3-Amino propanoic acid is a naturally occurring beta-amino acid and serves as an essential precursor for the biosynthesis of pantothenic acid. It is characterized as the only beta-amino acid discovered in nature to date [23].
A primary engineering strategy for its production involves the heterologous expression of L-aspartate alpha-decarboxylase (ADC) to catalyze the decarboxylation of aspartate into 3-amino propanoic acid. To enhance production efficiency, metabolic flux toward the precursor oxaloacetate is often increased by overexpressing phosphoenolpyruvate carboxylase (PPC) and pyruvate carboxylase (PC), while competing pathways that lead to the formation of byproducts such as lactate, formate, and acetate are deleted [23].
β-alanine
Description
Chemical Formula:
C3H7NO2
Molecular Weight:
89.094 Daltons
Monoisotopic Mass:
90.0555035062 Daltons
SMILES:
C(C[N+])C([O-])=O
InChI:
1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)
InChIKey:
Synonyms
- 3-azaniumylpropanoate
- 3-ammoniopropanoate
- 3-Aminopropionic acid
- 3-Aminopropanoate
- 3-AP
- 3-Amino propanoic acid
Databases
MetaCyc:
B-ALANINE
BiGG:
ala_B
MetaboLights:
MTBLC57966
HMDB:
HMDB00056
KEGG:
C00099
CAS:
107-95-9
PupChem (SID):
3399
CHEMBL:
CHEMBL297569
KNApSAcK:
C00001333
PDB-CCD:
BAL
3DMET:
B00025
NIKKAJI:
J4.070C
RefMet:
beta-Alanine
Beta-Alanine
Seed:
cpd00085
MetaNetX:
MNXM144