Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for β-alanine

Modifications
Strain Maximum production panDBs aspCEc ppcCg pykAEc pykFEc mdhEc aspAEc aspDHRe AspDHPa aspDHDs gdhAEc rocGBs galREc ptsGEc glkEc frdAEc frdBEc frdCEc frdDEc panDCg panDEc iclREc fumCEc fumAEc fumBEc ppcEc ADCBt thrAEc metLEc lysCEc sdhCEc sdhAEc sdhBEc pycCg ldhAEc pflBEc ptaEc adhEEc
E. coli BW25113/F' 0 mg/L
E. coli W3110/pTac15kPE 0 mg/L
E. coli CWF4N/pTac15kPC 0 mg/L
E. coli XB00 122.94972 mg/L
E. coli W3110/pTac15kPC 299 mg/L
E. coli CWF4NA/pTac15kPAC 300 mg/L
E. coli XB01 807.19164 mg/L
E. coli PldhA-PadcRBS-BtADC 820 mg/L
E. coli CWF4NA/pTac15kPC 855 mg/L
E. coli XD11-2 873.1212 mg/L
E. coli XB11 892.72188 mg/L
E. coli XB02 909.64974 mg/L
E. coli PldhA-Pt7RBS-BtADC 930 mg/L
E. coli XD11-3 1,129.71192 mg/L
E. coli XD11-1 1,251.7707 mg/L
E. coli Padc-PadcRBS-BtADC 1,320 mg/L
E. coli PadcPt7RBS-BtADC 1,410 mg/L
E. coli CWF4NA/pTac15kPC/pSynPPC1 1,450 mg/L
E. coli CWF4NA/pTac15kPRA/pSynPPC1 1,630 mg/L
E. coli PpET28am-PadcRBS-BtADC 1,800 mg/L
E. coli PpET28am-Pt7RBS-BtADC 2,340 mg/L
E. coli FZβA-1 2,760 mg/L
E. coli XBG11 2,866.15398 mg/L
E. coli FZβA-2 3,390 mg/L
E. coli CWF4NA/pTac15kPTA/pSynPPC1 3,490 mg/L
E. coli CWF4NA/pTac15kPTA/pSynPPC7 3,940 mg/L
E. coli XBR11 4,299.67644 mg/L
E. coli FZβA-4 4,430 mg/L
E. coli XBR27 5,624.50422 mg/L
E. coli FZβA-5 5,820 mg/L
E. coli XBR21 5,830.31136 mg/L
E. coli XBR22 6,395.16732 mg/L
E. coli FZβA-6 8,710 mg/L
E. coli FZβA-7 9,220 mg/L
E. coli FZβA-7-28am 9,220 mg/L
E. coli FZβA-8 12,320 mg/L
E. coli FZβA-9 18,210 mg/L
E. coli FZβA-10 24,510 mg/L

Titer in Fed-Batch for β-alanine

Modifications
Strain Maximum production ppcCg pykAEc pykFEc mdhEc frdAEc frdBEc frdCEc frdDEc aspAEc galREc ptsGEc glkEc panDBs aspCEc rocGBs ADCTc acsEc pckAMs iclREc fumCEc fumAEc fumBEc panDCg ppcEc
E. coli CWF4NA/pTac15kPTA/pSynPPC7 20,100 mg/L
E. coli CWF4NA2/pTac15kPTA/pSynPPC7 32,300 mg/L
E. coli XBR22 32,786.592 mg/L
E. coli XBR41 37,775.856 mg/L

Substrate yield in Flask for β-alanine

Modifications
Strain Maximum production ppcCg pykAEc pykFEc mdhEc aspAEc panDBs aspCEc rocGBs galREc ptsGEc glkEc frdAEc frdBEc frdCEc frdDEc iclREc fumCEc fumAEc fumBEc panDCg ppcEc
E. coli CWF4NA/pTac15kPTA/pSynPPC7 0.25 g/g of sustrate
E. coli XBR11 0.39068 g/g of sustrate
E. coli XBR21 0.6429 g/g of sustrate
E. coli XBR22 0.71213 g/g of sustrate

Substrate yield in Fed-Batch for β-alanine

Modifications
Strain Maximum production ppcCg pykAEc pykFEc mdhEc rocGBs aspAEc galREc ptsGEc glkEc frdAEc frdBEc frdCEc frdDEc ADCTc acsEc pckAMs panDBs aspCEc iclREc fumCEc fumAEc fumBEc panDCg ppcEc
E. coli CWF4NA2/pTac15kPTA/pSynPPC7 0.135 g/g of sustrate
E. coli XBR41 0.4253 g/g of sustrate

Volumetric productivity in Fed-Batch for β-alanine

Modifications
Strain Maximum production iclREc fumCEc fumAEc fumBEc ptsGEc aspAEc panDCg ppcEc acsEc ADCBt thrAEc metLEc lysCEc AspDHPa aspCEc gdhAEc pycCg ldhAEc pflBEc ptaEc adhEEc
E. coli CWF4NA/pTac15kPTA/pSynPPC7 457 mg/L/h
E. coli CWF4NA2/pTac15kPTA/pSynPPC7 828 mg/L/h
E. coli FZβA-10 890 mg/L/h