prsA

Escherichia coli

Sequence

                GTGCCTGATATGAAGCTTTTTGCTGGTAACGCCACCCCGGAACTAGCACAACGTATTGCCAACCGCCTGTACACTTCACTCGGCGACGCCGCTGTAGGTCGCTTTAGCGATGGCGAAGTCAGCGTACAAATTAATGAAAATGTACGCGGTGGTGATATTTTCATCATCCAGTCCACTTGTGCCCCTACTAACGACAACCTGATGGAATTAGTCGTTATGGTTGATGCCCTGCGTCGTGCTTCCGCAGGTCGTATCACCGCTGTTATCCCCTACTTTGGCTATGCGCGCCAGGACCGTCGCGTCCGTTCCGCTCGTGTACCAATCACTGCGAAAGTGGTTGCAGACTTCCTCTCCAGCGTCGGTGTTGACCGTGTGCTGACAGTGGATCTGCACGCTGAACAGATTCAGGGTTTCTTCGACGTTCCGGTTGATAACGTATTTGGTAGCCCGATCCTGCTGGAAGACATGCTGCAGCTGAATCTGGATAACCCAATTGTGGTTTCTCCGGACATCGGCGGCGTTGTGCGTGCCCGCGCTATCGCTAAGCTGCTGAACGATACCGATATGGCAATCATCGACAAACGTCGTCCGCGTGCGAACGTTTCACAGGTGATGCATATCATCGGTGACGTTGCAGGTCGTGACTGCGTACTGGTCGATGATATGATCGACACTGGCGGTACGCTGTGTAAAGCTGCTGAAGCTCTGAAAGAACGTGGTGCTAAACGTGTATTTGCGTACGCGACTCACCCGATCTTCTCTGGCAACGCGGCGAACAACCTGCGTAACTCTGTAATTGATGAAGTCGTTGTCTGCGATACCATTCCGCTGAGCGATGAAATCAAATCACTGCCGAACGTGCGTACTCTGACCCTGTCAGGTATGCTGGCCGAAGCGATTCGTCGTATCAGCAACGAAGAATCGATCTCTGCCATGTTCGAACACTAA

prs encodes phosphoribosyl pyrophosphate synthetase (Prs), which catalyzes the formation of 5-phospho-α-D-ribose-1-diphosphate (PRPP) from ribose-5-phosphate (R5P) and ATP, a key precursor in purine biosynthesis [340, 341]. Prs is feedback-inhibited by Mg-ADP, thereby coupling PRPP synthesis to the cellular energy status. In metabolic engineering, the feedback-insensitive prs^D128A allele is employed to relieve this inhibition and increase PRPP availability [341].

`Synonyms:`	prs
`Gene size:`
`Protein size:`
`Reactions`	R115
`Compounds affected`	xanthine , uridine , IMP , hypoxanthine , L-tryptophan , β-nicotinamide D-ribonucleotide , L-histidine and riboflavin

Databases

`EraGene:`	2111904
`UniProt:`	P0A717
`KEGG:`	eco:b1207