ispA

Escherichia coli

Sequence

                ATGGACTTTCCGCAGCAACTCGAAGCCTGCGTTAAGCAGGCCAACCAGGCGCTGAGCCGTTTTATCGCCCCACTGCCCTTTCAGAACACTCCCGTGGTCGAAACCATGCAGTATGGCGCATTATTAGGTGGTAAGCGCCTGCGACCTTTCCTGGTTTATGCCACCGGTCATATGTTCGGCGTTAGCACAAACACGCTGGACGCACCCGCTGCCGCCGTTGAGTGTATCCACGCTTACTCATTAATTCATGATGATTTACCGGCAATGGATGATGACGATCTGCGTCGCGGTTTGCCAACCTGCCATGTGAAGTTTGGCGAAGCAAACGCGATTCTCGCTGGCGACGCTTTACAAACGCTGGCGTTCTCGATTTTAAGCGATGCCGATATGCCGGAAGTGTCGGACCGCGACAGAATTTCGATGATTTCTGAACTGGCGAGCGCCAGTGGTATTGCCGGAATGTGCGGTGGTCAGGCATTAGATTTAGACGCGGAAGGCAAACACGTACCTCTGGACGCGCTTGAGCGTATTCATCGTCATAAAACCGGCGCATTGATTCGCGCCGCCGTTCGCCTTGGTGCATTAAGCGCCGGAGATAAAGGACGTCGTGCTCTGCCGGTACTCGACAAGTATGCAGAGAGCATCGGCCTTGCCTTCCAGGTTCAGGATGACATCCTGGATGTGGTGGGAGATACTGCAACGTTGGGAAAACGCCAGGGTGCCGACCAGCAACTTGGTAAAAGTACCTACCCTGCACTTCTGGGTCTTGAGCAAGCCCGGAAGAAAGCCCGGGATCTGATCGACGATGCCCGTCAGTCGCTGAAACAACTGGCTGAACAGTCACTCGATACCTCGGCACTGGAAGCGCTAGCGGACTACATCATCCAGCGTAATAAATAA

ispA encodes the native farnesyl diphosphate synthase in Escherichia coli [346], which catalyzes the condensation of isopentenyl diphosphate and dimethylallyl diphosphate to form farnesyl diphosphate (FPP) [344, 346]. FPP acts as a central branching-point intermediate in terpenoid biosynthesis [344], and overexpression of ispA enhances precursor supply, resulting in increased retinal production [344].

`Gene size:`
`Protein size:`
`Reactions`	R315 and R574
`Compounds affected`	(2E,6E)-farnesol , valerena-4,7(11)-diene , (E,E)-α-farnesene , all-trans-lycopene and (-)-patchoulol

Databases

`EraGene:`	2111291
`UniProt:`	P22939
`KEGG:`	eco:b0421