Escherichia coli PA124

Ancestors

All strains

Escherichia coli K12

Escherichia coli W1485

Escherichia coli MG1655

Escherichia coli PA100

Escherichia coli PA101

Escherichia coli PA102

Escherichia coli PA103

Escherichia coli PA104

Escherichia coli PA105

Escherichia coli PA107

Escherichia coli PA111

Escherichia coli PA112

Escherichia coli PA113

Escherichia coli PA116

Escherichia coli PA117

Escherichia coli PA119

Escherichia coli PA124

Genotype with respect to parental

ΔsthA

Genotype with respect to wild type

F⁺ (λ) | λ- | F- λ- ilvG- rfb-50 rph-1 | Grows vigorously in the presence of β-alanine | ilvG :: P_M1-93-alsS_cgl, panBC :: PM1-93-panBC | Δglk | ΔavtA | Replacing the start codon of ilvE from ATG to GTG | ΔldhA | ΔpoxB | gltA :: P_fliC-gltA | yjiP :: panBC | thrW :: panBC | ykgH :: PM1-93-ilvD | ypjC :: P_M1-93-panE | gapC :: gapC_cac | ΔsthA

Bars (|) indicate differences between strains.

Modifications

Gene	Organism	Modification
sthA	Escherichia coli	Silencing

Production

Metabolites	Heterologous	Production type	Production	Biomass	Carbon source	Time	Scale	Ref.
(R)-pantothenate		Titer	3.569 g/L ^*		Glucose	48 h ^*	Flask	[ 233 ]
(R)-pantothenate		Titer	3.74 g/L ^*		Glucose	60 h ^*	Flask	[ 233 ]

* Inferred from plots using RetroPlot.

References

Fuqiang Song, Zhijie Qin, Kun Qiu, Zhongshi Huang, Lian Wang, Heng Zhang, Xiaoyu Shan, Hao Meng, Xirong Liu & Jingwen Zhou (2024). Development of a vitamin B5 hyperproducer in Escherichia coli by multiple metabolic engineering. Metabolic Engineering.