxylate + H⁺ ↔ a reduced electron donor + benzoyl-CoA + CO₂

H₂O + β-D-galactopyranose + ATP ↔ β-D-galactopyranose + H⁺ + phosphate + ADP

2 H⁺ + H₂O + urea ↔ 2 ammonium + CO₂

NADP⁺ + (6R)-L-threo-5,6,7,8-tetrahydrobiopterin ↔ NADPH + H⁺ + (6R)-6-lactoyl-5,6,7,8-tetrahydropterin

O-succinyl-L-homoserine + methanethiol ↔ H⁺ + L-methionine + succinate

agmatine + ATP ↔ 2 H⁺ + N⁴-phosphoagmatine + ADP

NAD(P)H + H⁺ + 4-hydroxybutanoyl-CoA ↔ coenzyme A + NAD(P)+ + 4-hydroxybutyraldehyde

H₂O + H⁺ + ADP ↔ ammonium + IDP

L-quinate + NAD(P)+ ↔ 3-dehydroquinate + NAD(P)H + H⁺

benzyl alcohol + NAD⁺ ↔ NADH + benzaldehyde + H⁺

streptomycin + ATP ↔ streptomycin 3''-phosphate + H⁺ + ADP

H₂O + (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate ↔ H⁺ + succinate + (2Z)-2-hydroxypenta-2,4-dienoate

netilmicin + GTP ↔ H⁺ + netilmycin 2''-phosphate + GDP

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + pyruvate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + acetyl-CoA + CO₂

2-epi-5-epi-valiolone + ATP ↔ 2-epi-5-epi-valiolone 7-phosphate + H⁺ + ADP

H₂O + 4-aminobutanal + NADP⁺ ↔ 2 H⁺ + 4-aminobutanoate + NADPH

2-deoxygluconate + NAD⁺ ↔ 3-dehydro-2-deoxy-D-gluconate + NADH + H⁺

tetrahydrogeranylgeranyl diphosphate + NADP⁺ ↔ dihydrogeranylgeranyl diphosphate + NADPH + H⁺

NADP⁺ + 5β-cholestan-3-one ↔ NADPH + H⁺ + cholest-4-en-3-one

NADPH + H⁺ + oxygen + gibberellin A₄ ↔ H₂O + NADP⁺ + gibberellin A₁

Fe²⁺ + protoporphyrin IX ↔ 2 H⁺ + protoheme

acetyl-CoA + D-tryptophan ↔ coenzyme A + H⁺ + N-acetyl-D-tryptophan

β-D-fructofuranose 6-phosphate + diphosphate ↔ β-D-fructose 1,6-bisphosphate + H⁺ + phosphate

β-L-arabinose 1-phosphate + H⁺ + UDP ↔ phosphate + UDP-β-L-arabinopyranose

avenastenone + NADPH + H⁺ ↔ NADP⁺ + avenasterol

H₂O + UDP-α-D-sulfoquinovopyranose ↔ H⁺ + sulfite + UDP-α-D-glucose

(R)-4-dehydropantoate + H₂O + NAD⁺ ↔ 2 H⁺ + NADH + (R)-3,3-dimethylmalate

H₂O + N⁶-(Δ²-isopentenyl)-adenosine 5'-diphosphate ↔ N⁶-(Δ²-isopentenyl)-adenosine 5'-monophosphate + H⁺ + phosphate

NADPH + H⁺ + formononetin + oxygen ↔ H₂O + 2-hydroxyformononetin + NADP⁺

H⁺ + (E)-glutaconyl-CoA ↔ crotonyl-CoA + CO₂

H⁺ + MoO₂-molybdopterin cofactor + GTP ↔ guanylyl molybdenum cofactor + diphosphate

(S)-3-hydroxyoctanoyl-CoA + NAD⁺ ↔ NADH + H⁺ + 3-oxooctanoyl-CoA

(R,R)-2,3-butanediol + NAD⁺ ↔ (R)-acetoin + NADH + H⁺

5-α-androstan-3β,17β-diol + NADP⁺ ↔ 17-β-hydroxy-5-α-androstan-3-one + NADPH + H⁺

NAD⁺ + 3-β-hydroxyandrost-5-en-17-one ↔ 5-androstene-3,17-dione + NADH + H⁺

2 coenzyme A + NADP⁺ ↔ NADPH + H⁺ + CoA-disulfide

an oxidized electron donor + H₂O + quinaldate ↔ kynurenate + a reduced electron donor + H⁺

2 H₂O + GDP-β-L-galactose ↔ 2 H⁺ + β-L-galactopyranose + phosphate + GMP

isopentenyl diphosphate + di-trans,poly-cis-heptaprenyl diphosphate ↔ di-trans,poly-cis-octaprenyl diphosphate + H⁺ + diphosphate

3'-phosphoadenylyl-sulfate + cortisol ↔ adenosine 3',5'-bisphosphate + H⁺ + cortisol 21-sulfate

H₂O + cytidine + H⁺ ↔ uridine + ammonium

H⁺ + (3S)-hydroxyadipyl-CoA ↔ H₂O + 3,6-lactone of 3-hydroxyadinyl-CoA

coenzyme A + NAD⁺ + (R)-lactaldehyde ↔ NADH + H⁺ + (R)-lactoyl-CoA

H₂O + P¹,P⁶-bis(5'-adenosyl) hexaphosphate ↔ adenosine pentaphosphate + H⁺ + AMP

histidinol + NAD⁺ ↔ histidinal + NADH + H⁺

2 GTP + H⁺ ↔ P¹,P⁴-bis(5'-guanosyl) tetraphosphate + diphosphate

zymosterone + NADPH + H⁺ ↔ zymosterol + NADP⁺

2 NADP⁺ + cinchonidine + cinchonine ↔ 2 NADPH + 2 cinchoninone + 4 H⁺

2-C-methyl-D-erythritol 4-phosphate + NADP⁺ ↔ NADPH + H⁺ + 1-deoxy-D-xylulose 5-phosphate

S-adenosyl-L-methionine + (E)-4-coumaroyl-CoA ↔ N-4-coumaroyl-L-homoserine lactone + coenzyme A + S-methyl-5'-thioadenosine + H⁺

(R)-2-hydroxystearate + NAD⁺ ↔ NADH + 2-oxostearate + H⁺

H₂O + NAD⁺ + IMP ↔ NADH + H⁺ + XMP

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + 2-oxobutanoate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + propanoyl-CoA + H⁺ + CO₂

NADPH + H⁺ + (4-octanoyl-5-oxo-2H-furan-3-yl)methyl phosphate ↔ NADP⁺ + [(3S)-4-octanoyl-5-oxooxolan-3-yl]methyl phosphate

putrescine + trans-caffeoyl-CoA ↔ coenzyme A + N-caffeoylputrescine + H⁺

NADPH + H⁺ + phyta-2,10,14-trienyl bacteriochlorophyllide a ↔ NADP⁺ + phyta-2,14-dienyl bacteriochlorophyllide a

NADP⁺ + (2E)-dec-2-enoyl-CoA ↔ NADPH + trans-Δ², cis-Δ⁴-decadienoyl-CoA + H⁺

NADP⁺ + codeine ↔ NADPH + H⁺ + codeinone

H₂O + H⁺ + L-mimosine ↔ 3-hydroxy-4h-pyrid-4-one + L-serine

all-trans-retinol + NAD⁺ ↔ NADH + all-trans-retinal + H⁺

trans-4-hydroxy-L-proline + NAD⁺ ↔ 2 H⁺ + 4-oxoproline + NADH

NAD(P)H + H⁺ + keto-L-sorbose 1-phosphate ↔ NAD(P)+ + D-sorbitol 6-phosphate

NADP⁺ + 3α,7α,12β-trihydroxy-5β-cholan-24-oate ↔ NADPH + H⁺ + 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD⁺ ↔ 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H⁺

3 NADP⁺ + H₂O + magnesium-protoporphyrin IX 13-monomethyl ester ↔ 3 NADPH + 4 H⁺ + 3,8-divinyl protochlorophyllide a

guanidinoethyl methyl phosphate + ATP ↔ N'-phosphoguanidinoethyl methyl phosphate + H⁺ + ADP

methanol + NAD⁺ ↔ NADH + formaldehyde + H⁺

H⁺ + indole-3-carboxylate ↔ indole + CO₂

NADP⁺ + 18-hydroxyoleoyl-CoA ↔ NADPH + 18-oxo-oleoyl-CoA + H⁺

H₂O + NAD(P)+ + 2-acetamidofluorene ↔ N-hydroxy-2-acetamidofluorene + NAD(P)H + H⁺

NADPH + (Z)-but-2-enal + H⁺ ↔ (Z)-but-2-enol + NADP⁺

γ-resorcylate + H⁺ ↔ resorcinol + CO₂

guanidinoacetate + ATP ↔ N^ω-phosphoguanidinoacetate + H⁺ + ADP

H₂O + NADP⁺ + L-valine ↔ NADPH + 3-methyl-2-oxobutanoate + H⁺ + ammonium

H₂O + pyruvate + ATP ↔ 2 H⁺ + phosphoenolpyruvate + phosphate + AMP

α-D-xylose 1-phosphate + H⁺ + UTP ↔ diphosphate + UDP-α-D-xylose

clavaldehyde + NADPH + H⁺ ↔ clavulanate + NADP⁺

H₂O + phosphonoacetaldehyde ↔ acetaldehyde + H⁺ + phosphate

2,3-dihydroxybenzoate + H⁺ ↔ catechol + CO₂

coenzyme A + NAD(P)+ + butan-1-al ↔ butanoyl-CoA + NAD(P)H + H⁺

O-acetyl-L-serine + thiosulfate ↔ acetate + S-sulfo-L-cysteine + H⁺

H₂O + L-serine O-sulfate ↔ pyruvate + H⁺ + ammonium + sulfate

(S)-NADPHX + ATP ↔ NADPH + H⁺ + phosphate + ADP

17-β-hydroxy-5-α-androstan-3-one + NADP⁺ ↔ testosterone + NADPH + H⁺

NADP⁺ + chlordecone alcohol ↔ NADPH + H⁺ + chlordecone

NADPH + H⁺ + oxygen + (2S)-eriodictyol ↔ (2S)-dihydrotricetin + H₂O + NADP⁺

FMNH₂ + NAD(P)+ ↔ 2 H⁺ + FMN + NAD(P)H

2'-deoxyadenosine + UTP ↔ H⁺ + dAMP + UDP

2-chloro-2-(2-chloro-5-oxofuran-2-yl)acetate ↔ 2,3-dichloro-cis,cis-muconate + H⁺

NADP⁺ + CDP-α-abequose ↔ NADPH + H⁺ + CDP-4-dehydro-3,6-dideoxy-α-D-glucose

S-adenosyl-L-methionine + indol-3-ylmethylcarbamodithiolate ↔ S-adenosyl-L-homocysteine + H⁺ + brassinin

3'-phosphoadenylyl-sulfate + taurolithocholate ↔ adenosine 3',5'-bisphosphate + H⁺ + taurolithocholate sulfate

2 H₂O + 6-oxocyclohex-1-ene-1-carbonyl-CoA ↔ 3-hydroxypimeloyl-CoA + H⁺

5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate ↔ H⁺

NAD(P)+ + D-mannitol 1-phosphate ↔ NAD(P)H + β-D-fructofuranose 6-phosphate + H⁺

S-adenosyl-L-methionine + dehypoxanthine futalosine ↔ 2 H⁺ + L-methionine + cyclic dehypoxanthine futalosine + 5'-deoxyadenosin-5'-yl radical

viomycin + ATP ↔ H⁺ + O-phosphoviomycin + ADP

protoaphin aglucone + H⁺ ↔ xanthoaphin + H₂O

H₂ + NADP⁺ ↔ NADPH + H⁺

H₂O + 5,10-methenyltetrahydrofolate mono-L-glutamate ↔ 10-formyl-tetrahydrofolate mono-L-glutamate + H⁺

H₂O + L-5-carboxymethylhydantoin ↔ N-carbamoyl-L-aspartate + H⁺

NADPH + H⁺ + GDP-6-deoxy-4-keto-L-xylo-heptose ↔ GDP-6-deoxy-L-gluco-heptose + NADP⁺

NADPH + tert-amyl alcohol + H⁺ + oxygen ↔ H₂O + 2-methyl-butane-1,2-diol + NADP⁺

(E)-cinnamoyl-CoA + glycine ↔ coenzyme A + H⁺ + cinnamoylglycine

Fe²⁺ + sirohydrochlorin ↔ 2 H⁺ + siroheme

NAD(P)+ + (20S)-17,20-dihydroxypregn-4-en-3-one ↔ 17-α-hydroxyprogesterone + NAD(P)H + H⁺

D-sorbitol 6-phosphate + NAD⁺ ↔ NADH + D-fructose 6-phosphate + H⁺

(2R)-3-sulfolactate + NADP⁺ ↔ 3-sulfopyruvate + NADPH + H⁺

H₂O + ADP-D-ribose ↔ 2 H⁺ + aldehydo-D-ribose 5-phosphate + AMP

FAD + D-gluconate + H⁺ ↔ FADH₂ + 2-keto-D-gluconate

2 H₂O + 3 NAD(P)+ + ammonium ↔ 3 NAD(P)H + 5 H⁺ + nitrite

prostaglandin D₂ + NADP⁺ ↔ (5Z,13E)-9-α-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H⁺

