1,2-Propanediol is a metabolic intermediate associated with the catabolism and fermentation of deoxysugars in Escherichia coli [35]. It can serve as a growth substrate for specific mutant strains of Escherichia coli K-12 [35, 361]. The metabolism of this compound is facilitated by propanediol dehydrogenase, a ferrous-activated, nicotinamide adenine dinucleotide (NAD)-dependent enzyme encoded within the fucose operon [35].
The 1,2-propanediol metabolic pathway can be recruited in engineered microorganisms to enable the utilization of alternative carbon substrates. For example, E. coli mutants have been shown to grow on xylitol by incorporating enzymatic activities from the L-1,2-propanediol and D-xylose metabolic pathways [361].
(S)-propane-1,2-diol
Description
Chemical Formula:
C3H8O2
Molecular Weight:
76.095 Daltons
Monoisotopic Mass:
76.05242950099999 Daltons
SMILES:
CC(CO)O
InChI:
1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
InChIKey:
Synonyms
- (S)-1,2-propane-diol
- (S)-1,2-propanediol
- (S)-1,2-dihydroxypropane
- L-1,2-propanediol
Databases
MetaCyc:
PROPANE-1-2-DIOL
BiGG:
12ppd__S
ChemSpider:
388890
MetaboLights:
MTBLC29002
HMDB:
HMDB06213
DRUGBANK:
DB04349
PubChem (CID):
439846
KEGG:
C02917
ChEBI:
29002
CAS:
57-55-6
RefMet:
Propylene glycol
Seed:
cpd19024
MetaNetX:
MNXM1255