EraGene - Genetic Analysis Platform

Tunable Genes for Metabolic Engineering in Escherichia coli

EraGene is an integrative database of tunable genes that limit the production of high-value metabolites in Escherichia coli. It combines flux balance analysis, machine learning predictions, and manually curated metabolic knowledge to support the rational design of engineered strains for industrial biotechnology.

Explore Metabolite Production

Browse metabolites produced in E. coli and identify the genes, reactions, and genetic interventions that enhance production yields across reported strains.

Compare Engineering Strategies

Compare engineered strains and metabolic strategies to identify shared and compound-specific genetic modifications used to overcome biosynthetic bottlenecks.

Simulate Metabolic Interventions

Perform in silico simulations highlighting reactions modified in successful production systems, enabling the transfer of validated strategies to new target metabolites.