tyrA

Escherichia coli

Sequence

                ATGGTTGCTGAATTGACCGCATTACGCGATCAAATTGATGAAGTCGATAAAGCGCTGCTGAATTTATTAGCGAAGCGTCTGGAACTGGTTGCTGAAGTGGGCGAGGTGAAAAGCCGCTTTGGACTGCCTATTTATGTTCCGGAGCGCGAGGCATCTATGTTGGCCTCGCGTCGTGCAGAGGCGGAAGCTCTGGGTGTACCGCCAGATCTGATTGAGGATGTTTTGCGTCGGGTGATGCGTGAATCTTACTCCAGTGAAAACGACAAAGGATTTAAAACACTTTGTCCGTCACTGCGTCCGGTGGTTATCGTCGGCGGTGGCGGTCAGATGGGACGCCTGTTCGAGAAGATGCTGACCCTCTCGGGTTATCAGGTGCGGATTCTGGAGCAACATGACTGGGATCGAGCGGCTGATATTGTTGCCGATGCCGGAATGGTGATTGTTAGTGTGCCAATCCACGTTACTGAGCAAGTTATTGGCAAATTACCGCCTTTACCGAAAGATTGTATTCTGGTCGATCTGGCATCAGTGAAAAATGGGCCATTACAGGCCATGCTGGTGGCGCATGATGGTCCGGTGCTGGGGCTACACCCGATGTTCGGTCCGGACAGCGGTAGCCTGGCAAAGCAAGTTGTGGTCTGGTGTGATGGACGTAAACCGGAAGCATACCAATGGTTTCTGGAGCAAATTCAGGTCTGGGGCGCTCGGCTGCATCGTATTAGCGCCGTCGAGCACGATCAGAATATGGCGTTTATTCAGGCACTGCGCCACTTTGCTACTTTTGCTTACGGGCTGCACCTGGCAGAAGAAAATGTTCAGCTTGAGCAACTTCTGGCGCTCTCTTCGCCGATTTACCGCCTTGAGCTGGCGATGGTCGGGCGACTGTTTGCTCAGGATCCGCAGCTTTATGCCGACATCATTATGTCGTCAGAGCGTAATCTGGCGTTAATCAAACGTTACTATAAGCGTTTCGGCGAGGCGATTGAGTTGCTGGAGCAGGGCGATAAGCAGGCGTTTATTGACAGTTTCCGCAAGGTGGAGCACTGGTTCGGCGATTACGCACAGCGTTTTCAGAGTGAAAGCCGCGTGTTATTGCGTCAGGCGAATGACAATCGCCAGTAA

The tyrA gene encodes a bifunctional chorismate mutase/prephenate dehydrogenase that catalyzes the first two steps of L-tyrosine biosynthesis through distinct catalytic domains, converting chorismate to 4-hydroxyphenylpyruvate via the intermediate prephenate [342, 343, 351]. Both enzymatic activities are subject to feedback inhibition by L-tyrosine [342]. As a rate-limiting step in tyrosine biosynthesis, expression of feedback-resistant variants (tyrA^fbr) has been widely used to increase intracellular tyrosine availability and enhance the production of tyrosine-derived metabolites, including flavonoids, in engineered Escherichia coli [351, 360]. One example of a tyrA^fbr variant is the M53I/A354V mutant [342]. In addition, tyrA transcription is repressed by the TyrR regulator [343].

`Gene size:`
`Protein size:`
`Reactions`	R727 and R69
`Compounds affected`	L-tyrosine , rosin , dopamine , L-dopa , 4-tyrosol , genkwanin , L-tryptophan , avenanthramide D , cinnamyl alcohol , L-phenylalanine and L-(-)-3-Phenyllactic acid

Databases

`EraGene:`	2111234
`UniProt:`	P07023
`KEGG:`	eco:b2600