NADP⁺ + cholate ↔ NADPH + H⁺ + 3-dehydrocholate

2 NADP⁺ + (R)-canadine ↔ 2 NADPH + H⁺ + berberine

3 H⁺ + a reduced electron donor + nitrite ↔ an oxidized electron donor + H₂O + hydroxylamine

2 Fe²⁺ + NADP⁺ + H⁺ ↔ 2 Fe³⁺ + NADPH

glycine + 3-phenylpropanoyl-CoA ↔ coenzyme A + H⁺ + N-(3-phenylpropanoyl)glycine

2-phenylethanol + NAD⁺ ↔ NADH + phenylacetaldehyde + H⁺

2 NADP⁺ + (-)-epicatechin ↔ 2 NADPH + 3 H⁺ + cyanidin

2 H₂O + 1-piperideine 6-carboxylate + NAD(P)+ ↔ NAD(P)H + L-2-aminoadipate + H⁺

hydrogen cyanide + L-cysteine ↔ 3-cyano-L-alanine + H⁺ + hydrogen sulfide

H₂O + chloride + ATP ↔ H⁺ + phosphate + chloride + ADP

H₂O + 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate ↔ H⁺ + phosphate + 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate

NADPH + 2-keto-D-gluconate + H⁺ ↔ L-idonate + NADP⁺

anthranilate + H⁺ ↔ aniline + CO₂

precorrin-8x + H⁺ ↔ hydrogenobyrinate

an oxidized electron donor + D-proline ↔ 1-pyrroline-2-carboxylate + a reduced electron donor + H⁺

H₂O + aurachin B + NAD⁺ ↔ NADH + 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide + H⁺

UDP-α-D-glucose + β-D-fructofuranose ↔ sucrose + H⁺ + UDP

FAD + H⁺ + succinate ↔ FADH₂ + fumarate

H₂O + NADP⁺ + 10-formyl-tetrahydrofolate mono-L-glutamate ↔ NADPH + H⁺ + 5,6,7,8-tetrahydrofolate + CO₂

D-gluconate + NAD(P)+ ↔ 5-dehydro-D-gluconate + NAD(P)H + H⁺

2 H⁺ + 2-hexaprenyl-6-methoxyphenol + oxygen ↔ H₂O + 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol

scytalone + NADP⁺ ↔ NADPH + H⁺ + 1,3,6,8-naphthalenetetrol

2 NAD(P)+ + H₂O + 4-hydroxyaminoquinoline-N-oxide ↔ 2 NAD(P)H + 2 H⁺ + 4-nitroquinoline-N-oxide

3 (L-seryl)adenylate + 3 (2,3-dihydroxybenzoyl)adenylate ↔ 6 H⁺ + 6 AMP + enterobactin

L-dopa + NADH + H⁺ ↔ hydrocaffeate + NAD⁺ + ammonium

L-gulonate + NAD⁺ ↔ 3-keto-L-gulonate + NADH + H⁺

2-hydroxymalonate + NAD⁺ ↔ oxomalonate + NADH + H⁺

H₂O + NAD⁺ + 2-formylbenzoate ↔ 2 H⁺ + phthalate + NADH

(2S,3R,4S)-4-hydroxy-L-isoleucine + NAD⁺ ↔ (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H⁺

5,6-dihydrouracil + NAD⁺ ↔ NADH + H⁺ + uracil

2 benzoyl-CoA + L-ornithine ↔ 2 coenzyme A + 2 H⁺ + N2,N5-dibenzoyl-L-ornithine

H₂O + ferric-enterobactin complex + ATP ↔ H⁺ + phosphate + ferric-enterobactin complex + ADP

NAD⁺ + L-lysine ↔ 2 H⁺ + 1-piperideine 6-carboxylate + NADH + ammonium

6α-hydroxy-castasterone ↔ 2 H⁺ + castasterone

H₂O + juvenile hormone I ↔ juvenile hormone I acid + methanol + H⁺

pentane + NADH + H⁺ + oxygen ↔ H₂O + (2R)-pentan-2-ol + NAD⁺

FAD + octanoyl-CoA + H⁺ ↔ FADH₂ + (2E)-oct-2-enoyl-CoA

(+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD⁺ ↔ phenanthrene-3,4-diol + NADH + H⁺

phytyl diphosphate + H⁺ + chlorophyllide a ↔ chlorophyll a + diphosphate

NADPH + H⁺ + 4α-methyl-5α-cholesta-8-en-3-one ↔ NADP⁺ + 4α-methyl-5α-cholesta-8-en-3-ol

S-methyl-L-methionine + L-selenocysteine ↔ H⁺ + L-methionine + Se-methyl-L-selenocysteine

3'-phosphoadenylyl-sulfate + 5-β-scymnol ↔ 5-β-scymnol sulfate + adenosine 3',5'-bisphosphate + H⁺

cyclopentanol + NAD⁺ ↔ cyclopentanone + NADH + H⁺

H₂O + 2-oxoglutarate + ATP + CO₂ ↔ 2 H⁺ + oxalosuccinate + phosphate + ADP

NAD(P)+ + morphine ↔ morphinone + NAD(P)H + H⁺

coenzyme A + palmitaldehyde + NAD⁺ ↔ NADH + H⁺ + palmitoyl-CoA

3-dehydro-4-methylzymosterol + NADPH + H⁺ ↔ 4α-methyl-5α-cholesta-8,24-dien-3β-ol + NADP⁺

3-hydroxy-L-glutamate + H⁺ ↔ 4-amino-3-hydroxybutanoate + CO₂

chloroethene + a reduced electron donor ↔ an oxidized electron donor + ethene + H⁺ + chloride

L-glutamate-5-semialdehyde ↔ H₂O + H⁺ + (S)-1-pyrroline-5-carboxylate

NAD(P)+ + (4R)-(-)-ipsdienol ↔ NAD(P)H + ipsdienone + H⁺

a reduced electron donor + NAD⁺ ↔ an oxidized electron donor + H⁺ + 1,2-dihydro-β-NAD

H₂O + H⁺ + carbamate ↔ ammonium + hydrogencarbonate

L-phenylalanine + acetyl-CoA ↔ coenzyme A + N-acetyl-L-phenylalanine + H⁺

NAD(P)+ + (-)-endo-fenchol ↔ NAD(P)H + D-fenchone + H⁺

N-acetyl-α-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose ↔ β-D-galactosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + H⁺ + UDP

oxidized DCPIP + (+)-trans-carveol ↔ reduced DCPIP + H⁺ + (+)-carvone

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + D-glyceraldehyde 3-phosphate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + 3-phospho-D-glycerate

2-chloro-4-fluoromuconate + H⁺ ↔ 2-chloro-4-fluoromuconolactone

2 NAD⁺ + H₂O + 2-hydroxyethyl-CoM ↔ 2 NADH + 3 H⁺ + 2-carboxyethyl-CoM

H⁺ + L-valine ↔ 2-methylpropan-1-amine + CO₂

L-pipecolate ↔ 3 H⁺ + 1-piperideine 6-carboxylate

1-chloro-2,4-dinitrobenzene + glutathione ↔ H⁺ + 2,4-dinitrophenyl-S-glutathione + chloride

2 H⁺ + (22S,24R)-22-hydroxy-5α-ergostan-3-one ↔ 6-deoxocathasterone

acarbose + ATP ↔ H⁺ + acarbose 7^IV-phosphate + ADP

NAD⁺ + melilotate ↔ NADH + 2-coumarate + H⁺

β-nicotinate D-ribonucleotide + diphosphate ↔ 5-phospho-α-D-ribose 1-diphosphate + nicotinate + H⁺

1-chloro-4-nitrobenzene + NADPH + H⁺ ↔ 1-chloro-4-nitrosobenzene + H₂O + NADP⁺

2-oxoglutarate + acetyl-CoA ↔ coenzyme A + H⁺ + trans-homoaconitate

NADPH + calycosin + H⁺ + oxygen ↔ 2 H₂O + pseudobaptigenin + NADP⁺

shikimate + NADP⁺ ↔ 3-dehydroshikimate + NADPH + H⁺

caffeoyl-4'-hydroxyphenyllactate + NADPH + H⁺ + oxygen ↔ H₂O + rosmarinate + NADP⁺

L-threo-7,8-dihydrobiopterin + NADP⁺ ↔ sepiapterin + NADPH + H⁺

H₂O + isopentenyl diphosphate + NAD(P)+ ↔ (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + geranylgeraniol + oxygen ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (2E,6E,10E,14E)-2,6,10,14-tetramethylhexadeca-2,6,10,14-tetraene-1,16-diol

4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + NADPH + H⁺ ↔ 4,4-dimethyl-5α-cholesta-8-en-3β-ol + NADP⁺

ethylene glycol + NAD⁺ ↔ NADH + glycolaldehyde + H⁺

NADP⁺ + (1'S)-averantin ↔ NADPH + H⁺ + norsolorinate

H⁺ + 4-aminobenzoate ↔ aniline + CO₂

(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate ↔ 3-chloro-cis,cis-muconate + H⁺

H₂O + puberulonate ↔ puberulate + H⁺ + CO₂

2-hydroxyethylphosphonate + NAD⁺ ↔ NADH + phosphonoacetaldehyde + H⁺

N-acetyl-α-D-glucosamine 1-phosphate + H⁺ + UTP ↔ diphosphate + UDP-N-acetyl-α-D-glucosamine

2 H₂O + 2 cob(II)alamin + NADP⁺ + H⁺ ↔ 2 aquacobalamin + NADPH

H₂O + glycine + NAD⁺ ↔ NADH + glyoxylate + H⁺ + ammonium

NAD⁺ + (-)-thujan-3-ol ↔ NADH + H⁺ + (-)-thujan-3-one

coenzyme A + sulfoacetaldehyde + NADP⁺ ↔ NADPH + H⁺ + sulfoacetyl-CoA

CDP-ethanolamine + L-serine ↔ CMP + L-serine-phosphoethanolamine + H⁺

trans-chalcone + pyruvate + H⁺ ↔ (R)-1,3-diphenyl-pentane-1,4-dione + CO₂

prostaglandin E₂ + NAD⁺ ↔ 15-dehydro-prostaglandin E₂ + NADH + H⁺

2 H⁺ + 1'-hydroxy-γ-carotene + a reduced ferredoxin [iron-sulfur] cluster + oxygen ↔ plectaniaxanthin + an oxidized ferredoxin [iron-sulfur] cluster + H₂O

H₂O + sulfate + ATP ↔ H⁺ + phosphate + sulfate + ADP

dihydrogeranylgeranyl diphosphate + NADP⁺ ↔ NADPH + H⁺ + geranylgeranyl diphosphate

(+)-cis-sabinol + NAD⁺ ↔ NADH + (+)-sabinone + H⁺

H₂O + acetylenedicarboxylate + H⁺ ↔ pyruvate + CO₂

an oxidized ferredoxin [iron-sulfur] cluster + H₂O + carbon monoxide ↔ a reduced ferredoxin [iron-sulfur] cluster + H⁺ + CO₂

2 H⁺ + 5,6-epoxy,18R-hydroxy-icosapentaenoate ↔ resolvin E2

2 H⁺ + glycerone phosphate ↔ sn-glycerol 3-phosphate

S-adenosyl-L-methionine + L-glutamine ↔ S-adenosyl-L-homocysteine + H⁺ + N⁵-methyl-L-glutamine

NADP⁺ + xylitol ↔ NADPH + α-D-xylopyranose + H⁺

L-ascorbate + hydrogen peroxide + H⁺ ↔ 2 H₂O + L-dehydro-ascorbate

NAD⁺ + 4-tyrosol ↔ NADH + (4-hydroxyphenyl)acetaldehyde + H⁺

NAD⁺ + lithocholate ↔ 3-dehydrolithocholate + NADH + H⁺

H₂O + pyrethrin I ↔ (1R)-trans-chrysanthemate + (S)-pyrethrolone + H⁺

(E)-2,4-dihydroxycinnamate + H⁺ ↔ H₂O + umbelliferone

3-nitropropanoate + NADP⁺ ↔ 3-nitroacrylate + NADPH + H⁺

NAD⁺ + sitosterol ↔ NADH + 3-oxo-24-ethyl-cholest-5-ene + H⁺

NAD⁺ + D-arabinitol ↔ NADH + D-ribulose + H⁺

glycerol + NAD⁺ ↔ NADH + dihydroxyacetone + H⁺

O-succinyl-L-homoserine + L-cysteine ↔ H⁺ + L-cystathionine + succinate

3'-phosphoadenylyl-sulfate + L-tyrosine-methyl-ester ↔ L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-bisphosphate + H⁺

spermidine + acetyl-CoA ↔ coenzyme A + N¹-acetylspermidine + H⁺

xylitol + ATP ↔ xylitol 5-phosphate + H⁺ + ADP

NAD⁺ + L-iditol ↔ NADH + H⁺ + keto-L-sorbose

NAD⁺ + D-ribitol ↔ NADH + D-ribulose + H⁺

3'-phosphoadenylyl-sulfate + glycochenodeoxycholate ↔ adenosine 3',5'-bisphosphate + H⁺ + glycochenodeoxycholate 7-sulfate

5β-cholestane-3α,7α,12α-triol + NAD(P)+ ↔ 7α,12α-dihydroxy-5β-cholestan-3-one + NAD(P)H + H⁺

3 NADPH + 5 malonyl-CoA + 7 H⁺ + acetyl-CoA ↔ 3 NADP⁺ + 4 H₂O + 5 CO₂ + 6 coenzyme A + 5-methyl-1-naphthoate

H₂O + 5,10-methenyltetrahydromethanopterin ↔ 5-formyl-tetrahydromethanopterin + H⁺

FAD + H₂O + H⁺ + lithocholate ↔ FADH₂ + chenodeoxycholate

H₂O + deethylatrazine ↔ H⁺ + 2-hydroxy-4-isopropylamino-6-amino-s-triazine + chloride

butane + NADH + H⁺ + oxygen ↔ H₂O + (2R)-butan-2-ol + NAD⁺

H₂O + (S)-dihydroorotate ↔ N-carbamoyl-L-aspartate + H⁺

2-keto-D-gluconate + NADP⁺ ↔ NADPH + 2,5-didehydro-D-gluconate + H⁺

NAD(P)H + 4,4-dimethyl-5α-cholest-7-en-3β-ol + H⁺ + oxygen ↔ H₂O + 4α-hydroxymethyl-4β-methyl-5α-cholest-7-en-3β-ol + NAD(P)+

