nuoI

Escherichia coli

Sequence

                atgACCTTAAAAGAATTGTTAGTAGGTTTCGGCACCCAGGTTCGTAGTATCTGGATGATCGGCCTGCACGCGTTCGCCAAACGCGAAACGCGAATGTACCCGGAAGAGCCGGTCTATCTGCCGCCCCGTTATCGTGGTCGTATCGTTCTGACCCGCGACCCGGACGGCGAAGAGCGTTGCGTAGCCTGTAACCTCTGCGCGGTAGCCTGCCCGGTCGGCTGTATCTCGCTGCAAAAAGCAGAAACCAAAGACGGTCGCTGGTACCCGGAATTTTTCCGCATCAACTTCTCACGCTGCATTTTCTGTGGTCTGTGCGAAGAAGCCTGTCCGACCACGGCGATTCAGTTAACCCCGGATTTCGAAATGGGGGAATACAAGCGCCAGGATCTGGTTTACGAGAAAGAGGATCTGCTGATCTCCGGTCCGGGCAAATACCCGGAATATAACTTCTACCGGATGGCAGGTATGGCAATCGACGGCAAAGATAAGGGCGAAGCAGAGAACGAAGCCAAGCCTATCGACGTCAAGAGCCTGTTACCGtaa

The nuo genes encode NADH dehydrogenase I (NDH-1), a 13-subunit enzyme complex in Escherichia coli that transfers electrons from NADH to the quinone pool while generating a proton motive force, with a stoichiometry of two protons translocated per electron transferred (H⁺/e⁻ = 2). Inactivation of NDH-1, as in Δnuo mutants, increases the intracellular NADH/NAD⁺ ratio, shifts energy metabolism toward substrate-level phosphorylation, and improves the production of reduced metabolites such as 2,3-butanediol and isobutanol [356].

`Gene size:`
`Protein size:`
`Reactions`	R6528 and R00893
`Compounds affected`	L-histidine , isobutanol and (R,R)-2,3-butanediol

Databases

`EraGene:`	2197894
`KEGG:`	eco:b2281