N1-acetylspermine
Description
N1-Acetylspermine is an acetylated polyamine derivative. It is synthesized through the acetylation of the polyamine spermine at the N1 position, representing the aminopropyl end, a reaction catalyzed by the enzyme spermidine/spermine N1-acetyltransferase (SSAT). Within cells, N1-acetylspermine serves as a substrate for further acetylation by SSAT to yield N1,N12-diacetylspermine, or it can undergo oxidative cleavage by peroxisomal acetylpolyamine oxidase (APAO) to form N-acetylaminopropanal and spermidine, thereby participating in the polyamine back-conversion pathway [366].
Chemical Formula:
C12H31N4O
Molecular Weight:
247.403 Daltons
Monoisotopic Mass:
247.249786638 Daltons
SMILES:
CC(=O)NCCC[N+]CCCC[N+]CCC[N+]
InChI:
1S/C12H28N4O/c1-12(17)16-11-5-10-15-8-3-2-7-14-9-4-6-13/h14-15H,2-11,13H2,1H3,(H,16,17)/p+3
InChIKey:
Databases
MetaCyc:
N1-ACETYLSPERMINE
RefMet:
N1-Acetylspermine
MetaboLights:
MTBLC58101
HMDB:
HMDB01186
ChEBI:
58101
KEGG:
C02567
CAS:
77928-70-2
Seed:
cpd01680
MetaNetX:
MNXM600
BiGG:
N1sprm