2 H⁺ + 2 S-sulfanylglutathione ↔ bisorganyltrisulfane + hydrogen sulfide

glycerol + NADP⁺ ↔ NADPH + H⁺ + D-glyceraldehyde

2 coenzyme A + NAD(P)+ ↔ NAD(P)H + H⁺ + CoA-disulfide

mycosporine glycine + L-serine + ATP ↔ 2 H⁺ + shinorine + diphosphate + AMP

2-hydroxyliquiritigenin ↔ H⁺ + licodione

2 cob(II)yrinate a,c-diamide + 3 H⁺ + FMN ↔ 2 cob(I)yrinate a,c-diamide + FMNH₂

L-cysteate ↔ H⁺ + 2-aminoprop-2-enoate + hydrogensulfite

erythritol + ATP ↔ D-erythritol 4-phosphate + H⁺ + ADP

propanoyl-CoA + hydrogencarbonate + ATP ↔ H⁺ + (S)-methylmalonyl-CoA + phosphate + ADP

diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP⁺ ↔ diethyl-2-methyl-3-oxosuccinate + NADPH + H⁺

5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADP⁺ ↔ NADPH + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + H⁺

α-D-mannosyl-1,3-(R1)-β-D-mannosyl-R2 + UDP-N-acetyl-α-D-glucosamine ↔ N-acetyl-β-D-glucosaminyl-1,2-α-D-mannosyl-1,3-(R1)-β-D-mannosyl-R2 + H⁺ + UDP

xanthine + H₂O + NAD⁺ ↔ NADH + urate + H⁺

2 a reduced electron donor + H⁺ + nitrite ↔ 2 an oxidized electron donor + H₂O + hydroxylamine

isoscopoletin ↔ 2 H⁺ + ayapin

FAD + decanoyl-CoA + H⁺ ↔ FADH₂ + (2E)-dec-2-enoyl-CoA

H₂O + H⁺ + urethan ↔ ethanol + ammonium + CO₂

2 NADP⁺ + preQ₁ ↔ 2 NADPH + 3 H⁺ + preQ₀

H₂O + ADP-D-ribose ↔ 2 H⁺ + α-D-ribose-1-phosphate + AMP

acetyl-CoA + L-leucine ↔ coenzyme A + N-acetyl-L-leucine + H⁺

(S)-dihydroorotate + NADP⁺ ↔ orotate + NADPH + H⁺

H₂O + NAD(P)+ + L-tryptophan ↔ NAD(P)H + H⁺ + ammonium + (indol-3-yl)pyruvate

NAD⁺ + 3-phospho-D-glycerate ↔ 3-phosphooxypyruvate + NADH + H⁺

2 cyclohexane-1-carboxylate + coenzyme A + H₂O + ATP ↔ 2 cyclohexane-1-carbonyl-CoA + 2 H⁺ + 2 phosphate + AMP

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + (2E,6E)-farnesol + oxygen ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + (2E,6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene-1,12-diol + H₂O

imidazole-lactate + NAD(P)+ ↔ imidazole-pyruvate + NAD(P)H + H⁺

(S)-2-hydroxystearate + NAD⁺ ↔ NADH + 2-oxostearate + H⁺

NAD⁺ + L-arabinitol ↔ NADH + H⁺ + L-xylulose

NAD⁺ + xylitol ↔ NADH + H⁺ + L-xylulose

H₂O + 2-hydroxy-2-methyl-butanal + NAD⁺ ↔ 2 H⁺ + NADH + 2-hydroxy-2-methylbutanoate

(S,S)-2,3-butanediol + NAD⁺ ↔ (S)-acetoin + NADH + H⁺

cis-1,2-dichloroethene + a reduced electron donor ↔ an oxidized electron donor + chloroethene + H⁺ + chloride

H₂O + NAD⁺ + L-glutamate ↔ NADH + 2-oxoglutarate + H⁺ + ammonium

NAD⁺ + (R)-2-hydroxyglutarate ↔ NADH + 2-oxoglutarate + H⁺

NAD⁺ + (S)-2-hydroxyglutarate ↔ NADH + 2-oxoglutarate + H⁺

NAD⁺ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene ↔ NADH + H⁺ + 1,2-dihydroxydibenzothiophene

2 formaldehyde + H₂O ↔ formate + methanol + H⁺

2 H⁺ + 3-nonaprenyl-4-hydroxybenzoate + oxygen ↔ 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + H₂O

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + (S)-3-methyl-2-oxopentanoate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + 2-methylbutanoyl-CoA + CO₂

prostaglandin F_2α + NADP⁺ ↔ NADPH + prostaglandin D₂ + H⁺

N-hydroxy-L-valine + NADPH + H⁺ + oxygen ↔ H₂O + N,N-dihydroxy-L-valine + NADP⁺

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane ↔ 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + H⁺ + chloride

12α-hydroxy-3-oxocholan-24-oyl-CoA + H₂O ↔ coenzyme A + H⁺ + 3-dehydrodeoxycholate

2 cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine ↔ 2 aminopropylcadaverine + S-methyl-5'-thioadenosine + H⁺

prephenate + H⁺ ↔ H₂O + 3-phenyl-2-oxopropanoate + CO₂

NADP⁺ + dihydrozeatin ↔ NADPH + H⁺ + trans-zeatin

dihydrobiochanin-A + NADP⁺ ↔ 2 H⁺ + NADPH + biochanin-A

D-galactaro-1,4-lactone + H₂O ↔ H⁺ + D-galactarate

oleandomycin + ATP ↔ oleandomycin 2'-O-phosphate + H⁺ + ADP

D-mannonate + NAD(P)+ ↔ NAD(P)H + D-mannuronate + H⁺

H₂O + 2-oxobutanoate + acetyl-CoA ↔ coenzyme A + (R)-2-Ethylmalate + H⁺

H⁺ + 3-methyl-cis,cis-muconate ↔ 4-methylmuconolactone

H₂O + N(α)-benzyloxycarbonyl-L-leucine + H⁺ ↔ benzyl alcohol + L-leucine + CO₂

aldehydo-D-arabinose + ATP ↔ H⁺ + ADP + aldehydo-D-arabinose 5-phosphate

3-[(4'-methylsulfanyl)butyl]malate + NAD⁺ ↔ NADH + 3-carboxy-7-(methylsulfanyl)-2-oxoheptanoate + H⁺

7-deoxyloganin + NADPH + H⁺ + oxygen ↔ H₂O + loganin + NADP⁺

NAD⁺ + 1-hexadecanol ↔ palmitaldehyde + NADH + H⁺

(2R,3S)-3-isopropylmalate + NAD⁺ ↔ (2S)-2-isopropyl-3-oxosuccinate + NADH + H⁺

O-acetyl-L-serine + hydrogen sulfide ↔ acetate + H⁺ + L-cysteine

2 H⁺ + hydrogen peroxide + 6-hydroxy-2-(6-oxo-1-oxaspiro[2.5]octa-4,7-dien-2-yl)-1-benzofuran-3-one ↔ H₂O + 2-[hydroperoxy(4-hydroxyphenyl)methyl]-6-hydroxy-1-benzofuran-3-one

NAD⁺ + 1-octanol ↔ NADH + 1-octanal + H⁺

NAD(P)+ + (2R)-3-sulfolactate ↔ 3-sulfopyruvate + NAD(P)H + H⁺

isopentenyl diphosphate + 2-cis,6-trans,10-trans-geranylgeranyl diphosphate ↔ di-trans,di-cis-pentaprenyl diphosphate + H⁺ + diphosphate

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + phytanate + oxygen ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + 16-hydroxyphytanate + H₂O

NAD⁺ + (R)-lactaldehyde ↔ NADH + H⁺ + methylglyoxal

1-oleoyl-2-palmitoyl-glycerol + UDP-α-D-galactose ↔ H⁺ + 1-18:1-2-16:0-monogalactosyldiacylglycerol + UDP

isopentenyl diphosphate + di-trans,poly-cis-hexaprenyl diphosphate ↔ di-trans,poly-cis-heptaprenyl diphosphate + H⁺ + diphosphate

NADPH + H⁺ + (glutathion-S-yl)-L-cysteine ↔ NADP⁺ + glutathione + L-cysteine

NADP⁺ + D-mannitol ↔ NADPH + keto-D-fructose + H⁺

ethyl (R)-3-hydroxyhexanoate + NADP⁺ ↔ ethyl-3-oxohexanoate + NADPH + H⁺

11-cis-retinol + NADP⁺ ↔ 11-cis-retinal + NADPH + H⁺

5β-cholestane-3α,7α-diol + NAD(P)+ ↔ 7α-hydroxy-5β-cholestan-3-one + NAD(P)H + H⁺

NADPH + tert-amyl alcohol + H⁺ + oxygen ↔ H₂O + 2-methyl-butan-2,3-diol + NADP⁺

β-nicotinate D-ribonucleotide + H⁺ + ATP ↔ diphosphate + nicotinate adenine dinucleotide

(1S,4S)-2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD⁺ ↔ NADH + 2,5-dichloro-p-quinol + H⁺

(2S)-methylbutanenitrile + NADPH + H⁺ + oxygen ↔ H₂O + 2-hydroxy-2-methylbutyronitrile + NADP⁺

H₂O + hydantoin ↔ N-carbamoylglycine + H⁺

hydroquinone + H⁺ + glutathione disulfide + chloride ↔ 2 glutathione + chlorohydroquinone

ent-kaurenol + NADPH + H⁺ + oxygen ↔ 2 H₂O + ent-kaurenal + NADP⁺

H₂O + 2,3-diaminopropionate ↔ 2 ammonia + pyruvate + H⁺

kanamycin B + GTP ↔ H⁺ + kanamycin B 2''-phosphate + GDP

2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine ↔ 2 S-methyl-5'-thioadenosine + 2 H⁺ + N⁴-bis(aminopropyl)spermidine

(4-hydroxyphenyl)acetate + NADH + H⁺ + oxygen ↔ H₂O + 3,4-dihydroxyphenylacetate + NAD⁺

trichloroethene + a reduced electron donor ↔ an oxidized electron donor + cis-1,2-dichloroethene + H⁺ + chloride

undecaprenyldiphospho-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-α-D-glucosamine ↔ ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-β-D-glucosaminyl)-(1,4)-]-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H⁺ + UDP

2 H⁺ + NADH + trimethylamine N-oxide ↔ H₂O + NAD⁺ + trimethylamine

H₂O + 2,5-dihydroxypyridine + oxygen ↔ 2 H⁺ + maleamate + formate

(E)-dec-3-en-2-one + pyruvate + H⁺ ↔ (S)-3-hexanylhexane-2,5-dione + CO₂

2 a reduced ferredoxin [iron-sulfur] cluster + 2 NADP⁺ + NADH + H⁺ ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 NADPH + NAD⁺

D-altronate + NAD⁺ ↔ NADH + D-tagaturonate + H⁺

glycine + acetyl-CoA ↔ coenzyme A + L-2-amino-3-oxobutanoate + H⁺

GTP + gentamicin A ↔ H⁺ + GDP + gentamicin A (2'')-phosphate

3-chloro-L-alanine + thioglycolate ↔ S-carboxymethyl-L-cysteine + H⁺ + chloride

L-arginine + ATP ↔ N^ω-phospho-L-arginine + H⁺ + ADP

N-hydroxy-L-phenylalanine + NADPH + H⁺ + oxygen ↔ H₂O + N,N-dihydroxy-L-phenylalanine + NADP⁺

H⁺ ↔ 2-oxoglutarate + CO₂

NAD(P)+ + sn-glycerol 3-phosphate ↔ glycerone phosphate + NAD(P)H + H⁺

3 H⁺ + 3 malonyl-CoA + hexanoyl-CoA ↔ 3 coenzyme A + 3 CO₂ + 3,5,7-trioxododecanoyl-CoA

NADPH + H⁺ + [4-(6-methyloctanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate ↔ NADP⁺ + [(3S)-4-(6-methyloctanoyl)-5-oxooxolan-3-yl]methyl phosphate

NAD⁺ + (+)-borneol ↔ NADH + H⁺ + (+)-camphor

2-oxoglutarate + H⁺ + 3-O-methyldopa ↔ 3-methoxy-4-hydroxyphenylpyruvate + L-glutamate

H₂O + NADP⁺ + L-glutamate ↔ NADPH + 2-oxoglutarate + H⁺ + ammonium

ADP-α-D-glucose + sn-glycerol 3-phosphate ↔ 2-(β-D-glucosyl)-sn-glycerol 3-phosphate + H⁺ + ADP

androsterone + NADP⁺ ↔ NADPH + 3-β-hydroxyandrost-5-en-17-one + H⁺

(2R,3S)-3-methylmalate + NAD⁺ ↔ methyloxaloacetate + NADH + H⁺

dibekacin + GTP ↔ H⁺ + dibekacin 2''-phosphate + GDP

5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP⁺ ↔ 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H⁺

2-hydroxyferulate + H⁺ ↔ H₂O + scopoletin

ethanol + NAD⁺ ↔ acetaldehyde + NADH + H⁺

(S)-propane-1,2-diol + NAD⁺ ↔ hydroxyacetone + NADH + H⁺

pseudobaptigenin + NADPH + H⁺ + oxygen ↔ H₂O + 2'-hydroxypseudobaptigenin + NADP⁺

