ldhA

Escherichia coli

Sequence

                ATGAAACTCGCCGTTTATAGCACAAAACAGTACGACAAGAAGTACCTGCAACAGGTGAACGAGTCCTTTGGCTTTGAGCTGGAATTTTTTGACTTTCTGCTGACGGAAAAAACCGCTAAAACTGCCAATGGCTGCGAAGCGGTATGTATTTTCGTAAACGATGACGGCAGCCGCCCGGTGCTGGAAGAGCTGAAAAAGCACGGCGTTAAATATATCGCCCTGCGCTGTGCCGGTTTCAATAACGTCGACCTTGACGCGGCAAAAGAACTGGGGCTGAAAGTAGTCCGTGTTCCAGCCTATGATCCAGAGGCCGTTGCTGAACACGCCATCGGTATGATGATGACGCTGAACCGCCGTATTCACCGCGCGTATCAGCGTACCCGTGATGCTAACTTCTCTCTGGAAGGTCTGACCGGCTTTACTATGTATGGCAAAACGGCAGGCGTTATCGGTACCGGTAAAATCGGTGTGGCGATGCTGCGCATTCTGAAAGGTTTTGGTATGCGTCTGCTGGCGTTCGATCCGTATCCAAGTGCAGCGGCGCTGGAACTCGGTGTGGAGTATGTCGATCTGCCAACCCTGTTCTCTGAATCAGACGTTATCTCTCTGCACTGCCCGCTGACACCGGAAAACTATCATCTGTTGAACGAAGCCGCCTTCGAACAGATGAAAAATGGCGTGATGATCGTCAATACCAGTCGCGGTGCATTGATTGATTCTCAGGCAGCAATTGAAGCGCTGAAAAATCAGAAAATTGGTTCGTTGGGTATGGACGTGTATGAGAACGAACGCGATCTATTCTTTGAAGATAAATCCAACGACGTGATCCAGGATGACGTATTCCGTCGCCTGTCTGCCTGCCACAACGTGCTGTTTACCGGGCACCAGGCATTCCTGACAGCAGAAGCTCTGACCAGTATTTCTCAGACTACGCTGCAAAACTTAAGCAATCTGGAAAAAGGCGAAACCTGCCCGAACGAACTGGTTTAA

The ldhA gene encodes lactate dehydrogenase [353, 344], an enzyme responsible for lactate formation and native NAD⁺ regeneration [353]. Deletion of ldhA eliminates competing fermentative pathways [353] and facilitates the use of alternative metabolites, such as butyrate, as final electron acceptors [353], while also serving as a strategy to reduce lactic acid by-product formation [344].

`Gene size:`
`Protein size:`
`Reactions`	R504
`Compounds affected`	trans-aconitate , (S)-malate , (-)-patchoulol , succinate , L-aspartate , (R,R)-2,3-butanediol , L-leucine , L-tyrosine , glycolate , ectoine , L-homoserine , (R)-pantothenate , N-acetyl-L-glutamate , 3-methyl-2-oxobutanoate , L-alanine , butanoate , 1,5-pentanediol , (4S)-limonene , pyruvate , L-valine , L-arginine , (S)-lactate , β-alanine and isobutanol

Databases

`EraGene:`	2111308
`UniProt:`	P52643
`KEGG:`	eco:b1380