PAICS

Homo sapiens

Sequence
                ATGGAGAGTGGAGCAGGAAAGCACTGGACTGAGGAGGAGGTTAAAGCTTTGCTAAGTGTCTGGGCAGAAAAAAATATACGAAAACAACTTTATGGAACACTAAGAAATAAAGGAATATTTATTTACATTGCTAAAAGGCTGCAATCATTAGGAGTATACAGAGACTGGAAACAGTGCTGGGCTAAGTACAAAAATCTCAAATATGAATATAGAACAGTTAAATATGCCCATAACTCTGGAGACAGCTCTAAAACTATGAAGTTCTTCCATGATTTGGATGTAATCCTGCAGTATGAACCTGCCACACAATTTACAGAGGAAGATGCAAATGGCAGGTACCTGGAAACGCTCAGCCCAAGTACAGCCCCAGAGACCACTGAAGCAGAATTTTTATTGGTGTGTGATACACGGAAGAAGGGAAGAAAACGAAAGTGCCTTTTCCACTGTTGGGATCAACCTCATGCAAGTGAGCCTCTGCCTACAGTTTTAGGATTCATGCTGTGGAATGAGCAACTTAAGAAAAAATTATCTGAAGAGGTTGGAGAGAGAGCTTTTCTGTTTCACTACCATCTGTATGTTTGGTCCAGACTCTTTTCTATGGACGTAAATCTGGACTCTAAACCAGGTAAAATGTCAATTGCATCAGTAGATAAGGAAGATGTCTCAGGAAATCCTTTACTTCTGGTTTCTCATGTCAGACCAATGGAACTAGCAAATGAAGGAGGAAAGCACTGGACTGTGCCAGAAGTCAGGGCTCTAATAGACATCTGGTCTGATAAAAGCATACAACGACAACTAGAGGGAACAGTGAGAAATAAGAGGATATTTCAACAAATTGCAGCCAAGCTTCAGAAATTTGGAATAGACAGAGACTGGAAACAGTGCAGAACAAAATACAAAAACCTAAAACACGAATACAAGATCGTAAGAACAGCTCAAGATCTAGGCATGACTAAGAGTATGAAATTTTTTACTGAGTTGGATGCTATTCTGGGACCCAATAAAACAGAAAAATCACGAGACCAGGAATCCCAAGATGGAGAACATGTCACAGAATGTGCCAACGTAAAAATGGGAGAGGACCAGACAGTACATCCAGATAGAGAAGAACTTATTACTAAAACTTCAGAAAACCGAAGACTTACAAATGTGAAAAAAGAAAGCTCAGACATAGAATTATTTGAAGGTCACAACAAAAGCCAAGGAACTTTGAGCTTCAAGAGAAAAGCACATGAAGATGAACCAGTGTCTAAATCTCTTAAGAAAAGTGCTCCTGAGATCATTACAAATCAGTTTCCTCAAAGCGTAATAACAGAACCAAAAGATTCTACAGAATGTTTCTGCAGACAGAAAACCCAACTTCATCAGAGTTCTGCCTCGCTTCCCGGCGCGGTCGCAGCCCTCAGCCCACTTAGGATAATGGCGACAGCTGAGGTACTGAACATTGGTAAAAAATTATATGAGGGTAAAACAAAAGAAGTCTACGAATTGTTAGACAGTCCAGGAAAAGTCCTCCTGCAGTCCAAGGACCAGATTACAGCAGGAAATGCAGCTAGAAAAAACCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATCACCAGTTGTATTTTTCAGTTATTACAGGAAGCAGGTATTAAAACTGCCTTCACCAGAAAATGTGGGGAGACAGCTTTCATTGCACCGCAGTGTGAAATGATTCCAATTGAATGGGTTTGCAGAAGAATAGCAACTGGTTCTTTTCTCAAAAGAAATCCTGGTGTCAAGGAAGGATATAAGTTTTACCCACCTAAAGTGGAGTTGTTTTTCAAGGATGATGCCAATAATGACCCACAGTGGTCTGAGGAACAGCTGATTGCTGCAAAATTTTGCTTTGCTGGACTTCTTATAGGCCAGACTGAAGTGGATATCATGAGTCATGCTACACAGGCTATATTTGAAATACTGGAGAAATCCTGGTTGCCCCAGAATTGTACACTGGTTGATATGAAGATTGAATTTGGTGTTGATGTAACCACCAAAGAAATTGTTCTTGCTGATGTTATTGACAATGATTCCTGGAGACTCTGGCCATCAGGAGATCGAAGCCAACAGAAAGACAAACAGTCTTATCGGGACCTCAAAGAAGTAACTCCTGAAGGGCTCCAAATGGTAAAGAAAAACTTTGAGTGGGTTGCAGAGAGAGTAGAGTTGCTTTTGAAATCAGAAAGTCAGTGCAGGGTTGTAGTGTTGATGGGCTCTACTTCTGATCTTGGTCACTGTGAAAAAATCAAGAAGGCCTGTGGAAATTTTGGCATTCCATGTGAACTTCGAGTAACATCTGCGCATAAAGGACCAGATGAAACTCTGAGGATTAAAGCTGAGTATGAAGGGGATGGCATTCCTACTGTATTTGTGGCAGTGGCAGGCAGAAGTAATGGTTTGGGACCAGTGATGTCTGGGAACACTGCATATCCAGTTATCAGCTGTCCTCCCCTCACACCAGACTGGGGAGTTCAGGATGTGTGGTCTTCTCTTCGACTACCCAGTGGTCTTGGCTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGATATTTGGGTTAAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAATCAGAGAATGTAATTTATAA

PAICS encodes a bifunctional enzyme with both phosphoribosylaminoimidazole-succinocarboxamide synthase and phosphoribosylaminoimidazole carboxylase activities. Its heterologous expression from human sources in Escherichia coli increases flux through the purine pathway and inosine monophosphate (IMP) titers, but also results in hypoxanthine accumulation [341].

Synonyms: ADE2, ADE2H1, AIRC, PAICSD, PAIS
Gene size:
Protein size:
Reactions R1103 and R327
Compounds affected IMP

Databases
EraGene: 2197902