O-acetyl-L-serine + L-homocysteine ↔ acetate + H⁺ + L-cystathionine

H⁺ + malonyl-CoA ↔ acetyl-CoA + CO₂

coenzyme A + glyoxylate + NADP⁺ ↔ NADPH + H⁺ + oxalyl-CoA

phosphoenolpyruvate + H⁺ + sulfite ↔ (2R)-phospho-3-sulfolactate

3-β-hydroxy-5-β-pregnane-20-one + NADP⁺ ↔ 5-β-pregnan-3,20 dione + NADPH + H⁺

coenzyme A + 1-propanal + NAD⁺ ↔ propanoyl-CoA + NADH + H⁺

trans-feruloyl-CoA + tyramine ↔ coenzyme A + H⁺ + N-feruloyltyramine

3-mercapto-2-mercaptomethylpropanoate + NAD⁺ ↔ NADH + H⁺ + asparagusate

NAD(P)+ + (+)-thujan-3-ol ↔ NAD(P)H + H⁺ + (+)-thujan-3-one

2-methylbutanol + NAD⁺ ↔ 2-methylbutanal + NADH + H⁺

2-chloro-cis,cis-muconate + H⁺ ↔ (+)-2-chloromuconolactone

(3S)-3-hydroxy-L-arginine ↔ H₂O + H⁺ + (2S,3R)-capreo-mycidine 5

2 NAD(P)H + 2 H⁺ + 2 L-arginine + 2 oxygen ↔ 2 H₂O + 2 NAD(P)+ + 2 N^ω-hydroxy-L-arginine

10-hydroxydecanoate + NAD⁺ ↔ NADH + 10-oxodecanoate + H⁺

L-ornithine + carbamoyl phosphate ↔ L-citrulline + H⁺ + phosphate

prostaglandin I₂ + NADP⁺ ↔ 15-dehydro-prostaglandin I2 + NADPH + H⁺

(S)-reticuline + S-adenosyl-L-methionine ↔ S-adenosyl-L-homocysteine + (S)-tembetarine + H⁺

2 H⁺ + 3-hexaprenyl-4-hydroxybenzoate + oxygen ↔ 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H₂O

FADH₂ + oxygen + 7-hydroxy-3-isocyanochromen-2-one ↔ FAD + H₂O + H⁺ + paerucumarin

2 H⁺ + L-tryptophan + oxygen ↔ ammonia + H₂O + (indol-3-yl)acetaldehyde + CO₂

H⁺ + 2-chloro-4-methyl-cis,cis-muconate ↔ 5-chloro-3-methyl-cis-dienelactone

NAD⁺ + D-Iditol ↔ NADH + H⁺ + keto-D-sorbose

NADP⁺ + 5,6-dihydrothymine ↔ thymine + NADPH + H⁺

NADH + 3-methoxy-4-hydroxyphenylpyruvate + H⁺ ↔ NAD⁺ + 3-methoxy-4-hydroxyphenyllactate

NAD⁺ + (S)-3-hydroxy-(5Z)-tetradecenoyl-CoA ↔ NADH + H⁺ + 3-oxo-(5Z)-tetradecenoyl-CoA

O-acetyl-L-serine + isoxazolin-5-one ↔ acetate + 3-(5-oxoisoxazolin-2-yl)-L-alanine + H⁺

O-acetyl-L-serine + isoxazolin-5-one ↔ acetate + 3-(5-oxoisoxazolin-4-yl)-L-alanine + H⁺

NAD(P)+ + dTDP-L-pneumose ↔ NAD(P)H + dTDP-4-dehydro-β-L-rhamnose + H⁺

H⁺ + dTTP + α-D-glucopyranose 1-phosphate ↔ dTDP-α-D-glucose + diphosphate

FMNH₂ + NAD⁺ ↔ 2 H⁺ + FMN + NADH

2 NADP⁺ + H₂O + dTDP-α-D-galactose ↔ 2 NADPH + 3 H⁺ + dTDP-D-galacturonate

L-glutamine + chorismate ↔ anthranilate + pyruvate + H⁺ + L-glutamate

1,3-propanediol + NAD⁺ ↔ 3-hydroxypropanal + NADH + H⁺

ent-7α-hydroxykaur-16-en-19-oate + NADPH + H⁺ + oxygen ↔ 2 H₂O + NADP⁺ + gibberellin A₁₂-aldehyde

(R)-glycerate + NAD⁺ ↔ tartronate semialdehyde + NADH + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + oxygen + (2E,6E)-farnesyl diphosphate ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + (2E,6E,10E)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl phosphonatooxyphosphonate

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + 4-methyl-2-oxopentanoate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + isovaleryl-CoA + CO₂

UDP-α-D-glucuronate + scutellarein ↔ H⁺ + UDP + scutellarin

2 NADP⁺ + quinine + quinidine ↔ 2 NADPH + 2 quinidinone + 4 H⁺

(R)-reticuline + NADP⁺ ↔ NADPH + 1,2-dehydroreticuline + H⁺

H₂O + NAD(P)+ + L-malic semialdehyde ↔ 2 H⁺ + NAD(P)H + (S)-malate

L-ascorbate + acetyl phosphate ↔ 2-phospho-L-ascorbate + acetate + H⁺

2 H⁺ + FAD + L-tryptophan + chloride ↔ FADH₂ + 5-chloro-L-tryptophan

(6α)-hydroxycampestanol ↔ 2 H⁺ + 6-oxocampestanol

4,5-dihydroxyphthalate + H⁺ ↔ protocatechuate + CO₂

NAD⁺ + galactitol ↔ NADH + L-xylo-3-hexulose + H⁺

(6S,9R)-vomifoliol + NAD⁺ ↔ NADH + (6R)-dehydrovomifoliol + H⁺

NADPH + β-amyrin + H⁺ + oxygen ↔ H₂O + NADP⁺ + sophoradiol

NADH + 3-(3-hydroxyphenyl)propanoate + H⁺ + oxygen ↔ H₂O + 3-(2,3-dihydroxyphenyl)propanoate + NAD⁺

ent-kaur-16-en-19-oate + NADPH + H⁺ + oxygen ↔ ent-7α-hydroxykaur-16-en-19-oate + H₂O + NADP⁺

2 H⁺ + hexane-6-keto-1,3,4,6-tetracarboxylate ↔ hexane-6-ol-1,3,4,6-tetracarboxylate

acetyl-CoA + hydrogen sulfide ↔ coenzyme A + thioacetate + H⁺

cis-dienelactone + H⁺ + fluoride ↔ (+)-5-fluoromuconolactone

H₂O + (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate + NAD⁺ ↔ NADH + pyruvate + H⁺ + L-norvaline

geranylgeranyl bacteriochlorophyllide a + NADPH + H⁺ ↔ NADP⁺ + phyta-2,10,14-trienyl bacteriochlorophyllide a

dTDP-β-L-mycarose + erythronolide B ↔ 3-α-mycarosylerythronolide B + H⁺ + dTDP

L-carnitine + H⁺ ↔ 2-methylcholine + CO₂

dihydrolipoate + NADP⁺ ↔ (R)-lipoate + NADPH + H⁺

2,5-dichloro-4-methyl-muconolactone ↔ 2,5-dichloro-3-methyl-muconate + H⁺

H₂O + 4-carboxybenzaldehyde + NAD⁺ ↔ 2 H⁺ + terephthalate + NADH

malonyl-CoA + D-tryptophan ↔ coenzyme A + H⁺ + N2-malonyl-D-tryptophan

2 NADP⁺ + (+/-)-trans-acenaphthene-1,2-diol ↔ 2 NADPH + 2 H⁺ + acenaphthenequinone

tobramycin + GTP ↔ H⁺ + tobramycin 2''-phosphate + GDP

chloroorienticin B + dTDP-β-L-4-epi-vancosamine ↔ chloroeremomycin + H⁺ + dTDP

NAD⁺ + L-arabinitol ↔ NADH + H⁺ + L-ribulose

NADP⁺ + D-threitol ↔ NADPH + D-erythrulose + H⁺

H₂O + H⁺ + ATP ↔ ammonium + ITP

H₂O + thiamine diphosphate ↔ thiamine phosphate + H⁺ + phosphate

2 H⁺ + pyruvate ↔ (R)-lactate

NAD(P)+ + UDP-N-acetyl-β-L-pneumosamine ↔ NAD(P)H + H⁺ + UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose

trans-2-butene + NADH + H⁺ + oxygen ↔ H₂O + trans-2R,3R-epoxybutane + NAD⁺

(3R)-sophorol + NADPH + H⁺ ↔ H₂O + NADP⁺ + (-)-maackiain

a reduced ferredoxin [iron-sulfur] cluster + NADP⁺ ↔ an oxidized ferredoxin [iron-sulfur] cluster + NADPH + H⁺

3-keto-L-gulonate + NAD(P)+ ↔ NAD(P)H + 2,3-dioxo-L-gulonate + H⁺

NADH + NADP⁺ + H⁺ ↔ NADPH + NAD⁺ + H⁺

NAD⁺ + (-)-trans-carveol ↔ NADH + H⁺ + (-)-carvone

2 H⁺ + (S)-usnate + NADH ↔ reduced-(S)-usnate + NAD⁺

a phenolic steroid + 3'-phosphoadenylyl-sulfate ↔ steroid O sulfate + adenosine 3',5'-bisphosphate + H⁺

NAD(P)+ + estradiol-17α ↔ NAD(P)H + estrone + H⁺

(E)-non-3-en-2-one + pyruvate + H⁺ ↔ (S)-3-pentanylhexane-2,5-dione + CO₂

5,12-dihydroxanthommatin + NAD⁺ ↔ xanthommatin + NADH + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + spermidine ↔ S-methyl-5'-thioadenosine + thermospermine + H⁺

β-D-fructofuranose 6-phosphate + ADP ↔ β-D-fructose 1,6-bisphosphate + H⁺ + AMP

2 H⁺ + oxygen + (indol-3-yl)acetate ↔ H₂O + indole-3-glycolate

H⁺ + hydrogencarbonate ↔ H₂O + CO₂

H₂O + N-ethylammelide + H⁺ ↔ ethylamine + cyanuric acid

trans-zeatin + UDP-α-D-xylose ↔ O-β-D-xylosylzeatin + H⁺ + UDP

NADP⁺ + (2E,6E)-farnesol ↔ NADPH + (2E,6E)-farnesal + H⁺

glycerol + NADP⁺ ↔ NADPH + dihydroxyacetone + H⁺

3'-phosphoadenylyl-sulfate + 5-α-cholan-3-α,7-α,12-α,24 tetrol ↔ 5-α-cholan-3-α,7 α,12-α-triol 24-sulfate + adenosine 3',5'-bisphosphate + H⁺

galactitol 1-phosphate + NAD⁺ ↔ keto-D-tagatose 6-phosphate + NADH + H⁺

12 H⁺ + 4 (R)-methylmalonyl-CoA + 8 NADPH + stearoyl-CoA ↔ 4 coenzyme A + 4 H₂O + 4 CO₂ + 8 NADP⁺ + C30 mycocerosyl-CoA

S-adenosyl-L-methionine + 2-demethylmenaquinone-7 ↔ menaquinone-7 + S-adenosyl-L-homocysteine + H⁺

3-[(6'-methylsulfanyl)hexyl]malate + NAD⁺ ↔ NADH + 3-carboxy-9-(methylsulfanyl)-2-oxononanoate + H⁺

2 N^ω-hydroxy-L-arginine + 2 oxygen + NAD(P)H ↔ 2 H₂O + 2 L-citrulline + 2 nitric oxide + NAD(P)+ + H⁺

H₂O + pentanoyl-CoA + glyoxylate ↔ coenzyme A + 3-propylmalate + H⁺

NADPH + H⁺ + demethylsuberosin + oxygen ↔ (+)-marmesin + H₂O + NADP⁺

2 H⁺ + 3-octaprenyl-4-hydroxybenzoate + oxygen ↔ 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + H₂O

trans-cyclohexane-1,2-diol + NAD⁺ ↔ NADH + 2-hydroxycyclohexan-1-one + H⁺

FAD + all-trans-lycopene + H⁺ ↔ FADH₂ + all-trans-3,4-didehydrolycopene

1,4-dihydroxy-2-naphthoate + H⁺ + all-trans-heptaprenyl diphosphate ↔ demethylmenaquinol-7 + diphosphate + CO₂

α-D-glucuronate 1-phosphate + H⁺ + UTP ↔ diphosphate + UDP-α-D-glucuronate

NAD(P)H + 4α-hydroxymethyl-4β-methyl-5α-cholest-7-en-3β-ol + H⁺ + oxygen ↔ H₂O + 3β-hydroxy-4β-methyl-5α-cholest-7-ene-4α-carbaldehyde + NAD(P)+

ATP + C32-mycoketide ↔ H⁺ + C32-phosphomycoketide + ADP

H₂O + NADP⁺ + nitrous oxide ↔ 2 nitric oxide + NADPH + H⁺

NADP⁺ + pyridoxine ↔ NADPH + pyridoxal + H⁺

N-hydroxy-L-isoleucine + NADPH + H⁺ + oxygen ↔ H₂O + N,N-dihydroxy-L-isoleucine + NADP⁺

sn-glycerol 3-phosphate + UDP-α-D-galactose ↔ α-D-galactosyl-(1,1')-sn-glycerol 3-phosphate + H⁺ + UDP

galactitol 1-phosphate + NAD⁺ ↔ keto-L-tagatose 6-phosphate + NADH + H⁺

UDP-α-D-xylose + kaempferol ↔ H⁺ + kaempferol 3-O-β-D-xyloside + UDP

NADP⁺ + cinnamyl alcohol ↔ NADPH + cinnamaldehyde + H⁺

ent-kaurene + NADPH + H⁺ + oxygen ↔ H₂O + ent-kaurenol + NADP⁺

2 glutathione + 2,5-dichloro-p-quinol ↔ chlorohydroquinone + H⁺ + glutathione disulfide + chloride

