hisG

Corynebacterium glutamicum

Sequence
                ATGTTGAAAATCGCTGTCCCAAACAAAGGCTCGCTGTCCGAGCGCGCCATGGAAATCCTCGCCGAAGCAGGCTACGCAGGCCGTGGAGATTCCAAATCCCTCAACGTTTTTGATGAAGCAAACAACGTTGAATTCTTCTTCCTTCGCCCTAAAGATATCGCCATCTACGTTGCTGGTGGCCAGCTCGATTTGGGTATCACCGGCCGCGACCTTGCTCGCGATTCCCAGGCTGATGTCCACGAAGTTCTTTCCCTCGGCTTCGGTTCCTCCACTTTCCGTTACGCAGCACCAGCTGATGAAGAGTGGAGCATCGAAAAGCTCGACGGCAAGCGCATCGCTACCTCTTACCCCAACCTTGTTCGCGATGACCTCGCAGCACGTGGGCTTTCCGCTGAGGTGCTCCGCCTCGACGGTGCAGTAGAGGTATCCATCAAGCTTGGTGTCGCAGATGCCATCGCCGATGTTGTATCCACCGGCCGCACGCTGCGTCAGCAAGGTCTTGCACCTTTCGGCGAGGTTCTGTGCACCTCTGAGGCTGTCATTGTTGGCCGCAAGGATGAAAAGGTCACCCCAGAGCAGCAGATCCTGCTTCGCCGCATCCAGGGAATTTTGCACGCGCAGAACTTCCTCATGCTGGATTACAACGTCGACCGCGACAACCTGGACGCTGCCACTGCAGTAACCCCAGGCTTATCCGGCCCAACGGTATCCCCACTGGCACGCGACAACTGGGTTGCTGTACGCGCCATGGTGCCACGCAGGTCAGCTAACGCCATCATGGATAAGCTTGCTGGACTCGGCGCTGAAGCCATCCTGGCTTCTGAAATCCGCATCGCCCGCATCTAG

hisG encodes ATP-phosphoribosyltransferase from Corynebacterium glutamicum, an enzyme subject to feedback inhibition by L-histidine. The mutant variant hisGfbr carries a deletion of the C-terminal regulatory domain and an S143F substitution, which together relieve L-histidine–mediated feedback inhibition and enhance L-histidine production when overexpressed in Escherichia coli [340].

Gene size:
Protein size:
Reactions R568
Compounds affected L-histidine

Databases
EraGene: 2070528