acs

Escherichia coli

Sequence

                ATGAGCCAAATTCACAAACACACCATTCCTGCCAACATCGCAGACCGTTGCCTGATAAACCCTCAGCAGTACGAGGCGATGTATCAACAATCTATTAACGTACCTGATACCTTCTGGGGCGAACAGGGAAAAATTCTTGACTGGATCAAACCTTACCAGAAGGTGAAAAACACCTCCTTTGCCCCCGGTAATGTGTCCATTAAATGGTACGAGGACGGCACGCTGAATCTGGCGGCAAACTGCCTTGACCGCCATCTGCAAGAAAACGGCGATCGTACCGCCATCATCTGGGAAGGCGACGACGCCAGCCAGAGCAAACATATCAGCTATAAAGAGCTGCACCGCGACGTCTGCCGCTTCGCCAATACCCTGCTCGAGCTGGGCATTAAAAAAGGTGATGTGGTGGCGATTTATATGCCGATGGTGCCGGAAGCCGCGGTTGCGATGCTGGCCTGCGCCCGCATTGGCGCGGTGCATTCGGTGATTTTCGGCGGCTTCTCGCCGGAAGCCGTTGCCGGGCGCATTATTGATTCCAACTCACGACTGGTGATCACTTCCGACGAAGGTGTGCGTGCCGGGCGCAGTATTCCGCTGAAGAAAAACGTTGATGACGCGCTGAAAAACCCGAACGTCACCAGCGTAGAGCATGTGGTGGTACTGAAGCGTACTGGCGGGAAAATTGACTGGCAGGAAGGGCGCGACCTGTGGTGGCACGACCTGGTTGAGCAAGCGAGCGATCAGCACCAGGCGGAAGAGATGAACGCCGAAGATCCGCTGTTTATTCTCTACACCTCCGGTTCTACCGGTAAGCCAAAAGGTGTGCTGCATACTACCGGCGGTTATCTGGTGTACGCGGCGCTGACCTTTAAATATGTCTTTGATTATCATCCGGGTGATATCTACTGGTGCACCGCCGATGTGGGCTGGGTGACCGGACACAGTTACTTGCTGTACGGCCCGCTGGCCTGCGGTGCGACCACGCTGATGTTTGAAGGCGTACCCAACTGGCCGACGCCTGCCCGTATGGCGCAGGTGGTGGACAAGCATCAGGTCAATATTCTCTATACCGCACCCACGGCGATCCGCGCGCTGATGGCGGAAGGCGATAAAGCGATCGAAGGCACCGACCGTTCGTCGCTGCGCATTCTCGGTTCCGTGGGCGAGCCAATTAACCCGGAAGCGTGGGAGTGGTACTGGAAAAAAATCGGCAACGAGAAATGTCCGGTGGTCGATACCTGGTGGCAGACCGAAACCGGCGGTTTCATGATCACCCCGCTGCCTGGCGCTACCGAGCTGAAAGCCGGTTCGGCAACACGTCCGTTCTTCGGCGTGCAACCGGCGCTGGTCGATAACGAAGGTAACCCGCTGGAGGGGGCCACCGAAGGTAGCCTGGTAATCACCGACTCCTGGCCGGGTCAGGCGCGTACGCTGTTTGGCGATCACGAACGTTTTGAACAGACCTACTTCTCCACCTTCAAAAATATGTATTTCAGCGGCGACGGCGCGCGTCGCGATGAAGATGGCTATTACTGGATAACCGGGCGTGTGGACGACGTGCTGAACGTCTCCGGTCACCGTCTGGGGACGGCAGAGATTGAGTCGGCGCTGGTGGCGCATCCGAAGATTGCCGAAGCCGCCGTAGTAGGTATTCCGCACAATATTAAAGGTCAGGCGATCTACGCCTACGTCACGCTTAATCACGGGGAGGAACCGTCACCAGAACTGTACGCAGAAGTCCGCAACTGGGTGCGTAAAGAGATTGGCCCGCTGGCGACGCCAGACGTGCTGCACTGGACCGACTCCCTGCCTAAAACCCGCTCCGGCAAAATTATGCGCCGTATTCTGCGCAAAATTGCGGCGGGCGATACCAGCAACCTGGGCGATACCTCGACGCTTGCCGATCCTGGCGTAGTCGAGAAGCTGCTTGAAGAGAAGCAGGCTATCGCGATGCCATCGTAA

The acs gene encodes acetyl CoA synthase from Escherichia coli, which converts acetate to acetyl CoA in an ATP dependent reaction [349, 359]. Overexpression of acs increased intracellular malonyl CoA levels [349, 359], and its coexpression with acetyl CoA carboxylase further enhanced malonyl CoA availability in engineered strains [359].

`Gene size:`
`Protein size:`
`Reactions`	R946 and R1142
`Compounds affected`	L-threonine , β-alanine , curcumin , L-tryptophan , (2S)-eriodictyol , L-arginine , L-aspartate , malonyl-CoA , N-acetyl-L-glutamate and riboflavin

Databases

`EraGene:`	2111784
`UniProt:`	P27550
`KEGG:`	eco:b4069
`KEGG:`	eco:b4069