NADP⁺ + xylitol ↔ NADPH + H⁺ + L-xylulose

isopentenyl diphosphate + di-trans,di-cis-pentaprenyl diphosphate ↔ di-trans,poly-cis-hexaprenyl diphosphate + H⁺ + diphosphate

blasticidin S + acetyl-CoA ↔ coenzyme A + N-acetylblasticidin S + H⁺

NADP⁺ + H⁺ + primary fluorescent chlorophyll catabolite ↔ NADPH + red chlorophyll catabolite

N-acetyl-L-glutamate 5-semialdehyde + NADP⁺ + phosphate ↔ N-acetylglutamyl-phosphate + NADPH + H⁺

L-ascorbate + diphosphate ↔ 2-phospho-L-ascorbate + H⁺ + phosphate

precorrin-6B + NADP⁺ ↔ NADPH + precorrin-6A + H⁺

D-ribulose + ATP ↔ D-ribulose 5-phosphate + H⁺ + ADP

H⁺ + L-aspartate + ATP ↔ (L-aspartyl)adenylate + diphosphate

2 (E)-4-coumaroyl-CoA + spermidine ↔ 2 coenzyme A + 2 H⁺ + N¹,N⁸-bis(coumaroyl)-spermidine

NAD⁺ + (E)-2-hexenol ↔ NADH + (E)-2-hexenal + H⁺

NAD⁺ + D-glyceraldehyde 3-phosphate + phosphate ↔ NADH + H⁺ + 3-phospho-D-glyceroyl-phosphate

NADPH + H⁺ + oxygen + gibberellin A₁₂-aldehyde ↔ H₂O + NADP⁺ + gibberellin A₁₄-aldehyde

O-acetyl-L-homoserine + hydrogen sulfide ↔ acetate + L-homocysteine + H⁺

β-D-glucopyranose + UDP-α-D-galactose ↔ H⁺ + α-lactose + UDP

NADPH + H⁺ + oxygen + gibberellin A₇ ↔ H₂O + NADP⁺ + gibberellin A₃

H⁺ + flaviolin + geranyl diphosphate ↔ diphosphate + 3-linalylflaviolin

(S)-3-hydroxyhexadecanoyl-CoA + NAD⁺ ↔ NADH + H⁺ + 3-oxo-palmitoyl-CoA

2 H⁺ + 6-deoxocathasterone + oxygen ↔ H₂O + 6-deoxoteasterone

3-methyl-cis-dienelactone + H⁺ + chloride ↔ 5-chloro-3-methyl-cis-dienelactone

D-ribulose 5-phosphate + ATP ↔ H⁺ + ADP + D-ribulose-1,5-bisphosphate

NAD(P)+ + 17β-estradiol ↔ NAD(P)H + estrone + H⁺

α-D-galactopyranose + ATP ↔ H⁺ + ADP + α-D-galactose 1-phosphate

NAD⁺ + xylitol ↔ NADH + D-xylulose + H⁺

L-aspartate 4-semialdehyde + NADP⁺ + phosphate ↔ L-aspartyl-4-phosphate + NADPH + H⁺

sphingosine + UDP-α-D-galactose ↔ H⁺ + O-galactosylsphingosine + UDP

NADP⁺ + squalene + diphosphate ↔ NADPH + presqualene diphosphate + H⁺

NAD⁺ + D-threitol ↔ NADH + D-erythrulose + H⁺

NAD⁺ + erythritol ↔ NADH + D-erythrulose + H⁺

2,6-dioxo-6-phenylhexanoate + NADP⁺ ↔ 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H⁺

(-)-ephedrine + NAD⁺ ↔ (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H⁺

2 H⁺ + 3 nitrite ↔ 2 nitric oxide + H₂O + nitrate

H₂O + 2-oxoglutarate + acetyl-CoA ↔ coenzyme A + H⁺ + (2R)-homocitrate

H⁺ + oxaloacetate ↔ pyruvate + CO₂

campestanol + NADPH + H⁺ + oxygen ↔ H₂O + 6-deoxocathasterone + NADP⁺

isobutanol + NAD⁺ ↔ NADH + isobutanal + H⁺

NADP⁺ + benzyl (2r,3s)-2-methyl-3-hydroxybutanoate ↔ NADPH + H⁺ + benzyl-2-methyl-3-oxobutanoate

NAD(P)H + H⁺ + oxygen + tryptamine ↔ H₂ + serotonin + NAD(P)+

arbekacin + GTP ↔ H⁺ + arbekacin 2''-phosphate + GDP

myo-inositol + NAD⁺ ↔ scyllo-inosose + NADH + H⁺

NAD(P)+ + allopregnanolone ↔ NAD(P)H + H⁺ + 5-α-pregnane-3,20-dione

coenzyme M + methanethiol ↔ methyl-CoM + H⁺ + HS^-

(5α)-campestan-3-one + NADPH + H⁺ + oxygen ↔ H₂O + (22S,24R)-22-hydroxy-5α-ergostan-3-one + NADP⁺

NAD(P)+ + 5-α-androstan-3α,17β-diol ↔ 17-β-hydroxy-5-α-androstan-3-one + NAD(P)H + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + NADP⁺ + H⁺ ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + NADPH

3 H⁺ + 3 malonyl-CoA + hexanoyl-CoA ↔ 4 coenzyme A + 4 CO₂ + olivetol

N²-succinyl-L-ornithine + carbamoyl phosphate ↔ H⁺ + phosphate + N-succinyl-L-citrulline

hydrogen peroxide + Reactive Blue 5 ↔ 4 H⁺ + phthalate + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2,2'-disulfonyl azobenzene

2 L-ascorbate + 2 H⁺ + violaxanthin ↔ 2 H₂O + 2 L-dehydro-ascorbate + zeaxanthin

H₂O + 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(β-hydroxyethyl)-2-methylpyridinium + H⁺ ↔ 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(β-hydroxyethyl)-2-methylpyridinium + ammonium

oxygen + hydroxyquinol ↔ 2,4,6-trioxohexanoate + H⁺

1,4-benzoquinone + NADPH + H⁺ ↔ hydroquinone + NADP⁺

(R)-2,3-dihydroxy-3-methylpentanoate + NADP⁺ ↔ NADPH + H⁺ + (S)-2-aceto-2-hydroxybutanoate

lauroyl-CoA + H⁺ + malonyl-CoA ↔ coenzyme A + 3-oxo-myristoyl-CoA + CO₂

NADP⁺ + 3-α-hydroxyglycyrrhetinate ↔ 3-oxoglycyrrhetinate + NADPH + H⁺

H⁺ + sulfite ↔ hydrogensulfite

NADH + H⁺ + cortisol ↔ NAD⁺ + 20α-hydroxycortisol

NADPH + H⁺ + oxygen + geraniol ↔ H₂O + NADP⁺ + (6E)-8-hydroxygeraniol

(3R)-3-hydroxybutanoyl-CoA + NAD⁺ ↔ NADH + acetoacetyl-CoA + H⁺

GDP-α-D-glucose + (R)-glycerate ↔ H⁺ + 2-O-(α-D-glucopyranosyl)-D-glycerate + GDP

H₂O + benzaldehyde + NAD⁺ ↔ 2 H⁺ + NADH + benzoate

FAD + lauroyl-CoA + H⁺ ↔ FADH₂ + (2E)-dodec-2-enoyl-CoA

3'-phosphoadenylyl-sulfate + (S)-equol ↔ adenosine 3',5'-bisphosphate + (S)-equol 4'-sulfate + H⁺

(R)-mevalonate + ATP ↔ (R)-5-phosphomevalonate + H⁺ + ADP

D-carnitine + NAD⁺ ↔ 3-dehydrocarnitine + NADH + H⁺

4-dimethylaminophenylazobenzene + H₂O + NADP⁺ ↔ 4-(dimethylamino)phenylazoxybenzene + NADPH + H⁺

H₂O + NADP⁺ + (1Z,2S)-2-methylbutanal oxime ↔ 3 H⁺ + (2S)-methylbutanenitrile + NADPH + oxygen

3-({[(2R,3R)-3-carbamoyloxiran-2-yl]carbonyl}amino)-L-alanine + L-valine + ATP ↔ dapdiamide E + H⁺ + phosphate + ADP

3 H⁺ + 2-methyl-1,4-benzoquinone + NADPH ↔ methyl-1,4-benzoquinol + NADP⁺

FAD + (S)-malate + H⁺ ↔ FADH₂ + oxaloacetate

L-tartrate + H⁺ ↔ (R)-glycerate + CO₂

D-arabitol 1-phosphate + NAD⁺ ↔ NADH + H⁺ + D-xylulose 5-phosphate

2-butyne-1,4-diol + NAD⁺ ↔ 4-hydroxy-2-butynal + NADH + H⁺

campest-4-en-3β-ol ↔ 2 H⁺ + campest-4-en-3-one

carbamoyl phosphate + L-lysine ↔ L-homocitrulline + H⁺ + phosphate

galactitol 1-phosphate + NAD⁺ ↔ D-tagatofuranose 6-phosphate + NADH + H⁺

NADP⁺ + D-sorbitol ↔ NADPH + H⁺ + keto-L-sorbose

H₂O + umbelliferone ↔ 2 H⁺ + esculetin

2 glutathione + thiosulfate ↔ H⁺ + glutathione disulfide + sulfite + hydrogen sulfide

12α-hydroxy-3-oxocholan-24-oyl-CoA + NADH + H⁺ ↔ NAD⁺ + deoxycholoyl-CoA

2 H₂O + 2-methylfumaryl-CoA ↔ coenzyme A + H⁺ + (R)-citramalate

3-[(5'-methylsulfanyl)pentyl]malate + NAD⁺ ↔ NADH + 3-carboxy-8-(methylsulfanyl)-2-oxooctanoate + H⁺

4-coumaroyl-4'-hydroxyphenyllactate + NADPH + H⁺ + oxygen ↔ H₂O + caffeoyl-4'-hydroxyphenyllactate + NADP⁺

NAD⁺ + L-threitol ↔ NADH + H⁺ + L-erythrulose

H₂O + NADP⁺ + N-methyl-L-alanine ↔ methylamine + NADPH + pyruvate + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + putrescine ↔ S-methyl-5'-thioadenosine + spermidine + H⁺

3α-hydroxy-3,5-dihydromonacolin L acid + H⁺ ↔ H₂O + 3α-hydroxy-3,5-dihydromonacolin L lactone

H₂O + bis(p-nitrophenyl) phosphate ↔ 2 H⁺ + 4-nitrophenol + 4-nitrophenyl phosphate

2-(2,4-dichloro-5-oxofuran-2-yl)propanoate ↔ 3,5-dichloro-2-methyl-muconate + H⁺

3 (R)-methylmalonyl-CoA + 6 NADPH + 9 H⁺ + icosanoyl-CoA ↔ 3 coenzyme A + 3 H₂O + 3 CO₂ + 6 NADP⁺ + C29-mycolipanoyl-CoA

β-nicotinamide D-ribonucleotide + H⁺ + ATP ↔ NAD⁺ + diphosphate

lipid IV_A + CMP-3-deoxy-β-D-manno-octulosonate ↔ α-Kdo-(2→6)-lipid IV_A + CMP + H⁺

acetyl-CoA + gentamicin C ↔ coenzyme A + N³-acetylgentamicin C + H⁺

2 H⁺ + geranylgeranyl diphosphate + chlorophyllide b ↔ diphosphate + geranylgeranyl chlorophyll b

NADPH + H⁺ + formononetin + oxygen ↔ H₂O + calycosin + NADP⁺

GDP-α-D-glucose + phosphate ↔ H⁺ + GDP + α-D-glucopyranose 1-phosphate

pyruvate + ATP ↔ phosphoenolpyruvate + H⁺ + ADP

butan-1-ol + NAD⁺ ↔ NADH + butan-1-al + H⁺

H⁺ + 2-fluoromuconate ↔ (+)-5-fluoromuconolactone

phosphoenolpyruvate + H⁺ ↔ 3-phosphonopyruvate

phthalate 4,5-cis-dihydrodiol + NAD⁺ ↔ 4,5-dihydroxyphthalate + NADH + H⁺

4-amino-4-deoxychorismate ↔ pyruvate + H⁺ + 4-aminobenzoate

FAD + butanoyl-CoA + H⁺ ↔ FADH₂ + crotonyl-CoA

H₂O + H⁺ + N-benzyloxycarbonylglycine ↔ glycine + benzyl alcohol + CO₂

cis-1,2-dihydro-3-ethylcatechol + NAD⁺ ↔ NADH + 3-ethylcatechol + H⁺

NADPH + acetone + H⁺ + oxygen ↔ hydroxyacetone + H₂O + NADP⁺

2 H₂O + coenzyme A + 2-[(1R,6S)-1,6-dihydroxycyclohexa-2,4-dien-1-yl]acetyl-coA ↔ 3 H⁺ + acetyl-CoA + (3S)-hydroxyadipyl-CoA

H⁺ + malonyl-CoA + acetyl-CoA ↔ coenzyme A + acetoacetyl-CoA + CO₂

trans-4-hydroxycyclohexanecarboxylate + NAD⁺ ↔ 4-oxocyclohexanecarboxylate + NADH + H⁺

