Escherichia coli PA106

Ancestors

All strains

Escherichia coli K12

Escherichia coli W1485

Escherichia coli MG1655

Escherichia coli PA100

Escherichia coli PA101

Escherichia coli PA102

Escherichia coli PA103

Escherichia coli PA104

Escherichia coli PA105

Escherichia coli PA106

Genotype with respect to parental

Δpta

Genotype with respect to wild type

F⁺ (λ) | λ- | F- λ- ilvG- rfb-50 rph-1 | Grows vigorously in the presence of β-alanine | ilvG :: P_M1-93-alsS_cgl, panBC :: PM1-93-panBC | Δglk | ΔavtA | Replacing the start codon of ilvE from ATG to GTG | ΔldhA | Δpta

Bars (|) indicate differences between strains.

Modifications

Gene	Organism	Modification
pta	Escherichia coli	Silencing

Production

Metabolites	Heterologous	Production type	Production	Biomass	Carbon source	Time	Scale	Ref.
(R)-pantothenate		Titer	0.26 g/L	16.74 OD₆₀₀^*	Glucose	48 h	Flask	[ 233 ]
(R)-pantothenate		Biomass-specific productivity	0.033 g/L/OD₆₀₀ ^*	16.74 OD₆₀₀^*	Glucose		Flask	[ 233 ]
acetate		Titer	1.52 g/L ^*		Glucose	60 h ^*	Flask	[ 233 ]

* Inferred from plots using RetroPlot.

References

Fuqiang Song, Zhijie Qin, Kun Qiu, Zhongshi Huang, Lian Wang, Heng Zhang, Xiaoyu Shan, Hao Meng, Xirong Liu & Jingwen Zhou (2024). Development of a vitamin B5 hyperproducer in Escherichia coli by multiple metabolic engineering. Metabolic Engineering.