crp

Escherichia coli

Sequence

                atgGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAAGAGCACGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAGACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGCCAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGATTCAGGTAAACCCGGACATTCTGATGCGTTTGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCAACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAATCTGGCAAAACAACCAGACGCTATGACTCACCCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATTGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCATTCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGTtaa

The cyclic AMP receptor protein (CRP) is a global transcriptional regulator that mediates carbon catabolite repression by inhibiting the expression of genes involved in the utilization of alternative carbon sources when glucose is available. The mutant allele crp⁎ encodes a cyclic AMP–independent variant of CRP that alleviates catabolite repression, resulting in constitutive expression of transport and metabolic genes for alternative sugars. Consequently, engineered Escherichia coli strains harboring crp⁎ can simultaneously uptake and metabolize glucose and secondary carbon sources, thereby eliminating diauxic growth. [361]

`Gene size:`
`Protein size:`
`Compounds affected`	L-valine , xylitol and L-homoserine

Databases

`EraGene:`	2197687
`KEGG:`	eco:b3357