(R)-glycerate + NAD⁺ ↔ hydroxypyruvate + NADH + H⁺

3-chloro-D-alanine + thioglycolate ↔ S-carboxymethyl-D-cysteine + H⁺ + chloride

2 ATP + D-myo-inositol (1,4,5)-trisphosphate ↔ 2 H⁺ + 2 ADP + D-myo-inositol 1,3,4,5,6-pentakisphosphate

H₂O + L-phenylalanine + ATP ↔ H⁺ + diphosphate + AMP + D-phenylalanine

phosphoenolpyruvate + H⁺ + phosphate ↔ pyruvate + diphosphate

NADP⁺ + cortisol ↔ NADPH + H⁺ + cortisone

2-hydroxyadipate + NAD⁺ ↔ NADH + 2-oxoadipate + H⁺

2 an oxidized ferredoxin [iron-sulfur] cluster + tetrahydrosarcinapterin + H₂O + acetyl-CoA ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + coenzyme A + 5-methyl-tetrahydrosarcinapterin + CO₂

β-alanine + (R)-pantolactone ↔ (R)-pantothenate + H⁺

NAD⁺ + L-pipecolate ↔ 2 H⁺ + 1-piperideine-2-carboxylate + NADH

2 H₂O + NAD(P)+ + (S)-1-pyrroline-5-carboxylate ↔ NAD(P)H + H⁺ + L-glutamate

3-methylbutanol + NAD⁺ ↔ 3-methylbutanal + NADH + H⁺

H₂O + N-acetyl-α-D-glucosamine + NAD⁺ ↔ 2 H⁺ + N-acetyl-D-glucosaminate + NADH

α-Kdo-(2→6)-lipid IV_A + CMP-3-deoxy-β-D-manno-octulosonate ↔ α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV_A + CMP + H⁺

H₂O + L-saccharopine + NADP⁺ ↔ NADPH + 2-oxoglutarate + H⁺ + L-lysine

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme M + coenzyme B ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + CoB-CoM heterodisulfide

campest-4-en-3-one + NADPH + H⁺ + oxygen ↔ H₂O + (22α)-hydroxy-campest-4-en-3-one + NADP⁺

H⁺ + oxygen + 1,2-dihydro-β-NAD ↔ hydrogen peroxide + NAD⁺

H⁺ + oxygen + 1,6-dihydro-β-NAD ↔ hydrogen peroxide + NAD⁺

3 H₂O + an oxidized electron donor + hydrogen sulfide ↔ 6 H⁺ + a reduced electron donor + sulfite

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD⁺ ↔ NADH + (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H⁺

NAD⁺ + D-altritol ↔ NADH + H⁺ + keto-D-psicose

2 hydroxylamine + 2 NAD⁺ ↔ 2 NADH + 2 H⁺ + hyponitrous acid

galactitol 1-phosphate + NAD⁺ ↔ L-tagatofuranose 6-phosphate + NADH + H⁺

UDP-α-D-galactose + kaempferol ↔ H⁺ + kaempferol 3-O-β-D-galactoside + UDP

dihydrolipoate + NAD⁺ ↔ (R)-lipoate + NADH + H⁺

kanamycin A + GTP ↔ H⁺ + kanamycin A 2''-phosphate + GDP

NADP⁺ + 4α-methyl-5α-ergosta-8,24-dien-3β-ol ↔ NADPH + 4α-methyl-5α-ergosta-8,14,24(28)-trien-3β-ol + H⁺

2 H⁺ + 2 3-phospho-D-glycerate ↔ H₂O + CO₂ + D-ribulose-1,5-bisphosphate

2 NADP⁺ + (-)-epigallocatechin ↔ 2 NADPH + 3 H⁺ + delphinidin

estradiol-17-α-3-D-glucuronoside + UDP-N-acetyl-α-D-glucosamine ↔ 17-α-(N-acetyl-α-D-glucosaminyl)estradiol 3-D-glucuronoside + H⁺ + UDP

propan-2-ol + NAD⁺ ↔ NADH + acetone + H⁺

3-[(3'-methylsulfanyl)propyl]malate + NAD⁺ ↔ NADH + 3-carboxy-6-(methylsulfanyl)-2-oxohexanoate + H⁺

2-ethylbenzoate + NADP⁺ ↔ NADPH + H⁺ + 2-formylbenzoate

N¹-(5-phospho-β-D-ribosyl)glycinamide + 10-formyl-tetrahydrofolate mono-L-glutamate ↔ N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide + H⁺ + 5,6,7,8-tetrahydrofolate

H₂O + NAD(P)+ + D-glyceraldehyde 3-phosphate ↔ 2 H⁺ + NAD(P)H + 3-phospho-D-glycerate

H₂O + maleimide ↔ maleamate + H⁺

2-chloro-2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate ↔ 2,3-dichloro-5-methyl-muconate + H⁺

shikimate + ATP ↔ shikimate 3-phosphate + H⁺ + ADP

H₂O + 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate ↔ 2 H⁺ + phosphate + phytate

1-chloro-2,4-dinitrobenzene + glutathione ↔ HCl + H⁺ + 2,4-dinitrophenyl-S-glutathione

isopentenyl diphosphate + di-trans,poly-cis-nonaprenyl diphosphate ↔ di-trans,poly-cis-decaprenyl diphosphate + H⁺ + diphosphate

3 FAD + 3 H⁺ + 15-cis-4,4'-diapophytoene ↔ 3 FADH₂ + all-trans-4,4'-diaponeurosporene

3-hydroxypimeloyl-CoA + NAD⁺ ↔ 3-oxopimeloyl-CoA + NADH + H⁺

dihydroxyfumarate + H⁺ ↔ tartronate semialdehyde + CO₂

2 H⁺ + oxalosuccinate + NADP⁺ ↔ NADPH + 2-oxoglutarate + CO₂

4-bromo-2,3-dihydroxydiphenyl ether + oxygen ↔ (2Z,4E)-2-hydroxy-6-oxo-(4-bromophenoxy)-hexa-2,4-dienoate + H⁺

indole-3-glycol aldehyde ↔ 2 H⁺ + indole-3-glyoxal

H₂O + acetoacetyl-CoA + acetyl-CoA ↔ coenzyme A + H⁺ + (S)-3-hydroxy-3-methylglutaryl-CoA

sisomicin + GTP ↔ H⁺ + sisomicin 2''-phosphate + GDP

4 FAD + 4 H⁺ + 15-cis-4,4'-diapophytoene ↔ 4 FADH₂ + all-trans-4,4'-diapolycopene

butan-1-ol + NADP⁺ ↔ NADPH + butan-1-al + H⁺

pyruvate + formaldehyde + H⁺ ↔ hydroxyacetone + CO₂

NAD⁺ + (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA ↔ NADH + H⁺ + 2-methylacetoacetyl-CoA

keto-D-fructose + NADP⁺ ↔ 5-dehydro-D-fructose + NADPH + H⁺

L-threo-sphinganine + NADP⁺ ↔ NADPH + H⁺ + 3-dehydrosphinganine

FAD + H⁺ + myristoyl-CoA ↔ FADH₂ + 2E)-tetradec-2-enoyl-CoA

6-oxocampestanol + NADPH + H⁺ + oxygen ↔ H₂O + cathasterone + NADP⁺

2 H⁺ + oxygen + (indol-3-yl)acetaldehyde ↔ H₂O + indole-3-glycol aldehyde

NAD⁺ + cholate ↔ NADH + H⁺ + 3-dehydrocholate

NADH + 4-methyl-2-oxopentanoate + H⁺ ↔ (R)-2-hydroxy-4-methylpentanoate + NAD⁺

3,6-dichloro-3a-methyl-dihydro-3H-furo[3,2-b]furan-2,5-dione ↔ 2,5-dichloro-3-methyl-muconolactone + H⁺

H⁺ + N-[2-(carboxylatoamino)-1,2-bis(1H-indol-3-yl)ethyl]carbamate ↔ ammonium + chromopyrrolate

NAD(P)+ + 1-indanol ↔ NAD(P)H + H⁺ + indanone

ammonium + ATP ↔ 2 H⁺ + phosphoramidate + ADP

acetyl-CoA + GDP-α-D-perosamine ↔ GDP-4-acetamido-4-amino-4,6-dideoxy-α-D-mannose + coenzyme A + H⁺

NADPH + H⁺ + dihydrogeranylgeranyl chlorophyll a ↔ NADP⁺ + tetrahydrogeranylgeranyl chlorophyll a

NADP⁺ + (S)-benzoin ↔ NADPH + benzil + H⁺

NADP⁺ + (R)-benzoin ↔ NADPH + benzil + H⁺

tropine + NADP⁺ ↔ tropinone + NADPH + H⁺

H⁺ + 3-[(2Z,4Z)-5-carbamoyl-3-(dimethylamino)-4-hydroxypenta-2,4-dien-1-yl]-1,8-dihydroxy-4-methylnaphthalene-2-carboxylate ↔ (2Z)-4-{9,10-dihydroxy-5-methyl-1-oxo-3H,4H-naphtho[2,3-c]pyran-3-yl}-4-(dimethylamino)-3-hydroxybut-2-enamide

L-glutamine + chorismate ↔ pyruvate + H⁺ + L-glutamate + 4-aminobenzoate

NAD⁺ + 1-ethyl-4-hydroxybenzene ↔ NADH + H⁺ + 4-vinylphenol

H₂O + trithionate ↔ H⁺ + sulfate + thiosulfate

NAD(P)H + H⁺ + gliotoxin ↔ NAD(P)+ + dithiolgliotoxin

5,10-methylene-tetrahydromethanopterin (iminium form) + NADP⁺ ↔ NADPH + 5,10-methenyltetrahydromethanopterin + H⁺

2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + carbon monoxide ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + CO₂

dithioerythritol + thiosulfate ↔ 4,5-cis-dihydroxy-1,2-dithiacyclohexane + H⁺ + sulfite + hydrogen sulfide

NADPH + H⁺ + tirandamycin C + oxygen ↔ H₂O + NADP⁺ + tirandamycin F

2 H⁺ + 24-methyldesmosterol ↔ campesterol

NADH + H⁺ + 3-dehydrocholate ↔ NAD⁺ + isocholate

α-1,3-D-mannobiose + UDP-α-D-xylose ↔ 3-O-(6-O-α-D-xylosylphospho-α-D-mannopyranosyl)-α-D-mannopyranose + UMP + H⁺

dihydrolipoamide + NADP⁺ ↔ lipoamide + NADPH + H⁺

2 H₂O + 2 ATP + a reduced electron donor + 4-methylbenzoyl-CoA ↔ 2 H⁺ + 2 phosphate + 2 ADP + an oxidized electron donor + 4-methylcyclohex-1,5-diene-1-carbonyl-CoA

scyllo-inositol + NADP⁺ ↔ scyllo-inosose + NADPH + H⁺

H₂O + aldehydo-D-ribose + NADP⁺ ↔ 2 H⁺ + D-ribonate + NADPH

NAD⁺ + 5-hydroxytryptophol ↔ NADH + H⁺ + 5-hydroxyindole acetaldehyde

H₂O + propanoyl-CoA + oxaloacetate ↔ coenzyme A + H⁺ + (2S,3S)-2-methylcitrate

H⁺ + GDP-α-D-mannuronate ↔ GDP-guluronate

2 NADPH + 2 H⁺ + nitrobenzene ↔ 2 NADP⁺ + H₂O + N-phenylhydroxylamine

H⁺ + L-methionine ↔ 3-(methylsulfanyl)propanamine + CO₂

FADH₂ + acryloyl-CoA ↔ FAD + propanoyl-CoA + H⁺

acetyl-CoA + L-histidine ↔ coenzyme A + N-acetyl-L-histidine + H⁺

H₂O + benzylbenzoate ↔ benzyl alcohol + H⁺ + benzoate

dihydromonacolin L acid + H⁺ ↔ H₂O + dihydromonacolin L lactone

2-methylpropanenitrile + NADPH + H⁺ + oxygen ↔ H₂O + NADP⁺ + 2-hydroxy-2-methylpropanenitrile

NAD(P)+ + 1,2-dihydrosantonin ↔ α-santonin + NAD(P)H + H⁺

(2S)-3-sulfolactate + NAD⁺ ↔ 3-sulfopyruvate + NADH + H⁺

β-D-cellobiose + ATP ↔ H⁺ + β-D-cellobiose 6'-phosphate + ADP

2 H⁺ + hydrogen peroxide + Reactive Blue 5 ↔ 2 H₂O + oxidized Reactive Blue 5

GDP-4-dehydro-3,6-dideoxy-α-D-mannose + NAD(P)H + H⁺ ↔ NAD(P)+ + GDP-β-colitose

NAD⁺ + (3S)-hydroxyadipyl-CoA ↔ 3-oxoadipyl-CoA + NADH + H⁺

3 H₂O + an oxidized electron donor + trithionate ↔ 3 sulfite + 4 H⁺ + a reduced electron donor

7,8-dihydroneopterin + oxygen ↔ 7,8-dihydroxanthopterin + glycolaldehyde + formate + H⁺

aldehydo-D-ribose 5-phosphate + ATP ↔ 5-phospho-α-D-ribose 1-diphosphate + H⁺ + AMP

2-undecylpyrrole + 4-methoxy-2,2'-bipyrrole-5-carbaldehyde + ATP ↔ H⁺ + phosphate + undecylprodigiosin + ADP

3-methyl-butane-1,3-diol + NAD⁺ ↔ NADH + 3-hydroxy-3-methyl-butanal + H⁺

uridine + ATP ↔ UMP + H⁺ + ADP

hygromycin-B + ATP ↔ H⁺ + 4-O-phosphohygromycin + ADP

2 D-Man-β-(1→4)-GlcA-β-(1→2)-D-Man-α-(1→3)-D-Glc-β-(1→4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol ↔ xanthan dimer + H⁺ + all-trans-undecaprenyl diphosphate

1,3-propanediol + NADP⁺ ↔ 3-hydroxypropanal + NADPH + H⁺

NAD(P)+ + D-glyceraldehyde 3-phosphate + phosphate ↔ NAD(P)H + H⁺ + 3-phospho-D-glyceroyl-phosphate

2 NAD(P)H + 2 H⁺ + malonyl-CoA + stearoyl-CoA ↔ 2 NAD(P)+ + coenzyme A + H₂O + icosanoyl-CoA + CO₂

coenzyme A + acetaldehyde + NAD⁺ ↔ NADH + H⁺ + acetyl-CoA

NADPH + 24-hydroxy-β-amyrin + H⁺ + oxygen ↔ H₂O + soyasapogenol B + NADP⁺

oxalosuccinate + H⁺ ↔ 2-oxoglutarate + CO₂

NAD⁺ + L-arabinitol ↔ NADH + H⁺ + aldehydo-L-arabinose

coenzyme A + succinate semialdehyde + NADP⁺ ↔ NADPH + H⁺ + succinyl-CoA

D-gluconate + NAD⁺ ↔ 5-dehydro-D-gluconate + NADH + H⁺

nocardicin G + oxygen ↔ H₂O + H⁺ + nocardicin E

zymosterol + NADP⁺ ↔ NADPH + H⁺ + 26,27-dehydrozymosterol

3-keto-L-gulonate + NAD⁺ ↔ 2,3-dioxo-L-gulonate + NADH + H⁺

NAD⁺ + methionol ↔ NADH + H⁺ + 3-(methylsulfanyl)propanal

hydroxypyruvate + H⁺ ↔ glycolaldehyde + CO₂

4-bromo-2,3-dihydrodiol-diphenyl ether + NAD⁺ ↔ NADH + 4-bromo-2,3-dihydroxydiphenyl ether + H⁺

2 H⁺ + NADPH + glutathioselenol ↔ hydrogen selenide + NADP⁺ + glutathione

an oxidized electron donor + NADPH + H⁺ ↔ a reduced electron donor + NADP⁺

ethyl (S)-3-hydroxyhexanoate + NADP⁺ ↔ ethyl-3-oxohexanoate + NADPH + H⁺

NADP⁺ + sn-glycerol 3-phosphate ↔ NADPH + H⁺ + L-glyceraldehyde 3-phosphate

NAD⁺ + diiodo-4-hydroxyphenyl-lactate ↔ NADH + H⁺ + diiodo-4-hydroxyphenylpyruvate

H₂O + Nα,Nε-diacetyl-lysyl-D-alanyl-D-alanine ↔ H⁺ + Nα,Nε-diacetyl-lysyl-D-alanine + D-alanine

H₂O + L-gulono-1,4-lactone ↔ L-gulonate + H⁺

NAD⁺ + 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate ↔ NADH + 3-(2,3-dihydroxyphenyl)propanoate + H⁺

7-deoxyloganate + NADPH + H⁺ + oxygen ↔ H₂O + loganate + NADP⁺

2,5,7-trihydroxyflavanone + H⁺ ↔ 1-phenyl-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione

meso-tartrate + NAD⁺ ↔ 2-hydroxy-3-oxosuccinate + NADH + H⁺

H₂O + malonyl-CoA + ATP + ononin ↔ 2 H⁺ + coenzyme A + formononetin-7-O-glucoside-6''-malonate + diphosphate + AMP

H₂O + dimethylsulfoniopropanoate ↔ 3-hydroxypropanoate + H⁺ + dimethyl sulfide

glycerol + diphosphate ↔ H⁺ + phosphate + sn-glycerol 3-phosphate

NAD⁺ + sulcatol ↔ NADH + sulcatone + H⁺

2 H⁺ + 6-deoxocastasterone + oxygen ↔ H₂O + 6α-hydroxy-castasterone

acetyl-CoA + L-aspartate ↔ coenzyme A + N-acetyl-L-aspartate + H⁺

tetrahydroxypteridine ↔ xanthine-8-carboxylate + H⁺

H₂ + 5,10-methenyltetrahydromethanopterin ↔ 5,10-methylene-tetrahydromethanopterin + H⁺

2-dehydro-3-deoxy-D-gluconate + NAD⁺ ↔ 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H⁺

isopentenyl diphosphate + di-trans,poly-cis-octaprenyl diphosphate ↔ di-trans,poly-cis-nonaprenyl diphosphate + H⁺ + diphosphate

NADPH + tert-amyl alcohol + H⁺ + oxygen ↔ H₂O + 3-methyl-butane-1,3-diol + NADP⁺

sn-glycerol 3-phosphate + UDP-α-D-galactose ↔ 2-(α-D-galactosyl)-sn-glycerol 3-phosphate + H⁺ + UDP

2 NAD⁺ + coenzyme A + (R)-mevalonate ↔ 2 NADH + 2 H⁺ + (S)-3-hydroxy-3-methylglutaryl-CoA

H₂O + P¹,P⁴-bis(5'-adenosyl) tetraphosphate ↔ 2 H⁺ + AMP + ATP

H₂O + 4-sulfobenzaldehyde + NAD⁺ ↔ 2 H⁺ + 4-sulfobenzoate + NADH

D-myo-inositol (1,3,4,6)-tetrakisphosphate + ATP ↔ 2 H⁺ + 1D-myo-inositol (1,2,3,4,6)-pentakisphosphate + ADP

NADPH + H⁺ + phyta-2,14-dienyl bacteriochlorophyllide a ↔ bacteriochlorophyll a + NADP⁺

amikacin + GTP ↔ H⁺ + amikacin 2''-phosphate + GDP

thiamine diphosphate + H⁺ + ADP ↔ adenosine thiamine triphosphate + phosphate

4-carboxybenzyl alcohol + NAD⁺ ↔ 4-carboxybenzaldehyde + NADH + H⁺

2 oxygen + 2 nitric oxide + NAD(P)H ↔ 2 nitrate + NAD(P)+ + H⁺

H⁺ + malonyl-CoA + myristoyl-CoA ↔ coenzyme A + 3-oxo-palmitoyl-CoA + CO₂

H₂O + 10-formyl-tetrahydrofolate mono-L-glutamate ↔ formate + H⁺ + 5,6,7,8-tetrahydrofolate

(S)-malate + NADP⁺ ↔ NADPH + H⁺ + oxaloacetate

2 malonyl-CoA + H⁺ + isovaleryl-CoA ↔ 2 CO₂ + 3 coenzyme A + 6-isobutyl-4-hydroxy-2-pyrone

(R)-glycerate + NAD(P)+ + CO₂ ↔ 2 H⁺ + NAD(P)H + 2-hydroxy-3-oxosuccinate

UDP-N-acetyl-α-D-glucosamine + UDP-α-D-galactose ↔ UMP + H⁺ + UDP-N-acetyl-6-(α-D-galactose-1-phospho)-α-D-glucosamine

2 H₂O + 8-oxo-dGTP ↔ 2 H⁺ + 2 phosphate + 8-oxo-dGMP

NAD⁺ + (S)-lactate ↔ NADH + pyruvate + H⁺

NAD(P)+ + S-(hydroxymethyl)glutathione ↔ NAD(P)H + H⁺ + S-formylglutathione

1D-chiro-inositol + NAD⁺ ↔ 1-keto-D-chiro-inositol + NADH + H⁺

1D-myo-inositol (1,2,3,4,6)-pentakisphosphate + ATP ↔ 2 H⁺ + phytate + ADP

E-FAD + (2S)-methylsuccinyl-CoA ↔ 2 H⁺ + E-FAD + 2-methylfumaryl-CoA

L-tryptophan ↔ H⁺ + 2-aminoprop-2-enoate + indole

bromochloromethane + H₂O ↔ 2 H⁺ + formaldehyde + chloride + bromide

dTDP-β-L-4-epi-vancosamine + devancosaminyl-vancomycin ↔ chloroorienticin B + H⁺ + dTDP

H₂O + phenylacetaldehyde + NAD⁺ ↔ 2 H⁺ + phenylacetate + NADH

H₂O + NAD⁺ + L-valine ↔ NADH + 3-methyl-2-oxobutanoate + H⁺ + ammonium

ε-rhodomycinone + NADP⁺ ↔ NADPH + maggiemycin + H⁺

an oxidized electron donor + NADH + H⁺ ↔ a reduced electron donor + NAD⁺

H⁺ + UTP + α-D-galactose 1-phosphate ↔ diphosphate + UDP-α-D-galactose

2 H⁺ + 2 (S)-lactate ↔ 2 H₂O + L-lactide

hypotaurocyamine + ATP ↔ N^ω-phosphohypotaurocyamine + H⁺ + ADP

butanoyl-CoA + NAD⁺ ↔ crotonyl-CoA + NADH + H⁺

NADPH + H⁺ + tirandamycin F + oxygen ↔ H₂O + NADP⁺ + tirandamycin E

NAD⁺ + 10-formyl-tetrahydrofolate mono-L-glutamate ↔ N¹⁰-formyldihydrofolate + NADH + H⁺

uridine + H⁺ + L-cysteine + ATP ↔ L-alanine + 2-thiouridine + diphosphate + AMP

β-nicotinate D-ribonucleotide + diphosphate + CO₂ ↔ 2 H⁺ + 5-phospho-α-D-ribose 1-diphosphate + quinolinate

NADPH + dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H⁺ ↔ dTDP-β-L-rhamnose + NADP⁺

H₂O + 1-piperideine-2-carboxylate + H⁺ ↔ 6-amino-2-oxohexanoate

NAD⁺ + geraniol ↔ NADH + geranial + H⁺

2 NADH + 2 H⁺ + 2 oxygen + (3S,3'S)-astaxanthin ↔ 2 H₂O + 2 NAD⁺ + 2,3,2',3'-tetrahydroxy-β,β-carotene-4,4'-dione

dihydrostreptomycin 6-phosphate + ATP ↔ dihydrostreptomycin 3'-α-6-bisphosphate + H⁺ + ADP

α-D-xylopyranose + NADP⁺ ↔ D-xylono-1,5-lactone + NADPH + H⁺

5-S-cysteinyldopa ↔ H₂O + 1,4-benzothiazinyl-alanine + H⁺

cholesterol + NAD⁺ ↔ cholest-5-en-3-one + NADH + H⁺

hygromycin-B + ATP ↔ 7''-O-phosphohygromycin B + H⁺ + ADP

H₂O + phenyl phosphate + CO₂ ↔ H⁺ + phosphate + 4-hydroxybenzoate

N⁴-{N-acetyl-β-D-glucosaminyl-(1,2)-α-D-mannosyl-(1,3)-[N-acetyl-β-D-glucosaminyl-(1,2)-α-D-mannosyl-(1,6)]-β-D-mannosyl-(1,4)-N-acetyl-β-D-glucosaminyl-(1,4)-N-acetyl-β-D-glucosaminyl}asparagine + GDP-β-L-fucose ↔ N(4)-{N-acetyl-β-D-glucosaminyl-(1,2)-α-D-mannosyl-(1,3)-[N-acetyl-β-D-glucosaminyl-(1,2)-α-D-mannosyl-(1,6)]-β-D-mannosyl-(1,4)-N-acetyl-β-D-glucosaminyl-(1,4)-[α-L-fucosyl-(1,3)]-N-acetyl-β-D-glucosaminyl}asparagine + H⁺ + GDP

NAD(P)H + H⁺ + oxygen + rifampicin ↔ H₂O + NAD(P)+ + 2'-N-hydroxyrifampicin

coenzyme A + NAD⁺ + (S)-lactaldehyde ↔ NADH + H⁺ + (S)-lactoyl-CoA

gallate + H⁺ ↔ pyrogallol + CO₂

NADP⁺ + trypanothione ↔ trypanothione disulfide + NADPH + H⁺

4-methyl-5-nitrocatechol + NADPH + oxygen ↔ H₂O + 2-hydroxy-5-methylquinone + NADP⁺ + H⁺ + nitrite

NADP⁺ + meso-diaminopimelate ↔ 2 H⁺ + (S)-2,3,4,5-tetrahydrodipicolinate + NADPH + ammonium

H₂O + NADP⁺ + (Z)-2-methylpropanal-oxime ↔ 3 H⁺ + 2-methylpropanenitrile + NADPH + oxygen

gallate + oxygen ↔ 2 H⁺ + (1Z,3Z)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate

H₂O + trimetaphosphate ↔ 2 H⁺ + triphosphate

L-homocysteine + thetin ↔ (methylsulfanyl)acetate + H⁺ + L-methionine

NADP⁺ + sphinganine (C20) ↔ NADPH + H⁺ + 3-dehydrosphinganine (C20)

H₂O + sepiapterin + H⁺ ↔ xanthopterin-B2 + ammonium

2 H⁺ + oxygen + 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol ↔ H₂O + 3-demethylubiquinol-6

2 NADP⁺ + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin ↔ 2 NADPH + 2 H⁺ + L-erythro-biopterin

carbamoyl phosphate + L-aspartate ↔ N-carbamoyl-L-aspartate + H⁺ + phosphate

lanosterol + NADPH + H⁺ ↔ 24,25-dihydrolanosterol + NADP⁺

3-chloro-D-alanine + H₂O ↔ pyruvate + H⁺ + ammonium + chloride

an oxidized electron donor + L-pipecolate ↔ 1-piperideine 6-carboxylate + a reduced electron donor + H⁺

NAD(P)+ + UDP-N-acetyl-β-L-pneumosamine ↔ NAD(P)H + H⁺ + UDP-2-acetamido-2,6-dideoxy-β-L-lyxo-4-hexulose

acetyl-CoA + L-glutamate ↔ coenzyme A + N-acetyl-L-glutamate + H⁺

furfuryl alcohol + NAD⁺ ↔ NADH + furfural + H⁺

H⁺ + L-serine + ATP ↔ (L-seryl)adenylate + diphosphate

2-hydroxy-1-phenyl-1-propanone + NADP⁺ ↔ 1-phenylpropane-1,2-dione + NADPH + H⁺

H₂ + oxidized coenzyme F₄₂₀-2 + H⁺ ↔ reduced coenzyme F₄₂₀-2

H⁺ + OH^- ↔ H₂O

(S)-malate + NAD⁺ ↔ NADH + H⁺ + oxaloacetate

salutaridinol + NADP⁺ ↔ salutaridine + NADPH + H⁺

H₂O + glyoxylate + acetyl-CoA ↔ coenzyme A + (S)-malate + H⁺

3'-phosphoadenylyl-sulfate + desulfo-A47934 ↔ adenosine 3',5'-bisphosphate + H⁺ + A47934

aldehydo-L-galactonate + NAD⁺ ↔ NADH + D-tagaturonate + H⁺

2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺ + testosterone + oxygen ↔ 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O + 1α-hydroxytestosterone

3'-phosphoadenylyl-sulfate + choline ↔ adenosine 3',5'-bisphosphate + choline sulfate + H⁺

2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H⁺ ↔ NAD⁺ + sequoyitol

NADPH + H⁺ + tirandamycin A + oxygen ↔ H₂O + NADP⁺ + tirandamycin B

3,5-dichloro-2-methyl-muconate + H⁺ ↔ 3,5-dichloro-2-methyl-muconolactone

coenzyme A + isobutanal + NAD⁺ ↔ NADH + H⁺ + isobutanoyl-CoA

2 ferrileghemoglobin + NAD(P)H ↔ 2 ferroleghemoglobin + NAD(P)+ + H⁺

hydroxylamine + H⁺ + L-asparagine ↔ ammonium + β-L-aspartylhydroxamate

2 H⁺ + pentane-1,3,4,5-tetracarboxylate + CO₂ ↔ H₂O + hexane-6-keto-1,3,4,6-tetracarboxylate

a reduced electron donor + NAD⁺ ↔ an oxidized electron donor + H⁺ + 1,6-dihydro-β-NAD

hydroxylamine + ammonium ↔ H₂O + H⁺ + hydrazine

L-ascorbate + ATP ↔ 2-phospho-L-ascorbate + H⁺ + ADP

2 H₂O + 2 H⁺ + methylenediurea ↔ 2 ammonium + N-(hydroxymethyl)urea + CO₂

NADP⁺ + D-glyceraldehyde 3-phosphate + phosphate ↔ NADPH + H⁺ + 3-phospho-D-glyceroyl-phosphate

NADPH + L-xylo-3-hexulose + H⁺ ↔ NADP⁺ + D-sorbitol

3 NADPH + 4 H⁺ + oxygen + 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoate ↔ 3 NADP⁺ + 5 H₂O + homo-UWM6 + CO₂

NADP⁺ + sn-glycerol 3-phosphate ↔ NADPH + H⁺ + D-glyceraldehyde 3-phosphate

H₂O + (S)-2,3,4,5-tetrahydrodipicolinate + H⁺ ↔ L-α-amino-ε-keto-pimelate

CDP-choline + sphingosine ↔ CMP + H⁺ + sphingosylphosphorylcholine

octanoyl-CoA + H⁺ + 2-(hydroxylamino)benzoylacetate ↔ coenzyme A + H₂O + 2-n-heptyl-4-hydroxyquinoline-N-oxide + CO₂

2 sinapoyl-CoA + spermidine ↔ 2 coenzyme A + 2 H⁺ + N¹,N⁸-bis(sinapoyl)-spermidine

2 NADP⁺ + coenzyme A + (R)-mevalonate ↔ 2 NADPH + 2 H⁺ + (S)-3-hydroxy-3-methylglutaryl-CoA

NAD⁺ + D-sorbitol ↔ NADH + keto-D-fructose + H⁺

2 an oxidized ferredoxin [iron-sulfur] cluster + 2 formate + NAD⁺ ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + 2 CO₂ + NADH + H⁺

NAD⁺ + D-mannitol ↔ NADH + keto-D-fructose + H⁺

Cu²⁺ + NADH ↔ NAD⁺ + H⁺ + Cu⁺

2 H⁺ + GDP-4-dehydro-α-D-rhamnose ↔ GDP-4-dehydro-3,6-dideoxy-α-D-mannose + H₂O

D-mannitol 1-phosphate + NADP⁺ ↔ NADPH + H⁺ + α-D-mannopyranose 6-phosphate

2 H⁺ + 2-phosphoglycolate + 3-phospho-D-glycerate ↔ oxygen + D-ribulose-1,5-bisphosphate

H₂O + acryloyl-CoA ↔ coenzyme A + acrylate + H⁺

2-oxoglutarate + glyoxylate + H⁺ ↔ 2-hydroxy-3-oxoadipate + CO₂

H₂O + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate ↔ 2 H⁺ + phosphate + phytate

GDP-α-D-mannose + 2-O-(α-D-glucopyranosyl)-D-glycerate ↔ H⁺ + 2-[2-O-(α-D-mannopyranosyl)-(1→2)-α-D-glucopyranosyl]-D-glycerate + GDP

NADH + 4-bromodiphenyl ether + H⁺ + oxygen ↔ 4-bromo-2,3-dihydrodiol-diphenyl ether + NAD⁺

(3R)-3-hydroxybutanoyl-CoA + NADP⁺ ↔ NADPH + acetoacetyl-CoA + H⁺

NAD(P)H + H⁺ + 4-hydroxybutyraldehyde ↔ 1,4-butanediol + NAD(P)+

(R)-propane-1,2-diol + NAD⁺ ↔ NADH + H⁺ + (R)-lactaldehyde

acetyl-CoA + gentamicin C1a ↔ coenzyme A + N2'-acetylgentamicin C_1A + H⁺

glycolate + NAD⁺ ↔ NADH + glyoxylate + H⁺

2 H⁺ + 3-heptaprenyl-4-hydroxybenzoate + oxygen ↔ 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + H₂O

2-methyl-3-pentyl-1H-pyrrole + 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde + ATP ↔ H⁺ + phosphate + norprodigiosin + ADP

H₂O + NAD⁺ + chloroacetaldehyde ↔ 2 H⁺ + 2-chloroacetate + NADH

2 FMNH₂ + 2 oxygen + dibenzothiophene ↔ 2 FMN + 2 H₂O + 2 H⁺ + dibenzothiophene-5,5-dioxide

5,10-methenyl-tetrahydrosarcinapterin + H₂O ↔ 5-formyl-tetrahydrosarcinapterin + H⁺

L-gulono-1,4-lactone + NADP⁺ ↔ D-glucurono-6,3-lactone + NADPH + H⁺

3-carboxy-2,5-dihydro-5-oxofuran-2-acetate ↔ H⁺ + 3-carboxy-cis,cis-muconate

phytyl diphosphate + NADP⁺ ↔ tetrahydrogeranylgeranyl diphosphate + NADPH + H⁺

FAD + hexanoyl-CoA + H⁺ ↔ FADH₂ + trans-hex-2-enoyl-CoA

geranylgeraniol + CTP ↔ H⁺ + all-trans-geranyl-geranyl monophosphate + CDP

L-tartrate + NAD⁺ ↔ 2-hydroxy-3-oxosuccinate + NADH + H⁺

H⁺ + oxygen + 1,6-dihydro-β-NADP ↔ hydrogen peroxide + NADP⁺

2 H⁺ + H₂O + N-carbamoyl-L-aspartate ↔ ammonium + L-aspartate + CO₂

NADH + butan-2-one + H⁺ + oxygen ↔ H₂O + 1-hydroxy-2-butanone + NAD⁺

pregnenolone + NAD⁺ ↔ pregn-5-ene-3,20-dione + NADH + H⁺

NADP⁺ + D-threo-isocitrate ↔ oxalosuccinate + NADPH + H⁺

(R)-1-aminopropan-2-ol + NAD⁺ ↔ aminoacetone + NADH + H⁺

dTDP-β-L-rhamnose + NAD⁺ ↔ NADH + dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H⁺

2 H₂O + butan-2-one + ATP + CO₂ ↔ 2 phosphate + 3 H⁺ + 3-oxopentanoate + AMP

H₂O + (2Z,4E)-2-aminomuconate + H⁺ ↔ (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + ammonium

(R)-pantolactone + NADP⁺ ↔ NADPH + 2-dehydropantolactone + H⁺

chlorophyllide a₂ + phytyl diphosphate + H⁺ ↔ chlorophyll a₂ + diphosphate

deoxycholate + NAD(P)⁺ ↔ 3-dehydrodeoxycholate + NAD(P)H + H⁺

H⁺ + GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala ↔ H⁺ + GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala

levoglucosan + NAD⁺ ↔ 3-dehydrolevoglucosan + NADH + H⁺

L-homocysteine thiolactone + H₂O ↔ L-homocysteine + H⁺

UDP-N-acetyl-α-D-glucosamine + O-mannopyranosyl-alpha-1,3-[O-mannopyranosyl-alpha-1,3-(O-mannopyranosyl-alpha-1,6)-O-mannopyranosyl-alpha-1,6]-O-mannopyranosyl-beta-1,4-N-acetyl-D-glucosamine ↔ UDP + O-mannopyranosyl-alpha-1,3-O-mannopyranosyl-alpha-1,3-(O-mannopyranosyl-alpha-1,6)-[N-acetylglucosamine-beta-1,4-O-mannopyranosyl-alpha-1,6]-O-mannopyranosyl-beta-1,4-N-acetyl-D-glucosamine + H⁺

D-glucopyranose 6-phosphate + NAD(P)⁺ ↔ 6-phospho D-glucono-1,5-lactone + NAD(P)H + H⁺

D-glucopyranose + NAD⁺ ↔ D-glucono-1,5-lactone + NADH + H⁺

D-galactopyranose + NAD(P)⁺ ↔ D-galactono-1,5-lactone + NAD(P)H + H⁺

ammonium + hydrogencarbonate + ATP ↔ H₂O + carbamoyl phosphate + H⁺ + ADP

5,10-methylene-tetrahydromethanopterin + an oxidized factor 420 + H⁺ ↔ 5,10-methenyltetrahydromethanopterin + a reduced factor 420

GDP-4-dehydro-α-D-rhamnose + H₂O + L-glutamate ↔ 2 H⁺ + 2-oxoglutarate + GDP-α-D-perosamine

D-galactopyranose + NADP⁺ ↔ D-galactono-1,5-lactone + NADPH + H⁺

H₂O + juvenile hormone II ↔ juvenile hormone II acid + methanol + H⁺

H₂O + 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA ↔ 3-hydroxypimeloyl-CoA + H⁺

NADP⁺ + 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one ↔ 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NADPH + H⁺

4-diphospho-1D-myo-inositol pentakisphosphate + H2O ↔ 2 H+ + phytate + phosphate

1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + 2 H+ + phosphate ↔ 4,5-bis(diphospho)-1D-myo-inositol tetrakisphosphate + H2O

1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + 2 H+ + phosphate ↔ 5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate + H2O

6-diphospho-1D-myo-inositol pentakisphosphate + H2O ↔ 2 H+ + phytate + phosphate

dethiobiotin + S0 ↔ biotin + 2 H+

H+ + CTP + phosphatidate ↔ diphosphate + a CDP-diacylglycerol

CTP + H+ + phosphatidate ↔ diphosphate + a CDP-diacylglycerol

DL-allothreonine + NADP+ ↔ H+ + L-2-amino-3-oxobutanoate + NADPH

allantoin + H2O ↔ allantoate + H+

dTTP + uridine ↔ dTDP + H+ + UMP

dCTP + uridine ↔ dCDP + H+ + UMP

H2O + 2 NAD+ + decan-1-ol ↔ 2 H+ + 2 NADH + decanal

H2O + 2 NAD+ + 1-dodecanol ↔ 2 H+ + 2 NADH + dodecanal

4-hydroxybenzoate + di-trans,poly-cis-nonaprenyl diphosphate ↔ diphosphate + 2 H+ + 3-nonaprenyl-4-hydroxybenzoate

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O ↔ 6-(alpha-D-Glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate + H+

ATP + L-glutamate + 5,6,7,8-tetrahydrofolate ↔ 5,6,7,8-tetrahydrofolyl-L-glutamic acid + ADP + H+ + phosphate

acetyl-CoA + α-D-glucosamine 6-phosphate ↔ coenzyme A + H+ + N-acetyl-D-glucosamine-6-phosphate

H2O + 2 NAD+ + 1-hexadecanol ↔ 2 H+ + 2 NADH + palmitaldehyde

NADP+ + D-mannitol ↔ D-Fructose + H+ + NADPH

H+ + NADPH + acylglycerone phosphate ↔ NADP+ + a 1-acyl-sn-glycerol 3-phosphate

phosphate + β-D-ribosylnicotinate ↔ α-D-ribose-1-phosphate + H+ + nicotinate

H2O + 2 NAD+ + C00289 ↔ 3 H+ + 2 NADH + UDP-α-D-glucuronate

cytidine + UTP ↔ CMP + H+ + UDP

cytidine + ITP ↔ CMP + H+ + IDP

uridine + UTP ↔ H+ + UDP + UMP

ITP + uridine ↔ H+ + IDP + UMP

cytidine + dATP ↔ CMP + dADP + H+

dATP + uridine ↔ dADP + H+ + UMP

dGTP + uridine ↔ dGDP + H+ + UMP

cytidine + dGTP ↔ CMP + dGDP + H+

cytidine + dTTP ↔ CMP + dTDP + H+

dUTP + uridine ↔ dUDP + H+ + UMP

cytidine + dCTP ↔ CMP + dCDP + H+

cytidine + dUTP ↔ CMP + dUDP + H+

H+ + NADH + D-erythrose ↔ NAD+ + erythritol

L-tryptophan + H⁺ ↔ L-tryptophan + H⁺